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1. 发明授权

US07642054B2 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的蛇纹石跨膜抗原及其用途
公开(公告)号：US07642054B2
公开(公告)日：2010-01-05
申请号：US11225661
申请日：2005-09-12
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： C12Q1/68
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and Intracellular N- and C-termini, suggesting that It folds In a “serpentine” manner Into three extracellular and two intracellular loops. STRAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed In certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。这个家族中的两个蛋白质完全或主要地在前列腺中表达，以及在前列腺癌中，因此该家族的成员被称为前列腺的“STRAP”蛇纹石TRANmembrane抗原。本文描述和表征了四种特定的人类STRAP。人类STRAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STRAP家族STRAP-1的原型成员似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STRAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”方式折叠成三个细胞外和两个细胞内环。 STRAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STRAP-1在某些其他人类癌症中高度过度表达。

2. 发明授权

US07928201B2 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的蛇纹石跨膜抗原及其用途
公开(公告)号：US07928201B2
公开(公告)日：2011-04-19
申请号：US12575092
申请日：2009-10-07
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： C07K16/00
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的六个跨膜上皮原体）。本文描述和表征了四种特定的人STEAP。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

3. 发明授权

US07053186B2 Antibodies immunospecific for STEAP1 有权
标题翻译：针对STEAP1免疫特异性的抗体
公开(公告)号：US07053186B2
公开(公告)日：2006-05-30
申请号：US10011095
申请日：2001-12-06
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” (serpentine transmembrane antigens of the prostate). Four particular human STEAPs are described and characterized herein. The human STREPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STREP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要在前列腺以及前列腺癌中表达，因此该家族的成员被称为“STRAP”（前列腺的蛇纹状跨膜抗原）。本文描述和表征了四种特定的人STEAP。人类STREP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。前列腺癌各阶段的STREP-1蛋白表达维持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

4. 发明授权

US06329503B1 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的蛇纹石跨膜抗原及其用途
公开(公告)号：US06329503B1
公开(公告)日：2001-12-11
申请号：US09323873
申请日：1999-06-01
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： C07K100
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的六个跨膜上皮原体）。本文描述和表征了四种特定的人STEAP。人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

5. 发明申请

US20100190962A1 NOVEL SERPENTINE TRANSMEMBRANE ANTIGENS EXPRESSED IN HUMAN CANCERS AND USES THEREOF 有权
公开(公告)号：US20100190962A1
公开(公告)日：2010-07-29
申请号：US12575092
申请日：2009-10-07
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： C07K16/18
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

6. 发明授权

US07611904B2 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的蛇纹石跨膜抗原及其用途
公开(公告)号：US07611904B2
公开(公告)日：2009-11-03
申请号：US11580538
申请日：2006-10-12
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： G01N33/53
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (SIX Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的第六跨膜上皮原体）。本文描述和表征了四种特定的人STEAP。人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

7. 发明授权

US08414898B2 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的蛇纹石跨膜抗原及其用途
公开(公告)号：US08414898B2
公开(公告)日：2013-04-09
申请号：US13134650
申请日：2011-06-13
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： A61K39/395
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两个蛋白质完全或主要地在前列腺以及前列腺癌中表达，因此该家族的成员被称为STEAP（前列腺的六个跨膜上皮原体抗原）。本文描述和表征了四种特定的人STEAP。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明其以蛇纹石的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

8. 发明申请

US20110318371A1 Novel serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的新型蛇纹石跨膜抗原及其用途
公开(公告)号：US20110318371A1
公开(公告)日：2011-12-29
申请号：US13134650
申请日：2011-06-13
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： A61K39/395 , C12N13/00 , A61P35/00 , C12N5/09
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的六个跨膜上皮原体）。本文描述和表征了四种特定的人STEAP。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

9. 发明授权

US07968307B2 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
公开(公告)号：US07968307B2
公开(公告)日：2011-06-28
申请号：US12575164
申请日：2009-10-07
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： G01N33/574
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

10. 发明授权

US06887975B2 Peptides derived from STEAP1 有权
标题翻译：衍生自STEAP1的肽
公开(公告)号：US06887975B2
公开(公告)日：2005-05-03
申请号：US10010667
申请日：2001-12-06
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran , Stephen Chappell Mitchell
IPC分类号： G01N33/574 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12P21/00 , C12P21/08 , C12Q1/68 , A61K39/00 , G01N33/48
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (serpentine transmembrane antigens of the prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要在前列腺以及前列腺癌中表达，因此该家族的成员被称为“STEAP”（前列腺的蛇纹石跨膜抗原）。本文描述和表征了四种特定的人STEAP。人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族STEAP-1的原型成员似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个细胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

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