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1. 发明申请

US20060035279A1 Anti-GPE antibodies, their uses and assays for weakly immunogenic molecules 审中-公开
标题翻译：抗GPE抗体，其用于弱免疫原性分子的用途和测定
公开(公告)号：US20060035279A1
公开(公告)日：2006-02-16
申请号：US10971359
申请日：2004-10-22
申请人： David Batchelor , Gregory Thomas , Bernhard Breier
发明人： David Batchelor , Gregory Thomas , Bernhard Breier
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/18
摘要： Anti-GPE antibodies are provided that can be used to detect the presence of GPE in a sample. GPE antibodies can be raised against conjugated GPE to produce antibodies that are specific for a GPE that has been derivatized using a similar coupling chemistry as was used for making the GPE conjugate. To detect GPE in a sample, the sample is exposed to a derivatizing agent to produce a derivatized GPE that is recognized by the anti-GPE antibody. Using similar strategies, antibodies can be raised against other weakly immunogenic molecules (WIMs) that can be the basis for assays and kits for assaying for WIMs.
摘要翻译：提供抗GPE抗体，可用于检测样品中GPE的存在。 GPE抗体可以针对缀合的GPE产生，以产生针对已经使用与用于制备GPE缀合物的类似偶联化学衍生化的GPE特异性的抗体。为了检测样品中的GPE，将样品暴露于衍生试剂以产生由抗GPE抗体识别的衍生化GPE。使用类似的策略，抗体可以针对其他弱免疫原性分子（WIMs），可以作为测定的基础和用于测定WIM的试剂盒。

2. 发明申请

US20070224165A1 Neuroprotective Effects of Gly-Pro-Glu Following Intravenous Infusion 审中-公开
标题翻译：静脉注射后Gly-Pro-Glu的神经保护作用
公开(公告)号：US20070224165A1
公开(公告)日：2007-09-27
申请号：US10574280
申请日：2004-10-22
申请人： Jian Guan , Gregory Thomas , David Batchelor , Peter Gluckman
发明人： Jian Guan , Gregory Thomas , David Batchelor , Peter Gluckman
IPC分类号： A61K38/06
CPC分类号： A61K38/06 , A61K2300/00
摘要： Gly-Pro-Glu (GPE) is rapidly metabolized in vivo. We found that GPE infusion elicits potent and consistent neuroprotection in all brain regions examined, and in certain embodiments, the effects were greater than those of a bolus injection followed by infusion (“loading dose/infusion”). GPE reduced apoptosis in the hippocampus and inhibited microglial proliferation and prevented the injury-induced loss of astrocytes and improved long-term somatofunction. GPE after infusion showed a broad effective dose range (0.3-30 mg/kg/h) and had a surprisingly extended window of treatment efficacy, permitting its use from 1 to at least as late as 24 h after neural injury. We also found that neuroprotective effects of acute GPE administration were prolonged and therefore capable of being used effectively to treat a variety of neurodegenerative conditions, even when administered after a neural injury. Thus, GPE can be an effective neuroprotective agent used either alone or co-administered along with other neuroprotective agents, antiinflammatory agents or peptidase or protease inhibitors. Compositions of GPE and protease and/or peptidase inhibitors are provided.
摘要翻译： Gly-Pro-Glu（GPE）在体内迅速代谢。我们发现GPE输注在所检查的所有脑区域中引起有效和一致的神经保护作用，并且在某些实施方案中，效果大于进行推注，随后输注（“加载剂量/输注”）的效果。 GPE减少海马细胞凋亡并抑制小胶质细胞增殖，并防止损伤诱导的星形胶质细胞的丧失和改善长期的生物功能。输注后的GPE显示广泛的有效剂量范围（0.3-30mg / kg / h），并且具有惊人的延长的治疗效果窗口，允许其在神经损伤后至少至迟24小时使用。我们还发现，急性GPE给药的神经保护作用延长，因此即使在神经损伤后施用，也能有效地用于治疗各种神经退行性疾病。因此，GPE可以是单独使用或与其它神经保护剂，抗炎剂或肽酶或蛋白酶抑制剂一起使用的有效的神经保护剂。提供GPE和蛋白酶和/或肽酶抑制剂的组合物。

3. 发明申请

US20070128660A1 Methods for detecting weakly immunogenic analytes 失效
公开(公告)号：US20070128660A1
公开(公告)日：2007-06-07
申请号：US11591302
申请日：2006-10-31
申请人： David Batchelor , Gregory Thomas , Bernhard Heinrich Breier
发明人： David Batchelor , Gregory Thomas , Bernhard Heinrich Breier
IPC分类号： G01N33/53 , C07K16/40 , C07K16/46
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/18
摘要： GPE antibodies recognize GPE with high specificity. When used in a radioimmunoassay, they reliably measure the concentration of GPE. They may be used to extend the half-life of GPE both in vivo and in vitro, and in methods of purifying the GPE receptor. Two methods of rpHPLC accurately revolve GPE on the basis of its hydrophobicity.

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