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1. 发明授权

US06986601B2 Piezoelectric mixing method 失效
标题翻译：压电混合法
公开(公告)号：US06986601B2
公开(公告)日：2006-01-17
申请号：US10437515
申请日：2003-05-13
申请人： Daniel J. Sadler , Rajnish G. Changrani , Chia Fu Chou , Frederic Zenhausern
发明人： Daniel J. Sadler , Rajnish G. Changrani , Chia Fu Chou , Frederic Zenhausern
IPC分类号： B01F11/02
CPC分类号： B01F11/0062 , B01F13/0059 , B01F2215/0098 , B01F2215/0454 , B01L3/5027
摘要： A method for mixing at least two fluids includes introducing the at least two fluids into a mixing chamber. The mixing chamber includes a piezoelectric component (500) for mechanical actuation of fluid motion within or adjacent the mixing chamber. The piezoelectric component includes at least first (400), second (410), third (420), and fourth (430) actuation domains, the first and third actuation domains being on first and third opposed sides of the piezoelectric component, and the second and fourth actuation domains being on second and fourth opposed sides of the piezoelectric component. The first and third domains are actuated at a first phase of a frequency of oscillation, and the second and fourth domains are actuated at a second phase of the frequency of oscillation.
摘要翻译：用于混合至少两种流体的方法包括将至少两种流体引入混合室。混合室包括用于在混合室内或邻近混合室内的流体运动的机械致动的压电元件（500）。压电元件至少包括第一（400），第二（410），第三（420）和第四（430）致动域，第一和第三致动域位于压电元件的第一和第三相对侧上，第二并且第四致动域位于压电元件的第二和第四相对侧上。第一和第三域在振荡频率的第一阶段被激励，并且第二和第四域在振荡频率的第二阶段被致动。

2. 发明授权

US06989235B2 Single molecule detection of bio-agents using the F1-ATPase biomolecular motor 有权
标题翻译：使用F1-ATPase生物分子运动的单分子检测生物试剂
公开(公告)号：US06989235B2
公开(公告)日：2006-01-24
申请号：US10365378
申请日：2003-02-11
申请人： Lars Chapsky , Wayne D. Frasch , Chia Fu Chou , Frederic Zenhausern , Herbert Goronkin
发明人： Lars Chapsky , Wayne D. Frasch , Chia Fu Chou , Frederic Zenhausern , Herbert Goronkin
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： B82Y5/00 , C12Q1/6825 , C12Q2563/155
摘要： An exemplary system and method of employing DNA hybridization for the detection of bio-agents is disclosed as comprising inter alia a biomolecular rotary motor (150); a capture probe DNA fragment (140) effectively attached to said biomolecular motor (150); a target DNA fragment (130) suitably adapted for hybridization with said capture probe DNA (140); a signal probe DNA fragment (120) suitably adapted for hybridization with said target DNA (130); and a fluorescent bead (100) attached to said signal probe DNA (120). Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to improve certain device fabrication parameters and/or performance metrics.
摘要翻译：公开了使用DNA杂交来检测生物试剂的示例性系统和方法，其特别包括生物分子旋转马达（150）; 有效连接到所述生物分子马达（150）的捕获探针DNA片段（140）; 适于与所述捕获探针DNA（140）杂交的靶DNA片段（130）; 适于与所述靶DNA（130）杂交的信号探针DNA片段（120）; 和连接到所述信号探针DNA（120）上的荧光珠（100）。公开的特征和规范可以被不同地控制，适应或以其他方式任意地修改以改进某些设备制造参数和/或性能度量。

3. 发明授权

US06824664B1 Electrode-less dielectrophorises for polarizable particles 失效
标题翻译：用于可极化颗粒的无电极介电性能
公开(公告)号：US06824664B1
公开(公告)日：2004-11-30
申请号：US09707892
申请日：2000-11-06
申请人： Robert H. Austin , Jonas O. Tegenfeldt , Edward C. Cox , Chia Fu Chou , Olgica Bakajin
发明人： Robert H. Austin , Jonas O. Tegenfeldt , Edward C. Cox , Chia Fu Chou , Olgica Bakajin
IPC分类号： C02F140
CPC分类号： B01L3/502761 , B01L7/52 , B01L2200/0668 , B01L2300/0819 , B01L2300/0822 , B01L2400/0421 , B01L2400/0424 , B03C5/024 , B03C5/026
摘要： The present invention further provides a device for the integrated micromanipulation, amplification, and analysis of polarized particles such as DNA comprises a microchip which contains constrictions of insulating material for dielectrophoresis powered by an alternating current or direct current signal generator, and attached to a hot source that can be heated to specific temperatures. Nucleic acids can be heated and cooled to allow for denaturation, and the annealing of complementary primers and enzymatic reactions, as in a thermocycling reaction. After such a reaction has been completed at the constriction, the dielectrophoretic field can be switched to a direct field to release the product and direct it through a matrix for fractionation. The device includes data analysis equipment for the control of these operations, and imaging equipment for the analysis of the products. The invention permits the efficient handling of minute samples in large numbers, since reactions occur while sample material is trapped between constrictions. Because the positioning, reactions, and release into a fractioning matrix all occur at the constriction which serves as a focusing locus, the need to transfer samples into different tubes is eliminated, thus increasing the efficiency and decreasing the possibility of damage to the samples.
摘要翻译：本发明还提供了用于对诸如DNA的极化粒子进行集成显微操作，放大和分析的装置，包括微芯片，其包含用于由交流电或直流信号发生器供电的介电电泳的绝缘材料的收缩部分，并连接到热源可以加热到特定温度。核酸可被加热和冷却以允许变性，以及互补引物的退火和酶反应，如在热循环反应中。在收缩处完成这样的反应之后，介电电泳场可以切换到直接场以释放产物并将其引导通过基质进行分馏。该设备包括用于控制这些操作的数据分析设备和用于分析产品的成像设备。本发明允许有效地处理微量样品，因为在样品材料被捕获在收缩之间时发生反应。因为定位，反应和释放到分级矩阵中都会发生在用作聚焦轨迹的收缩处，消除了将样品转移到不同管中的需要，从而提高了效率并降低了样品损伤的可能性。

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