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1. 发明授权

US5382518A Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells 失效
标题翻译： Urate氧化酶活性蛋白，编码重组基因，表达载体，微生物和转化细胞
公开(公告)号：US5382518A
公开(公告)日：1995-01-17
申请号：US920519
申请日：1992-07-28
申请人： Daniel Caput , Pascual Ferrara , Jean-Claude Guillemot , Mourad Kaghad , Richard Legoux , Gerard Loison , Elisabeth Larbre , Johannes Lupker , Pascal Leplatois , Marc Salome , Patrick Laurent
发明人： Daniel Caput , Pascual Ferrara , Jean-Claude Guillemot , Mourad Kaghad , Richard Legoux , Gerard Loison , Elisabeth Larbre , Johannes Lupker , Pascal Leplatois , Marc Salome , Patrick Laurent
IPC分类号： C07K20060101 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/16 , C12N9/06 , C12N15/53 , C12N15/63 , C12N9/00 , C12P21/00
CPC分类号： C12N9/0046
摘要： The invention concerns a new urate oxidase activity protein which has the following sequence:______________________________________ Ser Ala Val Lys Ala Ala Arg Tyr Gly Lys Asp Asn Val Arg Val Tyr Lys Val His Lys Asp Glu Lys Thr Gly Val Gln Thr Val Tyr Glu Met Thr Val Cys Val Leu Leu Glu Gly Glu Ile Glu Thr Ser Tyr Thr Lys Ala Asp Asn Ser Val Ile Val Ala Thr Asp Ser Ile Lys Asn Thr Ile Tyr Ile Thr Ala Lys Gln Asn Pro Val Thr Pro Pro Glu Leu Phe Gly Ser Ile Leu Gly Thr His Phe Ile Glu Lys Tyr Asn His Ile His Ala Ala His Val Asn Ile Val Cys His Arg Trp Thr Arg Met Asp Ile Asp Gly Lys Pro His Pro His Ser Phe Ile Arg Asp Ser Glu Glu Lys Arg Asn Val Gln Val Asp Val Val Glu Gly Lys Gly Ile Asp Ile Lys Ser Ser Leu Ser Gly Leu Thr Val Leu Lys Ser Thr Asn Ser Gln Phe Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr Leu Lys Glu Thr Trp Asp Arg Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Gln Trp Lys Asn Phe Ser Gly Leu Gln Glu Val Arg Ser His Val Pro Lys Phe Asp Ala Thr Trp Ala Thr Ala Arg Glu Val Thr Leu Lys Thr Phe Ala Glu Asp Asn Ser Ala Ser Val Gln Ala Thr Met Tyr Lys Met Ala Glu Gln Ile Leu Ala Arg Gln Gln Leu Ile Glu Thr Val Glu Tyr Ser Leu Pro Asn Lys His Tyr Phe Glu Ile Asp Leu Ser Trp His Lys Gly Leu Gln Asn Thr Gly Lys Asn Ala Glu Val Phe Ala Pro Gln Ser Asp Pro Asn Gly Leu Ile Lys Cys Thr Val Gly Arg Ser Ser Leu Lys Ser Lys Leu ______________________________________ optionally preceeded by a methionine, or in that it may present a degree of substantial homology with this sequence.The invention is also aimed at medicines containing this protein as well as the genetic engineering implements to obtain it.
摘要翻译： PCT No.PCT / FR90 / 00532 Sec。 371日期：1991年4月25日 102（e）日期1991年4月25日PCT提交1990年7月13日PCT公布。公开号WO91 / 00909 1991年1月24日。本发明涉及新的尿酸氧化酶活性蛋白，其具有以下序列： - Ser Ala Val Lys Ala Ala Arg Tyr Gly -Lys Asp Asn Val Arg Val Tyr Lys Val His -Lys Asp Glu Lys Thr Gly Val Gln Thr Val -Tyr Glu Met Thr Val Cys Val Leu Leu Glu -Gly Glu Ile Glu Thr Ser Tyr Thr Lys Ala -Asp Asn Ser Val Ile Val Ala Thr Asp SerIle Lys Asn Thr Ile Tyr Ile Thr Ala Lys -Gln Asn Pro Val Thr Pro Pro Glu Leu Phe -Gly Ser Ile Leu Gly Thr His Phe Ile Glu -Lys Tyr Asn His Ile His Ala Ala His Val-Asn Ile Val Cys His Arg Trp Thr Arg Met -Asp Ile Asp Gly Lys Pro His Pro His Ser -Phe Ile Arg Asp Ser Glu Glu Lys Arg Asn -Val Gln Val Asp Val Val Glu Gly Lys Gly -Ile Asp Ile Lys Ser Ser Leu Ser Gly Leu -Thr Val Leu Lys Ser Thr Asn Ser Gln Phe -Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr -Leu Lys Glu Thr Trp Asp Arg Ile Leu Ser -Thr Asp Val Asp Ala Thr Trp Gln Trp Lys-Asn Phe Ser Gly Leu Gln Glu Val Arg Ser -His Val Pro Lys Phe Asp Ala Thr Trp Ala -Thr Ala Arg Glu Val Thr Leu Lys Thr Phe -Ala Glu Asp Asn Ser Ala Ser Val Gln Ala -Thr Met Tyr Lys Met Ala Glu Gln Ile Leu -Ala Arg Gln Gln Leu Ile Glu Thr Val Glu -Tyr Ser Leu Pro Asn Lys His Tyr Phe Glu -Ile Asp Leu Ser Trp His Lys Gly Leu Gln-Asn Thr Gly Lys Asn Ala Glu Val Phe Ala -Pro Gln Ser Asp Pro Asn Gly Leu Ile Lys -Cys Thr Val Gly Arg Ser Ser Leu Lys Ser -Lys Leu - 任选地被甲硫氨酸，或者它可以呈现与该序列一定程度的基本同源性。本发明还涉及含有该蛋白质的药物以及获得该蛋白质的遗传工程工具。

2. 发明授权

US5541098A Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells 失效
标题翻译： Urate氧化酶活性蛋白，编码重组基因，表达载体，微生物和转化细胞
公开(公告)号：US5541098A
公开(公告)日：1996-07-30
申请号：US314586
申请日：1994-09-28
申请人： Daniel Caput , Pascual Ferrara , Jean-Claude Guillemot , Mourad Kaghad , Richard LeGoux , G erard Loison , Elisabeth Larbre , Johannes Lupker , Pascal Leplatois , Marc Salome , Patrick Laurent
发明人： Daniel Caput , Pascual Ferrara , Jean-Claude Guillemot , Mourad Kaghad , Richard LeGoux , G erard Loison , Elisabeth Larbre , Johannes Lupker , Pascal Leplatois , Marc Salome , Patrick Laurent
IPC分类号： C07K20060101 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/16 , C12N9/06 , C12N15/53 , C12N15/63
CPC分类号： C12N9/0046
摘要： The invention concerns a new urate oxidase activity protein which has the following sequence (SEQ ID NO:1): ##STR1## optionally preceded by a methionine, or in that it may present a degree of substantial homology with this sequence.The invention is also aimed at medicines containing this protein as well as the genetic engineering implements to obtain it.
摘要翻译：本发明涉及新的尿酸氧化酶活性蛋白，其具有以下序列（SEQ ID NO：1）：Ser Ala Val Lys Ala Ala Arg Tyr Gly Lys Asp Asn Val Arg Val Tyr Lys Val His Lys Asp Glu Lys Thr Gly Val Gln Thr Val Tyr Glu Met Thr Val Cys Val Leu Leu Glu Gly Glu Ile Glu Thr Ser Tyr Thr Lys Ala Asp Asn Ser Val Ile Val Ala Thr Asp Ser Ile Lys Asn Thr Ile Tyr Ile Thr Ala Lys Gln Asn Pro Val Thr Pro Pro Glu Leu Phe Gly Ser Ile Leu Gly Thr His Phe Ile Glu Lys Tyr Asn His Ile His Ala Ala His Val Asn Ile Val Cys His Arg Trp Thr Arg Met Asp Ile Asp Gly Lys Pro His Pro His Ser Phe Ile Arg Asp Ser Glu Glu Lys Arg Asn Val Gln Val Asp Val Val Glu Gly Lys Gly Ile Asp Ile Lys Ser Ser Leu Ser Gly Leu Thr Val Leu Lys Ser Thr Asn Ser Gln Phe Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr Leu Lys Glu Thr Trp Asp Arg Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Gln Trp Lys Asn Phe Ser Gly Leu Gln Glu Val Arg Ser His Val Pro Lys Phe Asp Ala Thr Trp Ala Thr Ala Arg Glu Val Thr Leu Lys Thr Phe Ala Glu Asp Asn Ser Ala Ser Val Gln Ala Thr Met Tyr Lys Met Ala Glu Gln Ile Leu Ala Arg Gln Gln Leu Ile Glu Thr Val Glu Tyr Ser Leu Pro Asn Lys His Tyr Phe Glu Ile Asp Leu Ser Trp His Lys Gly Leu Gln Asn Thr Gly Lys Asn Ala Glu Val Phe Ala Pro Gln Ser Asp Pro Asn Gly Leu Ile Lys Cys Thr Val Gly Arg Ser Ser Leu Lys Ser Lys Leu，任选地先于甲硫氨酸，或者可以与该序列呈现一定程度的基本同源性。本发明还涉及含有该蛋白质的药物以及获得该蛋白质的遗传工程工具。

3. 发明授权

US5652123A Protein having interleukin 13 activity, recombinant DNA coding for this protein, transformed cells and microorganisms 失效
标题翻译：具有白细胞介素13活性的蛋白质，编码该蛋白质的重组DNA，转化细胞和微生物
公开(公告)号：US5652123A
公开(公告)日：1997-07-29
申请号：US371121
申请日：1995-01-11
申请人： Daniel Caput , Pascual Ferrara , Jean-Claude Guillemot , Mourad Kaghad , Christine Labit-Le Bouteiller , Pascal Leplatois , Marilyn Magazin , Adrian Minty
发明人： Daniel Caput , Pascual Ferrara , Jean-Claude Guillemot , Mourad Kaghad , Christine Labit-Le Bouteiller , Pascal Leplatois , Marilyn Magazin , Adrian Minty
IPC分类号： A61K38/00 , A61P37/00 , C07H21/04 , C07K14/00 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12R1/19 , C12R1/865 , C12R1/91 , F02B75/02 , C12N15/24
CPC分类号： C07K14/5446 , C07K14/5437 , C07K16/244 , A61K38/00 , F02B2075/027
摘要： The subject of the present invention is a protein having cytokine type activity, or a precursor of this protein, which comprises the following amino acid sequence (a1): ##STR1## in which Xaa represents Asp or Gly.
摘要翻译：本发明的主题是具有细胞因子型活性的蛋白质或该蛋白质的前体，该蛋白质包含以下氨基酸序列（a1）：其中包含下列氨基酸序列（IMA）：图像其中Xaa表示Asp或Gly。

4. 发明授权

US07557187B2 Purified SR-p70 protein 失效
标题翻译：纯化的SR-p70蛋白
公开(公告)号：US07557187B2
公开(公告)日：2009-07-07
申请号：US11122636
申请日：2005-05-05
申请人： Daniel Caput , Pascual Ferrara , Ahmed Mourad Kaghad
发明人： Daniel Caput , Pascual Ferrara , Ahmed Mourad Kaghad
IPC分类号： C07K14/00 , A61K38/16
CPC分类号： C07K14/4703 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The invention relates to new nucleic acid sequences of the family of tumour-suppressing genes related to the gene for the p53 protein, and to the corresponding protein sequences.
摘要翻译：本发明涉及与p53蛋白基因相关的肿瘤抑制基因家族的新核酸序列以及相应的蛋白质序列。

5. 发明授权

US07838648B2 Purified SR-p70 protein 失效
标题翻译：纯化的SR-p70蛋白
公开(公告)号：US07838648B2
公开(公告)日：2010-11-23
申请号：US12464274
申请日：2009-05-12
申请人： Daniel Caput , Pascual Ferrara , Ahmed Mourad Kaghad
发明人： Daniel Caput , Pascual Ferrara , Ahmed Mourad Kaghad
IPC分类号： C07H21/02 , C07H21/04 , C12N5/00 , C12N1/21 , C12N15/00
CPC分类号： C07K14/4703 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The invention relates to new nucleic acid sequences of the family of tumor-suppressing genes related to the gene for the p53 protein, and to corresponding protein sequences.
摘要翻译：本发明涉及与p53蛋白的基因相关的肿瘤抑制基因家族的新核酸序列，以及相应的蛋白质序列。

6. 发明申请

US20060035855A1 Purified polypeptides having IL-13 receptor activity 有权
标题翻译：具有IL-13受体活性的纯化多肽
公开(公告)号：US20060035855A1
公开(公告)日：2006-02-16
申请号：US11182384
申请日：2005-07-15
申请人： Daniel Caput , Pascual Ferrara , Patrick Laurent , Natalio Vita
发明人： Daniel Caput , Pascual Ferrara , Patrick Laurent , Natalio Vita
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , C07K14/715
CPC分类号： C07K14/7155 , A61K38/00
摘要： This invention relates to a purified polypeptide comprising an amino acid sequence chosen from the sequence SEQ ID NO:4 or biologically active amino acid sequences derived from SEQ ID NO:4.
摘要翻译：本发明涉及包含选自SEQ ID NO：4的氨基酸序列或源自SEQ ID NO：4的生物活性氨基酸序列的纯化多肽。

7. 发明授权

US08318910B2 IL-13 receptor antibodies 有权
标题翻译： IL-13受体抗体
公开(公告)号：US08318910B2
公开(公告)日：2012-11-27
申请号：US13027425
申请日：2011-02-15
申请人： Daniel Caput , Pascual Ferrara , Patrick Laurent , Natalio Vita
发明人： Daniel Caput , Pascual Ferrara , Patrick Laurent , Natalio Vita
IPC分类号： C07K16/00 , A61K39/395 , C07K14/00
CPC分类号： C07K14/7155 , A61K38/00
摘要： This invention relates to monoclonal and polyclonal antibodies capable of specifically recognizing IL-13 receptor α and uses thereof.
摘要翻译：本发明涉及能够特异性识别IL-13受体α的单克隆抗体和多克隆抗体及其用途。

8. 发明授权

US07928073B2 Purified polypeptides having IL-13 receptor activity 有权
标题翻译：具有IL-13受体活性的纯化多肽
公开(公告)号：US07928073B2
公开(公告)日：2011-04-19
申请号：US11182384
申请日：2005-07-15
申请人： Daniel Caput , Pascual Ferrara , Patrick Laurent , Natalio Vita
发明人： Daniel Caput , Pascual Ferrara , Patrick Laurent , Natalio Vita
IPC分类号： A61K38/16
CPC分类号： C07K14/7155 , A61K38/00
摘要： This invention relates to a purified polypeptide comprising an amino acid sequence chosen from the sequence SEQ ID NO:4 or biologically active amino acid sequences derived from SEQ ID NO:4.
摘要翻译：本发明涉及包含选自SEQ ID NO：4的氨基酸序列或源自SEQ ID NO：4的生物活性氨基酸序列的纯化多肽。

9. 发明申请

US20060035856A1 Purified polypeptides having IL-13 receptor activity 审中-公开
标题翻译：具有IL-13受体活性的纯化多肽
公开(公告)号：US20060035856A1
公开(公告)日：2006-02-16
申请号：US11183599
申请日：2005-07-15
申请人： Daniel Caput , Pascual Ferrara , Patrick Laurent , Natalio Vita
发明人： Daniel Caput , Pascual Ferrara , Patrick Laurent , Natalio Vita
IPC分类号： A61K48/00 , C07H21/04 , C07K14/715
CPC分类号： C07K14/7155 , A61K38/00
摘要： This invention relates to monoclonal and polyclonal antibodies capable of specifically recognizing IL-13 receptor α and/or IL13 receptor β and uses thereof.
摘要翻译：本发明涉及能够特异性识别IL-13受体α和/或IL13受体β的单克隆抗体和多克隆抗体及其用途。

10. 发明申请

US20050282216A1 Purified polypeptides having IL-13 receptor activity 审中-公开
标题翻译：具有IL-13受体活性的纯化多肽
公开(公告)号：US20050282216A1
公开(公告)日：2005-12-22
申请号：US11185230
申请日：2005-07-18
申请人： Daniel Caput , Pascual Ferrara , Patrick Laurent , Natalio Vita
发明人： Daniel Caput , Pascual Ferrara , Patrick Laurent , Natalio Vita
IPC分类号： G01N33/53 , A61K31/00 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K14/715 , C07K16/18 , C07K16/28 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/566 , C07H21/04 , C12P21/06
CPC分类号： C07K14/7155 , A61K38/00
摘要： This invention relates to a purified polypeptide, comprising an amino acid sequence chosen from: a) the sequence SEQ ID No. 2, b) any biologically active sequence derived from SEQ ID No. 2.
摘要翻译：本发明涉及纯化的多肽，其包含选自以下的氨基酸序列：a）序列SEQ ID No.2，b）衍生自SEQ ID No.2的任何生物活性序列。

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