专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20180346448A1 SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS 审中-公开
公开(公告)号：US20180346448A1
公开(公告)日：2018-12-06
申请号：US16001883
申请日：2018-06-06
申请人： DART NEUROSCIENCE (CAYMAN) LTD.
发明人： Venkataiah Bollu , James Breitenbucher , Alan Kaplan , Robert Lemus , Andrew Lindstrom , Troy Vickers , Michael Weinhouse , Mark E. Wilson , James Zapf
IPC分类号： C07D403/06 , C07D409/14 , C07D409/06 , C07D413/06 , C07D405/14 , C07D401/06 , C07D405/12 , C07D401/14 , C07D241/18 , A61K51/04 , C07D213/81 , C07D213/74 , C07D213/73 , C07D213/64 , C07D239/34 , C07D417/06
CPC分类号： C07D403/06 , A61K51/0459 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/81 , C07D239/34 , C07D241/18 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要： The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders, including inflammatory and renal disorders.

2. 发明授权

US09932345B2 Substituted [1,2,4]triazolo[1,5-A]pyrimidin-7-yl compounds as PDE2 inhibitors 有权
公开(公告)号：US09932345B2
公开(公告)日：2018-04-03
申请号：US15306069
申请日：2015-04-22
申请人： DART NEUROSCIENCE (CAYMAN) LTD.
发明人： James Breitenbucher , Graeme Freestone , Laurent Gomez , Robert Lemus , Kiev Ly , Margaret McCarrick , William Vernier , Troy Vickers
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides a chemical entity of Formula (I) wherein R1, R2, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods as disclosed herein, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.

3. 发明申请

US20170057967A1 SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS 有权
标题翻译：取代[1,2,4]三唑并[1,5-A]吡啶二酮-7-YL化合物作为PDE2抑制剂
公开(公告)号：US20170057967A1
公开(公告)日：2017-03-02
申请号：US15306069
申请日：2015-04-22
申请人： DART NEUROSCIENCE (CAYMAN) LTD.
发明人： James Breitenbucher , Graeme Freestone , Laurent Gomez , Robert Lemus , Kiev Ly , Margaret McCarrick , William Vernier , Troy Vickers
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides a chemical entity of Formula (I) wherein R1, R2, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods as disclosed herein, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.
摘要翻译：本发明提供式（I）的化学实体：其中R1，R2，X，Y和Z具有本文所述的任何值，以及包含这些化学实体的组合物; 制作方法; 以及它们在本文公开的广泛方法中的用途，包括代谢和反应动力学研究; 检测和成像技术; 放射治疗; 调节和治疗由PDE2活性介导的疾病; 治疗神经系统疾病，中枢神经系统疾病，痴呆，神经变性疾病和创伤依赖性功能丧失; 治疗中风，包括中风康复期间的认知和运动缺陷; 促进神经保护和神经恢复; 提高认知和运动训练的效率，包括动物技能训练方案; 和治疗外周疾病，包括血液学，心血管，胃肠病学和皮肤病学疾病。

4. 发明申请

US20180179216A1 SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS 审中-公开
公开(公告)号：US20180179216A1
公开(公告)日：2018-06-28
申请号：US15905672
申请日：2018-02-26
申请人： DART NEUROSCIENCE (CAYMAN) LTD.
发明人： James Breitenbucher , Graeme Freestone , Laurent Gomez , Robert Lemus , Kiev Ly , Margaret McCarrick , William Vernier , Troy Vickers
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , A61K31/519 , A61P25/28 , C07D519/00
摘要： The invention provides a chemical entity of Formula (I): wherein R1, R2, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods as disclosed herein, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.

5. 发明申请

US20170182052A1 THERAPEUTIC THIOPHENE-, FURAN-, AND PYRIDINE-FUSED AZOLOPYRIMIDIN-5-(6H)-ONES 审中-公开
公开(公告)号：US20170182052A1
公开(公告)日：2017-06-29
申请号：US15394058
申请日：2016-12-29
申请人： Dart Neuroscience (Cayman) Ltd.
发明人： Bryan Branstetter , James Breitenbucher , Brian Dyck , Laurent Gomez , Andrew Richard Hudson , Tami Jo Marrone , Marco Peters , Troy Vickers , Michael Weinhouse
IPC分类号： A61K31/519 , A61K31/551 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K31/5377
CPC分类号： A61K31/553 , A61K31/519 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/551 , C07D471/14 , C07D487/14 , C07D491/107 , C07D491/147 , C07D491/22 , C07D495/12 , C07D495/14 , C07D495/22 , C07D498/08 , C07D519/00
摘要： Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.

6. 发明申请

US20150329500A1 SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS 有权
标题翻译：取代的吡啶和吡嗪化合物作为PDE4抑制剂
公开(公告)号：US20150329500A1
公开(公告)日：2015-11-19
申请号：US14720321
申请日：2015-05-22
申请人： Dart Neuroscience (Cayman) Ltd.
发明人： Venkataiah Bollu , James Breitenbucher , Alan Kaplan , Robert Lemus , Andrew Lindstrom , Troy Vickers , Mark Wilson , James Zapf
IPC分类号： C07D241/18 , C07D401/06 , C07D401/14 , C07D409/14 , C07D405/12 , C07D417/06 , C07D405/14 , C07D413/06 , C07D403/06 , C07D213/64
CPC分类号： C07D403/06 , A61K51/0459 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/81 , C07D239/34 , C07D241/18 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要： The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders.
摘要翻译：本发明提供式（I）的化学实体，其中R 1，R 2，R 3，R 4，Y和Z具有本文所述的任何值，以及包含这些化学实体的组合物; 制作方法; 并在广泛的方法中使用，包括代谢和反应动力学研究，检测和成像技术以及放射性治疗; 和治疗方法，包括抑制PDE4，增强神经元可塑性，治疗神经障碍，提供神经保护，治疗与CNS病症相关的认知障碍，提高认知和运动训练的效率，提供神经复发和神经康复，提高非人类动物的效率训练方案和治疗外周疾病，包括炎症和肾脏疾病。

7. 发明授权

US10376514B2 Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6H)-ones 有权
公开(公告)号：US10376514B2
公开(公告)日：2019-08-13
申请号：US16164726
申请日：2018-10-18
申请人： Dart Neuroscience (Cayman) Ltd.
发明人： Bryan Branstetter , James Breitenbucher , Brian Dyck , Laurent Gomez , Andrew Richard Hudson , Tami Jo Marrone , Marco Peters , Troy Vickers , Michael I. Weinhouse
IPC分类号： C07D495/14 , C07D495/22 , C07D471/14 , C07D471/22 , C07D487/14 , C07D487/22 , C07D491/22 , A61K31/519 , C07D498/08 , C07D491/147 , C07D491/107 , C07D519/00 , C07D495/12 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/5386 , A61P25/00 , A61P9/00
摘要： Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.

8. 发明申请

US20160075719A1 THERAPEUTIC THIOPHENE-, FURAN-, AND PYRIDINE-FUSED AZOLOPYRIMIDIN-5-(6H)-ONES 有权
公开(公告)号：US20160075719A1
公开(公告)日：2016-03-17
申请号：US14853856
申请日：2015-09-14
申请人： Dart Neuroscience (Cayman) Ltd.
发明人： Bryan Branstetter , James Breitenbucher , Brian Dyck , Laurent Gomez , Andrew Richard Hudson , Tami Jo Marrone , Marco Peters , Troy Vickers , Michael Weinhouse
IPC分类号： C07D495/14 , C07D491/147 , C07D495/22 , C07D519/00
CPC分类号： A61K31/553 , A61K31/519 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/551 , C07D471/14 , C07D487/14 , C07D491/107 , C07D491/147 , C07D491/22 , C07D495/12 , C07D495/14 , C07D495/22 , C07D498/08 , C07D519/00
摘要： Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.

9. 发明申请

US20160009691A1 SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS 审中-公开
标题翻译：取代的吡啶和吡嗪化合物作为PDE4抑制剂
公开(公告)号：US20160009691A1
公开(公告)日：2016-01-14
申请号：US14770759
申请日：2014-03-06
申请人： DART NEUROSCIENCE (CAYMAN) LTD.
发明人： Venkataiah Bollu , James Breitenbucher , Alan Kaplan , Robert Lemus , Andrew Lindstrom , Troy Vickers , Michael Weinhouse , Mark Edward Wilson , James Zapf
IPC分类号： C07D403/06 , C07D401/06 , C07D239/34 , C07D213/64 , C07D405/12 , C07D417/06 , A61K51/04 , C07D401/14
CPC分类号： C07D403/06 , A61K51/0459 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/81 , C07D239/34 , C07D241/18 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要： The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders.
摘要翻译：本发明提供式（I）的化学实体和包含这些化学实体的组合物; 制作方法; 并在广泛的方法中使用，包括代谢和反应动力学研究，检测和成像技术以及放射性治疗; 和治疗方法，包括抑制PDE4，增强神经元可塑性，治疗神经障碍，提供神经保护，治疗与CNS病症相关的认知障碍，提高认知和运动训练的效率，提供神经复发和神经康复，提高非人类动物的效率训练方案和治疗外周疾病，包括炎症和肾脏疾病。

10. 发明申请

US20200024259A1 SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS 审中-公开
公开(公告)号：US20200024259A1
公开(公告)日：2020-01-23
申请号：US16424366
申请日：2019-05-28
申请人： DART NEUROSCIENCE (CAYMAN) LTD.
发明人： Venkataiah Bollu , James Breitenbucher , Alan Kaplan , Robert Lemus , Andrew Lindstrom , Troy Vickers , Michael Weinhouse , Mark E. Wilson , James Zapf
IPC分类号： C07D403/06 , C07D401/06 , C07D405/14 , C07D413/06 , C07D417/06 , C07D409/14 , C07D213/73 , C07D213/74 , C07D213/81 , C07D213/64 , C07D241/18 , C07D401/14 , C07D405/12 , C07D409/06 , A61K51/04 , C07D239/34
摘要： The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式