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    • 5. 发明授权
    • Apparatus and method for maintaining and/or restoring viability of organs
    • 用于维持和/或恢复器官活力的装置和方法
    • US08420381B2
    • 2013-04-16
    • US12926277
    • 2010-11-05
    • Donald R. OwenDavid C. KravitzJohn BrassilKelvin G. M. BrockbankAndrew BurroughsDickon IsaacsDennis J. SteibelRichard FraserStanley HarrisDouglas Schein
    • Donald R. OwenDavid C. KravitzJohn BrassilKelvin G. M. BrockbankAndrew BurroughsDickon IsaacsDennis J. SteibelRichard FraserStanley HarrisDouglas Schein
    • A01N1/02C12M1/36
    • G06F17/30876A01N1/02A01N1/0247A01N1/0273H04L67/02
    • An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
    • 器官灌注装置和方法监测,维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器,器官盒和器官诊断装置。 该方法包括在低温和/或正常体温温度下灌注器官,优选在用于器官运输和/或储存的低温器官冲洗之后。 该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。 通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官,恢复高能量核苷酸(例如ATP)水平来恢复器官存活力。 在灌注中,器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器,通过气动加压的医用液体储存器进行控制,提供灌注压力微调,超压预防和紧急流量截止。 在低体温模式中,器官用液体灌注,优选地是含有抗氧化剂的简单晶体溶液,间歇地或以缓慢的连续流动。 可以从具有低压头的中间容器将药液输送到器官中,以避免器官过压。 防止过度加压防止或减少对血管内皮衬里和器官组织的损害。 可以自动监测器官的活力,优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。
    • 6. 发明申请
    • Apparatus and method for maintaining and/or restoring viability of organs
    • 用于维持和/或恢复器官活力的装置和方法
    • US20110059429A1
    • 2011-03-10
    • US12926276
    • 2010-11-05
    • Donald R. OwenDavid C. KravitzJohn BrassilKelvin G.M. BrockbankAndrew BurroughsDickon IsaacsDennis J. SteibelRichard FraserStanley HarrisDouglas Schein
    • Donald R. OwenDavid C. KravitzJohn BrassilKelvin G.M. BrockbankAndrew BurroughsDickon IsaacsDennis J. SteibelRichard FraserStanley HarrisDouglas Schein
    • A01N1/02
    • G06F17/30876A01N1/02A01N1/0247A01N1/0273H04L67/02
    • An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
    • 器官灌注装置和方法监测,维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器,器官盒和器官诊断装置。 该方法包括在低温和/或正常体温温度下灌注器官,优选在用于器官运输和/或储存的低温器官冲洗之后。 该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。 通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官,恢复高能量核苷酸(例如ATP)水平来恢复器官存活力。 在灌注中,器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器,通过气动加压的医用液体储存器进行控制,提供灌注压力微调,超压预防和紧急流量截止。 在低体温模式中,器官用液体灌注,优选地是含有抗氧化剂的简单晶体溶液,间歇地或以缓慢的连续流动。 可以从具有低压头的中间容器将药液输送到器官中,以避免器官过压。 防止过度加压防止或减少对血管内皮衬里和器官组织的损害。 可以自动监测器官的活力,优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。
    • 8. 发明授权
    • Lacing aid and connector
    • 鞋带辅助和连接器
    • US06219891B1
    • 2001-04-24
    • US09010215
    • 1998-01-21
    • Denis S. MaurerRichard A. MaurerJohn BrassilAndrew BurroughsPeter EhlingDavid Little
    • Denis S. MaurerRichard A. MaurerJohn BrassilAndrew BurroughsPeter EhlingDavid Little
    • A43C700
    • A43C1/00A43C5/00Y10T24/3732Y10T24/3734Y10T24/3774Y10T24/3779
    • A lacing aid which assists in lacing two elements tightly together comprises a first open portion that is easily threaded and engages a lace with reduced friction, and a second portion for frictional restraint of the threaded lace. Such lacing aids of the invention may be formed by bending smooth and stiff but resilient wire to form a first portion providing an opening larger than a lace with smooth inner walls, permitting the lace to slip easily when it is being tightened, and a second lace-restraining portion formed adjacent to the first portion to which a tightened lace may be easily slipped and engaged. An eyelet-connecting structure that may be used to fasten a lacing aid to a substrate element can be formed by two legs projecting from a junction, with one of the legs including a sleeve for rotatably carrying a first portion of the lacing aid and with the distal ends of the legs providing structure, such as a pair of mating fasteners, for fastening the lacing aid to a substrate, one mate being carried by each of the legs. Detent-forming structure adjacent the sleeve can hold the eyelet being carried so it extends upwardly and away from the leg. Such a connecting structure can comprise thin sheet steel bent into a U-shape, with one of the legs of the U being stamped to form notch-like portions and bent adjacent the notch-like portions to form a sleeve sized to engage the first portion of the lacing aid with a snap-fit so the first portion of a lacing aid is captively, but rotatably, carried by the U-shaped clip and can be held in the notch-like portions upwardly away from the connecting structure for easy threading.
    • 有助于将两个元件紧密结合在一起的系带辅助件包括易于螺纹连接并且具有减小的摩擦接合花边的第一开口部分和用于螺纹花边的摩擦限制的第二部分。 本发明的这种系带辅助工具可以通过弯曲光滑而坚硬但弹性的线形成,以形成第一部分,该第一部分提供比具有平滑内壁的花边更大的开口,允许花边在被紧固时容易滑动,并且第二花边 - 紧固部分形成为与紧固的花边可容易地滑动并接合的第一部分相邻。 可用于将系带辅助件紧固到衬底元件的孔眼连接结构可以由从接头突出的两个腿形成,其中一个腿部包括用于可旋转地承载鞋带辅助件的第一部分的套筒 腿部提供结构的远端,例如一对配合紧固件,用于将系带辅助件紧固到基底上,一个伴侣由每个腿承载。 与套筒相邻的止动器形成结构可以保持携带的孔眼,使其向上延伸并远离腿部。 这种连接结构可以包括弯曲成U形的薄钢板,U的一个腿被冲压以形成切口状部分并且相邻于切口状部分弯曲以形成尺寸适于接合第一部分的套筒 的搭扣辅助装置,使得系带辅助装置的第一部分是由U形夹持件可旋转地支承的,并且可以被保持在凹口状部分中,远离连接结构,以便于穿线。