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1. 发明申请

US20170007547A1 SPRAY-DRIED SOLID-IN-OIL-IN-WATER DISPERSIONS FOR INHALATION OF ACTIVE PHARMACEUTICAL INGREDIENTS 审中-公开
标题翻译：用于吸入活性药物成分的喷雾干燥的水中固体分散体
公开(公告)号：US20170007547A1
公开(公告)日：2017-01-12
申请号：US15121161
申请日：2015-03-24
申请人： Daniel Huang , Nagaraja Rao , Trixie Tan , Danforth Miller , Jeffry Weers
发明人： Daniel Huang , Nagaraja Rao , Trixie Tan , Danforth Miller , Jeffry Weers
IPC分类号： A61K9/50 , B01J2/04 , A61K38/13 , A61K31/436 , A61K9/00 , A61K31/4704
摘要： Embodiments of the invention relate to particulate agents and compositions comprising particulate agents for inhalation, and methods for preparing such particulate agents and compositions for inhalation, as well as therapeutic methods. Embodiments of the method comprise preparing an emulsion by combining an oil phase dispersion of hydrophobic seed particles and an aqueous dispersion comprising an emulsifier and an emulsion stabilizer and preparing a feedstock comprising encapsulated particles by homogenizing the emulsion, and forming a plurality of coated particles by spray drying the feedstock, wherein resulting particles comprises a porous shell disposed on or over a core and the core comprises at least one hydrophobic seed particle.
摘要翻译：本发明的实施方案涉及包含用于吸入的颗粒剂的颗粒剂和组合物，以及用于制备这种颗粒剂和用于吸入的组合物的方法以及治疗方法。该方法的实施方案包括通过将疏水种子颗粒的油相分散体和包含乳化剂和乳液稳定剂的水性分散体组合制备乳液，并通过均化乳液制备包含包封颗粒的原料，并通过喷雾形成多个涂覆颗粒干燥原料，其中所得颗粒包括设置在芯上或其上的多孔壳，并且芯包含至少一个疏水种子颗粒。

2. 发明授权

US10744098B2 Spray-dried solid-in-oil-in-water dispersions for inhalation of active pharmaceutical ingredients 有权
公开(公告)号：US10744098B2
公开(公告)日：2020-08-18
申请号：US15121161
申请日：2015-03-24
申请人： Daniel Huang , Nagaraja Rao , Trixie Tan , Danforth Miller , Jeffry Weers
发明人： Daniel Huang , Nagaraja Rao , Trixie Tan , Danforth Miller , Jeffry Weers
IPC分类号： A61K9/50 , A61K9/00 , A61K38/13 , A61K31/436 , A61K31/4704 , A61K31/365 , A61K45/06 , B01J2/04
摘要： Embodiments of the invention relate to particulate agents and compositions comprising particulate agents for inhalation, and methods for preparing such particulate agents and compositions for inhalation, as well as therapeutic methods. Embodiments of the method comprise preparing an emulsion by combining an oil phase dispersion of hydrophobic seed particles and an aqueous dispersion comprising an emulsifier and an emulsion stabilizer and preparing a feedstock comprising encapsulated particles by homogenizing the emulsion, and forming a plurality of coated particles by spray drying the feedstock, wherein resulting particles comprises a porous shell disposed on or over a core and the core comprises at least one hydrophobic seed particle.

3. 发明授权

US09050267B2 Dry powder formulations of particles that contain two or more active ingredients for treating obstructive or inflammatory airways diseases 有权
标题翻译：含有两种或多种活性成分以治疗阻塞性或炎症性气道疾病的颗粒的干粉配方
公开(公告)号：US09050267B2
公开(公告)日：2015-06-09
申请号：US13982630
申请日：2012-02-03
申请人： Jeffry G. Weers , Nagaraja Rao , Daniel Huang , Danforth Miller , Thomas E. Tarara
发明人： Jeffry G. Weers , Nagaraja Rao , Daniel Huang , Danforth Miller , Thomas E. Tarara
IPC分类号： A61K9/14 , A61K9/50 , A61K9/00 , A61K45/06 , A61K31/40 , A61K31/4704 , A61K31/56 , A61K31/58 , A61M15/00 , A61K9/16
CPC分类号： A61K9/50 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/501 , A61K9/5015 , A61K31/40 , A61K31/4704 , A61K31/56 , A61K31/58 , A61K45/06 , A61M15/00
摘要： Dry powder formulations for inhalation comprising spray-dried particles and their use in the treatment of an obstructive or inflammatory airways disease. Each particle has a core of a first active ingredient in substantially crystalline form that is coated with a layer of a second active ingredient in substantially amorphous form that is dispersed in a pharmaceutically acceptable hydrophobic excipient. A process for preparing such formulations is also described.
摘要翻译：用于吸入的干粉制剂包括喷雾干燥颗粒及其用于治疗阻塞性或炎性气道疾病的用途。每个颗粒具有基本上结晶形式的第一活性成分的核心，其以基本上无定形形式的第二活性成分层涂覆，所述第二活性成分分散在药学上可接受的疏水性赋形剂中。还描述了制备这种制剂的方法。

4. 发明申请

US20130319411A1 Dry powder formulations of particles that contain two or more active ingredients for treating obstructive or inflammatory airways diseases 有权
公开(公告)号：US20130319411A1
公开(公告)日：2013-12-05
申请号：US13982630
申请日：2012-02-03
申请人： Jeffry G. Weers , Nagaraja Rao , Daniel Huang , Danforth Miller , Thomas E. Tarara
发明人： Jeffry G. Weers , Nagaraja Rao , Daniel Huang , Danforth Miller , Thomas E. Tarara
IPC分类号： A61K9/50 , A61K45/06 , A61K31/40 , A61K31/4704 , A61K31/58 , A61M15/00 , A61K31/56
CPC分类号： A61K9/50 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/501 , A61K9/5015 , A61K31/40 , A61K31/4704 , A61K31/56 , A61K31/58 , A61K45/06 , A61M15/00
摘要： Dry powder formulations for inhalation comprising spray-dried particles and their use in the treatment of an obstructive or inflammatory airways disease. Each particle has a core of a first active ingredient in substantially crystalline form that is coated with a layer of a second active ingredient in substantially amorphous form that is dispersed in a pharmaceutically acceptable hydrophobic excipient. A process for preparing such formulations is also described.

5. 发明授权

US07326691B2 Compositions comprising amphotericin B, methods, and systems 有权
标题翻译：包含两性霉素B，方法和系统的组合物
公开(公告)号：US07326691B2
公开(公告)日：2008-02-05
申请号：US11158332
申请日：2005-06-21
申请人： Sarma Duddu , Srinivas Palakodaty , David Lechuga-Ballesteros , Danforth Miller , Alan R. Kugler , Christopher Frantz , Trixie Tan , Richard Malcolmson , Keith Washco , Theresa Sweeney , Thomas E. Tarara , Sarvajna Dwivedi , Michael A. Eldon
发明人： Sarma Duddu , Srinivas Palakodaty , David Lechuga-Ballesteros , Danforth Miller , Alan R. Kugler , Christopher Frantz , Trixie Tan , Richard Malcolmson , Keith Washco , Theresa Sweeney , Thomas E. Tarara , Sarvajna Dwivedi , Michael A. Eldon
IPC分类号： A61K9/14 , A61K31/70
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1694 , A61K31/7048 , A61M15/0028 , A61M15/0041 , A61M2202/064
摘要： A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 μm to about 1.9 μm. Another composition also includes particles including at least about 95 wt % of amphotericin B, wherein at least about 80 wt % of the particles have a geometric diameter ranging from about 1.1 μm to about 1.9 μm. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 μm, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.
摘要翻译：组合物包括包含至少约95重量％的两性霉素B的颗粒，其中所述颗粒的质量中值直径范围为约1.1μm至约1.9μm。另一种组合物还包括包含至少约95wt％的两性霉素B的颗粒，其中至少约80wt％的颗粒具有约1.1μm至约1.9μm的几何直径。另一种组合物包括包括两性霉素B的颗粒，其中颗粒的质量中值直径小于约1.9μm，并且其中两性霉素B的结晶度水平至少为约20％。单位剂量形式，递送系统和方法可以涉及类似的组合物。

6. 发明申请

US20060025355A1 Compositions comprising amphotericin B, methods, and systems 有权
标题翻译：包含两性霉素B，方法和系统的组合物
公开(公告)号：US20060025355A1
公开(公告)日：2006-02-02
申请号：US11158332
申请日：2005-06-21
申请人： Sarma Duddu , Srinivas Palakodaty , David Lechuga-Ballesteros , Danforth Miller , Alan Kugler , Christopher Frantz , Trixie Tan , Richard Malcomson , Keith Washco , Theresa Sweeney , Thomas Tarara , Sarvajna Dwivedi , Michael Eldon
发明人： Sarma Duddu , Srinivas Palakodaty , David Lechuga-Ballesteros , Danforth Miller , Alan Kugler , Christopher Frantz , Trixie Tan , Richard Malcomson , Keith Washco , Theresa Sweeney , Thomas Tarara , Sarvajna Dwivedi , Michael Eldon
IPC分类号： A61K31/7048 , A61K9/14 , A61L9/04
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1694 , A61K31/7048 , A61M15/0028 , A61M15/0041 , A61M2202/064
摘要： A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 μm to about 1.9 μm. Another composition also includes particles including at least about 95 wt % of amphotericin B, wherein at least about 80 wt % of the particles have a geometric diameter ranging from about 1.1 μm to about 1.9 μm. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 μm, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.
摘要翻译：组合物包括包含至少约95重量％的两性霉素B的颗粒，其中所述颗粒的质量中值直径范围为约1.1μm至约1.9μm。另一种组合物还包括包含至少约95wt％的两性霉素B的颗粒，其中至少约80wt％的颗粒具有约1.1μm至约1.9μm的几何直径。另一种组合物包括包括两性霉素B的颗粒，其中颗粒的质量中值直径小于约1.9μm，并且其中两性霉素B的结晶度水平至少为约20％。单位剂量形式，递送系统和方法可以涉及类似的组合物。

7. 发明申请

US20170066823A1 THYMIC STROMAL LYMPHOPOIETIN (TSLP)-BINDING MOLECULES AND METHODS OF USING THE MOLECULES 有权
标题翻译： THYMIC STROMAL LYMPHOPOIETIN（TSLP） - 使用分子的分子和方法
公开(公告)号：US20170066823A1
公开(公告)日：2017-03-09
申请号：US15258683
申请日：2016-09-07
申请人： Matthew John EDWARDS , Jean-Michel Rene RONDEAU , Danforth Miller , Daniel Huang , Hans-Peter KNOPF , Gino Anselmus VAN HEEKE , Rene HEMMIG , Kapil GUPTA , Nicole HAUBST , Barbara ANDLAUER
发明人： Matthew John EDWARDS , Jean-Michel Rene RONDEAU , Danforth Miller , Daniel Huang , Hans-Peter KNOPF , Gino Anselmus VAN HEEKE , Rene HEMMIG , Kapil GUPTA , Nicole HAUBST , Barbara ANDLAUER
IPC分类号： C07K16/24 , A61K47/42 , A61K45/06 , A61K9/00 , A61K47/26 , A61K47/22 , A61K39/395 , A61K47/18
CPC分类号： C07K16/24 , A61K9/0043 , A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/544 , A61K2039/545 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention provides molecules, e.g., antibodies or antibody fragments, that specifically bind thymic stromal lymphopoietin (TSLP), compositions comprising these molecules, and methods of using and producing these molecules.
摘要翻译：本发明提供特异性结合胸腺基质淋巴细胞生成素（TSLP），包含这些分子的组合物的分子，例如抗体或抗体片段，以及使用和产生这些分子的方法。

8. 发明授权

US06919172B2 Preservation and storage medium for biological materials 有权
标题翻译：保存和储存培养基用于生物材料
公开(公告)号：US06919172B2
公开(公告)日：2005-07-19
申请号：US10657017
申请日：2003-09-05
申请人： Juan DePablo , Danforth Miller , Paul Conrad , Horacio Corti
发明人： Juan DePablo , Danforth Miller , Paul Conrad , Horacio Corti
IPC分类号： A01N1/02 , A01N1/00 , A61K31/7012
CPC分类号： A01N1/0221 , A01N1/02
摘要： A protectant mixture for use in preserving biological materials comprising (1) at least one polyhydroxy compound, where the total amount of polyhydroxy compound in the mixture is from about 5% to about 60% by weight of the mixture where the mixture is an aqueous solution and is from about 10% to about 95% where the mixture is in solid form, and (2) phosphate ions, where the total amount of phosphate ions in the mixture is such that the molar ratio of phosphate ions to hydroxy groups in the polyhydroxy compound is from about 0.025 to about 0.625; a preservation medium comprising (1) a biological material, (2) at least one polyhydroxy compound, where the total amount of polyhydroxy compound in the medium is from about 5% to about 60% by weight of the medium, and (3) phosphate ions, where the total amount of phosphate ions in the mixture is such that the molar ratio of phosphate ions to hydroxy groups in the polyhydroxy compound is from about 0.025 to about 0.625; methods of preserving the preservation medium; and the resulting preserved biological material composition.
摘要翻译：一种用于保存生物材料的保护剂混合物，其包含（1）至少一种多羟基化合物，其中混合物中多羟基化合物的总量为混合物的约5重量％至约60重量％，其中混合物为水溶液并且为约10％至约95％，其中混合物为固体形式，和（2）磷酸根离子，其中混合物中磷酸根离子的总量使得多羟基中的磷酸根离子与羟基的摩尔比化合物为约0.025至约0.625; 保存介质，其包含（1）生物材料，（2）至少一种多羟基化合物，其中介质中多羟基化合物的总量为介质重量的约5％至约60％，和（3）磷酸盐离子，其中混合物中磷酸根离子的总量使得多羟基化合物中磷酸根离子与羟基的摩尔比为约0.025至约0.625; 保存培养基的方法; 和所得保存的生物材料组成。

9. 发明授权

US06653062B1 Preservation and storage medium for biological materials 有权
标题翻译：保存和储存培养基用于生物材料
公开(公告)号：US06653062B1
公开(公告)日：2003-11-25
申请号：US09625735
申请日：2000-07-26
申请人： Juan DePablo , Danforth Miller , Paul Conrad , Horacio Corti
发明人： Juan DePablo , Danforth Miller , Paul Conrad , Horacio Corti
IPC分类号： A01N100
CPC分类号： A01N1/0221 , A01N1/02
摘要： A protectant mixture for use in preserving biological materials comprising (1) at least one polyhydroxy compound, where the total amount of polyhydroxy compound in the mixture is from about 5% to about 60% by weight of the mixture where the mixture is an aqueous solution and is from about 10% to about 95% where the mixture is in solid form, and (2) phosphate ions, where the total amount of phosphate ions in the mixture is such that the molar ratio of phosphate ions to hydroxy groups in the polyhydroxy compound is from about 0.025 to about 0.625; a preservation medium comprising (1) a biological material, (2) at least one polyhydroxy compound, where the total amount of polyhydroxy compound in the medium is from about 5% to about 60% by weight of the medium, and (3) phosphate ions, where the total amount of phosphate ions in the mixture is such that the molar ratio of phosphate ions to hydroxy groups in the polyhydroxy compound is from about 0.025 to about 0.625; methods of preserving the preservation medium; and the resulting preserved biological material composition.
摘要翻译：一种用于保存生物材料的保护剂混合物，其包含（1）至少一种多羟基化合物，其中混合物中多羟基化合物的总量为混合物的约5重量％至约60重量％，其中混合物为水溶液并且为约10％至约95％，其中混合物为固体形式，和（2）磷酸根离子，其中混合物中磷酸根离子的总量使得多羟基中的磷酸根离子与羟基的摩尔比化合物为约0.025至约0.625; 保存介质，其包含（1）生物材料，（2）至少一种多羟基化合物，其中介质中多羟基化合物的总量为介质重量的约5％至约60％，和（3）磷酸盐离子，其中混合物中磷酸根离子的总量使得多羟基化合物中磷酸根离子与羟基的摩尔比为约0.025至约0.625; 保存培养基的方法; 和所得保存的生物材料组成。

10. 发明授权

US08513204B2 Compositions comprising amphotericin B, mehods and systems 有权
标题翻译：包含两性霉素B，方法和系统的组合物
公开(公告)号：US08513204B2
公开(公告)日：2013-08-20
申请号：US11523978
申请日：2006-09-20
申请人： Richard Malcolmson , Alan Kugler , Theresa D. Sweeney , Keith Washco , Danforth Miller
发明人： Richard Malcolmson , Alan Kugler , Theresa D. Sweeney , Keith Washco , Danforth Miller
IPC分类号： A61K31/70
CPC分类号： A61K9/1617 , A61K9/0075 , A61K9/1611 , A61K9/1694 , A61K31/7048 , A61M15/0028 , A61M15/0041 , A61M2202/064
摘要： The present invention comprises compositions and formulations comprising amphotericin B, compositions and formulations comprising amphotericin B with one or more excipients, methods of making amphotericin B compositions and formulations, as well as systems for using amphotericin B compositions and formulations. Also provided are pharmaceutical compositions comprising the formulation, methods of administering the pharmaceutical compositions and methods of treating patients with the pharmaceutical compositions.
摘要翻译：本发明包括包含两性霉素B的组合物和制剂，包含两性霉素B与一种或多种赋形剂的组合物和制剂，制备两性霉素B组合物和制剂的方法，以及使用两性霉素B组合物和制剂的系统。还提供了药物组合物，其包含制剂，施用药物组合物的方法和用药物组合物治疗患者的方法。

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