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1. 发明申请

US20080221139A1 Novel Compounds 失效
标题翻译：新型化合物
公开(公告)号：US20080221139A1
公开(公告)日：2008-09-11
申请号：US11946517
申请日：2007-11-28
申请人： David Chapman , Balint Gabos , Magnus Munck af Rosenschold
发明人： David Chapman , Balint Gabos , Magnus Munck af Rosenschold
IPC分类号： C07D403/12 , A61K31/506 , A61P11/00 , A61P25/00 , A61P19/02
CPC分类号： C07D403/12 , C07D239/34
摘要： The invention provides compounds of formula (I): wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
摘要翻译：本发明提供式（I）化合物：其中R 1和R 2如说明书中所定义; 其准备过程; 含有它们的药物组合物制备药物组合物的方法; 及其在治疗中的应用。该化合物可用作MMP抑制剂。

2. 发明授权

US08183251B2 Hydantoin compounds and pharmaceutical compositions thereof 失效
标题翻译：乙内酰脲化合物及其药物组合物
公开(公告)号：US08183251B2
公开(公告)日：2012-05-22
申请号：US11946517
申请日：2007-11-28
申请人： David Chapman , Balint Gabos , Magnus Munck af Rosenschöld
发明人： David Chapman , Balint Gabos , Magnus Munck af Rosenschöld
IPC分类号： C07D403/12 , C07D239/34 , A61K31/506
CPC分类号： C07D403/12 , C07D239/34
摘要： The invention provides compounds of formula (I): wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
摘要翻译：本发明提供式（I）化合物：其中R1和R2如说明书中所定义; 其准备过程; 含有它们的药物组合物; 制备药物组合物的方法; 及其在治疗中的应用。该化合物可用作MMP抑制剂。

3. 发明申请

US20120232101A1 Novel Compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20120232101A1
公开(公告)日：2012-09-13
申请号：US13416510
申请日：2012-03-09
申请人： David Chapman , Balint Gabos , Magnus Munck af Rosenschöld
发明人： David Chapman , Balint Gabos , Magnus Munck af Rosenschöld
IPC分类号： A61K31/513 , A61P9/00 , C07D403/12
CPC分类号： C07D403/12 , C07D239/34
摘要： The invention provides compounds of formula (I): wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
摘要翻译：本发明提供式（I）化合物：其中R1和R2如说明书中所定义; 其准备过程; 含有它们的药物组合物; 制备药物组合物的方法; 及其在治疗中的应用。该化合物可用作MMP抑制剂。

4. 发明授权

US09566887B2 Seat cover, maintenance kit, and vehicle 有权
标题翻译：座椅盖，维护套件和车辆
公开(公告)号：US09566887B2
公开(公告)日：2017-02-14
申请号：US14382209
申请日：2013-03-01
申请人： David Chapman
发明人： David Chapman
IPC分类号： B60N2/60 , B60N2/58
CPC分类号： B60N2/6018 , B60N2/5816 , B60N2/6027 , B60N2/6054 , B60N2/6063
摘要： A seat cover, maintenance kit, and vehicle A removable seat cover for a seat of a vehicle, the removable seat cover comprising: a first (1A) and a second (IB) portion; a first coupling arrangement (14) configured to couple the first and second portions of the seat cover; at least one attachment arrangement (9) configured to fit the seat cover with respect to a seat of a vehicle, wherein the first coupling arrangement is configured such that the decoupling of the attachment arrangement permits the first and second portions of the seat cover to be moved with respect to each other whilst the seat cover is substantially fitted with respect to the seat.
摘要翻译：一种座椅盖，维护套件和车辆一种用于车辆座椅的可移动座椅罩，所述可移动座椅盖包括：第一（1A）和第二（IB）部分; 第一联接装置（14），其构造成联接所述座椅盖的第一和第二部分; 至少一个附接装置（9），其被配置成相对于车辆座椅安装所述座椅盖，其中所述第一联接装置构造成使得所述附接装置的所述解耦允许所述座椅盖的所述第一和第二部分为当座椅盖相对于座椅基本上配合时相对于彼此移动。

5. 发明授权

US07313041B1 Sense amplifier circuit and method 失效
标题翻译：感应放大器电路及方法
公开(公告)号：US07313041B1
公开(公告)日：2007-12-25
申请号：US10870289
申请日：2004-06-16
申请人： David Chapman , Richard Parent
发明人： David Chapman , Richard Parent
IPC分类号： G11C7/02
CPC分类号： G11C7/065 , G11C7/04 , G11C7/08 , G11C11/406 , G11C11/40615 , G11C11/40626 , G11C11/4091 , G11C2207/065 , G11C2211/4067
摘要： A semiconductor device memory device (300) can include a sense amplifier (302) enabled according to a first sense signal (setn) and a second sense signal (setp). In a sense operation, a first sense signal (setn) can be driven to a first, below ground potential. Subsequently, in the same sense operation, the first sense signal (setn) can be raised and maintained at a ground potential. Such an approach can substantially eliminate a sense amplifier stall condition that can occur under low temperature and/or low voltage operation. According to another aspect of the embodiments, a more negative logical “0” value can be written back into the memory cell during an access and/or refresh operation. This more negative value is available due to the below ground level provided during a sense operation.
摘要翻译：半导体器件存储器件（300）可以包括根据第一感测信号（setn）使能的读出放大器（302）和第二感测信号（setp）。在感测操作中，第一感测信号（setn）可以被驱动到第一低于地电势。随后，在相同的感测操作中，可以提高第一感测信号（setn）并将其保持在接地电位。这种方法可以基本上消除在低温和/或低电压操作下可能发生的读出放大器失速状态。根据实施例的另一方面，在访问和/或刷新操作期间可以将更负的逻辑“0”值写回到存储器单元中。由于在感测操作期间提供的地面水平较低，因此可以获得更多的负值。

6. 发明申请

US20070236049A1 MODULAR ASSEMBLY FOR A VEHICLE 审中-公开
标题翻译：车辆模块化组装
公开(公告)号：US20070236049A1
公开(公告)日：2007-10-11
申请号：US11692285
申请日：2007-03-28
申请人： David Chapman , Luis Lorenzo , Keith Kauffman , Ashish Kotnis
发明人： David Chapman , Luis Lorenzo , Keith Kauffman , Ashish Kotnis
IPC分类号： B60J7/00
CPC分类号： B62D29/001 , B60R19/24 , B62D25/087 , B62D29/005
摘要： There is disclosed a modular assembly and method of forming the assembly. The assembly is particularly suitable as at least part of a rear end of a transportation or automotive vehicle. The assembly preferably includes one or more plastic structure adhesively secured to one or more metal structures.
摘要翻译：公开了一种组件的组装和组装方法。该组件特别适用于运输或机动车辆的后端的至少一部分。组件优选地包括粘合地固定到一个或多个金属结构的一个或多个塑料结构。

7. 发明申请

US20070107651A1 TRANSITION DEVICE FOR COUPLED METAL FRAMES 有权
标题翻译：用于耦合金属框架的过渡装置
公开(公告)号：US20070107651A1
公开(公告)日：2007-05-17
申请号：US11560068
申请日：2006-11-15
申请人： Ernest Smith , David Chapman
发明人： Ernest Smith , David Chapman
IPC分类号： B63B17/02
CPC分类号： B63B17/00
摘要： A transition device for providing a smooth corner of a pair of angular oriented interconnected windshields on a boat, the boat having a forward facing or front windshield and a side facing windshield, both the windshields being mounted in a formed aluminum molding. The transition device comprises a first element attached to the molding of the forward facing windshield at an upper end of the joint and terminating at the joint in a ball and a second element attached to the molding of the side facing windshield at the upper end of the joint and terminating in a socket. The ball and the socket are shaped and sized to fit together to form a smooth transition at the upper end of the joint so that the corner joint appears to have a ball and socket joint.
摘要翻译：一种过渡装置，用于在船上提供一对角度定向的相互连接的挡风玻璃的平滑角，所述船具具有前向或前挡风玻璃和面向挡风玻璃的侧面，所述挡风玻璃都安装在成形的铝模制件中。过渡装置包括在接头的上端处附接到朝前挡风玻璃的模制件的第一元件，并且终止于球的接头处，并且第二元件附接到在侧面挡风玻璃的上端的侧面挡风玻璃的模制件连接并终止在插座中。球和插座的形状和尺寸被组合在一起以在接头的上端形成平滑的过渡，从而角接头似乎具有球窝接头。

8. 发明授权

US5569581A Alteration and prediction of male fertility using seminal plasma and its components 失效
标题翻译：使用精液等离子体及其组分改变和预测男性生殖力
公开(公告)号：US5569581A
公开(公告)日：1996-10-29
申请号：US154226
申请日：1993-11-17
申请人： Gary Killian , David Chapman , Aida Cancel , Margaret A. Henault
发明人： Gary Killian , David Chapman , Aida Cancel , Margaret A. Henault
IPC分类号： G01N33/68 , C12Q1/00
CPC分类号： G01N33/689 , G01N2800/367 , Y10S435/806
摘要： Two-dimensional polyacrylamide gel electrophoresis of seminal plasma samples indicate that two proteins (26 kDa, pI 6.2; 55 kDa, pI 4.5) predominated in higher fertility bulls and two proteins (16 kDa, pI 4.1; 16 kDa, pI 6.7) predominated in lower fertility bulls. A regression model was developed to predict bull fertility using the four fertility-associated protein densities. A plot of actual bull fertility versus that calculated by this model was linear and positively correlated (r=0.89). These findings indicate that bull seminal plasma contains fertility-associated proteins which are predictive of bull fertility. Additionally, the ability of seminal plasma to alter the in vitro fertility of ejaculated bull sperm was examined using a sperm penetration assay for zona-free bovine oocytes. Washed, ejaculated sperm from bulls of below (low) or above average (high) fertility were mixed with seminal plasma from the same bull, or with seminal plasma from a bull of contrasting fertility. Washed sperm exposed to seminal plasma from high fertility bulls penetrated more oocytes than when those sperm were mixed with seminal plasma from low fertility bulls (p
摘要翻译：精浆血浆样品的二维聚丙烯酰胺凝胶电泳表明，两种蛋白质（26 kDa，pI 6.2; 55 kDa，pI 4.5）在较高生育力公牛和两种蛋白质（16 kDa，pI 4.1; 16 kDa，pI 6.7）中占主导地位较低的生育力公牛。开发了一种回归模型，用四种生育相关蛋白质密度来预测公牛的生育能力。实际公牛生产力与该模型计算的情节呈线性相关（r = 0.89）。这些研究结果表明，牛精液血浆含有生育相关蛋白，可预测公牛的生育能力。另外，使用无精子牛卵母细胞的精子渗透测定法检查了精浆等离子体改变射精公牛精子体外生育能力的能力。从低于（低）或高于平均（高）生育率的公牛洗精，射精精子与来自同一头公牛的精液血浆或与生殖力相反的公牛的精浆混合。冲洗精子暴露于高生育力公牛的精液血浆，渗透更多的卵母细胞比那些精子与低生育力公牛的精浆混合（p <0.01）。混合低生殖力精子与高生育精液血浆相比，低生殖力精子与低生育精液等离子体相比，通常能提高穿透能力。

9. 发明授权

US4177968A Concrete formwork soldier 失效
标题翻译：混凝土模板兵
公开(公告)号：US4177968A
公开(公告)日：1979-12-11
申请号：US828630
申请日：1977-08-29
申请人： David Chapman
发明人： David Chapman
IPC分类号： E04C3/04 , E04C3/07 , E04C3/09 , E04G11/50 , E04G17/14 , E04G17/04 , E04C3/30
CPC分类号： E04C3/07 , E04C3/09 , E04G11/50 , E04G17/14 , E04C2003/0421 , E04C2003/0434 , E04C2003/0473
摘要： An elongate soldier for concrete framework comprising two spaced parallel substantially U-section members interconnected back to back in such a manner as to leave between the members, at least one channel or passage extending along the length of the soldier from each of its ends.
摘要翻译：用于混凝土框架的细长战士包括两个间隔开的平行的大致U形截面构件，其以相互靠近的方式相互背靠背相互连接，至少一个通道或通道沿其长度从其每个端部延伸。

10. 发明授权

US07685545B2 Methods and devices for independent evaluation of cell integrity, changes and origin in chip design for production workflow 有权
标题翻译：用于独立评估细胞完整性，生产工作流程芯片设计中的变化和起源的方法和设备
公开(公告)号：US07685545B2
公开(公告)日：2010-03-23
申请号：US12536413
申请日：2009-08-05
申请人： David Chapman , Thomas Grebinski
发明人： David Chapman , Thomas Grebinski
IPC分类号： G06F17/50
CPC分类号： G06F17/5045 , G06F17/504 , G06F17/5081 , G06F2217/12 , G06F2217/66 , Y02P90/265
摘要： The technology disclosed relates to granular analysis of design data used to prepare chip designs for manufacturing and to identification of similarities and differences among parts of design data files. In particular, it relates to parsing data and organizing into canonical forms, digesting the canonical forms, and comparing digests of design data from different sources, such as designs and libraries of design templates. Organizing the design data into canonical forms generally reduces the sensitivity of data analysis to variations in data that have no functional impact on the design. The details of the granular analysis vary among design languages used to represent aspects of a design. For various design languages, granular analysis includes partitioning design files by header/cell portions, by separate handling of comments, by functionally significant/non-significant data, by whitespace/non-whitespace, and by layer within a unit of design data. The similarities and differences of interest depend on the purpose of the granular analysis. The comparisons are useful in many ways.
摘要翻译：所公开的技术涉及用于制备芯片设计的设计数据的粒度分析以及设计数据文件部分之间的相似性和差异性的识别。具体来说，它涉及数据解析和组织成规范形式，消化规范形式，以及比较不同来源的设计数据的摘要，如设计模板和设计模板库。将设计数据组织成规范形式通常会降低数据分析对数据变化的敏感性，这些变化对设计没有任何功能影响。细粒度分析的细节因用于表示设计方面的设计语言而异。对于各种设计语言，粒度分析包括通过标题/单元部分划分设计文件，通过单独处理注释，功能重要/非重要数据，空白/非空格以及设计数据单位内的图层进行分割。感兴趣的相似点和不同之处取决于粒度分析的目的。比较在许多方面都是有用的。

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