专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06600028B1 Tricyclic base analogues 失效
标题翻译：三环基类似物
公开(公告)号：US06600028B1
公开(公告)日：2003-07-29
申请号：US09402048
申请日：2000-02-01
申请人： Daniel Brown , David Loakes , David Williams , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall , Alan Hamilton , Clifford Smith , Adrian Christopher Simmonds , William Jonathan Cummins , Patrick Finn
发明人： Daniel Brown , David Loakes , David Williams , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall , Alan Hamilton , Clifford Smith , Adrian Christopher Simmonds , William Jonathan Cummins , Patrick Finn
IPC分类号： C07H2100
CPC分类号： C07D498/16 , C07H19/04 , C07H21/00
摘要： Nucleoside analogues have structure (2) wherein Q is H or a sugar moiety or sugar analogue or a modified sugar or a nucleic backbone or backbone analogue, W is an alkylene or alkenylene chain of 0-5 carbon atoms, any of which may carry a substituent R8, X is O or N or NR12 or CR10, X′ is O or S or N, provided that when X′ is O or S, then X is C, Y is CH or N, R6 is NH2 or SMe or SO2Me or NHNH2, each of R7 and R8 is independently H or F or alkyl or alkenyl or aryl or acyl or a reporter moiety, R12 is independently H or alkyl or alkenyl or aryl or acyl or a reporter moiety, and R10 is H or ═O or F or alkyl or aryl or a reporter moiety.
摘要翻译：核苷类似物具有结构（2），其中Q是H或糖部分或糖类似物或修饰的糖或核心或骨架类似物，W是0-5个碳原子的亚烷基或亚烯基链，其中任何一个可携带取代基R8，X为O或N或NR12或CR10，X'为O或S或N，条件是当X'为O或S时，则X为C，Y为CH或N，R6为NH2或SMe或SO2Me 或NHNH 2，R 7和R 8各自独立地为H或F，或烷基或链烯基或芳基或酰基或报道部分，R 12独立地为H或烷基或链烯基或芳基或酰基或报道部分，R 10为H或= O 或F或烷基或芳基或报道部分。

2. 发明授权

US06444682B1 Base analogues 失效
标题翻译：基础类似物
公开(公告)号：US06444682B1
公开(公告)日：2002-09-03
申请号：US09463501
申请日：2000-04-18
申请人： Adrian Christopher Simmonds , Alan Hamilton , Clifford Smith , David Loakes , Daniel Brown , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall
发明人： Adrian Christopher Simmonds , Alan Hamilton , Clifford Smith , David Loakes , Daniel Brown , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall
IPC分类号： A61K3170
CPC分类号： G01N33/5308 , C07H21/00
摘要： Nucleotide or base analogues having structure (3) or (4) wherein X═O or NH or S and each R6 is independently H or alkyl or alkenyl or alkoxy or aryl or a reporter moiety.
摘要翻译：具有结构（3）或（4）的核苷酸或碱基类似物，其中X = O或NH或S，每个R6独立地为H或烷基或链烯基，烷氧基或芳基或报道部分。

3. 发明授权

US06605611B2 Base analogues 失效
标题翻译：基础类似物
公开(公告)号：US06605611B2
公开(公告)日：2003-08-12
申请号：US10233993
申请日：2002-09-03
申请人： Adrian Christopher Simmonds , Alan Hamilton , Clifford Smith , David Loakes , Daniel Brown , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall
发明人： Adrian Christopher Simmonds , Alan Hamilton , Clifford Smith , David Loakes , Daniel Brown , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall
IPC分类号： A61K31495
CPC分类号： G01N33/5308 , C07H21/00
摘要： Nucleoside analogues or base analogues having structure (I), where X=O or NH or S, Y=N or CHR6 or CR6, W=N or NR6 or CHR6 or CR6 or S, n=1 or 2; each R6 is independently H or O or alkyl or alkenyl or alkoxy or aryl or a reporter moiety; where necessary (i.e. when Y and/or W is N or CR6 where R6 is not O) a double bond is present between Y and W or W and W, and Q is H or a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue.
摘要翻译：具有结构（I）的核苷类似物或碱基类似物，其中X = O或NH或S，Y = N或CHR 6或CR 6，W = N或NR 6或CHR 6或CR 6或S，n = 1或2; 每个R 6独立地为H或O或烷基或链烯基或烷氧基或芳基或报道部分; 必要时（即当Y和/或W为N或R6，R6不为O时），Y与W或W和W之间存在双键，Q为H或糖或糖类似物或核酸骨架或骨架类似物。

4. 发明授权

US06239159B1 Nucleoside analogues 失效
标题翻译：核苷类似物
公开(公告)号：US06239159B1
公开(公告)日：2001-05-29
申请号：US09101978
申请日：1999-05-03
申请人： Daniel Brown , David Loakes , Alan Hamilton , Adrian Simmonds , Clifford Smith
发明人： Daniel Brown , David Loakes , Alan Hamilton , Adrian Simmonds , Clifford Smith
IPC分类号： A01N4352
CPC分类号： C07H21/00 , C07H19/044 , C07H19/052 , C07H19/056
摘要： Nucleoside analogues in which a group M replaces the natural base where M is (1) or (2) or (3), where each of X1, X2 and X3 are C or N, each of R6 and R7 is the same or different and each is H, NO2, CO, COR8, OR8, CN, O, CON(R8)2, COOR8, SO2R8, SO3R8, SR8, NHCHO, (CH2)n(R8)2, halogen, or a reporter moiety, each of R8 and R9 is H or hydrocarbyl or a reporter moiety, and n is 0-4. The analogues are substrates for polymerase and terminal transferase enzymes.
摘要翻译：其中M代替M为（1）或（2）或（3）的天然碱的核苷类似物，其中X1，X2和X3各自为C或N，R6和R7各自相同或不同，各自为H，NO 2，CO，COR 8，OR 8，CN，O，CON（R 8）2，COOR 8，SO 2 R 8，SO 3 R 8，SR 8，NHCHO，（CH 2）n（R 8）2，卤素或报道分子 R8和R9是H或烃基或报道部分，n是0-4。类似物是聚合酶和末端转移酶的底物。

5. 发明授权

US06313286B1 Nucleoside analogues 失效
标题翻译：核苷类似物
公开(公告)号：US06313286B1
公开(公告)日：2001-11-06
申请号：US09117494
申请日：1999-02-05
申请人： Daniel Brown , Alan Hamilton , David Loakes , Adrian Simmonds , Clifford Smith
发明人： Daniel Brown , Alan Hamilton , David Loakes , Adrian Simmonds , Clifford Smith
IPC分类号： C07H1900
CPC分类号： C07H19/06 , C07H21/00 , C12Q1/686 , C12Q1/6869 , G01N33/5308
摘要： Nucleoside analogues containing the degenerate base analogue P and derivatives thereof are provided with reporter moieties preferably comprising signal moieties. The nucleoside analogues are useful for labeling DNA or RNA or for incorporating in oligonucleotides.
摘要翻译：含有简并碱基类似物P及其衍生物的核苷类似物提供有优选包含信号部分的报道部分。核苷类似物可用于标记DNA或RNA或用于掺入寡核苷酸。

6. 发明授权

US06436640B1 Use of LNA in mass spectrometry 有权
标题翻译：在质谱中使用LNA
公开(公告)号：US06436640B1
公开(公告)日：2002-08-20
申请号：US09528705
申请日：2000-03-18
申请人： Adrian Simmons , Clifford Smith
发明人： Adrian Simmons , Clifford Smith
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , C12Q2565/627 , C12Q2525/113
摘要： DNA and RNA diagnostics based on mass spectrometry, e.g. Matrix-Assisted Laser Desorption/Ionisation Time-of-Flight (MALDI-TOF) mass spectrometry, Electrospray (ES) mass spectrometry, Ion Cyclotron Resonance (ICR) mass spectrometry, Fourier Transform mass spectrometry, or combinations thereof, where fully or partially LNA modified DNA probes are used in order to enhance stability and resolution. The invention in particular relates to a process for detecting a target nucleic acid sequence of a nucleic acid molecule or for detecting a mutation in a nucleic acid sequence of a nucleic acid molecule, wherein (a) the nucleic acid molecule or (b) a part of the nucleic acid molecule or (c) an oligonucleotide complementary to the sequence or at least a sub-sequence of the nucleic acid molecule is analysed by mass spectrometry in order to obtain direct or indirect information about the target nucleic acid sequence or mutation, and wherein the process involves the hybridisation of an LNA modified oligonucleotide to the nucleic acid molecule.
摘要翻译：基于质谱的DNA和RNA诊断，例如基质辅助激光解吸/电离飞行时间（MALDI-TOF）质谱，电喷雾（ES）质谱，离子回旋共振（ICR）质谱，傅立叶变换质谱或其组合，其中全部或部分LNA 使用修饰的DNA探针以增强稳定性和分辨率。本发明特别涉及用于检测核酸分子的靶核酸序列或检测核酸分子的核酸序列中的突变的方法，其中（a）核酸分子或（b）部分的核酸分子或（c）通过质谱分析与核酸分子的序列或至少子序列互补的寡核苷酸，以获得关于靶核酸序列或突变的直接或间接信息，以及其中所述方法涉及LNA修饰寡核苷酸与核酸分子的杂交。

7. 发明申请

US20150223550A1 BIG FOOT IMPRESSION DEVICE 审中-公开
标题翻译：大口径印象设备
公开(公告)号：US20150223550A1
公开(公告)日：2015-08-13
申请号：US14174965
申请日：2014-02-07
申请人： Clifford Smith
发明人： Clifford Smith
IPC分类号： A43B3/00
CPC分类号： A43B3/0078 , A43B3/122 , A43B3/128 , A43B13/143 , A43C11/14
摘要： A foot impression device comprising: an inner sole; a outer sole with a foot impression; a strap, where the strap secures a user's foot within the foot impression device during use; and a heel strap, where the heel strap provides heel support for the user's foot. The strap extends through the foot impression and includes two attachment ends exposed on the outer sole. The foot impression replicates an animal species and in one particular embodiment, the animal species includes a Sasquatch aka Big Foot.
摘要翻译：一种足部印模装置，包括：内底; 一个足底印象的外底; 带子，其中带在使用期间将使用者的脚固定在足部印模装置内; 和脚跟带，其中脚跟带为使用者的脚提供脚跟支撑。带子延伸穿过脚印，并且包括暴露在外底上的两个附接端。足部印象复制了动物物种，在一个具体实施方案中，动物物种包括Sasquatch又名Big Foot。

8. 发明授权

US08568693B2 Therapy selection method 失效
标题翻译：治疗选择方法
公开(公告)号：US08568693B2
公开(公告)日：2013-10-29
申请号：US12919019
申请日：2009-02-26
申请人： Antonios Danikas , Clifford Smith , Ian A Wilson
发明人： Antonios Danikas , Clifford Smith , Ian A Wilson
IPC分类号： A61K49/00
CPC分类号： A61K49/0032 , A61K49/0056 , A61K51/0446 , A61K51/0453 , A61K51/0455
摘要： The present invention relates to a method to assist in the determination of therapy for a patient suffering from Barrett's oesophagus, especially where first-line therapy has been unsuccessful and when dysplasia has been diagnosed. The method comprises the use of an imaging agent comprising a vector which targets (a) Her2, (b) cMet, (c) guanylyl cyclase or (d) IGF1R. The imaging agent is suitable for radioisotope or optical imaging in vitro or preferably in vivo.
摘要翻译：本发明涉及一种帮助确定患有巴雷特食管的患者的治疗方法，特别是在一线治疗不成功以及何时诊断发育不良的情况下。该方法包括使用包含靶向（a）Her2，（b）cMet，（c）鸟苷酸环化酶或（d）IGF1R）的载体的成像剂。成像剂适用于体外或优选体内的放射性同位素或光学成像。

9. 发明申请

US20110002849A1 THERAPY SELECTION METHOD 失效
标题翻译：治疗选择方法
公开(公告)号：US20110002849A1
公开(公告)日：2011-01-06
申请号：US12919019
申请日：2009-02-26
申请人： Antonios Danikas , Clifford Smith , Ian A. Wilson
发明人： Antonios Danikas , Clifford Smith , Ian A. Wilson
IPC分类号： A61K51/00 , A61K49/00
CPC分类号： A61K49/0032 , A61K49/0056 , A61K51/0446 , A61K51/0453 , A61K51/0455
摘要： The present invention relates to a method to assist in the determination of therapy for a patient suffering from Barrett's oesophagus, especially where first-line therapy has been unsuccessful and when dysplasia has been diagnosed. The method comprises the use of an imaging agent comprising a vector which targets (a) Her2, (b) cMet, (c) guanylyl cyclase or (d) IGF1R. The imaging agent is suitable for radioisotope or optical imaging in vitro or preferably in vivo.
摘要翻译：本发明涉及一种帮助确定患有巴雷特食管的患者的治疗方法，特别是在一线治疗不成功以及何时诊断发育不良的情况下。该方法包括使用包含靶向（a）Her2，（b）cMet，（c）鸟苷酸环化酶或（d）IGF1R）的载体的显像剂。成像剂适用于体外或优选体内的放射性同位素或光学成像。

10. 发明申请

US20050025893A1 Composite tool coating system 审中-公开
标题翻译：复合工具涂装系统
公开(公告)号：US20050025893A1
公开(公告)日：2005-02-03
申请号：US10798768
申请日：2004-03-11
申请人： Clifford Smith
发明人： Clifford Smith
IPC分类号： C23C4/02 , C23C4/18 , B05D1/36
CPC分类号： C23C4/02 , C23C4/18
摘要： My invention is a sequentially applied composite coating process that combines plate coating and spray coating techniques into an integrated system. A component, or part, is plated with a suitable material to build up surfaces of the part to a desired prepared specification. The part is then coated with a second molten material sprayed on, integrally bonding the spray-coating material into the plated-coating material layer of the part, to achieve the final spray coated composite material. Final grinding and/or polishing finish preparation may follow. Various materials and/or blends of materials known to the field of each individual art may be used in the plating stage and the spraying stage. In this fashion a relatively thick coating of highly durable material may be applied with superior bonding properties than achievable through currently practiced methods.
摘要翻译：我的发明是一个顺序应用的复合涂层工艺，将板涂和喷涂技术结合到一体的系统中。部件或部件镀有合适的材料，以将部件的表面构建成所需的制备规格。然后将该部分涂覆有喷涂在喷涂材料一体地粘合到该部件的镀覆材料层中的第二熔融材料，以实现最终的喷涂复合材料。可以进行最终研磨和/或抛光处理。各种技术领域已知的各种材料和/或材料的混合物可用于电镀阶段和喷涂阶段。以这种方式，相对厚的高度耐用材料的涂层可以应用具有优于通过目前实践的方法实现的粘合性能。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式