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1. 发明申请

US20080207753A1 Analogues of lipid mediators derived from omega-3 PUFAs and methods of use 有权
标题翻译：衍生自ω-3 PUFA的脂质介体的类似物和使用方法
公开(公告)号：US20080207753A1
公开(公告)日：2008-08-28
申请号：US12150794
申请日：2008-04-30
申请人： Daniel W. Goodman , Michael R. Hanley , Stuart L. Bursten , Charles N. Serhan
发明人： Daniel W. Goodman , Michael R. Hanley , Stuart L. Bursten , Charles N. Serhan
IPC分类号： A61K31/22 , A61K31/16 , A61K31/20
CPC分类号： C07C59/68 , C07C59/42 , C07C59/48 , C07C59/64 , C07C69/732 , C07C69/736 , C07C235/28 , C07C235/34
摘要： The present invention is directed to compounds that are analogues of lipid mediators derived from a fish oil-derived fatty acid, eicosapentaenoic acid [C20:5 ω-3; EPA], but with a longer tissue half-life and enhanced bioactivity. These analogues may be used to treat inflammatory, angioproliferative, cardiovascular, thrombophlebotic, vascular, ocular, dermatologic, neurodegenerative, pulmonary, endocrine, reproductive, rheumatologic and gastrointestinal diseases.
摘要翻译：本发明涉及衍生自鱼油衍生的脂肪酸，二十碳五烯酸[C20：5ω-3; EPA]，但具有更长的组织半衰期和增强的生物活性。这些类似物可用于治疗炎症，血管增生，心血管，血栓形成，血管，眼，皮肤病，神经变性，肺，内分泌，生殖，风湿病和胃肠道疾病。

2. 发明授权

US07378444B2 Analogues of lipid mediators derived from omega-3 PUFAs and methods of use 有权
公开(公告)号：US07378444B2
公开(公告)日：2008-05-27
申请号：US10460913
申请日：2003-06-13
申请人： Daniel W. Goodman , Michael R. Hanley , Stuart L. Bursten , Charles N. Serhan
发明人： Daniel W. Goodman , Michael R. Hanley , Stuart L. Bursten , Charles N. Serhan
IPC分类号： A61K31/22 , A61K31/20 , A61K31/16 , C07C231/00 , C07C59/00
CPC分类号： C07C59/68 , C07C59/42 , C07C59/48 , C07C59/64 , C07C69/732 , C07C69/736 , C07C235/28 , C07C235/34
摘要： The present invention is directed to compounds that are analogues of lipid mediators derived from a fish oil-derived fatty acid, eicosapentaenoic acid [C20:5 ω-3; EPA], but with a longer tissue half-life and enhanced bioactivity. These analogues may be used to treat inflammatory, angioproliferative, cardiovascular, thrombophlebotic, vascular, ocular, dermatologic, neurodegenerative, pulmonary, endocrine, reproductive, rheumatologic and gastrointestinal diseases.

3. 发明授权

US07595341B2 Analogues of lipid mediators derived from ω-3 PUFAs and methods of use 有权
标题翻译：衍生自ω-3 PUFA的脂质介体的类似物和使用方法
公开(公告)号：US07595341B2
公开(公告)日：2009-09-29
申请号：US12150794
申请日：2008-04-30
申请人： Daniel W. Goodman , Michael R. Hanley , Stuart L. Bursten , Charles N. Serhan
发明人： Daniel W. Goodman , Michael R. Hanley , Stuart L. Bursten , Charles N. Serhan
IPC分类号： A61K31/22 , A61K31/20 , A61K31/16 , C07C231/00 , C07C59/00
CPC分类号： C07C59/68 , C07C59/42 , C07C59/48 , C07C59/64 , C07C69/732 , C07C69/736 , C07C235/28 , C07C235/34
摘要： The present invention is directed to compounds that are analogues of lipid mediators derived from a fish oil-derived fatty acid, eicosapentaenoic acid [C20:5 ω-3; EPA], but with a longer tissue half-life and enhanced bioactivity. These analogues may be used to treat inflammatory, angioproliferative, cardiovascular, thrombophlebotic, vascular, ocular, dermatologic, neurodegenerative, pulmonary, endocrine, reproductive, rheumatologic and gastrointestinal diseases.
摘要翻译：本发明涉及衍生自鱼油衍生的脂肪酸，二十碳五烯酸[C20：5ω-3; EPA]，但具有更长的组织半衰期和增强的生物活性。这些类似物可用于治疗炎症，血管增生，心血管，血栓形成，血管，眼，皮肤病，神经变性，肺，内分泌，生殖，风湿病和胃肠道疾病。

4. 发明授权

US09364454B2 Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers 有权
标题翻译：神经保护素D1 /保护素D1及其天然立体异构体的抗炎作用
公开(公告)号：US09364454B2
公开(公告)日：2016-06-14
申请号：US13625865
申请日：2012-09-24
申请人： Charles N. Serhan , Nicos A. Petasis , Bruce D. Levy
发明人： Charles N. Serhan , Nicos A. Petasis , Bruce D. Levy
IPC分类号： C07C59/00 , A61K31/202 , C07C59/42 , C07C69/732
CPC分类号： A61K31/202 , C07C59/42 , C07C69/732
摘要： The invention describes novel isolated, purified, 10,17-dihydroxy-docosahexaenoic acids, esters, derivatives and their preparation.
摘要翻译：本发明描述了新的分离，纯化的10,17-二羟基 - 二十二碳六烯酸，酯，衍生物及其制备方法。

5. 发明授权

US08604229B2 Lipoxin analogs and methods for the treatment of periodontal disease 有权
标题翻译：脂氧素类似物和治疗牙周病的方法
公开(公告)号：US08604229B2
公开(公告)日：2013-12-10
申请号：US13346543
申请日：2012-01-09
申请人： Thomas E. Van Dyke , Nicos A. Petasis , Charles N. Serhan
发明人： Thomas E. Van Dyke , Nicos A. Petasis , Charles N. Serhan
IPC分类号： C07C59/00
CPC分类号： A61K31/202 , A61K31/22 , A61K31/365 , C07B2200/07 , C07C69/732 , C07C69/736 , C07C229/30 , C07C235/28 , C07C259/06 , C07C2601/16 , A61K2300/00
摘要： This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease with compositions containing COX-2 inhibitors. Further, the invention provides methods for preventing systemic diseases beyond the oral cavity that are related to periodontal disease using the composition containing lipoxin analogs, COX-2 inhibitors, or both.
摘要翻译：本发明提供了新的脂氧素类似物，含有类似物的组合物，以及使用这些化合物和组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其它形式的牙周病。本发明还提供了含有COX-2抑制剂的组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其他形式的牙周病。此外，本发明提供使用含有脂氧素类似物，COX-2抑制剂或两者的组合物来预防与牙周疾病相关的口腔以外的全身疾病的方法。

6. 发明申请

US20120245229A1 METHOD FOR TREATING NEUROPATHIC PAIN 审中-公开
标题翻译：治疗神经痛疼痛的方法
公开(公告)号：US20120245229A1
公开(公告)日：2012-09-27
申请号：US13395758
申请日：2010-09-15
申请人： Ru-Rong Ji , Charles N. Serhan
发明人： Ru-Rong Ji , Charles N. Serhan
IPC分类号： A61K31/202 , A61P25/00 , A61P29/00
CPC分类号： A61K31/202
摘要： The invention describes a method to treat neuropathic pain and/or inflammatory pain, comprising the step of administering to a subject in need thereof an effective amount of a resolvin, such that neuropathic pain and or inflammatory pain is treated.
摘要翻译：本发明描述了一种治疗神经性疼痛和/或炎性疼痛的方法，其包括向有需要的受试者施用有效量的阿维生素，以治疗神经性疼痛和/或炎性疼痛的步骤。

7. 发明申请

US20120114566A1 LIPOXIN ANALOGS AND METHODS FOR THE TREATMENT OF PERIODONTAL DISEASE 有权
标题翻译： LIPOXIN类似物和治疗周围疾病的方法
公开(公告)号：US20120114566A1
公开(公告)日：2012-05-10
申请号：US13346543
申请日：2012-01-09
申请人： Thomas E. Van Dyke , Nicos A. Petasis , Charles N. Serhan
发明人： Thomas E. Van Dyke , Nicos A. Petasis , Charles N. Serhan
IPC分类号： A61K9/68 , C07C229/40 , A61P29/00 , C07C59/48 , C07C59/42 , A61P1/04 , A61K31/20 , C07C59/46
CPC分类号： A61K31/202 , A61K31/22 , A61K31/365 , C07B2200/07 , C07C69/732 , C07C69/736 , C07C229/30 , C07C235/28 , C07C259/06 , C07C2601/16 , A61K2300/00
摘要： This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease with compositions containing COX-2 inhibitors. Further, the invention provides methods for preventing systemic diseases beyond theoral cavity that are related to periodontal disease using the composition containing lipoxin analogs, COX-2 inhibitors, or both.
摘要翻译：本发明提供了新的脂氧素类似物，含有类似物的组合物，以及使用这些化合物和组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其它形式的牙周病。本发明还提供了含有COX-2抑制剂的组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其他形式的牙周病。此外，本发明提供了使用含有脂氧素类似物，COX-2抑制剂或两者的组合物来预防与口腔疾病相关的全腔外疾病的方法。

8. 发明授权

US08093417B2 Lipoxin analogs and methods for the treatment of periodontal disease 有权
标题翻译：脂氧素类似物和治疗牙周病的方法
公开(公告)号：US08093417B2
公开(公告)日：2012-01-10
申请号：US12892872
申请日：2010-09-28
申请人： Thomas E. Van Dyke , Nicos A. Petasis , Charles N. Serhan
发明人： Thomas E. Van Dyke , Nicos A. Petasis , Charles N. Serhan
IPC分类号： C07C59/00
CPC分类号： A61K31/202 , A61K31/22 , A61K31/365 , C07B2200/07 , C07C69/732 , C07C69/736 , C07C229/30 , C07C235/28 , C07C259/06 , C07C2601/16 , A61K2300/00
摘要： This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease with compositions containing COX-2 inhibitors. Further, the invention provides methods for preventing systemic diseases beyond theoral cavity that are related to periodontal disease using the composition containing lipoxin analogs, COX-2 inhibitors, or both.
摘要翻译：本发明提供了新的脂氧素类似物，含有类似物的组合物，以及使用这些化合物和组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其它形式的牙周病。本发明还提供了含有COX-2抑制剂的组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其他形式的牙周病。此外，本发明提供了使用含有脂氧素类似物，COX-2抑制剂或两者的组合物来预防与口腔疾病相关的全腔外疾病的方法。

9. 发明申请

US20110064677A1 LIPOXIN ANALOGS AND METHODS FOR THE TREATMENT OF PERIODONTAL DISEASE 有权
标题翻译： LIPOXIN类似物和治疗周围疾病的方法
公开(公告)号：US20110064677A1
公开(公告)日：2011-03-17
申请号：US12892872
申请日：2010-09-28
申请人： Thomas E. Van Dyke , Nicos A. Petasis , Charles N. Serhan
发明人： Thomas E. Van Dyke , Nicos A. Petasis , Charles N. Serhan
IPC分类号： A61K31/201 , C07C59/48 , A61K31/635 , A61K31/341 , A61K31/42 , A61K8/365 , A61K9/68 , A61K9/12 , A61P1/00 , A61P29/00 , A61P43/00 , A61Q11/00
CPC分类号： A61K31/202 , A61K31/22 , A61K31/365 , C07B2200/07 , C07C69/732 , C07C69/736 , C07C229/30 , C07C235/28 , C07C259/06 , C07C2601/16 , A61K2300/00
摘要： This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease with compositions containing COX-2 inhibitors. Further, the invention provides methods for preventing systemic diseases beyond theoral cavity that are related to periodontal disease using the composition containing lipoxin analogs, COX-2 inhibitors, or both.
摘要翻译：本发明提供了新的脂氧素类似物，含有类似物的组合物，以及使用这些化合物和组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其它形式的牙周病。本发明还提供了含有COX-2抑制剂的组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其他形式的牙周病。此外，本发明提供了使用含有脂氧素类似物，COX-2抑制剂或两者的组合物来预防与牙周疾病相关的全腔外疾病的方法。

10. 发明授权

US07759395B2 Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma 有权
标题翻译：使用二十二烷，溶血凝素及其稳定的类似物治疗气道疾病和哮喘
公开(公告)号：US07759395B2
公开(公告)日：2010-07-20
申请号：US11081203
申请日：2005-03-16
申请人： Charles N. Serhan , Bruce D. Levy
发明人： Charles N. Serhan , Bruce D. Levy
IPC分类号： A01N37/00
CPC分类号： C07C59/42 , A61K31/202 , A61K31/275 , A61K31/445 , A61K31/495 , A61K31/537 , A61K31/551 , A61K31/655 , C07C59/48 , C07F7/1804
摘要： The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.
摘要翻译：本发明一般涉及由膳食ω-3多不饱和脂肪酸（PUFA）如二十碳五烯酸（EPA）或二十二碳六烯酸（DHA），环氧合酶II（COX）之间的相互作用产生的新型分离的治疗剂，称为溶血素 -2）和止痛剂，例如阿司匹林（ASA）。令人惊讶的是，在合适的环境中仔细分离由组分组合产生的化合物，提供了具有独特结构和生理特性的二羟基EPA或DHA化合物。因此，本发明提供了例如减少，预防或消除炎症或PMN迁移的许多新的有用的EPA或DHA（resolvins）治疗二 - 或三羟基衍生物。本发明还提供了用于本说明书中公开的化合物的药物用途，制备方法和包装药物的方法。

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