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1. 发明申请

US20050053917A1 Core structure of gp41 from the HIV envelope glycoprotein 失效
标题翻译：来自HIV包膜糖蛋白的gp41的核心结构
公开(公告)号：US20050053917A1
公开(公告)日：2005-03-10
申请号：US10680853
申请日：2003-10-07
申请人： David Chan , Deborah Fass , Min Lu , James Berger , Peter Kim
发明人： David Chan , Deborah Fass , Min Lu , James Berger , Peter Kim
IPC分类号： A61K38/00 , C07K14/16 , C12Q1/70 , A61K38/06 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Described are the crystal structure of the α-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.
摘要翻译：描述了代表融合活性gp41核心的HIV-1包膜糖蛋白的gp41组分的α-螺旋结构域的晶体结构，鉴定和设计抑制gp41功能的药物的方法和这样做的药物的方法。

2. 发明授权

US07402396B2 Core structure of gp41 from the HIV envelope glycoprotein 失效
标题翻译：来自HIV包膜糖蛋白的gp41的核心结构
公开(公告)号：US07402396B2
公开(公告)日：2008-07-22
申请号：US10680853
申请日：2003-10-07
申请人： David C. Chan , Deborah Fass , Min Lu , James M. Berger , Peter S. Kim
发明人： David C. Chan , Deborah Fass , Min Lu , James M. Berger , Peter S. Kim
IPC分类号： G01N33/53
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Described are the crystal structure of the α-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.
摘要翻译：描述了代表融合活性gp41核心的HIV-1包膜糖蛋白的gp41组分的α-螺旋结构域的晶体结构，鉴定和设计抑制gp41功能的药物的方法和这样做的药物的方法。

3. 发明授权

US06506554B1 Core structure of gp41 from the HIV envelope glycoprotein 有权
标题翻译：来自HIV包膜糖蛋白的gp41的核心结构
公开(公告)号：US06506554B1
公开(公告)日：2003-01-14
申请号：US09484925
申请日：2000-01-18
申请人： David C. Chan , Deborah Fass , Min Lu , James M. Berger , Peter S. Kim
发明人： David C. Chan , Deborah Fass , Min Lu , James M. Berger , Peter S. Kim
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Described are the crystal structure of the &agr;-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.
摘要翻译：描述了代表融合活性gp41核心的HIV-1包膜糖蛋白的gp41组分的α-螺旋结构域的晶体结构，鉴定和设计抑制gp41功能的药物的方法和这样做的药物的方法。

4. 发明授权

US6150088A Core structure of gp41 from the HIV envelope glycoprotein 失效
标题翻译：来自HIV包膜糖蛋白的gp41的核心结构
公开(公告)号：US6150088A
公开(公告)日：2000-11-21
申请号：US62241
申请日：1998-04-17
申请人： David C. Chan , Deborah Fass , Min Lu , James M. Berger , Peter S. Kim
发明人： David C. Chan , Deborah Fass , Min Lu , James M. Berger , Peter S. Kim
IPC分类号： A61K38/00 , C07K14/16 , C12Q1/70 , C07K5/00 , C12P21/06
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Described are the crystal structure of the .alpha.-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.
摘要翻译：描述了代表融合活性gp41核心的HIV-1包膜糖蛋白的gp41组分的α-螺旋结构域的晶体结构，鉴定和设计抑制gp41功能的药物的方法和这样做的药物的方法。

5. 发明授权

US11685761B2 Cyclic di-nucleotide compounds as sting agonists 有权
公开(公告)号：US11685761B2
公开(公告)日：2023-06-27
申请号：US16771814
申请日：2018-12-17
申请人： Merck Sharp & Dohme Corp. , Brian M. Andresen , Frank Bennett , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Jongwon Lim , Min Lu , Benjamin Wesley Trotter , Wen-Lian Wu
发明人： Brian M. Andresen , Frank Bennett , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Jongwon Lim , Min Lu , Benjamin Wesley Trotter , Wen-Lian Wu
IPC分类号： C07H21/00 , A61P37/04 , C07H21/02 , A61K31/7084 , C07H21/04
CPC分类号： C07H21/00 , A61K31/7084 , A61P37/04 , C07H21/02 , C07H21/04 , C07B2200/07
摘要： A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

6. 发明申请

US20220259188A1 1-PYRAZOLYL, 5-, 6- DISUBSTITUTED INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 有权
公开(公告)号：US20220259188A1
公开(公告)日：2022-08-18
申请号：US17614732
申请日：2020-06-01
申请人： Hua ZHOU , John J. ACTON, III , Michael J. ARDOLINO , Yi-Heng CHEN , Peter H. FULLER , Anmol GULATI , Rebecca Elizabeth JOHNSON , William P. KAPLAN , Solomon D. KATTAR , Mitchell H. KEYLOR , Derun LI , Kaitlyn Marie LOGAN , Min LU , Gregori J. MORRIELLO , Santhosh F. NEELAMKAVIL , Barbara PIO , Nunzio SCIAMMETTA , Vladimir SIMOV , Jing SU , Luis TORRES , Xin YAN , Merck Sharp & Dohme Corp.
发明人： Hua Zhou , John J. Acton, III , Michael J. Ardolino , Yi-Heng Chen , Peter H. Fuller , Anmol Gulati , Rebecca Elizabeth Johnson , William P. Kaplan , Solomon D. Kattar , Mitchell H. Keylor , Derun Li , Kaitlyn Marie Logan , Min Lu , Gregori J. Morriello , Santhosh F. Neelamkavil , Barbara Pio , Nunzio Sciammetta , Vladimir Simov , Jing Su , Luis Torres , Xin Yan
IPC分类号： C07D405/14 , C07D487/08 , C07D409/14 , C07D403/04 , C07D403/14 , C07D498/04 , C07D498/08 , C07D487/10 , C07D401/14 , C07D471/10 , C07D491/107 , C07D471/04 , C07D487/04 , A61P25/16
摘要： The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

7. 发明授权

US09589009B2 Long-lived data transactions 有权
标题翻译：长期的数据交易
公开(公告)号：US09589009B2
公开(公告)日：2017-03-07
申请号：US13365442
申请日：2012-02-03
申请人： Kanchan Shringi , Min Lu , Xiaopei (Joyce) Zhang , Siemel Naran , Rahim Yaseen , Jon Rexford Degenhardt
发明人： Kanchan Shringi , Min Lu , Xiaopei (Joyce) Zhang , Siemel Naran , Rahim Yaseen , Jon Rexford Degenhardt
IPC分类号： G06F17/30
CPC分类号： G06F17/30371
摘要： In one embodiment, a method includes accessing a mapping that represents a correspondence between a column in a source database and a column in a temporary storage table, in response to receiving a data operation request to execute a data operation on a column of the source database. The method further includes changing the temporary storage table by executing the data operation on the temporary storage table and performing a reconstruction operation using data from the temporary storage table and the source database.
摘要翻译：在一个实施例中，一种方法包括访问表示源数据库中的列与临时存储表中的列之间的对应关系的映射，响应于接收到对源数据库的列执行数据操作的数据操作请求。该方法还包括通过对临时存储表执行数据操作来改变临时存储表，并使用来自临时存储表和源数据库的数据执行重建操作。

8. 发明授权

US08669066B2 Rationale, methods, and assays for identifying human and non-human primate taste specific genes and use thereof in taste modulator and therapeutic screening assays 有权
标题翻译：用于鉴定人和非人灵长类动物味道特异性基因的理由，方法和测定及其在味觉调节剂和治疗性筛选测定中的用途
公开(公告)号：US08669066B2
公开(公告)日：2014-03-11
申请号：US13090335
申请日：2011-04-20
申请人： Bryan Moyer , Albert Zlotnik , Peter Hevezi , Hortensia Soto , Dalia Kalabat , Min Lu , Na Gao , Evan Carl White
发明人： Bryan Moyer , Albert Zlotnik , Peter Hevezi , Hortensia Soto , Dalia Kalabat , Min Lu , Na Gao , Evan Carl White
IPC分类号： G01N33/567 , C12Q1/68 , C07K14/705
CPC分类号： G01N33/566 , C12Q1/6806 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C40B30/04 , C40B40/10 , G01N33/5005 , G01N33/5044 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.
摘要翻译：本发明涉及用于鉴定人类和灵长类动物特异性基因的新的理论和方法，包括涉及咸味感知的基因，特别是人类咸味感知，以及参与甜味，苦味，鲜味和酸味感觉的基因以及基因参与其他味觉细胞或味觉受体相关活性，如消化功能和消化相关疾病，味觉细胞周转，口服和消化道的免疫调节，以及代谢调节，如糖尿病和肥胖症，使用这些方法鉴定的基因和测定用于鉴定使用这些基因的味觉调节剂（增强子或阻断剂）和潜在的治疗剂。这些化合物具有潜在的应用于调节（增强或阻断）味觉，特别是咸味感和作为潜在的疗法。此外，本发明涉及用于鉴定可用作哺乳动物中不同味道细胞类型（包括甜味，苦味，鲜味，酸味，咸味和其他味觉细胞）的标记的味道特异性基因的新方法，以及测量在这些基因存在下甜味，苦味，鲜味或酸性受体的活性，以鉴定甜味，苦味，鲜味和酸味的调节剂，并鉴定治疗剂，特别是用于治疗消化或代谢紊乱，口味丧失和口腔感染。特别地，本文鉴定的基因和其抗体或寡核苷酸可以用作标识物，以通过使用FACS或磁珠细胞选择或其他已知的细胞纯化和分离程序来鉴定和/或纯化特定味细胞，例如来自味细胞悬浮液。

9. 发明授权

US08396445B2 Method to implement E911 services in IMS (IP Multimedia Subsystem) 有权
标题翻译：在IMS（IP多媒体子系统）中实现E911业务的方法
公开(公告)号：US08396445B2
公开(公告)日：2013-03-12
申请号：US12484514
申请日：2009-06-15
申请人： Dwayne Crawford , Richard L. Khan , Min Lu
发明人： Dwayne Crawford , Richard L. Khan , Min Lu
IPC分类号： H04M11/04 , H04W24/00
CPC分类号： H04W4/90 , H04L45/00 , H04L45/306 , H04L65/1016 , H04L65/1069 , H04L65/40 , H04L67/306 , H04M3/42348 , H04M3/5116 , H04M11/04 , H04M2207/18 , H04M2242/04 , H04M2242/15 , H04W4/02 , H04W76/50 , H04W88/18
摘要： A system and method that facilitates processing and/or routing of emergency call in an IMS (IP Multimedia Subsystem) for VoIP (Voice over IP) subscribers is provided. Specifically, an E911 profile is generated, for example, by an application server, for each VoIP subscriber based in part on current location information associated with the subscriber, such as, the subscriber's IP address. The E911 profile is pushed to the HSS (Home Subscriber Server) of the IMS. The E911 profile can then be stored in the HSS and can be queried by an E-CSCF (Emergency Call Session Control Function) during emergency call processing. Moreover, when an emergency call is received from the subscriber, the E-CSCF can retrieve the E911 profile associated with the subscriber from the HSS and route the call to an appropriate PSAP (Public Safety Answering Point) based on an analysis of the information in the E911 profile.
摘要翻译：提供了一种促进用于VoIP（IP语音）用户的IMS（IP多媒体子系统）中的紧急呼叫的处理和/或路由的系统和方法。具体地，例如，由应用服务器，针对每个VoIP用户，部分地基于与用户相关联的当前位置信息（例如用户的IP地址）生成E911简档。 E911配置文件被推送到IMS的HSS（归属订户服务器）。然后可以将E911配置文件存储在HSS中，并在紧急呼叫处理期间通过E-CSCF（紧急呼叫会话控制功能）进行查询。此外，当从用户接收到紧急呼叫时，E-CSCF可以从HSS检索与订户相关联的E911简档，并且基于对该信息的分析将呼叫路由到适当的PSAP（公共安全应答点） E911配置文件。

10. 发明授权

US08369313B2 IMS and method of multiple S-CSCF operation in support of single PUID 有权
标题翻译： IMS和多个S-CSCF操作的方法支持单个PUID
公开(公告)号：US08369313B2
公开(公告)日：2013-02-05
申请号：US12337375
申请日：2008-12-17
申请人： Min Lu , Mark Ratcliffe
发明人： Min Lu , Mark Ratcliffe
IPC分类号： H04L12/66
CPC分类号： H04L29/06217 , H04L65/1016 , H04L65/1073
摘要： A method for providing multimedia services to subscriber user equipment (UE) within an IP multimedia subsystem network (IMS) may include configuring the IMS to enable a single UE to fork register and cooperate with multiple serving-call session control functions (S-CSCFs). After obtaining IP connectivity, the single UE signals to register with the IMS and the IMS determines whether the UE is configured to fork register with multiple S-CSCFs. If the UE is configured, the IMS determines which S-CSCFs are eligible for the UE registration and fork registers the UE to multiple S-CSCFs of the eligible S-CSCFs. Consequently, incoming and outgoing calls to/from the UE are routed by the IMS to any of the multiple registered S-CSCFs.
摘要翻译：用于向IP多媒体子系统网络（IMS）内的用户用户设备（UE）提供多媒体业务的方法可包括配置IMS以使单个UE能够分支注册并与多个服务呼叫会话控制功能（S-CSCF）配合，。在获得IP连接之后，单个UE向IMS注册的信号，IMS确定UE是否被配置为向多个S-CSCF分叉注册。如果UE被配置，IMS确定哪个S-CSCF有资格进行UE注册，并且fork将UE注册到合格的S-CSCF的多个S-CSCF。因此，来往/来自UE的呼入呼叫和呼出呼叫由IMS路由到多个已注册的S-CSCF中的任何一个。

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