专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06482799B1 Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial 失效
标题翻译：结合多肽抗微生物剂的自我保存的多用途眼用溶液
公开(公告)号：US06482799B1
公开(公告)日：2002-11-19
申请号：US09318195
申请日：1999-05-25
申请人： Daniel Tusé , Kristien Mortelmans , Leslie A. Hokama , Michael E. Selsted , Larry L. Chapoy , Michael H. Quinn
发明人： Daniel Tusé , Kristien Mortelmans , Leslie A. Hokama , Michael E. Selsted , Larry L. Chapoy , Michael H. Quinn
IPC分类号： A61K3800
CPC分类号： A61L12/14
摘要： This invention provides a novel anti-microbial system suitable for formulation in a wide variety of ophthalmic solutions. In particular the composition comprises an antimicrobial peptide that is an indolicidin and a buffer compatible with application to a mammalian eye, wherein the buffer is a Good's buffer or the buffer has a halide ion concentration less than 0.85 wt %. The compositions are useful for storing, cleaning, or disinfecting a contact lens. In particular the compositions are self-preserving upon lengthy storage, effective in cleaning and sterilizing contact lenses upon exposure of the lens to the composition, do not require the need for physical or thermal treatment of the lens and enable the immediate application of the lens to the eye without the need for neutralization, deactivation or washing.
摘要翻译：本发明提供了适用于制备各种眼科溶液的新型抗微生物系统。特别地，该组合物包含抗微生物肽，其是吲哚多菌素和与应用于哺乳动物眼睛相容的缓冲液，其中缓冲液是Good's缓冲液或缓冲液的卤离子浓度小于0.85wt％。该组合物可用于储存，清洁或消毒隐形眼镜。特别地，组合物在长时间储存时是自我保存的，在将透镜暴露于组合物时有效地清洁和消毒隐形眼镜，不需要对镜片进行物理或热处理，并且能够立即将镜片应用于眼睛不需要中和，去激活或洗涤。

2. 发明授权

US11021518B2 Theta defensin analogs 有权
公开(公告)号：US11021518B2
公开(公告)日：2021-06-01
申请号：US16914038
申请日：2020-06-26
申请人： Michael E. Selsted , Dat Q. Tran , Justin B. Schaal
发明人： Michael E. Selsted , Dat Q. Tran , Justin B. Schaal
IPC分类号： C07K7/64 , A61P31/00 , A61K38/00
摘要： Novel peptide analogs of a θ-defensin have been developed that provide a biphasic effect in treating infection and/or sepsis. These analogs are active at concentrations below those needed to provide a bactericidal or bacteriostatic effect, and function by initially recruiting effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response characteristic of sepsis and septic shock. These novel θ-defensin analogs are protective at concentrations where naturally occurring θ-defensins have no apparent effect, and include a core set of structural and sequence features not found in native θ-defensin.

3. 发明授权

US06211148B1 Antimicrobial peptides from bovine neutrophis 失效
标题翻译：来自牛嗜中性粒细胞的抗菌肽
公开(公告)号：US06211148B1
公开(公告)日：2001-04-03
申请号：US08988705
申请日：1997-12-11
申请人： Michael E. Selsted , James S. Cullor
发明人： Michael E. Selsted , James S. Cullor
IPC分类号： A61K3816
CPC分类号： C07K14/4723 , A61K38/00
摘要： The present invention provides a new family of cysteine-rich antimicrobial peptides isolated from bovine neutrophils herein named beta defensins. Thirteen structurally homologous peptides were purified to homogeneity from a granule-rich cytoplasmic fraction of purified blood neutrophils. These antimicrobial compounds are useful in human and veterinary medicine, and as agents in agricultural, food science, and industrial applications.
摘要翻译：本发明提供了一种从牛中性粒细胞分离的命名为β-防御素的新的富含半胱氨酸的抗微生物肽家族。将13个结构同源的肽从纯化的血液中性粒细胞的富颗粒细胞质部分纯化至均质。这些抗菌化合物可用于人类和兽医学，也可用于农业，食品科学和工业应用。

4. 发明授权

US5840498A Antibiotic cryptdin peptides and methods of their use 失效
标题翻译：抗生素cryptdin肽及其使用方法
公开(公告)号：US5840498A
公开(公告)日：1998-11-24
申请号：US482279
申请日：1995-06-07
申请人： Michael E. Selsted , Andre J. Ouellette
发明人： Michael E. Selsted , Andre J. Ouellette
IPC分类号： C12P21/08 , A61K9/22 , A61K38/00 , A61K39/395 , A61P1/00 , A61P29/00 , C07K14/46 , C07K14/47 , C07K16/18 , C12N15/09 , C12Q1/68 , G01N33/564 , G01N33/569 , G01N33/68 , G01N33/53 , G01N33/537 , G01N33/542 , G01N33/543
CPC分类号： C07K14/4723 , G01N33/564 , G01N33/569 , G01N33/6872 , G01N33/6893 , A61K38/00 , G01N2333/4721
摘要： The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence: X.sub.1 -C-X.sub.2 -C-R-X.sub.3 -C-X.sub.4 -E-X.sub.5 -C-X.sub.6 -C-C-X.sub.7 wherein X.sub.1 is 3 to 9 amino acids; X.sub.2 is one amino acid, preferably Y, H or R; X.sub.3 is 2 or 3 amino acids; X.sub.4 is three amino acids; X.sub.5 is five amino acids; X.sub.6 is 6 to 10 amino acids; and X.sub.7 is 0 to 9 amino acids. The invention also provides a substantially purified mouse cryptdin having a consensus amino acid sequence: X.sub.1 -L-X.sub.2 -C-Y-C-R-X.sub.3 -C-K-X.sub.4 -E-X.sub.5 -G-T-C-X.sub.6 -C-C-X.sub.7 wherein X.sub.1 is 3 or 4 amino acids, preferably LRD, LSKK (SEQ ID NO: 1) or LRG; X.sub.2 is 1 amino acid, preferably V, L or I; X.sub.3 is 3 amino acids, preferably KGH or *RG, where * is S, T, K, I or A; X.sub.4 is 2 amino acids, preferably GR, RR or RG; X.sub.5 is 3 amino acids, preferably RMN, RVR, RVF HMN or HIN; X.sub.6 is 6 to 9 amino acids, preferably GIRFLY (SEQ ID NO: 2) or RNLFLTFVF (SEQ ID NO: 3), RRGHLMYTL (SEQ ID NO: 4) or RKGHL*YT* (SEQ ID NO: 5), where * independently is L or M; and X.sub.7 is 0 to 3 amino acids, preferably R, S or PRR. The invention also provides cryptdin analogs, which are devoid of one or more amino acids N-terminal to the first cysteine. In addition, the invention provides nucleic acid molecules encoding cryptdin peptides. The invention further provides methods for detecting inflammatory pathologies in a subject and for treating an inflammatory pathology in a subject by administering a pharmaceutical composition containing a cryptdin peptide.
摘要翻译：本发明提供具有共有氨基酸序列的基本上纯化的cryptdin肽：X1-C-X2-C-R-X3-C-X4-E-X5-C-X6-C-C-X7，其中X1为3至9个氨基酸; X2是一个氨基酸，优选Y，H或R; X3是2或3个氨基酸; X4是三个氨基酸; X5为5个氨基酸; X6为6-10个氨基酸; X7为0〜9个氨基酸。本发明还提供了具有共有氨基酸序列的基本上纯化的小鼠cryptdin：X1-L-X2-CYCR-X3-CK-X4-E-X5-GTC-X6-CC-X7，其中X1是3或4个氨基酸，优选 LRD，LSKK（SEQ ID NO：1）或LRG; X2为1个氨基酸，优选为V，L或I; X3为3个氨基酸，优选为KGH或* RG，其中*为S，T，K，I或A; X4是2个氨基酸，优选GR，RR或RG; X5是3个氨基酸，优选RMN，RVR，RVF HMN或HIN; X6为6至9个氨基酸，优选GIRFLY（SEQ ID NO：2）或RNLFLTFVF（SEQ ID NO：3），RRGHLMYTL（SEQ ID NO：4）或RKGHL * YT *（SEQ ID NO：5），其中* 独立为L或M; X7为0〜3个氨基酸，优选为R，S或PRR。本发明还提供了cryptdin类似物，其缺乏第一半胱氨酸N末端的一个或多个氨基酸。此外，本发明提供编码cryptdin肽的核酸分子。本发明还提供了通过给药含有cryptdin肽的药物组合物来检测受试者中的炎性病理学和治疗受试者的炎性病理学的方法。

5. 发明授权

US5324716A Broad spectrum antimicrobial compounds and methods of use 失效
标题翻译：广谱抗菌化合物及其使用方法
公开(公告)号：US5324716A
公开(公告)日：1994-06-28
申请号：US715271
申请日：1991-06-14
申请人： Michael E. Selsted , James S. Cullor
发明人： Michael E. Selsted , James S. Cullor
IPC分类号： A61K38/00 , A61P31/04 , C07K7/08 , A61K37/00 , A61K37/02 , C07K5/00 , C07K7/00
CPC分类号： C07K7/08 , A61K38/00
摘要： The invention provides a broad spectrum antimicrobial compound that includes a tryptophan-rich peptide exhibiting antimicrobial activity. A method of microbicidal inhibition or microbistatic inhibition of microbial growth is also provided. The method includes administering to an environment capable of sustaining microbial growth a microbicidally or microbistatically effective amount of a tryptophan-rich peptide exhibiting antimicrobial activity.
摘要翻译：本发明提供了一种广谱抗微生物化合物，其包括显示抗菌活性的富含色氨酸的肽。还提供了杀微生物抑制或微生物抑制微生物生长的方法。该方法包括向能够维持微生物生长的环境施用具有抗微生物活性的微生物或微生物有效量的富含色氨酸的肽。

6. 发明授权

US10512669B2 Blockade of inflammatory proteases with cyclic peptides 有权
公开(公告)号：US10512669B2
公开(公告)日：2019-12-24
申请号：US13486548
申请日：2012-06-01
申请人： Michael E. Selsted , Dat Q. Tran
发明人： Michael E. Selsted , Dat Q. Tran
IPC分类号： A61K38/10 , A61K38/17 , A61K38/12 , C07K14/47 , A61K9/00
摘要： Drug compositions for treatment of one or more inflammatory conditions can includes at least one of a θ-defensin, analog or derivative thereof. Inventive methods include researching θ-defensins, analogs or derivatives thereof for their efficacy with respect to anti-inflammatory effects, and providing such compositions to the marketplace for the purpose of treating inflammatory conditions. Of particular interest are drug compositions effective to produce clinically relevant inhibition of tumor necrosis factor alpha (TNF-α)-converting enzyme (TACE) or other proinflammatory proteases, and/or sheddases. it is contemplated that preferred compositions can be used to treat rheumatoid arthritis, inflammatory bowel disease, and other chronic inflammatory diseases, autoimmune diseases, cancer, and Alzheimer's, osteoarthritis, inflammation-related neurodegenerative and other inflammation-related diseases.

7. 发明授权

US07462598B2 Antimicrobial theta defensins, analogs thereof, and methods of use 有权
标题翻译：抗微生物θ防御素，其类似物和使用方法
公开(公告)号：US07462598B2
公开(公告)日：2008-12-09
申请号：US11512883
申请日：2006-08-29
申请人： Michael E. Selsted , Dat Q. Tran
发明人： Michael E. Selsted , Dat Q. Tran
IPC分类号： A61K38/00 , A61K38/01 , A61K38/04 , A61K38/10 , C07K7/00 , C07K7/08
CPC分类号： C07K14/4723 , A23L3/3526 , A61L2/16 , A61L12/14
摘要： The invention provides theta defensin analogs having antimicrobial activity. The invention also provides a method of reducing or inhibiting growth or survival of a microorganism in an environment capable of sustaining the growth or survival of the microorganism, comprising administering an effective amount of a theta defensin analog to the environment, thereby reducing or inhibiting the growth or survival of the microorganism.
摘要翻译：本发明提供了具有抗微生物活性的θ防御素类似物。本发明还提供一种在能够维持微生物生长或存活的环境中减少或抑制微生物的生长或存活的方法，包括向环境施用有效量的θ防御素类似物，由此减少或抑制生长或微生物的存活。

8. 发明授权

US07399823B1 Antimicrobial theta defensins and methods of using same 有权
标题翻译：抗微生物θ防御素及其使用方法
公开(公告)号：US07399823B1
公开(公告)日：2008-07-15
申请号：US10009317
申请日：2000-05-10
申请人： Michael E. Selsted , Yi-Quan Tang , Jun Yuan , Andre J. Ouellette
发明人： Michael E. Selsted , Yi-Quan Tang , Jun Yuan , Andre J. Ouellette
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/12 , C07K14/4723 , C12P21/00 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa8, wherein Xaa1 to Xaa8 are defined; wherein Xaa1 can be linked through a peptide bond to Xaa8; and wherein crosslinks can be formed between Xaa3 and Xaa3, between Xaa5 and Xaa5, and between Xaa7 and Xaa7. For example, the invention provides a theta defensin having the amino acid sequence Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg (SEQ ID NO:1), wherein the Gly at position 1 (Gly-1) is linked through a peptide bond to Arg-18, and wherein disulfide bonds are present between Cys-3 and Cys-16, between Cys-5 and Cys-14, and between Cys-7 and Cys-12. The invention also provides nucleic acids encoding theta defensins and antibodies that specifically bind a theta defensin. In addition, the invention relates to methods of using theta defensin to reduce or inhibit microbial growth or survival.
摘要翻译：本发明涉及具有抗微生物活性的分离的环肽，θ防御素，以及θ防御素类似物。 θ防御素可以具有氨基酸序列Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa8，其中Xaa1至Xaa8是定义其中Xaa1可通过肽键与Xaa8连接; 并且其中可以在Xaa3和Xaa3之间，Xaa5和Xaa5之间以及Xaa7和Xaa7之间形成交联。例如，本发明提供具有氨基酸序列Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg的θ防御素 SEQ ID NO：1），其中位置1处的Gly（Gly-1）通过肽键与Arg-18连接，并且其中二硫键存在于Cys-3和Cys-16之间，Cys-5和Cys之间 -14，以及Cys-7和Cys-12之间。本发明还提供编码θ防御素和特异性结合θ防御素的抗体的核酸。此外，本发明涉及使用θ防御素来减少或抑制微生物生长或存活的方法。

9. 发明授权

US06524585B1 Indolicidin analogs and methods of using same 失效
标题翻译：吲哚灵素类似物及其使用方法
公开(公告)号：US06524585B1
公开(公告)日：2003-02-25
申请号：US09416481
申请日：1999-10-12
申请人： Michael E. Selsted
发明人： Michael E. Selsted
IPC分类号： A61K3800
CPC分类号： C07K7/08 , A61K38/00 , C07K2319/00
摘要： The present invention relates to analogs of indolicidin, which is a naturally occurring peptide having the amino acid sequence Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2 (“Indol 1-13;” SEQ ID NO: 1). The indolicidin analogs of the invention include, for example, analogs such as Indol 2-13 (SEQ ID NO: 2) and Indol 3-13 (SEQ ID NO: 3), which are truncated at the amino terminus by one and two amino acids, respectively, as compared to Indol 1-13 (SEQ ID NO: 1); analogs in which at least one Trp residue in an amino terminal truncated indolicidin analog is replaced by a Phe residue (“Indol/F”) “analogs”); indolicidin analogs comprising, at the carboxy terminus, a homoserine residue; and fusion polypeptides comprising an indolicidin analog. In addition, the invention provides nucleic acid molecules encoding the indolicidin analogs of the invention or precursors of such analogs. The invention also relates to methods of using the indolicidin analogs to reduce or inhibit microbial growth or survival by contacting an environment capable of sustaining microbial growth with the indolicidin analog.
摘要翻译：本发明涉及吲哚他啶的类似物，其是具有氨基酸序列Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH 2的天然存在的肽（“Indol 1-13;“SEQ ID NO：1）。本发明的吲哚类抗生素包括例如在氨基末端被截短一个和两个氨基的类似物如Indol 2-13（SEQ ID NO：2）和Indol 3-13（SEQ ID NO：3）与Indol 1-13（SEQ ID NO：1）相比分别为：类似物，其中氨基末端截短的吲哚肽类似物中的至少一个Trp残基被Phe残基（“Indol / F”）“类似物”）代替; 在羧基末端包含高丝氨酸残基的吲哚类抗生素类似物; 和包含吲哚环肽类似物的融合多肽。此外，本发明提供编码本发明的吲哚肽类似物或此类类似物的前体的核酸分子。本发明还涉及使用吲哚来菌素类似物通过使能够维持微生物生长的环境与吲哚吡啶类似物接触来减少或抑制微生物生长或存活的方法。

10. 发明授权

US06303575B1 Indolicidin analogs and methods of using same 失效
标题翻译：吲哚灵素类似物及其使用方法
公开(公告)号：US06303575B1
公开(公告)日：2001-10-16
申请号：US09076227
申请日：1998-05-12
申请人： Michael E. Selsted
发明人： Michael E. Selsted
IPC分类号： A61K3800
CPC分类号： C07K7/08 , A61K38/00 , C07K2319/00
摘要： The present invention relates to analogs of indolicidin, which is a naturally occurring peptide having the amino acid sequence Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2 (“Indol 1-13;” SEQ ID NO: 1). The indolicidin analogs of the invention include, for example, analogs such as Indol 2-13 (SEQ ID NO: 2) and Indol 3-13 (SEQ ID NO: 3), which are truncated at the amino terminus by one and two amino acids, respectively, as compared to Indol 1-13 (SEQ ID NO: 1); analogs in which at least one Trp residue in an amino terminal truncated indolicidin analog is replaced by a Phe residue (“Indol/F”) analogs”); indolicidin analogs comprising, at the carboxy terminus, a homoserine residue; and fusion polypeptides comprising an indolicidin analog. In addition, the invention provides nucleic acid molecules encoding the indolicidin analogs of the invention or precursors of such analogs. The invention also relates to methods of using the indolicidin analogs to reduce or inhibit microbial growth or survival by contacting an environment capable of sustaining microbial growth with the indolicidin analog.
摘要翻译：本发明涉及吲哚他啶的类似物，其是具有氨基酸序列Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH 2的天然存在的肽（“Indol 1-13;“SEQ ID NO：1）。本发明的吲哚类抗生素包括例如在氨基末端被截短一个和两个氨基的类似物如Indol 2-13（SEQ ID NO：2）和Indol 3-13（SEQ ID NO：3）与Indol 1-13（SEQ ID NO：1）相比分别为：类似物，其中氨基末端截短的吲哚肽类似物中的至少一个Trp残基被Phe残基（“Indol / F”）类似物替代）;在羧基末端包含高丝氨酸残基的吲哚类抗生素类似物;以及包含此外，本发明还提供了编码本发明的吲哚肽类似物或这些类似物的前体的核酸分子。本发明还涉及使用吲哚来菌素类似物来减少或抑制微生物生长或存活的方法，用吲哚来啶类似物维持微生物生长。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式