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1. 发明授权

US6096315A Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same 失效
标题翻译：异种功能性细胞免疫试剂，含有相同的疫苗及其使用方法
公开(公告)号：US6096315A
公开(公告)日：2000-08-01
申请号：US469923
申请日：1995-06-06
申请人： Daniel H. Zimmerman , Donald A. Elliott
发明人： Daniel H. Zimmerman , Donald A. Elliott
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , C07K1/20 , C07K1/22 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/03 , C07K14/075 , C07K14/09 , C07K14/16 , C07K14/18 , C07K14/315 , C07K14/42 , C07K14/445 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/55 , C07K14/725 , C07K14/74 , C07K14/80 , C07K16/00 , C07K19/00 , G01N33/569 , C07K1/00
CPC分类号： A61K39/092 , C07K14/005 , C07K14/315 , C07K14/42 , C07K14/445 , C07K14/47 , C07K14/70539 , C07K14/80 , G01N33/56972 , A61K2039/6031 , A61K38/00 , C07K2319/00 , C12N2710/10322 , C12N2710/16222 , C12N2740/16122 , C12N2770/24022 , C12N2770/32122 , Y10S530/868
摘要： The present invention relates to a heterofunctional cellular immunological reagent comprising at least two T cell specific binding ligands covalently linked together, wherein one of the T cell specific binding ligands binds to a specific class or subclass of T cells and another of the T cell specific binding ligands is an antigen associated with disease or a causative agent of disease, or epitope thereof. The present invention also relates to vaccines containing the heterofunctional cellular immunological reagents and methods for the use of the same.
摘要翻译：本发明涉及包含共价连接在一起的至少两个T细胞特异性结合配体的异功能细胞免疫试剂，其中T细胞特异性结合配体之一与T细胞的特定类别或亚类结合，另一种T细胞特异性结合配体是与疾病或疾病的致病因子或其表位相关的抗原。本发明还涉及含有异功能细胞免疫学试剂的疫苗及其使用方法。

2. 发明授权

US5652342A Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same 失效
标题翻译：异种功能性细胞免疫试剂，含有相同的疫苗及其使用方法
公开(公告)号：US5652342A
公开(公告)日：1997-07-29
申请号：US354751
申请日：1994-12-08
申请人： Daniel H. Zimmerman , Donald A. Elliott
发明人： Daniel H. Zimmerman , Donald A. Elliott
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , C07K1/20 , C07K1/22 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/03 , C07K14/075 , C07K14/09 , C07K14/16 , C07K14/18 , C07K14/315 , C07K14/42 , C07K14/445 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/55 , C07K14/725 , C07K14/74 , C07K14/80 , C07K16/00 , C07K19/00 , G01N33/569 , C07K14/705 , A61K39/385
CPC分类号： A61K39/092 , C07K14/005 , C07K14/315 , C07K14/42 , C07K14/445 , C07K14/47 , C07K14/70539 , C07K14/80 , G01N33/56972 , A61K2039/6031 , A61K38/00 , C07K2319/00 , C12N2710/10322 , C12N2710/16222 , C12N2740/16122 , C12N2770/24022 , C12N2770/32122 , Y10S530/868
摘要： The present invention relates to a heterofunctional cellular immunological reagent comprising at least two T cell specific binding ligands covalently linked together, wherein one of the T cell specific binding ligands binds to a specific class or subclass of T cells and another of the T cell specific binding ligands is an antigen associated with disease or a causative agent of disease, or epitope thereof. The present invention also relates to vaccines containing the heterofunctional cellular immunological reagents and methods for the use of the same.
摘要翻译：本发明涉及包含共价连接在一起的至少两个T细胞特异性结合配体的异功能细胞免疫试剂，其中T细胞特异性结合配体之一与T细胞的特定类别或亚类结合，另一种T细胞特异性结合配体是与疾病或疾病的致病因子或其表位相关的抗原。本发明还涉及含有异功能细胞免疫学试剂的疫苗及其使用方法。

3. 发明授权

US11041013B2 Methods of preparation and composition of peptide constructs useful for treatment of rheumatoid arthritis 有权
公开(公告)号：US11041013B2
公开(公告)日：2021-06-22
申请号：US12922687
申请日：2009-03-16
申请人： Daniel H. Zimmerman
发明人： Daniel H. Zimmerman
IPC分类号： A61K39/008 , C07K14/705 , A61K39/00 , A61K38/00 , A61K35/12
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of autoimmune diseases, specifically rheumatoid arthritis (RA) and compositions containing same, methods for producing same and methods for using same; wherein the peptide constructs have the formula P1-x-P2 where P1 is a peptide associated with autoimmune disease, allergy, asthma, host-versus-graft rejection, myocarditis, diabetes, and immune-mediated disease, which binds to an antigen receptor on a set or subset of T cells; P2 is a peptide which will cause a Th2 directed immune response by the set or subset of T cells to which the peptide P1 is attached or which will bind to a T cell receptor which will cause the set or subset of T cells to which the peptide P1 is attached to initiate, but not complete, an immune response causing the set or subset of T cells to undergo anergy and apoptosis; and x is a direct bond or linker for covalently bonding P1 and P2.

4. 发明授权

US06995237B1 Preparation and composition of peptides useful for treatment of autoimmune and transplant related graft versus host conditions 有权
标题翻译：用于治疗自身免疫和移植相关移植物与宿主条件的肽的制备和组合物
公开(公告)号：US06995237B1
公开(公告)日：2006-02-07
申请号：US10111645
申请日：2000-10-27
申请人： Daniel H. Zimmerman
发明人： Daniel H. Zimmerman
IPC分类号： A61K39/00 , C07K14/435
CPC分类号： C07K14/4713 , A61K39/0008 , A61K39/35 , A61K39/36 , C07K5/1008 , C07K14/435 , C07K2319/33 , C07K2319/40 , C07K2319/74
摘要： Peptide constructs including a first peptide segment which includes an amino acid sequence associated with autoimmune disease, asthma, allergy or xeno- or allograft transplantation rejections bonded directly or via a linker or spacer to a second peptide which binds to T cells and which will redirect the immune response from a harmful Th1 response to a less harmful Th2 response, or which will bind to T cells to initiate, but not complete, an immune response causing the T cells to which the first peptide binds, to undergo anergy and apoptosis, are useful in treating autoimmune conditions. For instance, the peptide construct NGQEEKAGVVSTGLIGGGDSAFDVLSFTAEEKAGVYK (SEQ ID NO:14) wherein Th2 stimulating Peptide G (SEQ ID NO:15) is covalently linked, via spacer GGG, to cardiac myosin molecule My1 (SEQ ID NO:16), can be used for treatment or prevention of myocarditis.
摘要翻译：包括第一肽段的肽构建体，其包括与自身免疫性疾病，哮喘，变态反应或异种或同种异体移植排斥相关的氨基酸序列，其直接或通过接头或间隔基键合至与T细胞结合的第二肽，并且将重定向有害的Th1应答对不太有害的Th2应答的免疫应答，或与T细胞结合以引发但不完全的引起第一个肽所结合的T细胞的免疫应答进行无反应和凋亡的免疫应答是有用的在治疗自身免疫性疾病。例如，可以使用其中Th2刺激肽G（SEQ ID NO：15）通过间隔基GGG共价连接到心肌肌球蛋白分子My1（SEQ ID NO：16）的肽构建体NGQEEKAGVVSTGLIGGGDSAFDVLSFTAEEKAGVYK（SEQ ID NO：14）用于治疗或预防心肌炎。

5. 发明授权

US10238747B2 Method for inducing an immune response against avian, swine, spanish, H1N1, H5N9 influenza viruses and formulations thereof 有权
公开(公告)号：US10238747B2
公开(公告)日：2019-03-26
申请号：US13994092
申请日：2011-12-13
申请人： Daniel H. Zimmerman
发明人： Daniel H. Zimmerman
IPC分类号： A61K47/48 , A61K39/12 , A61K39/145 , A61K45/06 , A61K47/64 , A61K39/00
摘要： A vaccine for immunization against Type A influenza virus is provided having an immunologically effective amount of peptide constructs obtained by linking together two or more peptides based on or derived from different molecules, and methods for producing the same. The peptide constructs have the formula P1-x-P2 or P2-x-P1 where P1 is associated with Type A influenza highly conserved protein such as but not limited to M2e matrix protein, NP1 nucleoprotein, HA2 core 1, and HA2 core 2, where P2 is a peptide construct causing a Th1 directed immune response by a set or subset of T cells to which the peptide P1 is attached or that binds to a dendritic cell or T cell receptor causing said set or subset of dendritic cell or T cells to which the peptide P1 is attached to initiate and complete, an immune response, and x is a direct bond or divalent linker for covalently bonding P1 and P2.

6. 发明授权

US10179164B2 Method for inducing an immune response for treatment of cancer and autoimmune diseases or conditions 有权
公开(公告)号：US10179164B2
公开(公告)日：2019-01-15
申请号：US14122240
申请日：2012-05-24
申请人： Daniel H. Zimmerman , Eyal Talor , Kenneth Rosenthal
发明人： Daniel H. Zimmerman , Eyal Talor , Kenneth Rosenthal
IPC分类号： A61K38/00 , A61K39/00 , A61K38/16 , A61K35/12 , A61K51/02 , A61K47/64 , A61K47/68 , A61K47/69
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of cancer or the treatment of autoimmune diseases and compositions containing same, methods for producing same, and methods for using same; wherein the peptide constructs have the formula P1-x-P2 where P2 is a peptide associated with forms of cancer or an autoimmune condition and P1 is a peptide which will bind to a class of immune cells such as dendritic cells. The peptide construct can cause the maturation of immature dendritic cells to a more mature state. The peptide construct or the more mature dendritic cells can be administered to a subject to a modulate or to initiate an immune response against cancer cells, and can be used with dyes, radioisotopes, or therapeutic agents for detection of the immune target and/or treatment of cancer and autoimmune conditions.

7. 发明申请

US20110098444A1 METHODS OF PREPARATION AND COMPOSITION OF PEPTIDE CONSTRUCTS USEFUL FOR TREATMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译：用于治疗恶病质性肾炎的肽制剂的制备方法和组合物
公开(公告)号：US20110098444A1
公开(公告)日：2011-04-28
申请号：US12922687
申请日：2009-03-16
申请人： Daniel H. Zimmerman
发明人： Daniel H. Zimmerman
IPC分类号： C07K19/00 , C07K7/08
CPC分类号： C07K14/7055 , A61K38/00
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of autoimmune diseases, specifically rheumatoid arthritis (RA) and compositions containing same, methods for producing same and methods for using same; wherein the peptide constructs have the formula P1-x-P2 where P1 is a peptide associated with autoimmune disease, allergy, asthma, host-versus-graft rejection, myocarditis, diabetes, and immune-mediated disease, which binds to an antigen receptor on a set or subset of T cells; P2 is a peptide which will cause a Th2 directed immune response by the set or subset of T cells to which the peptide P1 is attached or which will bind to a T cell receptor which will cause the set or subset of T cells to which the peptide P1 is attached to initiate, but not complete, an immune response causing the set or subset of T cells to undergo anergy and apoptosis; and x is a direct bond or linker for covalently bonding P1 and P2.
摘要翻译：本发明涉及肽构建体，即通过将两种或更多种基于或衍生自不同分子的肽连接在一起而获得的多肽，其可用于治疗或预防自身免疫疾病，特别是类风湿性关节炎（RA）和含有它们的组合物，生产方法及使用方法; 其中所述肽构建体具有式P1-x-P2，其中P1是与自身免疫疾病，过敏，哮喘，宿主对移植物排斥，心肌炎，糖尿病和免疫介导的疾病相关的肽，其结合抗原受体 T细胞的集合或子集; P2是通过肽P1所连接的T细胞的集合或子集引起Th2定向免疫应答的肽，或者将与T细胞受体结合，所述T细胞受体将导致肽 P1连接以引发但不完全的导致T细胞的集合或亚群进行无反应和凋亡的免疫应答; x是用于共价键合P1和P2的直接键或连接体。

8. 发明授权

US06287565B1 Modified HGP-30 heteroconjugates, compositions and methods of use 失效
标题翻译：改性HGP-30杂合物，组合物和使用方法
公开(公告)号：US06287565B1
公开(公告)日：2001-09-11
申请号：US09594845
申请日：2000-06-15
申请人： Daniel H. Zimmerman , Prem S. Sarin
发明人： Daniel H. Zimmerman , Prem S. Sarin
IPC分类号： A61K3800
CPC分类号： C07K14/005 , A61K39/00 , C07K14/70539 , C07K16/1054 , C12N2740/16222 , Y10S530/826
摘要： A heteroconjugate is formed by linking a T cell binding ligand (TCBL) such as Peptide J of &bgr;-2 microglobulin to a modified HGP-30 antigentic peptide fragment of p17 gag peptide, such as, for example A T L Y S V H Q R I D V K D T (SEQ ID NO: 5) K E A L E K I E E E Q N K S The heteroconjugate is effective in eliciting a THI directed immune response and provides a vaccine composition for treating or preventing AIDS.
摘要翻译：通过将诸如β-2微球蛋白的肽J的T细胞结合配体（TCBL）与p17 gag肽的修饰的HGP-30抗原肽片段连接形成异源偶联物，例如异源偶联物有效引发THI指导免疫应答，并提供用于治疗或预防艾滋病的疫苗组合物。

9. 发明授权

US06951647B2 T cell binding ligand peptides and method of inducing a cellular immune response 失效
标题翻译： T细胞结合配体肽和诱导细胞免疫应答的方法
公开(公告)号：US06951647B2
公开(公告)日：2005-10-04
申请号：US10296317
申请日：2001-05-24
申请人： Daniel H. Zimmerman
发明人： Daniel H. Zimmerman
IPC分类号： A61K39/00 , A61K39/21 , C07K14/16 , C07K14/74 , C07K16/10
CPC分类号： C07K14/70539 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/605 , C07K14/005 , C07K16/1045 , C07K2319/00 , C12N2740/16222 , C12N2740/16234 , Y02A50/412
摘要： The present invention is based, in part, on the discovery that a modified version of Peptide G (Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile—SEQ ID NO:2) obtained by replacing Asn with Asp to form Peptide G′ (Asp Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile—SEQ ID NO: 1) overcomes the long range stabilization problem of the peptide conjugates and, quite surprisingly, also enhances the immune response, particularly the CD4 related (cell mediated) response, of conjugated peptides (L.E.A.P.S. constructs) as previously described.
摘要翻译：本发明部分基于以下发现：通过用Asp代替Asn而获得的肽G（Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile-SEQ ID NO：2）的修饰形式肽G'（Asp Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile-SEQ ID NO：1）克服了肽缀合物的长程稳定化问题，并且非常令人惊奇地还增强免疫应答，特别是CD4 相关（细胞介导）应答，如前所述缀合肽（LEAPS构建体）。

10. 发明授权

US06572860B1 Immunogenic conjugated polypeptide for treatment of herpes simplex virus 失效
标题翻译：用于治疗单纯疱疹病毒的免疫原性缀合多肽
公开(公告)号：US06572860B1
公开(公告)日：2003-06-03
申请号：US09509593
申请日：2000-03-30
申请人： Daniel H. Zimmerman , Kenneth S. Rosenthal
发明人： Daniel H. Zimmerman , Kenneth S. Rosenthal
IPC分类号： A61K39385
CPC分类号： C07K14/70539 , A61K39/00 , C07K14/005 , C07K2319/00 , C12N2710/16622
摘要： Peptide constructs chemically synthesized to contain a Herpes Simplex Virus specific antigenic peptide, such as, the 322-332 peptide (H1) from the ICP27 protein of Herpes Simplex Virus (HSV-1) and a peptide from a T cell binding ligand (TCBL), such as &bgr;-2M (aa 35-50), which elicits a TH1-like response in vitro tests in mice, were protective against challenge with HSV.
摘要翻译：化学合成含有单纯疱疹病毒特异性抗原肽的肽构建体，例如来自单纯疱疹病毒（HSV-1）的ICP27蛋白的322-332肽（H1）和来自T细胞结合配体（TCBL）的肽，，如β-2M（aa 35-50），其在小鼠中引起TH1样反应体外试验，是防止HSV攻击的。

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