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1. 发明申请

US20140023613A1 Nucleic Acid Molecule Encoding Hepatitis B Virus Core Protein And Vaccine Comprising The Same 审中-公开
标题翻译：编码乙型肝炎病毒核心蛋白的核酸分子和包含其的疫苗
公开(公告)号：US20140023613A1
公开(公告)日：2014-01-23
申请号：US13984771
申请日：2012-02-13
申请人： David B Weiner , Jian Yan , Nyamekye Obeng-Adjei
发明人： David B Weiner , Jian Yan , Nyamekye Obeng-Adjei
IPC分类号： C07K14/005
CPC分类号： A61K39/292 , A61K39/12 , A61K39/39 , A61K2039/53 , A61K2039/57 , A61K2039/572 , C07K14/005 , C07K14/02 , C12N7/00 , C12N2730/10134 , C12N2730/10171
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequence of HBV core protein, as well as genetic constructs/vectors and vaccines that express said protein sequences. Also provided herein are methods for generating an immune response against HBV using the nucleic acid sequences that are provided.
摘要翻译：本文提供了编码HBV核心蛋白的新的共有氨基酸序列的核酸序列，以及表达所述蛋白质序列的遗传构建体/载体和疫苗。本文还提供了使用提供的核酸序列产生针对HBV的免疫应答的方法。

2. 发明授权

US09050287B2 Vaccines for human papilloma virus and methods for using the same 有权
标题翻译：人乳头状瘤病毒疫苗及其使用方法
公开(公告)号：US09050287B2
公开(公告)日：2015-06-09
申请号：US13271576
申请日：2011-10-12
申请人： David B Weiner , Jian Yan
发明人： David B Weiner , Jian Yan
IPC分类号： C07H21/02 , C07K14/00 , A61K39/295 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N2710/20022 , C12N2710/20034 , C12N2800/22
摘要： Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV 6, HPV 11, HPV 33 and HPV58 E6 and E7. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
摘要翻译：公开了改进的抗HPV免疫原和编码它们的核酸分子。公开的免疫原包括具有共同的HPV 6，HPV 11，HPV 33和HPV 58 E 6和E 7的那些。公开了药物组合物，包含减毒活疫苗和减毒活疫苗的重组疫苗，并公开了在个体中针对HPV诱导免疫应答的方法。

3. 发明授权

US08921536B2 HCV vaccines and methods for using the same 有权
标题翻译： HCV疫苗及其使用方法
公开(公告)号：US08921536B2
公开(公告)日：2014-12-30
申请号：US13278160
申请日：2011-10-20
申请人： David B Weiner , Krystle Lang , Jian Yan , Ruxandra Draghia-Akli , Amir S Khan
发明人： David B Weiner , Krystle Lang , Jian Yan , Ruxandra Draghia-Akli , Amir S Khan
IPC分类号： C07H21/04 , A61K48/00 , A61K31/711 , A61K39/29 , A61K38/00 , A61K39/00
CPC分类号： C07K14/005 , A61K31/711 , A61K38/00 , A61K39/12 , A61K39/29 , A61K2039/53 , A61K2039/57 , C07K2319/02 , C12N2770/24222 , C12N2770/24234
摘要： Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype 1a, including for example, NS4B, NS5A and NS5B. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HCV are disclosed.
摘要翻译：公开了改进的抗HCV免疫原和编码它们的核酸分子。所公开的免疫原包括那些具有共有HCV基因型1a的那些，包括例如NS4B，NS5A和NS5B。公开了药物组合物，包含减毒活疫苗和减毒活疫苗的重组疫苗，并公开了针对HCV个体诱导免疫应答的方法。

4. 发明授权

US08829174B2 HCV vaccines and methods for using the same 有权
标题翻译： HCV疫苗及其使用方法
公开(公告)号：US08829174B2
公开(公告)日：2014-09-09
申请号：US13127008
申请日：2008-10-29
申请人： David B Weiner , Krystle A. Lang Kuhs , Jian Yan , Ruxandra Draghia-Akli , Amir Khan
发明人： David B Weiner , Krystle A. Lang Kuhs , Jian Yan , Ruxandra Draghia-Akli , Amir Khan
IPC分类号： C12N15/57 , C12N15/51 , C12N15/74 , C12N15/79 , C12N9/50
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , C12N7/00 , C12N9/506 , C12N15/86 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234
摘要： Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype 1 a/1 b NS3 and NS4A. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HCV are disclosed.
摘要翻译：公开了改进的抗HCV免疫原和编码它们的核酸分子。所公开的免疫原包括那些具有一致的HCV基因型1a / 1b NS3和NS4A的那些。公开了药物组合物，包含减毒活疫苗和减毒活疫苗的重组疫苗，并公开了针对HCV个体诱导免疫应答的方法。

5. 发明授权

US08298820B2 Influenza nucleic acid molecules and vaccines made therefrom 有权
标题翻译：流感核酸分子和由其制成的疫苗
公开(公告)号：US08298820B2
公开(公告)日：2012-10-30
申请号：US12694238
申请日：2010-01-26
申请人： David B Weiner , Jian Yan , Matthew P Morrow
发明人： David B Weiner , Jian Yan , Matthew P Morrow
IPC分类号： C12N15/00 , A61K39/145 , C12P21/06 , C07H21/02
CPC分类号： A61K39/145 , A61K31/7088 , A61K39/12 , A61K45/06 , A61K2039/53 , A61K2039/54 , C12N2760/16134
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotypes using the vaccines that are provided.
摘要翻译：本文提供了编码HA血凝素的新的共有氨基酸序列以及表达序列的遗传构建体/载体和疫苗的核酸序列。本文还提供了使用所提供的疫苗产生针对一种或多种流感A血清型的免疫应答的方法。

6. 发明授权

US08927692B2 Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same 有权
标题翻译：共识的前列腺抗原，编码相同的核酸分子和疫苗以及包含它们的用途
公开(公告)号：US08927692B2
公开(公告)日：2015-01-06
申请号：US13883978
申请日：2011-11-14
申请人： David B Weiner , Jian Yan , Bernadette Ferraro , Niranjan Y Sardesai , Mathura P Ramanathan
发明人： David B Weiner , Jian Yan , Bernadette Ferraro , Niranjan Y Sardesai , Mathura P Ramanathan
IPC分类号： C07K7/00 , A61K39/00
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/485 , C12N9/6424 , C12Y116/01 , C12Y304/17021 , C12Y304/21077
摘要： Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
摘要翻译：本文提供了能够在目标物种（包括PSA，PSMA，STEAP和PSCA抗原）中破坏耐受性的前列腺抗原的共有氨基酸序列。还提供编码前列腺抗原PSA，PSMA，STEAP和PSCA的一个或多个共有氨基酸序列的核酸序列，以及表达序列的遗传构建体/载体和疫苗。本文还提供了通过施用提供的一种或多种疫苗，蛋白质和/或核酸序列来产生针对前列腺癌细胞的自身免疫应答的方法。

7. 发明授权

US08697084B2 HIV consensus envelope sequences and methods for using the same 有权
标题翻译： HIV共识包膜序列及其使用方法
公开(公告)号：US08697084B2
公开(公告)日：2014-04-15
申请号：US13458013
申请日：2012-04-27
申请人： David B Weiner , Jian Yan , Dominick Laddy
发明人： David B Weiner , Jian Yan , Dominick Laddy
IPC分类号： A61K39/21 , A61K38/16
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/523 , A61K2039/53 , A61K2039/54 , A61K2039/55538 , A61K2039/585 , C12N7/00 , C12N2710/20034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2760/16134 , C12N2770/24234
摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
摘要翻译：公开了改进的抗HIV免疫原和编码它们的核酸分子。所公开的免疫原包括具有HIV亚型A包膜蛋白的共有序列的那些，对于HIV亚型B包膜蛋白具有共有序列的那些，对于HIV亚型C包膜蛋白具有共有序列的那些，对于HIV亚型D包膜蛋白具有共有序列的那些 HIV亚型B共有序列Nef-Rev蛋白和具有共有序列的序列形成HIV Gag蛋白亚型A，B，C和D.改进的抗HPV免疫原和编码它们的核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 公开了改进的抗流感免疫原和编码它们的核酸分子，以及在个体中针对HIV，HPV，HCV，hTERT和流感诱导免疫应答的方法。

8. 发明授权

US08168769B2 HPV vaccines and methods for using the same 有权
标题翻译： HPV疫苗及其使用方法
公开(公告)号：US08168769B2
公开(公告)日：2012-05-01
申请号：US12375518
申请日：2007-07-30
申请人： David B Weiner , Jian Yan
发明人： David B Weiner , Jian Yan
IPC分类号： C12N15/11 , C12N15/63
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/523 , A61K2039/53 , A61K2039/54 , A61K2039/55538 , A61K2039/585 , C12N7/00 , C12N2710/20034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2760/16134 , C12N2770/24234
摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed, Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
摘要翻译：公开了改进的抗HIV免疫原和编码它们的核酸分子，所公开的免疫原包括具有HIV亚型A包膜蛋白共有序列的那些，具有HIV亚型B包膜蛋白的共有序列的那些，具有HIV亚型C包膜蛋白的共有序列的那些具有HIV亚型D包膜蛋白共有序列的那些，具有HIV亚型共有序列Nef-Rev蛋白的共有序列的那些，以及具有共有序列的那些序列形成HIV Gag蛋白亚型A，B，C和D.改进的抗HPV免疫原和编码它们的核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 并且公开了改进的抗流感免疫原和编码它们的核酸分子。公开了药物组合物，包含和减毒病原体的重组疫苗，以及诱导个体对HIV，HPV，HCV，hTERT和流感的免疫应答的方法。

9. 发明申请

US20100166787A1 VACCINES AND METHODS FOR USING THE SAME 有权
标题翻译：疫苗及其使用方法
公开(公告)号：US20100166787A1
公开(公告)日：2010-07-01
申请号：US12375518
申请日：2007-07-30
申请人： David B Weiner , Jian Yan , Dominick Laddy
发明人： David B Weiner , Jian Yan , Dominick Laddy
IPC分类号： A61K39/275 , C07H21/02 , A61K31/713 , A61K39/00 , C12N7/01 , C07K14/00 , A61K38/16 , A61P31/18 , A61P37/04 , C07H21/04
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/523 , A61K2039/53 , A61K2039/54 , A61K2039/55538 , A61K2039/585 , C12N7/00 , C12N2710/20034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2760/16134 , C12N2770/24234
摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed, Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
摘要翻译：公开了改进的抗HIV免疫原和编码它们的核酸分子，所公开的免疫原包括具有HIV亚型A包膜蛋白共有序列的那些，具有HIV亚型B包膜蛋白的共有序列的那些，具有HIV亚型C包膜蛋白的共有序列的那些具有HIV亚型D包膜蛋白共有序列的那些，具有HIV亚型共有序列Nef-Rev蛋白的共有序列的那些，以及具有共有序列的那些序列形成HIV Gag蛋白亚型A，B，C和D.改进的抗HPV免疫原和编码它们的核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 并且公开了改进的抗流感免疫原和编码它们的核酸分子。公开了药物组合物，包含和减毒病原体的重组疫苗，以及诱导个体对HIV，HPV，HCV，hTERT和流感的免疫应答的方法。

10. 发明授权

US09109014B2 Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom 有权
标题翻译：口蹄疫病毒（FMDV）共有蛋白质，其编码序列和由其制备的疫苗
公开(公告)号：US09109014B2
公开(公告)日：2015-08-18
申请号：US13503828
申请日：2010-11-02
申请人： David B Weiner , Bernadette Ferraro , Jian Yan , Patricia A Brown , Rodney A Bowling , Douglas R Kern , Mathura P Ramanathan , Niranjan Y Sardesai , Karuppiah Muthumani
发明人： David B Weiner , Bernadette Ferraro , Jian Yan , Patricia A Brown , Rodney A Bowling , Douglas R Kern , Mathura P Ramanathan , Niranjan Y Sardesai , Karuppiah Muthumani
IPC分类号： A61K39/12 , C07K14/005 , A61K39/135 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/135 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/552 , A61M37/00 , A61N1/327 , C12N7/00 , C12N2770/32122 , C12N2770/32134 , G01N33/56983 , G01N2333/09 , G01N2469/20
摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
摘要翻译：本文提供的是包含FMDV亚型A，亚洲1，C，O，SAT1，SAT2和SAT3的口蹄疫FMDV VP1-4外壳蛋白的共有氨基酸序列的核酸，以及表达序列。本文还提供了使用上述疫苗产生针对一种或多种FMDV亚型的免疫应答的方法以及用疫苗接种的哺乳动物和用FMDV感染的哺乳动物之间进行解密的方法。

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