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1. 发明申请

US20080200656A1 Use Of Sucrose To Suppress Mannitol-Induced Protein Aggregation 审中-公开
标题翻译：使用蔗糖抑制甘露醇诱导的蛋白质聚集
公开(公告)号：US20080200656A1
公开(公告)日：2008-08-21
申请号：US12032490
申请日：2008-02-15
申请人： David C. Sek , Nicholas W. Warne , Kin Ho , Donna L. Luisi , Angela Kantor
发明人： David C. Sek , Nicholas W. Warne , Kin Ho , Donna L. Luisi , Angela Kantor
IPC分类号： C07K17/02
CPC分类号： A61K9/10 , A61K39/39591 , A61K47/26
摘要： The present invention provides a method for suppressing mannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannitol and sucrose such that the presence of sucrose suppresses mannitol-induced protein aggregation.
摘要翻译：本发明提供了通过向含有蛋白质的液体制剂提供蔗糖来抑制甘露醇诱导的蛋白质聚集的方法。本发明还提供了用于储存和制备含有蛋白质和甘露糖醇和蔗糖的组合的液体制剂的方法，使得蔗糖的存在抑制甘露醇诱导的蛋白质聚集。

2. 发明申请

US20080139792A1 High Protein Concentration Formulations Containing Mannitol 审中-公开
标题翻译：含有甘露醇的高蛋白浓缩配方
公开(公告)号：US20080139792A1
公开(公告)日：2008-06-12
申请号：US11950986
申请日：2007-12-05
申请人： David C. Sek , Kin Ho
发明人： David C. Sek , Kin Ho
IPC分类号： C07K16/00 , C07K2/00
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/19 , A61K39/39591
摘要： The present invention provides a method for inhibiting mannitol-induced aggregation of a protein in a liquid formulation by increasing the protein concentration to an amount greater than 50 mg/ml. The present invention also provides methods for storing and preparing a liquid formulation containing mannitol and a protein concentration greater than 50 mg/ml.
摘要翻译：本发明提供了通过将蛋白质浓度提高到大于50mg / ml的量来抑制甘露醇诱导的液体制剂中的蛋白质聚集的方法。本发明还提供了储存和制备含有甘露醇和蛋白质浓度大于50mg / ml的液体制剂的方法。

3. 发明申请

US20070264055A1 Toner cartridge 有权
标题翻译：墨粉盒
公开(公告)号：US20070264055A1
公开(公告)日：2007-11-15
申请号：US11432289
申请日：2006-05-11
申请人： William Thornton , Michael Kleiter , Kin Ho , Zhi He
发明人： William Thornton , Michael Kleiter , Kin Ho , Zhi He
IPC分类号： G03G15/08
CPC分类号： G03G15/087 , G03G2215/0668
摘要： A toner cartridge including a container body having a discharge opening. A drive transmitting member is fixedly coupled with the container body near the discharge opening. The drive transmitting member is sized and shaped to transmit rotational movement to the container body. A collar is moveably coupled along the container body, and the collar closes the discharge opening in a first position, and opens the discharge opening in a second position. The cartridge further includes, in one example, a biasing element sized and shaped to bias the collar toward the first position. In another example, the drive transmitting member includes at least one deflectable support member, and the deflectable support member includes a ramped drive element. The ramped drive element includes a first ramp face, a second ramp face, and at least one driving face. Optionally, the first and second ramp faces are sloped with respect to the support member.
摘要翻译：一种调色剂盒，包括具有排出口的容器主体。驱动传递部件与排出口附近的容器主体固定连接。驱动传递构件的尺寸和形状适于将旋转运动传递到容器主体。轴环沿着容器主体可移动地联接，并且套环在第一位置闭合排出口，并在第二位置打开排出口。在一个示例中，盒还包括偏置元件，其尺寸和形状适于朝向第一位置偏置套环。在另一示例中，驱动传递构件包括至少一个可偏转支撑构件，并且可偏转支撑构件包括倾斜的驱动元件。倾斜的驱动元件包括第一斜面，第二斜面和至少一个驱动面。可选地，第一和第二斜面相对于支撑构件倾斜。

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