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1. 发明授权

US08134707B2 On-chip polarimetry for high-throughput screening of nanoliter and smaller sample volumes 有权
标题翻译：用于高通量筛选纳升和较小样品体积的片上偏振法
公开(公告)号：US08134707B2
公开(公告)日：2012-03-13
申请号：US11666046
申请日：2005-10-24
申请人： Darryl J. Bornhop , Stephen Dotson , Brian O. Bachmann
发明人： Darryl J. Bornhop , Stephen Dotson , Brian O. Bachmann
IPC分类号： G01J4/00
CPC分类号： G01J4/04 , G01N21/21
摘要： A polarimetry technique for measuring optical activity that is particularly suited for high throughput screening employs a chip or substrate (22) having one or more microfluidic channels (26) formed therein. A polarized laser beam (14) is directed onto optically active samples that are disposed in the channels. The incident laser beam interacts with the optically active molecules in the sample, which slightly alter the polarization of the laser beam as it passes multiple times through the sample. Interference fringe patterns (28) are generated by the interaction of the laser beam with the sample and the channel walls. A photodetector (34) is positioned to receive the interference fringe patterns and generate an output signal that is input to a computer or other analyzer (38) for analyzing the signal and determining the rotation of plane polarized light by optically active material in the channel from polarization rotation calculations.
摘要翻译：特别适用于高通量筛选的用于测量光学活性的偏振测定技术采用在其中形成有一个或多个微流体通道（26）的芯片或衬底（22）。偏振激光束（14）被引导到设置在通道中的光学活性样品上。入射激光束与样品中的光学活性分子相互作用，当样品经过多次时，激光束的极化稍微改变。干涉条纹图案（28）通过激光束与样品和通道壁的相互作用产生。定位光电检测器（34）以接收干涉条纹图案并产生输入到计算机或其他分析器（38）的输出信号，用于分析信号并通过光通道材料在通道中确定平面偏振光的旋转，极化旋转计算。

2. 发明申请

US20100027008A1 On-Chip Polarimetry for High-Throughput Screening of Nanoliter and Smaller Sample Volumes 有权
标题翻译：用于高通量筛选纳升级和较小样品体积的片上偏振镜
公开(公告)号：US20100027008A1
公开(公告)日：2010-02-04
申请号：US11666046
申请日：2005-10-24
申请人： Daryl J. Bornhop , Stephen Dotson , Brian O. Bachmann
发明人： Daryl J. Bornhop , Stephen Dotson , Brian O. Bachmann
IPC分类号： G01J4/00
CPC分类号： G01J4/04 , G01N21/21
摘要： A polarimetry technique for measuring optical activity that is particularly suited for high throughput screening employs a chip or substrate (22) having one or more microfluidic channels (26) formed therein. A polarized laser beam (14) is directed onto optically active samples that are disposed in the channels. The incident laser beam interacts with the optically active molecules in the sample, which slightly alter the polarization or the loser beam as it passes multiple times through the sample. Interference fringe patters (28) are generated by the interaction of the laser beam with the sample and the channel walls. A photodetector (34) is positioned to receive the interference fringe patterns and generate an output signal that is input to a computer or other analyzer (38) for analyzing the signal and determining the rotation of plane polarized light by optically active material in the channel from polarization rotation calculations.
摘要翻译：特别适用于高通量筛选的用于测量光学活性的偏振测定技术采用在其中形成有一个或多个微流体通道（26）的芯片或衬底（22）。偏振激光束（14）被引导到设置在通道中的光学活性样品上。入射激光束与样品中的光学活性分子相互作用，当样品经过多次时，其稍微改变偏振或失败光束。干涉条纹图案（28）通过激光束与样品和通道壁的相互作用产生。定位光电检测器（34）以接收干涉条纹图案并产生输入到计算机或其他分析器（38）的输出信号，用于分析信号并通过光通道材料在通道中确定平面偏振光的旋转，极化旋转计算。

3. 发明授权

US07101872B2 Farnesyl dibenzodiazepinone, and processes for its production 有权
标题翻译：法呢基二苯并二氮杂酮及其制备方法
公开(公告)号：US07101872B2
公开(公告)日：2006-09-05
申请号：US10762107
申请日：2004-01-21
申请人： Brian O. Bachmann , James B. McAlpine , Emmanuel Zazopoulos , Chris M. Farnet , Mahmood Piraee
发明人： Brian O. Bachmann , James B. McAlpine , Emmanuel Zazopoulos , Chris M. Farnet , Mahmood Piraee
IPC分类号： C07D243/10 , A61K31/55
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
摘要翻译：本发明涉及名为ECO-04601的新型法呢基化二苯并二氮杂酮，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。获得ECO-04601化合物的一种方法是通过培养一种新型的小单孢菌属菌株046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。本发明还涉及小单孢菌属应用046-ECO11，使用ECO-04601及其药学上可接受的盐和衍生物作为药物，特别是其作为癌细胞生长抑制剂，细菌细胞生长，哺乳动物脂氧合酶的用途，以及包含ECO-04601或其药学上可接受的盐或衍生物。最后，本发明涉及参与ECO-04601的生物合成的新型多核苷酸序列及其编码的蛋白质。

4. 发明授权

US07312339B2 Polyene oxazoles and processes for their preparation 失效
标题翻译：聚烯恶唑及其制备方法
公开(公告)号：US07312339B2
公开(公告)日：2007-12-25
申请号：US10865767
申请日：2004-06-14
申请人： James B. McAlpine , Chris M. Farnet , Emmanuel Zazopoulos , Nargis Ismail , Brian O. Bachmann
发明人： James B. McAlpine , Chris M. Farnet , Emmanuel Zazopoulos , Nargis Ismail , Brian O. Bachmann
IPC分类号： C07D207/444 , C07D209/48
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： Polyene oxazoles of the following formula wherein R3 is selected from H and methyl, are disclosed. Such compounds, and pharmaceutically acceptable salts thereof, may be used in the inhibition of tumor cell growth. The polyene oxazoles and their pharmaceutically acceptable salts may be formulated as pharmaceutical compositions with pharmaceutically acceptable carriers for use in the inhibition of tumor cells. The polyene oxazoles may be obtained from strains of Streptomyces sparsogenes, such as strain 022 having deposit number IDAC 270504-04.
摘要翻译：公开了下式的多烯恶唑，其中R 3选自H和甲基。这些化合物及其药学上可接受的盐可用于抑制肿瘤细胞生长。多烯恶唑及其药学上可接受的盐可以配制成具有用于抑制肿瘤细胞的药学上可接受的载体的药物组合物。多烯恶唑可以从天竺葵链霉菌菌株获得，例如具有保藏号IDAC 270504-04的菌株022。

5. 发明授权

US07375088B2 Polyene polyketides, processes for their production and their use as a pharmaceutical 失效
公开(公告)号：US07375088B2
公开(公告)日：2008-05-20
申请号：US10760493
申请日：2004-01-21
申请人： Brian O. Bachmann , James B. McAlpine , Emmanuel Zazopoulos , Chris M. Farnet
发明人： Brian O. Bachmann , James B. McAlpine , Emmanuel Zazopoulos , Chris M. Farnet
IPC分类号： A01N43/07 , A61K31/70 , C07H15/00 , C07H17/00
CPC分类号： C07H15/203 , C07C215/24 , C07C225/14 , C07C235/28 , C07C237/16 , C07C279/22 , C07C305/14 , C07C2601/10 , C07C2601/14 , C07H15/10 , C07H15/18 , C07H15/26 , C12P7/42 , C12P11/00 , C12P13/001 , C12P13/02 , C12P19/44 , C12R1/465 , Y10S435/886
摘要： This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.

6. 发明申请

US20090069396A1 Polyene Oxazoles and Processes for Their Preparation 审中-公开
标题翻译：聚烯恶唑及其制备方法
公开(公告)号：US20090069396A1
公开(公告)日：2009-03-12
申请号：US11934125
申请日：2007-11-02
申请人： James B. McAlpine , Chris M. Farnet , Emmanuel Zazopoulos , Nargis Ismail , Brian O. Bachmann
发明人： James B. McAlpine , Chris M. Farnet , Emmanuel Zazopoulos , Nargis Ismail , Brian O. Bachmann
IPC分类号： A61K31/422 , C07D263/02 , A61P35/00
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： This invention relates to novel biologically active polyene oxazoles, their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of Streptomyces sparsogenes NRRL 2940 or a mutant or variant thereof.
摘要翻译：本发明涉及新的生物活性多烯恶唑，其药学上可接受的盐和衍生物，以及获得它们的方法。用于获得化合物的一种方法是通过培养链霉菌NRRL 2940或其突变体或变体。

7. 发明授权

US07186713B2 Farnesyl dibenzodiazepinones and methods of treating cancer using same 失效
标题翻译：法呢基二苯并二氮杂酮和使用其治疗癌症的方法
公开(公告)号：US07186713B2
公开(公告)日：2007-03-06
申请号：US10951436
申请日：2004-09-27
申请人： Chris M. Farnet , Violetta Dimitriadou , Brian O. Bachmann
发明人： Chris M. Farnet , Violetta Dimitriadou , Brian O. Bachmann
IPC分类号： A61P35/00
CPC分类号： A61K31/5513 , A61K31/55 , A61K31/551 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/52 , C12P17/10 , C12R1/29
摘要： This invention relates to methods of inhibiting growth of a cancer cell and methods of treating cancer using a novel farnesylated dibenzodiazepinone.
摘要翻译：本发明涉及抑制癌细胞生长的方法和使用新型法呢基化二苯并二氮杂酮治疗癌症的方法。

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