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1. 发明授权

US08790719B2 Phytocannabinoids in the treatment of cancer 有权
标题翻译：植物类大麻素治疗癌症
公开(公告)号：US08790719B2
公开(公告)日：2014-07-29
申请号：US13634343
申请日：2011-03-11
申请人： Daniela Parolaro , Paola Massi , Angelo Antonio Izzo , Francesca Borelli , Gabriella Aviello , Vincenzo Di Marzo , Luciano De Petrocellis , Aniello Schiano Moriello , Alessia Ligresti , Ruth Alexandra Ross , Lesley Ann Ford , Sharon Anavi-Goffer , Manuel Guzman , Guillermo Velasco , Mar Lorente , Sofia Torres , Tetsuro Kikuchi , Geoffrey Guy , Colin Stott , Stephen Wright , Alan Sutton , David Potter , Etienne De Meijer
发明人： Daniela Parolaro , Paola Massi , Angelo Antonio Izzo , Francesca Borelli , Gabriella Aviello , Vincenzo Di Marzo , Luciano De Petrocellis , Aniello Schiano Moriello , Alessia Ligresti , Ruth Alexandra Ross , Lesley Ann Ford , Sharon Anavi-Goffer , Manuel Guzman , Guillermo Velasco , Mar Lorente , Sofia Torres , Tetsuro Kikuchi , Geoffrey Guy , Colin Stott , Stephen Wright , Alan Sutton , David Potter , Etienne De Meijer
IPC分类号： A01N65/00
CPC分类号： A61K36/185 , A61K31/01 , A61K31/015 , A61K31/05 , A61K31/192 , A61K31/337 , A61K31/352 , A61K31/495 , A61K45/06 , A61K2300/00
摘要： This invention relates to the use of phytocannabinoids, either in an isolated form or in the form of a botanical drug substance (BDS) in the treatment of cancer. Preferably the cancer to be treated is cancer of the prostate, cancer of the breast or cancer of the colon.
摘要翻译：本发明涉及在治疗癌症中以分离形式或以植物药物物质（BDS）的形式使用植物大麻素。优选地，待治疗的癌症是前列腺癌，乳腺癌或结肠癌。

2. 发明申请

US20130059018A1 PHYTOCANNABINOIDS IN THE TREATMENT OF CANCER 有权
公开(公告)号：US20130059018A1
公开(公告)日：2013-03-07
申请号：US13634343
申请日：2011-03-11
申请人： Daniela Parolaro , Paola Massi , Angelo Antonio Izzo , Francesca Borelli , Gabriella Aviello , Vincenzo Di Marzo , Luciano De Petrocellis , Aniello Schiano Moriello , Alessia Ligresti , Ruth Alexandra Ross , Lesley Ann Ford , Sharon Anavi-Goffer , Manuel Guzman , Guillermo Velasco , Mar Lorente , Sofia Torres , Tetsuro Kikuchi , Geoffrey Guy , Colin Stott , Stephen Wright , Alan Sutton , David Potter , Etienne De Meijer
发明人： Daniela Parolaro , Paola Massi , Angelo Antonio Izzo , Francesca Borelli , Gabriella Aviello , Vincenzo Di Marzo , Luciano De Petrocellis , Aniello Schiano Moriello , Alessia Ligresti , Ruth Alexandra Ross , Lesley Ann Ford , Sharon Anavi-Goffer , Manuel Guzman , Guillermo Velasco , Mar Lorente , Sofia Torres , Tetsuro Kikuchi , Geoffrey Guy , Colin Stott , Stephen Wright , Alan Sutton , David Potter , Etienne De Meijer
IPC分类号： A61K36/185 , A61K31/05 , A61K31/192 , A61P1/00 , A61K31/357 , A61K31/443 , A61K31/4188 , A61P35/00 , A61K31/352 , A61K31/337
CPC分类号： A61K36/185 , A61K31/01 , A61K31/015 , A61K31/05 , A61K31/192 , A61K31/337 , A61K31/352 , A61K31/495 , A61K45/06 , A61K2300/00
摘要： This invention relates to the use of phytocannabinoids, either in an isolated form or in the form of a botanical drug substance (BDS) in the treatment of cancer. Preferably the cancer to be treated is cancer of the prostate, cancer of the breast or cancer of the colon.

3. 发明申请

US20140221469A1 PHYTOCANNABINOIDS FOR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的PHYTOCANNABINOIDS
公开(公告)号：US20140221469A1
公开(公告)日：2014-08-07
申请号：US14343877
申请日：2012-09-10
申请人： Ruth Alexandra Ross , Daniela Parolaro
发明人： Ruth Alexandra Ross , Daniela Parolaro
IPC分类号： A61K31/352 , A61K31/235 , A61K31/05
CPC分类号： A61K31/352 , A61K31/05 , A61K31/192 , A61K31/235 , A61K31/353 , A61K2300/00
摘要： The present invention relates to the use of phytocannabinoids in the treatment of cancer. More particularly it relates to the use of phytocannabinoids in the treatment of tumour cell invasion and cell migration or metastases. Cancers, where invasion and cell migration plays a key role in prognosis include brain tumours, more particularly gliomas, and most particularly Glioblastoma multiforme (GBM) and breast cancers. The phytocannabinoids tetrahydrocannabivarin (THCV) and cannabidivarin (CBDV) alone or in combination with each other and/or other phytocannabinoids, particularly cannabidiol (CBD), tetrahydrocannabinol (THC) and cannabigerol (CBG) or their respective acids are of particular use.
摘要翻译：本发明涉及植物大麻素在癌症治疗中的应用。更具体地说，它涉及植物大麻素在治疗肿瘤细胞侵袭和细胞迁移或转移中的应用。侵袭和细胞迁移在预后中起关键作用的癌症包括脑肿瘤，尤其是神经胶质瘤，特别是多形性成胶质细胞瘤（GBM）和乳腺癌。单独使用或与其他植物大变性动物，特别是大麻二酚（CBD），四氢大麻酚（THC）和大麻酚（CBG）或其各自的酸组合的植物大丁素四氢大戟素（THCV）和大麻素（CBDV））是特别有用的。

4. 发明申请

US20110076274A1 MATERIALS AND METHODS RELATING TO A G-PROTEIN COUPLED RECEPTOR 审中-公开
标题翻译：关于G蛋白偶联受体的材料和方法
公开(公告)号：US20110076274A1
公开(公告)日：2011-03-31
申请号：US12992312
申请日：2009-05-13
申请人： Ruth Alexandra Ross , Michael John Rogers , Lesley Ann Ford , Anke Jozefien Roelofs
发明人： Ruth Alexandra Ross , Michael John Rogers , Lesley Ann Ford , Anke Jozefien Roelofs
IPC分类号： A61K39/395 , G01N33/574 , C12Q1/68 , A61K39/39 , A61K31/704 , A61K31/675 , A61K31/337 , A61P35/00 , A61P35/04
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N2333/726 , G01N2500/04 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： The present inventors demonstrate that the G-protein coupled receptor 55 (GPR55) is highly expressed in human aggressive breast cancer cells, and that the expression level may be correlated with the invasiveness and metastatic potential of these cells (for example metastasis to bone). In various aspects of the invention there are disclosed diagnostic tools or biomarkers that relate to the metastatic profile of breast cancer tumours. The invention also relates to pharmacological agents targeting this receptor for the purposes of inhibiting progression and spread of breast cancer.
摘要翻译：本发明人证明，G蛋白偶联受体55（GPR55）在人侵袭性乳腺癌细胞中高度表达，并且表达水平可能与这些细胞（例如转移到骨）的侵袭和转移潜力相关。在本发明的各个方面，公开了与乳腺癌肿瘤的转移概况相关的诊断工具或生物标志物。本发明还涉及靶向该受体的药理学试剂，用于抑制乳腺癌的进展和扩散。

5. 发明申请

US20100022611A1 1,5-Diaryl-Pyrazoles As Cannabinoid Receptor Neutral Antagonists Useful As Therapeutic Agents 审中-公开
标题翻译： 1,5-二芳基吡唑作为大麻素受体中性拮抗剂有用作治疗剂
公开(公告)号：US20100022611A1
公开(公告)日：2010-01-28
申请号：US12525002
申请日：2008-02-07
申请人： Iain Robert Greig , Ruth Alexandra Ross , Roger Guy Pertwee
发明人： Iain Robert Greig , Ruth Alexandra Ross , Roger Guy Pertwee
IPC分类号： A61K31/415 , C07D231/10 , A61P3/00 , A61P25/00 , A61P19/00 , A61P29/00 , A61P37/00
CPC分类号： C07D231/12
摘要： The present invention pertains to cannabinoid (CB) receptor neutral antagonists, and especially CB1 neutral antagonists, and including, for example, certain 1,5-di-aryl-pyrazole compounds. The present invention also pertains to the use of such compounds in the treatment of diseases and disorders that are ameliorated by treatment with a neutral antagonist of the cannabinoid type 1 (CB1) receptor, for example: an eating disorder; obesity; a disease or disorder characterised by an addiction component; addiction; withdrawal; smoking addiction; smoking withdrawal; drug addiction; drug withdrawal; smoking cessation therapy; a bone disease or disorder; osteoporosis, Paget's disease of bone; bone related cancer; a disease or disorder with an inflammatory or autoimmune component; rheumatoid arthritis; inflammatory bowel disease; psoriasis; a psychiatric disease or disorder; anxiety; mania; schizophrenia; a disease or disorder characterised by impairment of memory and/or loss of cognitive function; memory impairment; loss of cognitive function; Parkinson's disease; Alzheimer's disease; dementia; a cardiovascular disease or disorder; congestive heart failure; cardiac hypertrophy; and myocardial infarction.
摘要翻译：本发明涉及大麻素（CB）受体中性拮抗剂，特别是CB1中性拮抗剂，并且包括例如某些1,5-二芳基吡唑化合物。本发明还涉及这种化合物在治疗通过用大麻素1型（CB1）受体的中性拮抗剂治疗而改善的疾病和病症的用途，例如：进食障碍; 肥胖; 以成瘾成分为特征的疾病或病症; 瘾; 退出; 吸烟成瘾; 戒烟药物成瘾; 戒毒戒烟治疗骨病或病症; 骨质疏松症，佩吉特氏骨病; 骨相关癌症; 具有炎症或自身免疫组分的疾病或病症; 类风湿关节炎; 炎症性肠病; 银屑病; 精神疾病或病症; 焦虑; 狂躁; 精神分裂症以记忆障碍和/或认知功能丧失为特征的疾病或病症; 记忆障碍认知功能丧失; 帕金森病阿尔茨海默氏病; 痴呆; 心血管疾病或病症; 充血性心力衰竭; 心脏肥大; 和心肌梗塞。

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