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1. 发明申请

US20100286277A1 METHOD TO ENHANCE AQUEOUS SOLUBILITY OF POORLY SOLUBLE ACTIVES 有权
标题翻译：提高不溶性活性水溶性的方法
公开(公告)号：US20100286277A1
公开(公告)日：2010-11-11
申请号：US12810962
申请日：2009-01-05
申请人： David B. Wurm , David A. Wilson , Bruce A. Barner , Cynthia L. Rand , Matthew D. Miller , Michael J. Johnson
发明人： David B. Wurm , David A. Wilson , Bruce A. Barner , Cynthia L. Rand , Matthew D. Miller , Michael J. Johnson
IPC分类号： A61K31/192 , A61K31/167 , A01P13/00 , A01P21/00 , A61Q17/00 , A61K8/36 , A61K8/42 , A01N37/10 , A01N37/18
CPC分类号： A61K31/167 , A61K9/08 , A61K31/192 , A61K47/10
摘要： A method to enhance solubility of an active compound comprises combining an active compound, having an aqueous solubility that is less than or equal to about 10 mg/mL, and an amount of methoxypolyethylene glycol that is sufficient to increase the aqueous solubility of the active compound. Enhancement of aqueous solubility for this combination may be significantly greater than that of an active compound in combination with an equivalent amount of polyethylene glycol. Particularly enhanced solubility is shown where a small amount of water is also included. The invention may be used in a wide variety of applications, such as for pharmaceutical, agricultural, antimicrobial, and personal care products.
摘要翻译：提高活性化合物的溶解度的方法包括组合具有小于或等于约10mg / mL的水溶解度的活性化合物和足以增加活性化合物的水溶性的甲氧基聚乙二醇的量。该组合的水溶性的增强可以显着大于活性化合物与等量的聚乙二醇的组合。显示出特别增加的溶解度，其中还包括少量的水。本发明可以用于各种各样的应用，例如用于制药，农业，抗微生物和个人护理产品。

2. 发明授权

US08497303B2 Method to enhance aqueous solubility of poorly soluble actives 有权
标题翻译：提高难溶性活性物质的水溶性的方法
公开(公告)号：US08497303B2
公开(公告)日：2013-07-30
申请号：US12810962
申请日：2009-01-05
申请人： David B. Wurn , David A. Wilson , Bruce A. Barner , Cynthia L. Rand , Matthew D. Miller , Michael J. Johnson
发明人： David B. Wurn , David A. Wilson , Bruce A. Barner , Cynthia L. Rand , Matthew D. Miller , Michael J. Johnson
IPC分类号： A61K9/08 , A61K47/10 , A61K31/192 , A61K31/167
CPC分类号： A61K31/167 , A61K9/08 , A61K31/192 , A61K47/10
摘要： A method to enhance solubility of an active compound comprises combining an active compound, having an aqueous solubility that is less than or equal to about 10 mg/mL, and an amount of methoxypolyethylene glycol that is sufficient to increase the aqueous solubility of the active compound. Enhancement of aqueous solubility for this combination may be significantly greater than that of an active compound in combination with an equivalent amount of polyethylene glycol. Particularly enhanced solubility is shown where a small amount of water is also included. The invention may be used in a wide variety of applications, such as for pharmaceutical, agricultural, antimicrobial, and personal care products.
摘要翻译：提高活性化合物的溶解度的方法包括组合具有小于或等于约10mg / mL的水溶解度的活性化合物和足以提高活性化合物的水溶性的甲氧基聚乙二醇的量。该组合的水溶性的增强可以显着大于活性化合物与等量的聚乙二醇的组合。显示特别增加的溶解度，其中也包括少量的水。本发明可以用于各种各样的应用，例如用于制药，农业，抗微生物和个人护理产品。

3. 发明授权

US10946407B2 Apparatus and method for atomization of fluid 有权
公开(公告)号：US10946407B2
公开(公告)日：2021-03-16
申请号：US16083971
申请日：2017-04-07
申请人： David B. Go , Michael J. Johnson , Zeinab Ramshani , Massood Z. Atashbar
发明人： David B. Go , Michael J. Johnson , Zeinab Ramshani , Massood Z. Atashbar
IPC分类号： B05B17/06
摘要： Various apparatus and methods for the atomization of fluid are disclosed herein. In one aspect, an apparatus for atomization of fluid includes a piezoelectric transformer comprising an electrode which is in communication a source of alternating current (AC) voltage at a proximate end of the piezoelectric transformer. A wick which is capable of absorbing a liquid is in contact with the piezoelectric transformer at the distal end, and the piezoelectric transformer is capable of inducing an electrospray of the liquid at the distal end.

4. 发明授权

US07334676B1 Compensating roller system 有权
标题翻译：补偿辊系统
公开(公告)号：US07334676B1
公开(公告)日：2008-02-26
申请号：US11671890
申请日：2007-02-06
申请人： Casey L. McGourin , Richard A. McQuary , Jacob M. Culley , Michael J. Johnson
发明人： Casey L. McGourin , Richard A. McQuary , Jacob M. Culley , Michael J. Johnson
IPC分类号： B65G15/12
CPC分类号： B65G15/14
摘要： A compensating roller system is adapted to adjust to size variation of product moving through a conveyor system. In one example, the compensating roller system is used to control a force resulting in deflection of a conveyor belt. In a specific implementation of such an example, a first rail is configured to support a first conveyor belt. A plurality of rollers is attached to the first rail and supports a conveyor belt moving over the rollers. The attachment allows each roller to pivot independently of movement of other rollers. Each of the rollers' movement is against a bias, and allows for deflection of the conveyor belt. A second rail may be configured as the first rail, and oriented define a channel for product movement between conveyor belts carried by the first and second rails.
摘要翻译：补偿辊系统适于调节通过输送机系统移动的产品的尺寸变化。在一个示例中，补偿辊系统用于控制导致传送带偏转的力。在这种示例的具体实现中，第一轨道被配置为支撑第一传送带。多个辊连接到第一轨道并且支撑在辊上移动的传送带。该附件允许每个滚子独立于其它滚筒的移动而枢转。每个辊子的运动都抵抗偏压，并允许传送带的偏转。第二轨道可以被配置为第一轨道，并且定向地限定用于由第一和第二轨道承载的输送带之间的产品运动的通道。

5. 发明授权

US07121182B2 Steel rule die with removable cutting units 失效
公开(公告)号：US07121182B2
公开(公告)日：2006-10-17
申请号：US10301848
申请日：2002-11-22
申请人： Michael J. Johnson
发明人： Michael J. Johnson
IPC分类号： B26D7/26
CPC分类号： B26D7/2614 , B26D2007/2607 , B26F1/44 , B26F2001/4463 , Y10T83/202 , Y10T83/944 , Y10T83/9454 , Y10T83/9473 , Y10T83/9478
摘要： A steel rule die for cutting cloth and synthetic materials. The cutting die includes a primary substrate and a plurality of cutting units that are removably attachable to the substrate in such a manner that they are easy to adjust, remove and replace. The cutting units include secondary substrates with lengths of steel rule attached to them. The cutting units are secured to the primary substrate. Each steel rule is fixedly attached to a secondary substrate that is substantially harder than the primary substrate. The secondary substrate distributes the cutting load applied to the rule over a large surface area on the primary substrate to prevent the cutting units from diving into the soft primary substrate. Substantially the entire length of the steel rule is supported by the secondary substrate, thereby yielding a rigid cutting unit that is not susceptible to deformation. The cutting units can also include bent internal cutting sections and adjustable and removable internal cutting units that allow scrap material to flow through the cutting die. Moreover, the secondary substrates can include openings for reducing the overall weight of the die without effecting the support it provides to the steel rule.

6. 发明授权

US06829425B2 Optical fiber management system and method 失效
公开(公告)号：US06829425B2
公开(公告)日：2004-12-07
申请号：US10125898
申请日：2002-04-19
申请人： William F. Barthel , Steven J. Kleis , Laurie M. Anderson , Michael J. Johnson
发明人： William F. Barthel , Steven J. Kleis , Laurie M. Anderson , Michael J. Johnson
IPC分类号： G02B600
CPC分类号： G02B6/4454 , G02B6/4452
摘要： An optical fiber ramp management system provides a system, device and method for organizing, managing and storing optical fiber during and after the production of an opto-electronic assembly. Opto-electronic components are arranged on a substrate located at a first level so as to define a space between the components. The space defines an optical fiber pathway along the surface of the substrate through which optical fibers formed as fiber bundle travel. A ramp supports the fiber bundle as it extends from the substrate to a storage tray located at a second level. The optical fibers are retained on the storage tray as a plurality of unconstrained loops. The pathway, ramp and tray are formed to maintain the radius of curvature of the optical fiber at or above the minimum bend radius of the fiber.

7. 发明授权

US5983766A Steel rule cutting die with removable cutting units and method for using same 失效
标题翻译：钢切割模具可移动切割装置
公开(公告)号：US5983766A
公开(公告)日：1999-11-16
申请号：US949855
申请日：1997-10-14
申请人： Michael J. Johnson
发明人： Michael J. Johnson
IPC分类号： B26F1/44
CPC分类号： B26F1/44 , B26F1/40 , B26F2001/4463 , Y10T83/9307 , Y10T83/9452 , Y10T83/9461 , Y10T83/9471
摘要： A steel rule die for cutting cloth and synthetic materials. The cutting die includes a primary substrate and a plurality of cutting units that are removably attachable to the substrate in such a manner that they are easy to adjust, remove and replace. The cutting units include secondary substrates with lengths of steel rule attached to them to form cutting cavities. Studs mounted to the primary substrate interface with tear-drop shared holes in the secondary substrates with to restrain them against motion perpendicular to the surface of the primary substrate while permitting movement of the cutting units in a horizontal plane with respect to the primary substrate. Adjustable securing rails positioned along the peripheries of the primary substrate are moved toward the fixed securing rails to restrain the secondary substrates against lateral and longitudinal motion. By moving the adjustable securing rails away from the fixed securing rails, the cutting units can be temporarily moved away from each other for cleaning scrap material therebetween. Foam can be disposed between the cutting units to minimize the possibility of scrap material becoming lodged between the cutting units, and aid in the removal of any scrap material that happens to become lodged between the cutting units.
摘要翻译：用于切割布和合成材料的钢规模。切割模具包括主基板和多个可拆卸地附接到基板的切割单元，使得它们易于调节，移除和更换。切割单元包括具有钢规定长度的二次基底，以形成切割腔。在第二基板上安装有主要基板界面的螺栓与泪滴共享孔，以限制它们抵抗垂直于初级基板表面的运动，同时允许切割单元相对于主基板在水平平面中移动。沿着主基板的周边定位的可调节的固定轨道朝着固定的固定轨道移动，以限制第二基板的横向和纵向运动。通过将可调整的固定轨道远离固定的固定轨道移动，切割单元可以彼此临时移开，以清除它们之间的废料。泡沫可以设置在切割单元之间，以最大限度地减少废料在切割单元之间的可能性，并且有助于去除恰好在切割单元之间倾倒的任何废料。

8. 发明授权

US4886343A Apparatus and method for additive/subtractive pixel arrangement in color mosaic displays 失效
标题翻译：彩色马赛克显示器中加减法像素排列的装置和方法
公开(公告)号：US4886343A
公开(公告)日：1989-12-12
申请号：US211827
申请日：1988-06-20
申请人： Michael J. Johnson
发明人： Michael J. Johnson
IPC分类号： G02F1/1335 , G02F1/1347 , G09F9/30
CPC分类号： G02F1/13475
摘要： A liquid crystal display unit is described in which a first panel of pixel elements is used to control red and green portions of a displayed image using an additive technique while a second panel, having pixels aligned with the first panel pixels, controls the blue portion of the image through subtractive techniques. The resulting display system can provide enhanced brightness, resolution and color characteristics. The display system makes use of the fact that the eye is less sensitive to blue radiation for several visual parameters. As a result of the decreased sensitivity, the second (blue) panel can operate with less stringent requirements.

9. 发明授权

US10783520B2 Fraud detection 有权
公开(公告)号：US10783520B2
公开(公告)日：2020-09-22
申请号：US14322499
申请日：2014-07-02
申请人： Beth Moss , Angela Berkery , Michael J. Johnson , Benjamin W. Geertz
发明人： Beth Moss , Angela Berkery , Michael J. Johnson , Benjamin W. Geertz
IPC分类号： G06Q20/40
摘要： Systems and methods of fraud prevention are discussed. One such method can include the acts of monitoring one or more events associated with at least one account at a financial institution; analyzing characteristics associated with a first event of the one or more events; determining whether to designate the first event as risky; and implementing one or more measures in response to the designation of the first event as risky.

10. 发明授权

US10194293B2 System and method for vital signs alerting privileged recipients 有权
公开(公告)号：US10194293B2
公开(公告)日：2019-01-29
申请号：US15863864
申请日：2018-01-06
申请人： William J. Johnson , Michael J. Johnson
发明人： William J. Johnson , Michael J. Johnson
IPC分类号： H04W4/38 , H04W4/04 , H04W4/30 , H04W4/02
摘要： Provided is a system and method for a situational proximity observation by a Mobile data processing System (MS) using one or more automated senses of the MS, for example as directed by a user of the MS, to cause an alert to be delivered to one or more other Mobile data processing Systems (MSs) for notifying those other users of the MSs that they are potentially involved in, or affected by, the sensing carried out by the MS making the observation. Specifically, a Situational Proximity Observation Device Reporter (SPODR) captures vital signs associated with a user and a TRaveling Observation Device Recipient (TRODR) can be notified when captured data is relevant to the TRODR. There is a variety of events and conditions under which the alert is provided, including in accordance with a variety of privileges configured between users.

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