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1. 发明申请

US20050171177A1 Method of treatment of Candida isolates 审中-公开
标题翻译：念珠菌分离株的处理方法
公开(公告)号：US20050171177A1
公开(公告)日：2005-08-04
申请号：US10767431
申请日：2004-01-30
申请人： Daniel Thompson , Elio Mariani , R. Levinson , Herbert Luther
发明人： Daniel Thompson , Elio Mariani , R. Levinson , Herbert Luther
IPC分类号： A61K9/00 , A61K31/01 , A61K31/22 , A61K31/4178 , A61K45/06 , A61K47/44
CPC分类号： A61K31/01 , A61K9/0014 , A61K31/22 , A61K31/4178 , A61K45/06 , A61K47/44
摘要： The present invention relates to methods of treatment vulvovaginitis caused by nonspecified Candida isolates using controlled release antimycotic delivery systems. The invention utilizes a minimal number of administrations to obtain cessation of the condition. The methods and systems are especially effective against any Candida species causing vaginal irritation, and thus reduce the need for identification of the isolate prior to treatment.
摘要翻译：本发明涉及使用控制释放的抗真菌递送系统治疗由非特异性假丝酵母属分离物引起的外阴阴道炎的方法。本发明利用最少数量的施用来获得条件的停止。所述方法和系统对于引起阴道刺激的任何念珠菌属物种特别有效，因此减少了在治疗前鉴定分离物的需要。

2. 发明申请

US20070110805A1 Modified-release pharmaceutical compositions 审中-公开
标题翻译：改性释放药物组合物
公开(公告)号：US20070110805A1
公开(公告)日：2007-05-17
申请号：US11430269
申请日：2006-05-08
申请人： R. Levinson , Jonathan Bortz , Elio Mariani , Daniel Thompson
发明人： R. Levinson , Jonathan Bortz , Elio Mariani , Daniel Thompson
IPC分类号： A61K31/485 , A61K31/46 , A61K31/445 , A61K9/22
CPC分类号： A61K31/135 , A61K9/0014 , A61K9/0019 , A61K9/0034 , A61K31/137 , A61K31/167 , A61K31/445 , A61K31/46 , A61K31/485 , A61K45/06 , A61K47/12
摘要： This invention is directed generally to modified-release pharmaceutical compositions, and, more particularly, to modified-release anesthetic- or analgesic-comprising pharmaceutical compositions that are bioadherent to a vaginal cavity surface, vulva surface, or skin. This invention also is directed generally to methods for preparing such compositions, methods of treatment using such compositions, uses of such compositions to prepare medicaments, and kits comprising such compositions.
摘要翻译：本发明一般涉及改性释放药物组合物，更具体地涉及对阴道腔表面，外阴表面或皮肤具有生物粘附性的改性释放麻醉或止痛剂的药物组合物。本发明还通常涉及制备这种组合物的方法，使用这种组合物的治疗方法，这种组合物的用途来制备药物，以及包含这些组合物的试剂盒。

3. 发明申请

US20050095245A1 Pharmaceutical delivery system 审中-公开
标题翻译：药物输送系统
公开(公告)号：US20050095245A1
公开(公告)日：2005-05-05
申请号：US10944416
申请日：2004-09-20
申请人： Thomas Riley , R. Levinson , Robert Cuca , Elio Mariani
发明人： Thomas Riley , R. Levinson , Robert Cuca , Elio Mariani
IPC分类号： A61F6/06 , A61K9/00 , A61K31/56 , A61K39/395 , A61K48/00
CPC分类号： A61K9/0036 , A61K9/0034
摘要： A pharmaceutical formulation to treat vaginal conditions in a human patient comprises: at least one active agent; a modified release dosage form which provides extended release of the anti-infective agent upon vaginal administration to the patient; and wherein the formulation, when containing a total dose of the anti-infective agent of about 25 μg to about 500 mg based on the active agent will produce a plasma concentration versus time curve (ng/mL versus hours) having an area under the curve (AUC) of less than about 600 ng/mL.hr.
摘要翻译：用于治疗人类患者的阴道病症的药物制剂包括：至少一种活性剂; 一种改良释放剂型，其在阴道给药时提供对抗感染药物的延长释放; 并且其中当基于活性剂含有约25至约500mg的总剂量的抗感染剂时，制剂将产生具有曲线下面积的血浆浓度对时间曲线（ng / mL对小时）（AUC）小于约600ng / mL.hr。

4. 发明申请

US20130102548A1 PHARMACEUTICAL DELIVERY SYSTEM 有权
标题翻译：药物输送系统
公开(公告)号：US20130102548A1
公开(公告)日：2013-04-25
申请号：US13555472
申请日：2012-07-23
申请人： Thomas C. Riley , R. Saul Levinson , Robert C. Cuca , Elio Mariani
发明人： Thomas C. Riley , R. Saul Levinson , Robert C. Cuca , Elio Mariani
IPC分类号： A61K9/00
CPC分类号： A61K9/0036 , A61K9/0034
摘要： A pharmaceutical formulation to treat vaginal conditions in a human patient comprises: at least one active agent; a modified release dosage form which provides extended release of the anti-infective agent upon vaginal administration to the patient; and wherein the formulation, when containing a total dose of the anti-infective agent of about 25 μg to about 500 mg based on the active agent will produce a plasma concentration versus time curve (ng/mL versus hours) having an area under the curve (AUC) of less than about 600 ng/mL·hr.
摘要翻译：用于治疗人类患者的阴道病症的药物制剂包括：至少一种活性剂; 一种改良释放剂型，其在阴道给药时提供对抗感染药物的延长释放; 并且其中当基于活性剂含有约25至约500mg的总剂量的抗感染剂时，制剂将产生具有曲线下面积的血浆浓度对时间曲线（ng / mL对小时）（AUC）小于约600ng / mL·hr。

5. 发明授权

US09789057B2 Pharmaceutical delivery system 有权
公开(公告)号：US09789057B2
公开(公告)日：2017-10-17
申请号：US13555472
申请日：2012-07-23
申请人： Thomas C. Riley , R. Saul Levinson , Robert C. Cuca , Elio Mariani
发明人： Thomas C. Riley , R. Saul Levinson , Robert C. Cuca , Elio Mariani
IPC分类号： A61K9/00
CPC分类号： A61K9/0036 , A61K9/0034
摘要： A pharmaceutical formulation to treat vaginal conditions in a human patient comprises: at least one active agent; a modified release dosage form which provides extended release of the anti-infective agent upon vaginal administration to the patient; and wherein the formulation, when containing a total dose of the anti-infective agent of about 25 μg to about 500 mg based on the active agent will produce a plasma concentration versus time curve (ng/mL versus hours) having an area under the curve (AUC) of less than about 600 ng/mL·hr.

6. 发明授权

US4435441A Method of frequency trimming surface acoustic wave devices 失效
标题翻译：频率调整表面声波装置的方法
公开(公告)号：US4435441A
公开(公告)日：1984-03-06
申请号：US454806
申请日：1982-12-30
申请人： Elio Mariani , Arthur Ballato
发明人： Elio Mariani , Arthur Ballato
IPC分类号： H03H3/10 , B05D3/06
CPC分类号： H03H3/10
摘要： The adjustment of the resonant frequency of a surface acoustical wave (SAW)evice is achieved utilizing the elastic deformation which occurs in a polymer when the polymer is energized. A film or patch of a polymer coating is applied to the substrate of the SAW device before sealing. The device is then subjected to an elevated temperature, to precure the polymer, and sealed. After being sealed with an appropriate transparent material, the device is subjected to a polymer-energizing media such as a light beam, high temperature or an electron beam. The applied polymer patch is energized resulting in elastic deformation of the patch. The polymer deformation results in a change in the elastic stiffness of the piezoelectric medium and thereby a change in the resonant frequency of the device.
摘要翻译：利用在聚合物通电时在聚合物中发生的弹性变形来实现表面声波（SAW）器件的谐振频率的调节。在密封前将聚合物涂层的膜或贴片施加到SAW器件的衬底上。然后将该装置进行升高的温度，以预固化聚合物并密封。在用适当的透明材料密封之后，对该装置进行聚合物激励介质，例如光束，高温或电子束。施加的聚合物贴片被通电，导致贴片的弹性变形。聚合物变形导致压电介质的弹性刚度的变化，从而导致器件的谐振频率的变化。

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