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1. 发明申请

US20130090542A1 IMPLANTABLE MICRO-COMPONENT ELECTRODES 有权
标题翻译：可植入的微组件电极
公开(公告)号：US20130090542A1
公开(公告)日：2013-04-11
申请号：US13805132
申请日：2011-06-16
申请人： Daryl R. Kipke , Takashi Daniel Yoshida Kozai , Nick Langhals , Joerg Lahann , Nicholas A. Kotov , Xiaopei Deng , Paras Patel
发明人： Daryl R. Kipke , Takashi Daniel Yoshida Kozai , Nick Langhals , Joerg Lahann , Nicholas A. Kotov , Xiaopei Deng , Paras Patel
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61B5/04001 , A61B5/685 , A61B2562/125 , A61N1/05 , A61N1/0529 , A61N1/0551 , B82Y5/00
摘要： The present disclosure provides robust implantable micro-component electrodes that can be used in a variety of medical devices. The medical device may be a neural probe that can monitor or stimulate neural activity in an organism's brain, spine, nerves, or organs, for example. The micro-component electrode has a small physical profile, with ultra-thin dimensions, while having high strength and flexibility. The micro-electrode has an electrically conductive core material, e.g., carbon. The surface of the core material includes one or more electrically conductive regions coated with an electrically conductive material and one or more non-conductive regions having an electrically non-conductive biocompatible polymeric coating. Implantable devices having such micro-components are capable of implantation in an organism for very long durations.
摘要翻译：本公开提供可用于各种医疗装置的可植入的微型组件电极。医疗装置可以是例如可以监测或刺激生物体的脑，脊柱，神经或器官中的神经活动的神经探针。微组件电极具有小的物理特性，具有超薄的尺寸，同时具有高的强度和柔韧性。微电极具有导电芯材料，例如碳。芯材料的表面包括涂覆有导电材料的一个或多个导电区域和具有不导电的生物相容性聚合物涂层的一个或多个非导电区域。具有这种微组件的可植入装置能够在生物体内植入非常长的持续时间。

2. 发明授权

US09907475B2 Implantable micro-component electrodes 有权
公开(公告)号：US09907475B2
公开(公告)日：2018-03-06
申请号：US13805132
申请日：2011-06-16
申请人： Daryl R. Kipke , Takashi Daniel Yoshida Kozai , Nick Langhals , Joerg Lahann , Nicholas A. Kotov , Xiaopei Deng , Paras Patel
发明人： Daryl R. Kipke , Takashi Daniel Yoshida Kozai , Nick Langhals , Joerg Lahann , Nicholas A. Kotov , Xiaopei Deng , Paras Patel
IPC分类号： A61B5/04 , A61N1/00 , A61B5/00 , A61N1/05 , B82Y5/00
CPC分类号： A61B5/04001 , A61B5/685 , A61B2562/125 , A61N1/05 , A61N1/0529 , A61N1/0551 , B82Y5/00
摘要： The present disclosure provides robust implantable micro-component electrodes that can be used in a variety of medical devices. The medical device may be a neural probe that can monitor or stimulate neural activity in an organism's brain, spine, nerves, or organs, for example. The micro-component electrode has a small physical profile, with ultra-thin dimensions, while having high strength and flexibility. The micro-electrode has an electrically conductive core material, e.g., carbon. The surface of the core material includes one or more electrically conductive regions coated with an electrically conductive material and one or more non-conductive regions having an electrically non-conductive biocompatible polymeric coating. Implantable devices having such micro-components are capable of implantation in an organism for very long durations.

3. 发明申请

US20090312770A1 PROBE INSERTION DEVICE FOR IMPLANTING A PROBE INTO TISSUE 有权
标题翻译：用于将探针植入组织的探针插入装置
公开(公告)号：US20090312770A1
公开(公告)日：2009-12-17
申请号：US12483313
申请日：2009-06-12
申请人： Takashi Daniel Yoshida Kozai , Daryl R. Kipke , Jeyakumar Subbaroyan
发明人： Takashi Daniel Yoshida Kozai , Daryl R. Kipke , Jeyakumar Subbaroyan
IPC分类号： A61B17/00
CPC分类号： A61B17/3468 , A61B5/0478 , A61B5/6846 , A61B5/6868 , A61B17/1604 , A61B90/10 , A61B2017/0084 , A61N1/0529 , A61N1/0534 , A61N1/0539
摘要： A probe insertion device for implanting a probe into tissue includes a rigid base that selectively attaches to the probe due to a bond between the base and the probe, that provides a structural backbone to the probe, is longitudinally aligned with the probe, and can be adapted to receive a fluid between the base and the probe. The probe insertion device can include a surface covering at least a portion of the base that reduces the bond between the base and the probe in the presence of the fluid.
摘要翻译：用于将探针植入组织中的探针插入装置包括由基底和探针之间的接合选择性地附接到探针的刚性基底，其提供了探针的结构骨架，与探针纵向对齐，并且可以是适于在基部和探针之间接收流体。探针插入装置可以包括覆盖基底的至少一部分的表面，其在流体存在的情况下减少基部和探针之间的结合。

4. 发明授权

US08852206B2 Probe insertion device for implanting a probe into tissue 有权
标题翻译：用于将探针植入组织的探针插入装置
公开(公告)号：US08852206B2
公开(公告)日：2014-10-07
申请号：US12483313
申请日：2009-06-12
申请人： Takashi Daniel Yoshida Kozai , Daryl R. Kipke , Jeyakumar Subbaroyan
发明人： Takashi Daniel Yoshida Kozai , Daryl R. Kipke , Jeyakumar Subbaroyan
IPC分类号： A61B5/04 , A61B5/00 , A61B17/34 , A61B17/00 , A61B17/16 , A61N1/05 , A61B19/00
CPC分类号： A61B17/3468 , A61B5/0478 , A61B5/6846 , A61B5/6868 , A61B17/1604 , A61B90/10 , A61B2017/0084 , A61N1/0529 , A61N1/0534 , A61N1/0539
摘要： A probe insertion device for implanting a probe into tissue includes a rigid base that selectively attaches to the probe due to a bond between the base and the probe, that provides a structural backbone to the probe, is longitudinally aligned with the probe, and can be adapted to receive a fluid between the base and the probe. The probe insertion device can include a surface covering at least a portion of the base that reduces the bond between the base and the probe in the presence of the fluid.
摘要翻译：用于将探针植入组织中的探针插入装置包括由基底和探针之间的接合选择性地附接到探针的刚性基底，其提供了探针的结构骨架，与探针纵向对齐，并且可以是适于在基部和探针之间接收流体。探针插入装置可以包括覆盖基底的至少一部分的表面，其在流体存在的情况下减少基部和探针之间的结合。

5. 发明授权

US08498720B2 Implantable electrode and method of making the same 有权
标题翻译：可植入电极及其制造方法
公开(公告)号：US08498720B2
公开(公告)日：2013-07-30
申请号：US12396107
申请日：2009-03-02
申请人： David S. Pellinen , Mayurachat Gulari , Jamille Farraye Hetke , David J. Anderson , Daryl R. Kipke , Rio J. Vetter
发明人： David S. Pellinen , Mayurachat Gulari , Jamille Farraye Hetke , David J. Anderson , Daryl R. Kipke , Rio J. Vetter
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61B5/04001 , A61B2562/0209 , A61N1/0529 , A61N1/0551 , H05K1/0393 , H05K1/113 , H05K3/4644 , H05K2201/09781 , H05K2201/2072 , Y10T29/49117
摘要： The implantable electrode system of the preferred embodiments includes a conductor, an interconnect coupled to the conductor, an insulator that insulates the interconnect, and an anchor that is connected to both the conductor and the insulating element. The anchor is mechanically interlocked with at least one of the conductor and the insulator.
摘要翻译：优选实施例的可植入电极系统包括导体，耦合到导体的互连件，绝缘体互连件的绝缘体以及连接到导体和绝缘元件两者的锚固件。锚固体与导体和绝缘体中的至少一个机械地互锁。

6. 发明授权

US08412302B2 Intracranial neural interface system 有权
公开(公告)号：US08412302B2
公开(公告)日：2013-04-02
申请号：US13314680
申请日：2011-12-08
申请人： Daryl R. Kipke , Justin C. Williams , Jamille Hetke , Jaimie Henderson , P. Charles Garell
发明人： Daryl R. Kipke , Justin C. Williams , Jamille Hetke , Jaimie Henderson , P. Charles Garell
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61B5/04001 , A61B5/7232 , A61B2018/00434 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , A61N1/3756
摘要： In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.

7. 发明申请

US20120078188A1 NEURAL DRUG DELIVERY SYSTEM WITH FLUIDIC THREADS 有权
标题翻译：具有流体螺纹的神经药物输送系统
公开(公告)号：US20120078188A1
公开(公告)日：2012-03-29
申请号：US13236973
申请日：2011-09-20
申请人： Jamille F. Hetke , Daryl R. Kipke , Rio J. Vetter
发明人： Jamille F. Hetke , Daryl R. Kipke , Rio J. Vetter
IPC分类号： A61M5/00
CPC分类号： A61M25/007 , A61M2025/0058 , A61M2210/1003
摘要： A neural drug delivery system with fluidic threads implantable into tissue, including: a plurality of fluid delivery conduits configured to transport fluid and having an array of fluid delivery ports through which the fluid is selectively released; a plurality of port gates each including a mesh structure coupled to a corresponding fluid delivery port and coated with an electroactive polymer; a voltage source providing a conductive signal; and an interconnect network that carries the conductive signal to the port gates. In response of the electroactive polymer to the conductive signal, each port gate is selectively operable between a closed mode that prevents transfer of fluid through its corresponding fluid delivery port to the tissue, and an open mode that allows transfer of the fluid through its corresponding fluid delivery port to the tissue.
摘要翻译：一种具有可植入组织中的流体线的神经药物递送系统，包括：多个流体输送导管，其构造成输送流体并具有流体选择性释放的流体排放口阵列; 多个端口门，每个端口门均包括耦合到相应的流体输送端口并涂覆有电活性聚合物的网状结构; 提供导电信号的电压源; 以及将导电信号传送到端口门的互连网络。响应于电活性聚合物对导电信号的响应，每个端口门可选择性地在封闭模式之间操作，该闭合模式防止流体通过其相应的流体输送端口传递到组织，以及允许流体通过其相应流体传递的开放模式输送端口到组织。

8. 发明申请

US20110154655A1 Modular multichannel microelectrode array and methods of making same 有权
公开(公告)号：US20110154655A1
公开(公告)日：2011-06-30
申请号：US12986081
申请日：2011-01-06
申请人： Jamille F. Hetke , Daryl R. Kipke , David S. Pellinen , David J. Anderson
发明人： Jamille F. Hetke , Daryl R. Kipke , David S. Pellinen , David J. Anderson
IPC分类号： H01R43/00
CPC分类号： A61B5/04001 , A61B2562/0209 , A61B2562/043 , A61N1/0534 , Y10T29/49117 , Y10T29/49147 , Y10T29/49149 , Y10T29/49155 , Y10T29/49211
摘要： Some embodiments of the invention comprise a customizable multichannel microelectrode array with a modular planar microfabricated electrode array attached to a carrier and a high density of recording and/or stimulation electrode sites disposed thereon. Novel methods of making and using same are also disclosed.

9. 发明申请

US20090118806A1 THREE-DIMENSIONAL SYSTEM OF ELECTRODE LEADS 有权
标题翻译：电极引线三维系统
公开(公告)号：US20090118806A1
公开(公告)日：2009-05-07
申请号：US12253803
申请日：2008-10-17
申请人： Rio J. Vetter , Daryl R. Kipke , Jamille F. Helke
发明人： Rio J. Vetter , Daryl R. Kipke , Jamille F. Helke
IPC分类号： A61N1/05
CPC分类号： A61B5/0478 , A61B5/04001 , A61N1/0534 , A61N1/0551
摘要： The electrode lead system of a preferred embodiment includes a series of first electrical subsystems; a guiding element that positions the series of first electrical subsystems in a three dimensional arrangement within body tissue; a second electrical subsystem; and at least one connector that couples the first electrical subsystems to the second electrical subsystem. The electrode lead system of another preferred embodiment includes a series of electrode arrays; a guide tube that facilitates implantation of electrode arrays within body tissue and temporarily contains the series of electrode arrays; and a guiding element that provides a bias on the series of electrode arrays such that (a) when contained by the guide tube, the first electrical subsystems maintain a substantially singular path within body tissue, and (b) when not contained by the guide tube, the first electrical subsystems diverge along more than one path into a three dimensional arrangement within body tissue.
摘要翻译：优选实施例的电极引线系统包括一系列第一电子子系统; 引导元件，其将所述一系列第一电子系统定位在身体组织内的三维排列中; 第二电子系统; 以及将第一电子系统耦合到第二电子系统的至少一个连接器。另一个优选实施例的电极引线系统包括一系列电极阵列; 引导管，其有助于将电极阵列植入体内组织并暂时包含一系列电极阵列; 以及引导元件，其在所述一系列电极阵列上提供偏置，使得（a）当由所述引导管容纳时，所述第一电子系统在所述主体组织内保持基本上奇异的路径，以及（b）当所述引导管未被所述导管，第一电子子系统沿着多于一条的路径发散成体内组织内的三维排列。

10. 发明授权

US08870857B2 Waveguide neural interface device 有权
标题翻译：波导神经接口装置
公开(公告)号：US08870857B2
公开(公告)日：2014-10-28
申请号：US12940748
申请日：2010-11-05
申请人： John P. Seymour , Mayurachat Gulari , Daryl R. Kipke , Kc Kong
发明人： John P. Seymour , Mayurachat Gulari , Daryl R. Kipke , Kc Kong
IPC分类号： A61N5/06 , A61B5/00
CPC分类号： A61N5/0622 , A61B5/0084 , A61B5/04001 , A61B5/4076 , A61B2562/0233 , A61B2562/046 , A61N2005/0626 , A61N2005/0643 , Y10T29/49016
摘要： A waveguide neural interface device including: a neural device implantable in tissue and including an array of electrode sites that electrically communicate with their surroundings, in which the array of electrode sites includes at least one recording electrode site; and a waveguide, coupled to the neural device, that carries light along a longitudinal axis and includes a light directing element that redirects the carried light from the waveguide to illuminate selectively targeted tissue, in which at least a portion of the redirected light is directed laterally away from the longitudinal axis and the recording electrode site is configured to sample illuminated tissue. A method for assembling a waveguide neural interface device is also described.
摘要翻译：一种波导神经接口装置，包括：可植入组织中并包括与其周围环境电连通的电极位置阵列的神经装置，其中电极位置阵列包括至少一个记录电极位置; 以及耦合到所述神经装置的波导，其沿着纵向轴线承载光，并且包括导光元件，所述光导向元件重新导向所述被传输的光从所述波导照射选择性地靶向的组织，其中所述重定向的光的至少一部分被侧向远离纵向轴线并且记录电极部位被配置为对照射的组织进行采样。还描述了一种用于组装波导神经接口装置的方法。

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