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1. 发明申请

US20080308548A1 Active Matrix Temperature Controller Array 审中-公开
标题翻译：有源矩阵温度控制器阵列
公开(公告)号：US20080308548A1
公开(公告)日：2008-12-18
申请号：US12097793
申请日：2006-12-15
申请人： David Andrew Fish , Marc Wilhemus Gijsbert Ponjee , Mark Thomas Johnson
发明人： David Andrew Fish , Marc Wilhemus Gijsbert Ponjee , Mark Thomas Johnson
IPC分类号： G05D23/20 , C12M1/34
CPC分类号： G05D23/20 , G05D23/1934
摘要： In an array for temperature controlled cells the cells are driven in an active matrix array. A temperature processing array may be employed in biochip, such as underneath a biosensor or underneath reaction chambers. Due to the active matrix complex driver circuitry may be positioned outside the actual array of cells. Each cell is provided with a switch for coupling the cell circuitry to the driver circuitry. When coupled to the driver circuitry, a memory element in the cell circuitry may be provided with a heating setting. Then, the cell circuitry is uncoupled from the driver circuitry and a heating element is controlled to heat the cell in accordance with the setting stored in the memory element.
摘要翻译：在温度控制单元阵列中，以有源矩阵阵列驱动单元。温度处理阵列可以用在生物芯片中，例如生物传感器下方或反应室下方。由于有源矩阵复合驱动器电路可以位于实际的单元阵列之外。每个单元设置有用于将单元电路耦合到驱动器电路的开关。当耦合到驱动器电路时，单元电路中的存储元件可以设置有加热设置。然后，单元电路与驱动器电路分离，并且加热元件被控制以根据存储在存储元件中的设置来加热单元。

2. 发明申请

US20090263891A1 DEVICE FOR ANALYZING SAMPLES INCLUDING A GAS EVOLVING MEANS 审中-公开
标题翻译：用于分析样品的装置，包括气体发展手段
公开(公告)号：US20090263891A1
公开(公告)日：2009-10-22
申请号：US12373993
申请日：2007-03-12
申请人： Murray Fulton Gillies , Erik Robbert Vossenaar , Mark Thomas Johnson , Hendrik Roelof Stapert , David Andrew Fish , Ralph Kurt
发明人： Murray Fulton Gillies , Erik Robbert Vossenaar , Mark Thomas Johnson , Hendrik Roelof Stapert , David Andrew Fish , Ralph Kurt
IPC分类号： C12M1/34
CPC分类号： G01N33/54366 , G01N33/54393
摘要： The invention relates to a device for analyzing one or more samples for the presence, amount or identity of one or more target molecules in the samples, comprising one or more capture sites whereby the device comprises a gas evolving means. The gas evolved by the gas evolving means moves unbound target molecules away from the capture site and therefore helps to increase the efficacy of the analysis.
摘要翻译：本发明涉及一种用于分析一个或多个样品中用于样品中一种或多种靶分子的存在，量或同一性的装置，其包含一个或多个捕获位点，由此该装置包括气体逸出装置。通过气体放出手段产生的气体将未结合的靶分子移动离开捕获位点，从而有助于提高分析的功效。

3. 发明申请

US20100181194A1 MICROELECTRONIC DEVICE WITH POWER LINES AND SIGNAL LINES 审中-公开
标题翻译：具有电源线和信号线的微电子设备
公开(公告)号：US20100181194A1
公开(公告)日：2010-07-22
申请号：US12376612
申请日：2007-07-10
申请人： David Andrew Fish , Mark Thomas Johnson
发明人： David Andrew Fish , Mark Thomas Johnson
IPC分类号： G01N27/26 , H02G5/02 , B23P17/04
CPC分类号： B03C5/005 , B03C5/026 , Y10T29/49002
摘要： The invention relates to a microelectronic device for manipulating a sample, the device comprising an array of actuator units (AU) and an array of sensitive units (SU). The actuator units (AU) may particularly exert dielectrophoretic forces on a sample (1) in an adjacent sample chamber, and the sensitive units (SU) optionally measure properties of said sample. Furthermore, the actuator units (AU) are linked to a set of power lines (PL) and the sensitive units (SU) are linked to a set of signal lines (SL), wherein the routing of these lines is such that the effects of parasitic couplings are minimized for a given set of alternating electrical power signals on the power lines. The power lines (PL) may particularly be supplied with alternating electrical signals that are identical besides a phase shift. Optionally, the couplings between the power lines and the signal lines are adapted to provide a maximal compensation of cross-talk effects.
摘要翻译：本发明涉及一种用于操纵样品的微电子装置，该装置包括一组致动器单元（AU）和一组敏感单元（SU）。致动器单元（AU）可以特别地在相邻的样品室中的样品（1）上施加介电电泳力，并且敏感单元（SU）可选地测量所述样品的性质。此外，致动器单元（AU）链接到一组电力线（PL），并且敏感单元（SU）链接到一组信号线（SL），其中这些线路的路由使得对于电力线上的给定的一组交流电功率信号，寄生耦合被最小化。电源线（PL）可以特别地提供除了相移之外相同的交替电信号。可选地，电力线和信号线之间的耦合适于提供串扰效应的最大补偿。

4. 发明申请

US20100167959A1 MICROELECTRONIC DEVICE WITH HEATING ARRAY 有权
标题翻译：具有加热阵列的微电子设备
公开(公告)号：US20100167959A1
公开(公告)日：2010-07-01
申请号：US12293602
申请日：2007-03-16
申请人： Mark Thomas Johnson , David Andrew Fish , Marc Wilhelmus Gijsbert Ponjee
发明人： Mark Thomas Johnson , David Andrew Fish , Marc Wilhelmus Gijsbert Ponjee
IPC分类号： C40B60/12
CPC分类号： B01L3/50273 , B01L3/5027 , B01L3/502792 , B01L7/52 , B01L2200/147 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/1827 , B01L2300/1883 , B01L2400/0406 , B01L2400/0415 , B01L2400/0442 , B01L2400/0448
摘要： The invention relates to different designs of a microelectronic device comprising an array of heating elements (HE) with local driving units (CU2) and optionally with an array of sensor elements (SE) adjacent to a sample chamber (SC). By applying appropriate currents to the heating elements (HE), the sample chamber can be heated according to a desired temperature profile. The local driving units comprise means for compensating variations of their individual characteristics.
摘要翻译：本发明涉及微电子装置的不同设计，其包括具有局部驱动单元（CU2）的加热元件阵列（HE）和可选地具有与样本室（SC）相邻的传感器元件阵列（SE）的阵列。通过向加热元件（HE）施加适当的电流，可以根据期望的温度分布来加热样品室。本地驱动单元包括用于补偿其各自特征的变化的装置。

5. 发明申请

US20100156444A1 MICROELECTRONIC DEVICE WITH HEATING ELECTRODES 审中-公开
标题翻译：具有加热电极的微电子器件
公开(公告)号：US20100156444A1
公开(公告)日：2010-06-24
申请号：US12293581
申请日：2007-03-19
申请人： Marc Wilhelmus Gijsbert Ponjee , Murray Fulton Gillies , Mark Thomas Johnson , David Andrew Fish
发明人： Marc Wilhelmus Gijsbert Ponjee , Murray Fulton Gillies , Mark Thomas Johnson , David Andrew Fish
IPC分类号： G01R27/08
CPC分类号： B01L3/50273 , B01L3/5027 , B01L3/502792 , B01L7/52 , B01L2200/147 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/1827 , B01L2300/1883 , B01L2400/0406 , B01L2400/0415 , B01L2400/0442 , B01L2400/0448
摘要： The invention relates to different designs of a microelectronic device comprising heating electrodes (HE) and field electrodes (FE) that have effect in the same sub-region of a sample chamber. By applying appropriate voltages to the field electrodes (FE), an electrical field (E) can be generated in the sample chamber. By applying appropriate currents to the heating electrodes (HE), the sample chamber can be heated according to a desired temperature profile. The heating electrodes (HE) may optionally be operated as field electrodes such that they generate an electrical field in the sample chamber, too.
摘要翻译：本发明涉及微电子器件的不同设计，其包括在样品室的相同子区域中具有效果的加热电极（HE）和场电极（FE）。通过向场电极（FE）施加适当的电压，可以在样品室中产生电场（E）。通过向加热电极（HE）施加适当的电流，可以根据期望的温度分布来加热样品室。加热电极（HE）可以可选地作为场电极操作，使得它们在样品室中也产生电场。

6. 发明授权

US08683877B2 Microelectronic device with heating array 有权
标题翻译：带加热阵列的微电子器件
公开(公告)号：US08683877B2
公开(公告)日：2014-04-01
申请号：US12293602
申请日：2007-03-16
申请人： Mark Thomas Johnson , David Andrew Fish , Marc Wilhelmus Gijsbert Ponjee
发明人： Mark Thomas Johnson , David Andrew Fish , Marc Wilhelmus Gijsbert Ponjee
IPC分类号： C40B60/12
CPC分类号： B01L3/50273 , B01L3/5027 , B01L3/502792 , B01L7/52 , B01L2200/147 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/1827 , B01L2300/1883 , B01L2400/0406 , B01L2400/0415 , B01L2400/0442 , B01L2400/0448
摘要： The invention relates to different designs of a microelectronic device comprising an array of heating elements (HE) with local driving units (CU2) and optionally with an array of sensor elements (SE) adjacent to a sample chamber (SC). By applying appropriate currents to the heating elements (HE), the sample chamber can be heated according to a desired temperature profile. The local driving units comprise means for compensating variations of their individual characteristics.
摘要翻译：本发明涉及微电子器件的不同设计，其包括具有局部驱动单元（CU2）的加热元件阵列（HE）和可选地具有与样本室（SC）相邻的传感器元件阵列（SE）的阵列。通过向加热元件（HE）施加适当的电流，可以根据期望的温度分布来加热样品室。本地驱动单元包括用于补偿其各自特征的变化的装置。

7. 发明授权

US09675291B2 Modifying a psychophysiological state of a subject 有权
公开(公告)号：US09675291B2
公开(公告)日：2017-06-13
申请号：US12920879
申请日：2009-03-06
申请人： Ralph Braspenning , Mark Thomas Johnson , Ronaldus Maria Aarts
发明人： Ralph Braspenning , Mark Thomas Johnson , Ronaldus Maria Aarts
IPC分类号： A61B5/16 , A61B5/024 , A61B5/0452
CPC分类号： A61B5/16 , A61B5/02405 , A61B5/0452 , A61B5/165
摘要： An apparatus and method for modifying a psychophysiological state of a subject include detecting a psychophysiological measure of the subject; processing the detected physiological measure so as to provide a signal indicative of a psychophysiological state of the subject; and outputting at least one of an audio stimulus, visual stimulus, haptic stimulus, temperature stimulus and scent stimulus to the subject. The output stimulus may be derived from an audio-visual data signal provided to the apparatus. Further, the output stimulus is adjusting in real time based on the signal indicative of a psychophysiological state of the subject.

8. 发明授权

US09610035B2 Method and system for maintaining a state in a subject 有权
公开(公告)号：US09610035B2
公开(公告)日：2017-04-04
申请号：US12920876
申请日：2009-03-05
申请人： Ronaldus Maria Aarts , Mark Thomas Johnson
发明人： Ronaldus Maria Aarts , Mark Thomas Johnson
IPC分类号： A61M21/00 , A61B5/18 , A61B5/0205 , A61B5/024 , A61B5/0245 , A61B5/0456 , A61B5/16 , A61B5/00
CPC分类号： A61B5/18 , A61B5/0205 , A61B5/02405 , A61B5/0245 , A61B5/0456 , A61B5/165 , A61B5/486 , A61M21/00 , A61M2021/0022 , A61M2021/0055 , A61M2021/0066 , A61M2021/0083 , A61M2230/06 , A61M2230/42 , G06F19/00
摘要： A method of maintaining a state in a subject includes measuring one or more physiological parameters of the subject, calculating, using the measured parameter(s), a value, determining if the calculated value is below a lower threshold or above an upper threshold, and generating an output to the subject if the calculated value is determined to be below the lower threshold or above the upper threshold. In one embodiment, the generating an output to the subject includes generating a first output if the calculated value is determined to be below the lower threshold and generating a second output if the calculated value is determined to be above the upper threshold, the second output being different from the first output.

9. 发明授权

US08982041B2 Moving particle display device with intermediate drive electrode 有权
标题翻译：具有中间驱动电极的移动颗粒显示装置
公开(公告)号：US08982041B2
公开(公告)日：2015-03-17
申请号：US12377606
申请日：2007-07-30
申请人： Mark Thomas Johnson , Franciscus Paulus Maria Budzelaar , Murray Fulton Gillies
发明人： Mark Thomas Johnson , Franciscus Paulus Maria Budzelaar , Murray Fulton Gillies
IPC分类号： G09G3/34 , G09G5/00 , G09G5/10 , G02F1/167 , G02F1/1343
CPC分类号： G02F1/167 , G02F1/134363 , G09G3/3446 , G09G2300/0434 , G09G2320/0252
摘要： A display device and a method for driving the display device is disclosed. The display device comprises drive circuitry (35) and a plurality of pixels (PIX1, PIX2, PIX3, PIX4, PIX5, PIX6) having movable charged particles (116). The drive circuitry is configured to apply control signals to the pixels to move the charged particles between first (110) and second (112) regions of each pixel in order to alter the optical appearance of each pixel. The method for each pixel comprises a pre-addressing stage (PRA) of moving the charged particles towards the boundary (114) between the first and second regions, and then an addressing stage (ADD) of moving the particles to one side or the other side of the boundary, in dependence on the desired optical appearance of the pixel.
摘要翻译：公开了一种用于驱动显示装置的显示装置和方法。显示装置包括具有可移动带电粒子（116）的驱动电路（35）和多个像素（PIX1，PIX2，PIX3，PIX4，PIX5，PIX6）。驱动电路被配置为向像素施加控制信号以将带电粒子移动到每个像素的第一（110）和第二（112）区域之间，以改变每个像素的光学外观。每个像素的方法包括将带电粒子移动到第一和第二区域之间的边界（114）的预寻址级（PRA），然后将粒子移动到一侧或另一侧的寻址级（ADD）边界，这取决于像素的期望的光学外观。

10. 发明授权

US08323570B2 Microelectronic sensor device with sensor array 有权
标题翻译：带传感器阵列的微电子传感器
公开(公告)号：US08323570B2
公开(公告)日：2012-12-04
申请号：US12293573
申请日：2007-03-01
申请人： Mark Thomas Johnson , Hendrikus Alfonsus Roelof Stapert , Marc Wilhelmus Gijsbert Ponjee
发明人： Mark Thomas Johnson , Hendrikus Alfonsus Roelof Stapert , Marc Wilhelmus Gijsbert Ponjee
IPC分类号： G01N33/00
CPC分类号： B01L3/50273 , B01L3/5027 , B01L3/502792 , B01L7/52 , B01L2200/147 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/1827 , B01L2300/1883 , B01L2400/0406 , B01L2400/0415 , B01L2400/0442 , B01L2400/0448
摘要： The invention relates to different designs of a microelectronic sensor device comprising an array of heating elements (HE) and an array of sensor elements (SE) that are aligned with respect to each other adjacent to a sample chamber (SC). By applying appropriate currents to the heating elements (HE), the sample chamber can be heated according to a desired temperature profile.
摘要翻译：本发明涉及微电子传感器装置的不同设计，该微电子传感器装置包括相对于彼此相邻于样品室（SC）对准的加热元件（HE）阵列和传感器元件阵列（SE）。通过向加热元件（HE）施加适当的电流，可以根据期望的温度分布来加热样品室。

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