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1. 发明申请

US20110039772A1 NOVEL USES OF VEGFXXXB 审中-公开
标题翻译： VEGFXXXB的新用途
公开(公告)号：US20110039772A1
公开(公告)日：2011-02-17
申请号：US12918363
申请日：2009-02-27
申请人： David Bates , Lucy Donaldson , Steven James Harper , Jing Hua
发明人： David Bates , Lucy Donaldson , Steven James Harper , Jing Hua
IPC分类号： A61K38/18 , A61K31/704 , A61K31/137 , A61P25/00 , A61P25/28
CPC分类号： A61K38/1866 , A61K45/06 , C12N15/85
摘要： The invention provides VEGFxxxb, or an agent which selectively promotes the expression of VEGFxxxb in preference to VEGFxxx in cells of a subject or in vitro, or an expression vector system which causes the expression of the VEGFxxxb in a host organism, for use in treating or preventing neuropathic and neurodegenerative disorders, or for use as a neuroprotective or neuroregenerative agent in vivo or in vitro. The VEGFxxxb is preferably VEGF165b.
摘要翻译：本发明提供VEGFxxxb或选择性促进VEGFxxxb在受试者或体外细胞中优于VEGFxxx的表达的试剂，或引起VEGF宿主生物体中VEGFxxxb表达的表达载体系统，用于治疗或预防神经病变和神经变性疾病，或用作体内或体外的神经保护或神经再生剂。 VEGFxxxb优选为VEGF165b。

2. 发明申请

US20070006886A1 Mouth closure 审中-公开
标题翻译：口关闭
公开(公告)号：US20070006886A1
公开(公告)日：2007-01-11
申请号：US11159636
申请日：2005-06-24
申请人： David Bates , Joanne Crawford
发明人： David Bates , Joanne Crawford
IPC分类号： A61F11/00
CPC分类号： A61G17/04 , A61G17/044
摘要： A system for holding the mouth of a human closed when lying in the supine position. Such a system can be used for deceased persons with the tendency for the mouth to relax open. Use of this system adds dignity to the cadaver for viewing by others prior to the embalming process.
摘要翻译：当躺在仰卧位时，用于保持人的嘴闭合的系统。这样一个制度可以用于死者的嘴巴放松的倾向。使用这个系统增加了对尸体的尊严，供其他人在防腐处理之前查看。

3. 发明申请

US20050143124A1 MOBILE TERMINAL WITH ERGONOMIC IMAGING FUNCTIONS 有权
标题翻译：移动终端与ERGONOMIC成像功能
公开(公告)号：US20050143124A1
公开(公告)日：2005-06-30
申请号：US10708410
申请日：2004-03-01
申请人： Peter Kennedy , Laurie Gray , Charles Hunt , Elisabeth Gibbons , David Middleton , James Cunningham , Stacy Smith , Amy Swanson , David Bates
发明人： Peter Kennedy , Laurie Gray , Charles Hunt , Elisabeth Gibbons , David Middleton , James Cunningham , Stacy Smith , Amy Swanson , David Bates
IPC分类号： G06F1/16 , H04B1/38 , H04M1/725 , H04N7/14 , H04M1/00 , H05K5/00 , H05K7/00
CPC分类号： H04N5/23293 , G06F1/1626 , G06F1/1686 , G06F2200/1614 , H04B1/38 , H04M1/27455 , H04M1/576 , H04M1/72522 , H04M1/72544 , H04M1/72555 , H04M2250/12 , H04M2250/52 , H04N7/142 , H04N7/147 , H04N21/41407 , H04N21/4402 , H04N21/442 , H04N2007/145
摘要： Mobile terminal with ergonomic imaging functions. The present invention, by way of example embodiments, provides for a mobile terminal with ergonomic imaging or camera functions. A single display can be used, for example in portrait mode while terminal functions are being used and in landscape mode while imaging functions are being used. The change between the two orientations can be accomplished automatically. In some embodiments, the capability is also provided to process an image for assignment to a terminal function, where the image has at least one display attribute that makes it at least partly unsuitable for use with the terminal function. The processing may include resizing, cropping, and/or rotating the image. This processing can be accomplished for example, so that a landscape image can be viewed conveniently in a portrait orientation.
摘要翻译：移动终端具有人体工程学成像功能。通过示例性实施例的本发明为移动终端提供符合人体工程学的成像或照相机功能。可以使用单个显示器，例如在使用终端功能的情况下以纵向模式，并且在使用成像功能时为横向模式。两个方向之间的变化可以自动完成。在一些实施例中，还提供该能力来处理用于分配给终端功能的图像，其中图像具有至少一个显示属性，使其至少部分地不适合与终端功能一起使用。处理可以包括调整大小，裁剪和/或旋转图像。该处理可以例如实现，使得可以以纵向方向方便地观看风景图像。

4. 发明申请

US20100210527A1 PRO- AND ANTI-ANGIOGENIC TREATMENTS 有权
标题翻译：抗原性抗原治疗
公开(公告)号：US20100210527A1
公开(公告)日：2010-08-19
申请号：US12530596
申请日：2008-03-10
申请人： David Bates , Steven James Harper , Dawid Grzegorz Nowak
发明人： David Bates , Steven James Harper , Dawid Grzegorz Nowak
IPC分类号： A61K38/16 , C07K14/00 , G01N33/53 , A61P43/00
CPC分类号： C12N15/1136 , A61K31/535 , C12N2310/11 , C12N2310/3233 , C12N2320/33
摘要： The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favours proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favours distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.
摘要翻译：本发明提供了一种哺乳动物受试者的选择性前体或反 - 血管生成治疗方法，包括使用控制剂进行剪接处理从VEGF基因的C末端外显子8转录的VEGF前体mRNA处理期间的选择性剪接的位点特异性控制其中在促血管生成治疗中使用有利于所述处理中的近端剪接位点（PSS）剪接的一种或多种控制剂，并且在所述处理中使用有利于所述处理中的远端剪接位点（DSS）剪接的一种或多种控制剂，血管生成治疗。

5. 发明申请

US20080018391A1 Discrete Resonator Made of Dielectric Material 有权
标题翻译：离散谐振器由电介质材料制成
公开(公告)号：US20080018391A1
公开(公告)日：2008-01-24
申请号：US11547947
申请日：2005-04-08
申请人： David Bates
发明人： David Bates
IPC分类号： H01P7/10 , H01P1/201
CPC分类号： H01P7/10
摘要： A discrete resonator is -provided, including a dielectric base having a dielectric constant. A metal contact formed on a major surface of the dielectric base has a predetermined area and is positioned at a predetermined location on the dielectric base to provide a predetermined loaded Q for the resonator. A metal ground coating is formed on the outer surface of the dielectric base with the exception of an isolation region surrounding the metal contact that is free of the metal ground coating. The area of the isolation region is sufficient to prevent significant coupling between the metal contact and the metal ground coating. The dielectric constant of the material used for the base, and the width and length of the dielectric base are each selected such that the resonator resonates at least at one predetermined resonant frequency in the GHz frequency range.
摘要翻译：提供了分立的谐振器，包括具有介电常数的电介质基底。形成在电介质基底的主表面上的金属接触件具有预定的面积并且位于电介质基底上的预定位置处，以为谐振器提供预定的加载的Q。金属接地涂层形成在电介质基体的外表面上，除了围绕金属接触件的隔离区域，该隔离区域没有金属地面涂层。隔离区域的面积足以防止金属接触和金属地面涂层之间的显着的耦合。用于基底的材料的介电常数以及电介质基底的宽度和长度各自被选择为使得谐振器在GHz频率范围内至少谐振至少一个预定的谐振频率。

6. 发明申请

US20050021429A1 Time recording and management system 失效
标题翻译：时间记录和管理系统
公开(公告)号：US20050021429A1
公开(公告)日：2005-01-27
申请号：US10763832
申请日：2004-01-23
申请人： David Bates
发明人： David Bates
IPC分类号： G06Q10/00 , G06F17/60
CPC分类号： G06Q10/109 , G06Q10/1091 , Y10S707/99943 , Y10S707/99945
摘要： A time entry recording and management system includes a plurality of fields, a selector and an actuator. The plurality of fields includes a date field configured to display a date, a start field configured to display a starting time of a time entry, a stop field configured to display an ending time of the time entry, a description field configured to display a description of the time entry, and at least one code or designation field configured to display a code or designation assigned to the time entry. The selector is movable between at least two of the plurality of fields. The actuator is configured to perform at least one of a plurality of functions upon being actuated depending upon in which of the plurality of fields the selector is located. The actuator is also configured to fill in at least two of the fields upon being actuated once in some instances.
摘要翻译：时间录入记录和管理系统包括多个场，选择器和致动器。多个字段包括被配置为显示日期的日期字段，被配置为显示时间条目的开始时间的起始字段，被配置为显示时间条目的结束时间的停止字段，被配置为显示描述的描述字段以及被配置为显示分配给时间条目的代码或指定的至少一个代码或指定字段。选择器可以在多个场中的至少两个之间移动。致动器被配置为根据选择器所位于的多个场中的哪一个被执行，执行多个功能中的至少一个。致动器还被配置为在一些情况下被致动一次时填充至少两个场。

7. 发明授权

US4693712A Bactericide valve on fluid collection bag 失效
标题翻译：流体收集袋上的杀菌剂阀
公开(公告)号：US4693712A
公开(公告)日：1987-09-15
申请号：US798209
申请日：1985-11-14
申请人： David Bates
发明人： David Bates
IPC分类号： A61F5/441 , A61M1/00
CPC分类号： A61F5/441 , Y10T137/4891
摘要： A liquid collection system for collecting and discharging urine from a catheterized patient. A collection bag receives urine through the catheter, and has a drain system therein, which comprises a valve having a bactericide element over which the urine must flow as it is being drained from the bag. The bactericide element is held in an openable cage, so as to permit replacement of the bactericide element as an "as needed" basis. The bactericide disposed within the valve helps prevent retrograde contamination of the liquid collection system.
摘要翻译：一种用于从导尿患者收集和排出尿液的液体收集系统。收集袋通过导管接收尿液，并且其中具有排水系统，其包括具有杀菌剂元件的阀，当尿液从袋中排出时，尿必须流过该阀。杀菌剂元件保持在可打开的笼中，以便允许以“根据需要”替代杀菌剂元件。设置在阀门内的杀菌剂有助于防止液体收集系统的逆向污染。

8. 发明授权

US09447418B2 Pro- and anti-angiogenic treatments 有权
标题翻译：抗血管生成治疗
公开(公告)号：US09447418B2
公开(公告)日：2016-09-20
申请号：US12530596
申请日：2008-03-10
申请人： David Bates , Steven James Harper , Dawid Grzegorz Nowak
发明人： David Bates , Steven James Harper , Dawid Grzegorz Nowak
IPC分类号： A61K38/16 , C12N15/113 , A61K31/535
CPC分类号： C12N15/1136 , A61K31/535 , C12N2310/11 , C12N2310/3233 , C12N2320/33
摘要： The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favors proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favors distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.
摘要翻译：本发明提供了一种哺乳动物受试者的选择性前体或反 - 血管生成治疗方法，包括使用控制剂进行剪接处理从VEGF基因的C末端外显子8转录的VEGF前体mRNA处理期间的选择性剪接的位点特异性控制其中在促血管生成治疗中使用有利于所述处理中的近端剪接位点（PSS）剪接的一种或多种控制剂，并且在所述处理中使用有利于所述处理中的远端剪接位点（DSS）剪接的一种或多种控制剂，血管生成治疗。

9. 发明授权

US07820178B2 VEGF isoforms and their use as anti-angiogenic, anti-vasodilatory, anti-permeability and anti-proliferative agents 有权
标题翻译： VEGF异构体及其作为抗血管生成，抗血管扩张，抗渗透和抗增殖剂的用途
公开(公告)号：US07820178B2
公开(公告)日：2010-10-26
申请号：US10485539
申请日：2002-07-12
申请人： David Bates , Steven Harper
发明人： David Bates , Steven Harper
IPC分类号： A61K38/18
CPC分类号： C07K14/475 , A61K38/1866 , A61K48/00 , C07K14/52 , C12N15/1136 , C12N2310/14 , G01N2333/475 , G01N2333/515 , G01N2333/71
摘要： An isolated VEGF polypeptide having anti-angiogenic activity, said polypeptide including the amino acid sequence of SEQ. ID NO. 1, or variants thereof.
摘要翻译：具有抗血管生成活性的分离的VEGF多肽，所述多肽包括SEQ ID NO：1的氨基酸序列。证件号码。 1，或其变体。

10. 发明申请

US20050054036A1 Growth factor isoform 有权
标题翻译：生长因子同种型
公开(公告)号：US20050054036A1
公开(公告)日：2005-03-10
申请号：US10485539
申请日：2002-07-12
申请人： David Bates , Steven Harper
发明人： David Bates , Steven Harper
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K38/18 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/02 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P15/00 , A61P17/06 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/06 , A61P43/00 , C07K14/52 , C07K16/24 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12Q1/02 , C12Q1/68 , G01N21/78 , G01N33/15 , C07H21/04 , C07K14/475
CPC分类号： C07K14/475 , A61K38/1866 , A61K48/00 , C07K14/52 , C12N15/1136 , C12N2310/14 , G01N2333/475 , G01N2333/515 , G01N2333/71
摘要： An isolated VEGF polypeptide having anti-angiogenic activity, said polypeptide including the amino acid sequence of SEQ. ID NO. 1, or variants thereof.
摘要翻译：具有抗血管生成活性的分离的VEGF多肽，所述多肽包括SEQ ID NO：1的氨基酸序列。证件号码。 1，或其变体。

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