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1. 发明授权

US08927715B2 Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 有权
标题翻译： 11＆bgr-羟基类固醇脱氢酶抑制剂1型
公开(公告)号：US08927715B2
公开(公告)日：2015-01-06
申请号：US12310457
申请日：2007-08-24
申请人： David A. Claremon , Suresh B. Singh , Colin M. Tice , Yuanjie Ye , Salvacion Cacatian , Wei He , Robert Simpson , Zhenrong Xu , Wei Zhao
发明人： David A. Claremon , Suresh B. Singh , Colin M. Tice , Yuanjie Ye , Salvacion Cacatian , Wei He , Robert Simpson , Zhenrong Xu , Wei Zhao
IPC分类号： A61K31/5377 , C07D471/10 , A61K31/438 , C07D221/20 , C07D401/10 , A61K31/496 , C07D413/10 , A61P3/00 , A61P9/12 , A61P9/00 , A61P25/22 , A61P25/28 , A61P25/24 , A61P15/08 , C07D211/26 , C07D413/06 , C07D211/22 , C07D491/107 , C07D211/16 , C07D211/34 , C07D401/08 , C07D401/06
CPC分类号： C07D221/20 , C07D211/16 , C07D211/22 , C07D211/26 , C07D211/34 , C07D401/06 , C07D401/08 , C07D413/06 , C07D471/10 , C07D491/107
摘要： This invention relates to novel compounds of the Formula (I*), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
摘要翻译：本发明涉及式（I *）的新化合物，其药学上可接受的盐及其药物组合物，其可用于治疗与哺乳动物中11β-HSD1的调节或抑制相关的疾病的治疗。本发明进一步涉及新化合物的药物组合物及其用于减少或控制细胞中皮质醇的产生或抑制细胞中可的松转化为皮质醇的方法。

2. 发明申请

US20110034455A1 INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 有权
标题翻译： 11BETA-羟基脱氢酶脱氢酶抑制剂1
公开(公告)号：US20110034455A1
公开(公告)日：2011-02-10
申请号：US12310457
申请日：2007-08-24
申请人： David A. Claremon , Suresh B. Singh , Colin M. Tice , Yuanjie Ye , Salvacion Cacatian , Wei He , Robert Simpson , Zhenrong Xu , Wei Zhao
发明人： David A. Claremon , Suresh B. Singh , Colin M. Tice , Yuanjie Ye , Salvacion Cacatian , Wei He , Robert Simpson , Zhenrong Xu , Wei Zhao
IPC分类号： A61K31/5377 , C07D471/10 , A61K31/438 , C07D221/20 , C07D401/10 , A61K31/496 , C07D413/10 , A61P3/00 , A61P9/12 , A61P9/00 , A61P25/22 , A61P25/28 , A61P25/24 , A61P15/08
CPC分类号： C07D221/20 , C07D211/16 , C07D211/22 , C07D211/26 , C07D211/34 , C07D401/06 , C07D401/08 , C07D413/06 , C07D471/10 , C07D491/107
摘要： This invention relates to novel compounds of the Formula (I*), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
摘要翻译：本发明涉及式（I *）的新化合物，其药学上可接受的盐及其药物组合物，其可用于治疗与哺乳动物中11β-HSD1的调节或抑制相关的疾病的治疗。本发明进一步涉及新化合物的药物组合物及其用于减少或控制细胞中皮质醇的产生或抑制细胞中可的松转化为皮质醇的方法。

3. 发明授权

US10986963B1 Barbecue cooking apparatus 有权
公开(公告)号：US10986963B1
公开(公告)日：2021-04-27
申请号：US17138631
申请日：2020-12-30
申请人： Robert Simpson
发明人： Robert Simpson
IPC分类号： A47J37/07 , A47J36/06 , A23B4/052 , B66D1/26 , B66D1/04
摘要： A barbecue cooking apparatus is an apparatus used to cook food items by utilizing different barbecue smoking methods. The apparatus includes a barrel, a lid, a frame, a shelved cooking system, a venting system, a winch mechanism, a lip, and a firebox gasket. The barrel provides a thermal enclosure for cooking the food items. The lid serves to close the barrel and to support the shelved cooking system. The lip and the firebox gasket seal the lid on the barrel when closed. The shelved cooking system holds both the food items within the barrel during the cooking process and the fuel source utilized to generate the heat energy to cook the food items. The frame holds the winch mechanism offset from the barrel. The winch mechanism facilitates the retrieval of the shelved cooking system from the barrel as well as the reintroduction of the shelved cooking system into the barrel.

4. 发明申请

US20100194007A1 NOVEL FILTRATION SYSTEM FOR LARGE CAST IRON CASTINGS 审中-公开
标题翻译：用于大型铸铁铸造的新型过滤系统
公开(公告)号：US20100194007A1
公开(公告)日：2010-08-05
申请号：US12679720
申请日：2008-09-25
申请人： Donald B. Craig , Steven H. Martin , Rudolph A. Olson , Robert Simpson , Eldon Rohlena
发明人： Donald B. Craig , Steven H. Martin , Rudolph A. Olson , Robert Simpson , Eldon Rohlena
IPC分类号： B01D25/00 , B01D29/50
CPC分类号： C22B9/023 , B22D43/004 , Y02P10/234
摘要： An improved filter assembly for molten metal is described. The assembly has a canister with at least one port wherein the port allows filtered molten metal to flow from the canister. A plurality of filter elements is in the canister wherein the filter elements separate a volume of the canister into a primary chamber and a secondary chamber wherein the secondary chamber is in direct flow communication with the port. A ported cover is over the canister wherein the ported cover prohibits unfiltered molten metal from flowing directly into the secondary chamber. The molten metal flows from the primary chamber to the secondary chamber through a filter element.
摘要翻译：描述了用于熔融金属的改进的过滤器组件。组件具有至少一个端口的罐，其中端口允许过滤的熔融金属从罐流出。多个过滤器元件位于罐中，其中过滤元件将容器的容积分成主室和次室，其中副室与端口直接流动连通。端口盖在罐上方，其中移动盖禁止未过滤的熔融金属直接流入二级室。熔融金属通过过滤元件从初级室流到次级室。

5. 发明申请

US20070181867A1 Phase change memory materials, devices and methods 有权
标题翻译：相变记忆材料，装置和方法
公开(公告)号：US20070181867A1
公开(公告)日：2007-08-09
申请号：US11643044
申请日：2006-12-20
申请人： Daniel Hewak , Richard Curry , Arshad Mairaj , Robert Simpson
发明人： Daniel Hewak , Richard Curry , Arshad Mairaj , Robert Simpson
IPC分类号： H01L47/00
CPC分类号： H01L45/141 , G11B7/243 , G11B7/2585 , G11B2007/24306 , G11B2007/2431 , G11B2007/24316 , G11C13/0004 , G11C13/0069 , G11C2013/008 , H01L27/2463 , H01L45/06 , H01L45/065 , H01L45/1233 , H01L45/126 , H01L45/1293 , H01L45/142 , H01L45/143 , H01L45/144 , H01L45/1625
摘要： A new class of phase change materials has been discovered based on compounds of: Ga; lanthanide; and chalcogenide. This includes compounds of Ga, La, and S (GLS) as well as related compounds in which there is substitution of S with O, Se and/or Te. Moreover, La can be substituted with other lanthanide series elements. It has been demonstrated that this class of materials exhibit low energy switching. For example, the GLS material can provide an optical recording medium with erasability 3-5 dB greater than the erasability of GeSbTe (GST) material which is the standard material for phase change memories.
摘要翻译：基于以下化合物发现了一类新型相变材料：Ga; 镧系元素和硫族化物。这包括Ga，La和S（GLS）的化合物以及其中用O，Se和/或Te取代S的相关化合物。此外，La可以被其他镧系元素代替。已经证明这类材料表现出低能量切换。例如，GLS材料可以提供比作为相变存储器的标准材料的GeSbTe（GST）材料的可擦除性更大3-5dB的光学记录介质。

6. 发明申请

US20070083184A1 Epidural catheter system and methods of use 审中-公开
公开(公告)号：US20070083184A1
公开(公告)日：2007-04-12
申请号：US11519258
申请日：2006-09-11
申请人： Robert Simpson
发明人： Robert Simpson
IPC分类号： A61M31/00
CPC分类号： A61B17/3401 , A61M25/0113 , A61M2025/0007
摘要： An epidural injection is used in medical procedure to administer medication to a patient's epidural space in the spine, usually to alleviate pain. Although effective in purpose, current medical procedure to administer an epidural injection does contain a flaw that exposes the patient to possible infection, usually manifested as an epidural abscess or bacterial meningitis. A source for infection stems from the manner the epidural catheter, specifically the proximal end not being inserted into the patient, is traditionally handled throughout the procedure—usually freely hanging, susceptible to breaking the sterile field and becoming contaminated. The current invention, an epidural catheter dispenser system, seeks to eliminate this risk of epidural catheter contamination by maintaining the epidural catheter, especially the proximal catheter end, in a sterile dispenser that can be easily manipulated by a physician. The epidural catheter dispenser system defines an inner cavity in which an epidural catheter may be loaded. When ready for use, a distal catheter end is extracted from the dispenser's inner cavity through a dispenser aperture on the dispenser's distal end piece, or top, allowing the physician to direct the epidural catheter into an epidural needle bore and into a patient's epidural space. Because the epidural catheter dispenser system and its epidural catheter contents fit easily into the palm of a physician's hand, the proximal catheter end is permanently in a controlled, contained sterile environment throughout the entire catheter placement procedure until extracted from the dispenser. The current invention minimizes and virtually eliminates the risk of epidural catheter contamination. Thus, the epidural catheter dispenser system provides benefits beyond existing epidural injection procedures including: (1) reduced risk of infection of the patient receiving an epidural injection; (2) easier catheter management for the physician; (3) better control of the medical microenvironment for the physician; and (4) improved medical efficiencies.

7. 发明申请

US20050148743A1 Supported activator 有权
标题翻译：支持激活剂
公开(公告)号：US20050148743A1
公开(公告)日：2005-07-07
申请号：US10753153
申请日：2004-01-07
申请人： Gary Casty , Smita Kacker , Jack Johnson , Murielle Scott , Steven Hegwood , Robert Simpson , Robert Reynolds
发明人： Gary Casty , Smita Kacker , Jack Johnson , Murielle Scott , Steven Hegwood , Robert Simpson , Robert Reynolds
IPC分类号： B01J31/02 , B01J31/12 , B01J31/14 , B01J31/16 , B01J31/22 , C08F4/6592 , C08F10/00 , C08F110/06 , C08F210/16 , C08F4/44 , B01J31/00
CPC分类号： C08F10/00 , B01J31/02 , B01J31/143 , B01J31/1608 , B01J31/2295 , B01J2531/48 , B01J2531/49 , C08F4/65927 , C08F110/06 , C08F210/16 , Y10S526/943 , C08F4/65912 , C08F4/65916 , C08F2500/04 , C08F2500/18 , C08F210/14 , C08F2500/03
摘要： This invention relates to supported activators comprising the product of the combination of an ion-exchange layered silicate, an organoaluminum compound, and a heterocyclic compound, which may be substituted or unsubstituted. This invention further relates to catalyst systems comprising catalyst compounds and such activators, as well as processes to polymerize unsaturated monomers using the supported activators. For the purposes of this patent specification and the claims thereto, the term “activator” is used interchangeably with the term “co-catalyst”, the term “catalyst” refers to a metal compound that when combined with an activator polymerizes olefins, and the term “catalyst system” refers to the combination of a catalyst and an activator with or without a support. The terms “support” or “carrier”, for purposes of this patent specification, are used interchangeably and are any ion-exchange layered silicates.
摘要翻译：本发明涉及负载的活化剂，其包括可以是取代或未取代的离子交换层状硅酸盐，有机铝化合物和杂环化合物的组合的产物。本发明还涉及包含催化剂化合物和这种活化剂的催化剂体系，以及使用负载的活化剂聚合不饱和单体的方法。为了本专利说明书及其权利要求的目的，术语“活化剂”可与术语“助催化剂”互换使用，术语“催化剂”是指当与活化剂组合时使烯烃聚合的金属化合物，术语“催化剂体系”是指催化剂和具有或不具有载体的活化剂的组合。为了本专利说明书的目的，术语“支持”或“载体”可互换使用，并且是任何离子交换层状硅酸盐。

8. 发明申请

US20050053455A1 Variable-sized molded product tray denesting apparatus 失效
标题翻译：可变尺寸模制产品托盘破碎装置
公开(公告)号：US20050053455A1
公开(公告)日：2005-03-10
申请号：US10919179
申请日：2004-08-16
申请人： Jerry Jaspers , Robert Simpson , Carl Van Doren , David Reed
发明人： Jerry Jaspers , Robert Simpson , Carl Van Doren , David Reed
IPC分类号： B65G59/06 , B65G59/10
CPC分类号： B65G59/106 , B65G47/91 , B65G47/918
摘要： A tray denesting apparatus is provided comprising a receptacle for holding at least one nested stack of packing trays. A conveyer belt is further provided for receiving each of the packing trays upon release from the receptacle. The denesting apparatus has at least one set of soft flexible suction cups disposed below the conveyer belt and which are disposed on a bellows assembly which is moveable between a first position and a second position so that at least one of the soft flexible suction cups may adhere to a first one of the packing trays, and successive packing trays. The tray denester further may include an automatic adjustment apparatus to correspond with selected size parameters of the trays being utilized. As a result, an individual tray may be removed from the receptacle, deposited on the conveyer belt and the conveyer belt then advancing the selected tray to the required area of use.
摘要翻译：提供了一种托盘破碎装置，其包括用于保持至少一个嵌套的堆叠堆叠的托盘的容器。输送带还设置成用于在从容器释放时接收每个包装托盘。该装置具有设置在输送带下方的至少一组柔软的柔性吸盘，它们设置在波纹管组件上，波纹管组件可在第一位置和第二位置之间移动，使得柔性柔性吸盘中的至少一个可以粘附到第一个包装托盘，以及连续的包装托盘。托盘减径器还可以包括与所使用的托盘的所选尺寸参数对应的自动调节装置。结果，可以将单独的托盘从容器中取出，沉积在输送带和输送带上，然后将所选托盘推进到所需的使用区域。

9. 发明授权

US6144640A ATM switch 失效
标题翻译： ATM交换机
公开(公告)号：US6144640A
公开(公告)日：2000-11-07
申请号：US920256
申请日：1997-08-28
申请人： Robert Simpson , Neil Richards , Peter Thompson , Pascal Moniot , Marcello Coppola , Pierre Dumas , Thierry Grenot , David Mouen Makoua
发明人： Robert Simpson , Neil Richards , Peter Thompson , Pascal Moniot , Marcello Coppola , Pierre Dumas , Thierry Grenot , David Mouen Makoua
IPC分类号： H04Q3/00 , H04L12/56 , H04Q11/04
CPC分类号： H04L12/5601 , H04L49/108 , H04L49/1553 , H04L49/255 , H04Q11/0478 , H04L2012/563 , H04L2012/5647 , H04L2012/5649 , H04L2012/5651 , H04L2012/5681
摘要： An ATM routing switch for bidirectional transmission of at least two types of cell, one type accepting variable bit rate of transmission and a second type accepting some loss of cells in transmission, includes first reserve buffer capacity for cells of the first type, a second reserve buffer capacity for cells of said second type and control circuitry for generating a flow control signal (FCT) if a predetermined threshold for the first buffer capacity is reached by input of cells of said first type, and discarding input cells of said second type if a predetermined threshold for said second buffer capacity has been reached by input of cells of said second type.
摘要翻译：用于至少两种类型的小区的双向传输的ATM路由交换机，接收可变比特率传输的一种类型和接收传输中的小区的一些丢失的第二类型，包括第一种类型的小区的第一预备缓冲器容量，第二种储备如果通过所述第一类型的单元的输入达到用于第一缓冲器容量的预定阈值，则产生流控制信号（FCT）的所述第二类型的单元的缓冲器容量和控制电路，以及丢弃所述第二类型的输入单元，如果通过输入所述第二类型的单元已经达到了所述第二缓冲器容量的预定阈值。

10. 发明授权

US5266378A Wheel positioning garage mat 失效
标题翻译：车轮定位车库
公开(公告)号：US5266378A
公开(公告)日：1993-11-30
申请号：US883106
申请日：1992-05-14
申请人： James Stephenson , Robert Simpson
发明人： James Stephenson , Robert Simpson
IPC分类号： B60T3/00 , B32B3/00
CPC分类号： B60T3/00 , Y10T428/24479 , Y10T428/2457 , Y10T428/24777 , Y10T428/2495 , Y10T428/24992
摘要： A vehicle positioning garage mat is formed as a unitary structure, including a substantially rectangular mat, with an upper surface having forward and rearward transverse bumps formed integrally thereon. The mat is to be placed on a support surface in a selected position in the path of vehicle tire, to indicate a desired parking position for the vehicle. The mat includes a rearward bump, positioned along the length of the mat forward of a trailing edge, and a forward bump spaced forwardly of the rearward bump. A tab section is provided between the rearward bump and a trailing edge of the mat for initial engagement with a vehicle tire. The tab first receives a forwardly moving vehicle tire and thus secures the mat before the tire engages the rearward bump. The forward and rearward bumps are reinforced from below by spaced longitudinal rib sections that provide resilient resistance to depression, while minimizing the amount of material required for the mat. The density of material within the mat is concentrated at the bumps such that the durometer value of the material at the bumps is greater than the overall durometer of the mat between the bumps.
摘要翻译：车辆定位车库垫形成为整体结构，包括大致矩形的垫，其上表面具有一体地形成在其上的向前和向后的横向凸起。垫子将被放置在车辆轮胎的路径中的选定位置的支撑表面上，以指示车辆的期望的停车位置。垫包括沿着后缘前方的垫的长度定位的向后凸起，以及与后凸块向前间隔开的前凸块。在后凸块和垫子的后缘之间提供突片部分，用于与车辆轮胎初始接合。突片首先接收向前移动的车辆轮胎，并且因此在轮胎接合后凸块之前固定垫。向下和向后的凸块从下方通过间隔开的纵向肋部分加强，该纵向肋段提供对凹陷的弹性阻力，同时最小化垫所需的材料的量。垫内的材料的密度集中在凸块处，使得凸块处的材料的硬度值大于凸块之间的垫的整体硬度。

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