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1. 发明申请

US20120177724A1 LIPID VESICLE COMPOSITIONS AND METHODS OF USE 有权
标题翻译： LIPID VESICLE组合物和使用方法
公开(公告)号：US20120177724A1
公开(公告)日：2012-07-12
申请号：US13400076
申请日：2012-02-19
申请人： Darrell J. Irvine , Anjali Yadava , Jaehyun Moon
发明人： Darrell J. Irvine , Anjali Yadava , Jaehyun Moon
IPC分类号： A61K9/127 , A61K47/44 , A61P33/06 , C12N5/071 , C07C51/347 , A61K39/015
CPC分类号： A61K39/385 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/217 , A61K38/45 , A61K39/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/39 , A61K39/39533 , A61K47/6811 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6018 , C07K14/005 , C12N15/88 , C12N2740/15034 , C12N2740/16234 , C12Y207/10001 , Y02A50/412
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
摘要翻译：本发明提供由稳定的多层囊泡构成的递送系统，以及组合物，合成方法及其使用方法。稳定的多层囊泡在其表面和/或内部包含带有末端半胱氨酸的抗原或半胱氨酸修饰的抗原。

2. 发明申请

US20090196883A1 Plasmodium vivax hybrid circumsporozoite protein and vaccine 有权
标题翻译：间日疟原虫混合环子孢子蛋白和疫苗
公开(公告)号：US20090196883A1
公开(公告)日：2009-08-06
申请号：US11334161
申请日：2006-01-18
申请人： Anjali Yadava , Christian F. Ockenhouse
发明人： Anjali Yadava , Christian F. Ockenhouse
IPC分类号： A61K39/015 , C07H21/00 , C12N15/63 , C07K14/445 , C12N5/10 , C12P21/02 , G01N33/569 , G01N33/536 , C07K16/20
CPC分类号： C07K16/205 , A61K39/015 , A61K2039/55566 , C07K2319/00 , Y02A50/412
摘要： Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any strain of P. vivax.
摘要翻译：在本申请中描述了可用作诊断试剂，用于抗体生产的合成的P.vivax环子孢子蛋白，以及用于任何针对间日疟原虫菌株感染的疫苗。

3. 发明授权

US09592282B2 Vaccines for malaria 有权
标题翻译：疟疾疫苗
公开(公告)号：US09592282B2
公开(公告)日：2017-03-14
申请号：US12374214
申请日：2007-07-16
申请人： Joseph D. Cohen , Martine Marchand , Christian F. Ockenhouse , Anjali Yadava
发明人： Joseph D. Cohen , Martine Marchand , Christian F. Ockenhouse , Anjali Yadava
IPC分类号： A61K39/015 , A61K39/00 , C07K14/445 , C12N7/00
CPC分类号： A61K39/015 , A61K2039/6075 , C07K14/445 , C07K2319/40 , Y02A50/412
摘要： The present invention relates to a novel hybrid/fusion protein derived from the CS protein of Plasmodium vivax (P. vivax), methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, for example those caused by P. vivax, compositions/vaccines containing the protein or antibodies against the protein such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. The invention also extends to lipoprotein particles of said hybrid protein and formulations/vaccines comprising the same and use thereof. In particular it relates to an immunogenic hybrid fusion protein comprising:a. at least one repeat unit derived from the repeating region of a type I circumsporozoite protein of P. vivax, b. at least one repeat unit derived from the repeating region of a type II circumsporozoite protein of P. vivax, andsurface antigen S derived from Hepatitis B virus, or a fragment thereof.
摘要翻译：衍生自乙型肝炎病毒的表面抗原S或其片段。

4. 发明申请

US20100150998A1 VACCINES FOR MALARIA 有权
标题翻译：疟疾疫苗
公开(公告)号：US20100150998A1
公开(公告)日：2010-06-17
申请号：US12374238
申请日：2007-07-16
申请人： Joseph D. Cohen , Martine Marchand , Christian F. Ockenhouse , Anjali Yadava
发明人： Joseph D. Cohen , Martine Marchand , Christian F. Ockenhouse , Anjali Yadava
IPC分类号： A61K39/29 , A61K9/127 , A61P33/06 , C12N15/63 , C12P21/00
CPC分类号： A61K39/015 , A61K2039/6075 , C07K14/445 , C07K2319/40 , Y02A50/412
摘要： The present invention relates to a novel lipoprotein particle, methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the particle or antibodies against the protein particle such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. In particular it relates to an immunogenic protein particle comprising the following monomers: a. a fusion protein comprising sequences derived from a CS protein of P. vivax and the S antigen of Hepatitis B (CSV-S), and b. a fusion protein comprising sequences derived from CS protein of P. falciparum and S antigen of Hepatitis B (RTS), and c. optionally the S antigen derived from Hepatitis B.
摘要翻译：本发明涉及一种新的脂蛋白颗粒，其制备和纯化方法，其在医学中的用途，特别是在预防疟疾感染中，含有颗粒的组合物/疫苗或针对蛋白质颗粒的抗体，例如单克隆或多克隆抗体，以及使用相同，特别是在治疗中。尤其涉及包含以下单体的免疫原性蛋白质颗粒：a。包含源自间日疟原虫的CS蛋白的序列和乙型肝炎的S抗原（CSV-S）的融合蛋白，以及b。包含衍生自恶性疟原虫的CS蛋白和乙型肝炎（RTS）的S抗原的序列的融合蛋白，以及c。任选地来自乙型肝炎的S抗原。

5. 发明申请

US20100062028A1 VACCINES FOR MALARIA 有权
标题翻译：疟疾疫苗
公开(公告)号：US20100062028A1
公开(公告)日：2010-03-11
申请号：US12374214
申请日：2007-07-16
申请人： Joseph D. Cohen , Martine Marchand , Christian F. Ockenhouse , Anjali Yadava
发明人： Joseph D. Cohen , Martine Marchand , Christian F. Ockenhouse , Anjali Yadava
IPC分类号： A61K39/015 , C07K2/00 , A61P33/02 , C07H21/04 , C12N1/19 , C12P21/00
CPC分类号： A61K39/015 , A61K2039/6075 , C07K14/445 , C07K2319/40 , Y02A50/412
摘要： The present invention relates to a novel hybrid/fusion protein derived from the CS protein of Plasmodium vivax (P. vivax), methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, for example those caused by P. vivax, compositions/vaccines containing the protein or antibodies against the protein such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. The invention also extends to lipoprotein particles of said hybrid protein and formulations/vaccines comprising the same and use thereof. In particular it relates to an immunogenic hybrid fusion protein comprising: a. at least one repeat unit derived from the repeating region of a type I circumsporozoite protein of P. vivax, b. at least one repeat unit derived from the repeating region of a type II circumsporozoite protein of P. vivax, and surface antigen S derived from Hepatitis B virus, or a fragment thereof.
摘要翻译：本发明涉及一种衍生自间日疟原虫（间日疟原虫）的CS蛋白的新型杂合体/融合蛋白，其制备和纯化方法，其在医学中的用途，特别是在预防疟疾感染中，例如引起由间日疟原虫，含有蛋白质的蛋白质或抗体的单克隆或多克隆抗体的组合物/疫苗，特别是在治疗中使用。本发明还延伸到所述杂合蛋白质的脂蛋白颗粒和包含其的制剂/疫苗及其用途。特别地，其涉及免疫原性杂合融合蛋白，其包含：a。至少一个源自间日疟原虫的I型环子孢子蛋白的重复区的重复单元，b。衍生自间日疟原虫的II型环子孢子蛋白的重复区域的至少一个重复单元和源自乙型肝炎病毒的表面抗原S或其片段。

6. 发明授权

US08697856B2 Plasmodium vivax hybrid circumsporozoite protein and vaccine 有权
标题翻译：间日疟原虫混合环子孢子蛋白和疫苗
公开(公告)号：US08697856B2
公开(公告)日：2014-04-15
申请号：US13566235
申请日：2012-08-03
申请人： Anjali Yadava , Christian F. Ockenhouse
发明人： Anjali Yadava , Christian F. Ockenhouse
IPC分类号： C07H21/04 , C12P21/04
CPC分类号： C07K16/205 , A61K39/015 , A61K2039/55566 , C07K2319/00 , Y02A50/412
摘要： Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any strain of P. vivax.
摘要翻译：在本申请中描述了可用作诊断试剂，用于抗体生产的合成的P.vivax环子孢子蛋白，以及用于任何针对间日疟原虫菌株感染的疫苗。

7. 发明申请

US20120301497A1 Plasmodium vivax Hybrid Circumsporozoite Protein and Vaccine 有权
标题翻译：疟原虫混合环孢子虫蛋白和疫苗
公开(公告)号：US20120301497A1
公开(公告)日：2012-11-29
申请号：US13566235
申请日：2012-08-03
申请人： Anjali Yadava , Christian F. Ockenhouse
发明人： Anjali Yadava , Christian F. Ockenhouse
IPC分类号： A61K39/015 , C07K14/445 , C07K16/20 , A61P37/04 , A61P33/02 , G01N33/566 , C12N1/19 , C12N1/15 , C12N1/21 , C12N5/10 , C12P21/02 , C12N15/30 , C12N15/63
CPC分类号： C07K16/205 , A61K39/015 , A61K2039/55566 , C07K2319/00 , Y02A50/412
摘要： Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any strain of P. vivax.
摘要翻译：在本申请中描述了可用作诊断试剂，用于抗体生产的合成的P.vivax环子孢子蛋白，以及用于任何针对间日疟原虫菌株感染的疫苗。

8. 发明申请

US20110189218A1 Plasmodium vivax hybrid circumsporozoite protein and vaccine 有权
标题翻译：间日疟原虫混合环子孢子蛋白和疫苗
公开(公告)号：US20110189218A1
公开(公告)日：2011-08-04
申请号：US12803940
申请日：2010-07-09
申请人： Anjali Yadava , Christian F. Ockenhouse
发明人： Anjali Yadava , Christian F. Ockenhouse
IPC分类号： A61K39/015 , C07H21/00 , C07K16/44 , C07K19/00 , A61P33/06 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/00 , G01N33/566 , A61P37/04
CPC分类号： C07K16/205 , A61K39/015 , A61K2039/55566 , C07K2319/00 , Y02A50/412
摘要： Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any strain of P. vivax.
摘要翻译：在本申请中描述了可用作诊断试剂，用于抗体生产的合成的P.vivax环子孢子蛋白，以及用于任何针对间日疟原虫菌株感染的疫苗。

9. 发明授权

US09364525B2 Vaccines for malaria 有权
标题翻译：疟疾疫苗
公开(公告)号：US09364525B2
公开(公告)日：2016-06-14
申请号：US12374238
申请日：2007-07-16
申请人： Joseph D. Cohen , Martine Marchand , Christian F. Ockenhouse , Anjali Yadava
发明人： Joseph D. Cohen , Martine Marchand , Christian F. Ockenhouse , Anjali Yadava
IPC分类号： A61K39/015 , A61K39/00 , C07K14/445 , C12N7/00
CPC分类号： A61K39/015 , A61K2039/6075 , C07K14/445 , C07K2319/40 , Y02A50/412
摘要： The present invention relates to a novel lipoprotein particle, methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the particle or antibodies against the protein particle such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. In particular it relates to an immunogenic protein particle comprising the following monomers: a. a fusion protein comprising sequences derived from a CS protein of P. vivax and the S antigen of Hepatitis B (CSV-S), and b. a fusion protein comprising sequences derived from CS protein of P. falciparum and S antigen of Hepatitis B (RTS), and c. optionally the S antigen derived from Hepatitis B.
摘要翻译：本发明涉及一种新的脂蛋白颗粒，其制备和纯化方法，其在医学中的用途，特别是在预防疟疾感染中，含有颗粒的组合物/疫苗或针对蛋白质颗粒的抗体，例如单克隆或多克隆抗体，以及使用相同，特别是在治疗中。尤其涉及包含以下单体的免疫原性蛋白质颗粒：a。包含源自间日疟原虫的CS蛋白的序列和乙型肝炎的S抗原（CSV-S）的融合蛋白，以及b。包含衍生自恶性疟原虫的CS蛋白和乙型肝炎（RTS）的S抗原的序列的融合蛋白，以及c。任选地来自乙型肝炎的S抗原。

10. 发明授权

US08258280B2 Plasmodium vivax hybrid circumsporozoite protein and vaccine 有权
标题翻译：间日疟原虫杂种环子孢子蛋白和疫苗
公开(公告)号：US08258280B2
公开(公告)日：2012-09-04
申请号：US12803940
申请日：2010-07-09
申请人： Anjali Yadava , Christian F. Ockenhouse
发明人： Anjali Yadava , Christian F. Ockenhouse
IPC分类号： C07H21/04 , C12P21/04 , C12P21/06
CPC分类号： C07K16/205 , A61K39/015 , A61K2039/55566 , C07K2319/00 , Y02A50/412
摘要： Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any strain of P. vivax.
摘要翻译：在本申请中描述了可用作诊断试剂，用于抗体生产的合成的P.vivax环子孢子蛋白，以及用于任何针对间日疟原虫菌株感染的疫苗。

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