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1. 发明申请

US20060287229A1 Novel CD40 variants 审中-公开
标题翻译：新型CD40变体
公开(公告)号：US20060287229A1
公开(公告)日：2006-12-21
申请号：US11172493
申请日：2005-06-30
申请人： Dani Eshel , Galit Rotman , Kinneret Savitsky , Amir Toporik , Rami Khosravi , Aviva Chen , Yona Bismuth
发明人： Dani Eshel , Galit Rotman , Kinneret Savitsky , Amir Toporik , Rami Khosravi , Aviva Chen , Yona Bismuth
IPC分类号： A61K38/17
CPC分类号： A61K38/177
摘要： The invention concerns CD40 skipping 5 nucleic acid sequences and amino acid sequences obtained by alternative splicing of CD40, pharmaceutical compositions comprising said sequences and methods for treatment of a disease, wherein a beneficial therapeutic effect is achieved by the up regulation of the CD40-R-CD40-L interaction. An antibody capable of selectively binding to the amino acid of CD40 skipping 5 and pharmaceutical composition comprising the above antibody and methods for detecting the presence of exon 5 skipping expression in a sample are also within the scope of the invention.
摘要翻译：本发明涉及跳过5个核酸序列和通过CD40的选择性剪接获得的氨基酸序列，包含所述序列的药物组合物和治疗疾病的方法的CD40，其中有益的治疗效果通过上调CD40-R- CD40-L相互作用。能够选择性地结合CD40跳跃5的氨基酸的抗体和包含上述抗体的药物组合物和用于检测样品中外显子5跳跃表达的存在的方法也在本发明的范围内。

2. 发明申请

US20050281815A1 CD40 splice variants and their uses 审中-公开
标题翻译： CD40拼接变体及其用途
公开(公告)号：US20050281815A1
公开(公告)日：2005-12-22
申请号：US11069856
申请日：2005-02-28
申请人： Dani Eshel , Galit Rotman , Kinneret Savitsky , Amir Toporik
发明人： Dani Eshel , Galit Rotman , Kinneret Savitsky , Amir Toporik
IPC分类号： A61K39/395 , C07H21/04 , C07K14/705 , C07K16/28 , C12N5/06 , C12P21/06
CPC分类号： C07K16/2878 , C07K14/70578 , C07K2317/34
摘要： Disclosed are CD40 splice variant polypeptides and methods of using the CD40 splice variant polypeptides, including in treatment for transplantation.
摘要翻译：公开了CD40剪接变体多肽和使用CD40剪接变体多肽的方法，包括用于移植治疗。

3. 发明授权

US07939634B2 Polynucleotides encoding polypeptides and methods using same 有权
标题翻译：编码多肽的多核苷酸和使用其的方法
公开(公告)号：US07939634B2
公开(公告)日：2011-05-10
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
IPC分类号： C12P21/08 , C07K16/28 , G01N33/53
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译：提供了新的多肽和编码它们的多核苷酸。还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，使用本发明的新型多肽和多核苷酸作为诊断标记。

4. 发明申请

US20100075891A1 Novel polynucleotides encoding polypeptides and methods using same 有权
标题翻译：编码多肽的新型多核苷酸和使用其的方法
公开(公告)号：US20100075891A1
公开(公告)日：2010-03-25
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
IPC分类号： A61K31/70 , A61K38/00 , A61P43/00 , C07H21/00 , C07H21/04 , C07K16/00 , C12N5/00
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译：提供了新的多肽和编码它们的多核苷酸。还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，其使用本发明的新型多肽和多核苷酸作为诊断标记。

5. 发明申请

US20110212051A1 VARIANTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR AND USE THEREOF 审中-公开
标题翻译：血管内皮生长因子（VEGF）受体及其用途的变异
公开(公告)号：US20110212051A1
公开(公告)日：2011-09-01
申请号：US13037196
申请日：2011-02-28
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
IPC分类号： A61K38/19 , G01N33/53 , C07K16/28 , C07K14/535 , C07K7/06 , C07K14/715 , C07K14/47 , C07K14/735 , C07K14/475 , A61K38/17 , C07K16/24 , C07K16/22 , C12N9/66 , C07K16/40 , G01N33/573 , A61K38/48 , A61K38/18 , A61K38/08 , A61P31/00 , A61P19/08 , A61P9/00 , A61P27/02 , A61P13/12 , A61P35/00 , A61P3/04 , A61P3/10 , A61P19/10 , A61P9/10 , A61P9/04 , A61P11/00 , A61P7/02 , A61P7/04 , A61P29/00 , A61P37/06 , A61P1/18 , A61P27/14 , A61P31/10 , A61P31/20 , A61P31/22 , A61P31/18 , A61P31/14 , A61P35/04 , A61P1/16 , A61P3/00 , A61P37/02 , A61P13/00 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译：提供了新的多肽和编码它们的多核苷酸。还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，其使用本发明的新型多肽和多核苷酸作为诊断标记。

6. 发明申请

US20050272050A1 CD40 splice variants, compositions for making and methods of using the same 审中-公开
标题翻译： CD40拼接变体，用于制备的组合物及其使用方法
公开(公告)号：US20050272050A1
公开(公告)日：2005-12-08
申请号：US10924074
申请日：2004-08-23
申请人： Liat Mintz , Jeanne Bernstein , Dani Eshel , Amir Toporik , Aviva Chen
发明人： Liat Mintz , Jeanne Bernstein , Dani Eshel , Amir Toporik , Aviva Chen
IPC分类号： A61K48/00 , C07H21/04 , C07K14/705 , C07K14/74 , C07K16/28 , C12N15/12 , C12Q1/68
CPC分类号： C07K16/2878 , A61K48/00 , C07K14/70578 , C12N2799/026
摘要： Provided are substantially pure CD40 splice variants that include altered internal sequences and unique tail sequences relative to previously described CD40 protein sequences. Also provided are fragments of the CD40 splice variants comprising at least 10 amino acids including at least 4 amino acids of the unique tail sequence; the unique tail sequences, and homologues thereof having at least 10 amino acids and 90% identity and antibodies which bind to an epitope on such proteins are disclosed. Pharmaceutical compositions comprising the protein, antibodies, isolated nucleic acid molecule that encode such proteins and pharmaceutical composition comprising such nucleic acid molecules are also disclosed. The present invention additionally relates to recombinant expression vectors that include the nucleic acid molecules and host cells which comprise such recombinant expression vectors are disclosed. In vitro methods of detecting in a sample the presence and/or quantity of such proteins or transcript which encodes such proteins are disclosed as are kits and reagents for performing the methods. Methods of modulating CD40-CD154 interactions in an individual are disclosed.
摘要翻译：提供基本上纯的CD40剪接变体，其包括相对于先前描述的CD40蛋白序列的改变的内部序列和唯一的尾部序列。还提供了CD40剪接变体的片段，其包含至少10个氨基酸，包括唯一尾部序列的至少4个氨基酸; 公开了具有至少10个氨基酸和90％同一性的独特的尾部序列及其同源物，并且与这些蛋白质上的表位结合的抗体。还公开了包含蛋白质，抗体，编码这种蛋白质的分离的核酸分子和包含此类核酸分子的药物组合物的药物组合物。本发明还涉及包含核酸分子和包含这种重组表达载体的宿主细胞的重组表达载体。在样本中检测体外的方法，公开了编码这种蛋白质的这些蛋白质或转录物的存在和/或数量，作为用于进行该方法的试剂盒和试剂。公开了调节个体中CD40-CD154相互作用的方法。

7. 发明授权

US09428574B2 Polypeptides and uses thereof for treatment of autoimmune disorders and infection 有权
标题翻译：多肽及其用于治疗自身免疫性疾病和感染的用途
公开(公告)号：US09428574B2
公开(公告)日：2016-08-30
申请号：US14129974
申请日：2012-07-01
申请人： Amir Toporik , Avi Yeshah Rosenberg , Galit Rotman , Iris Hecht , Zurit Levine
发明人： Amir Toporik , Avi Yeshah Rosenberg , Galit Rotman , Iris Hecht , Zurit Levine
IPC分类号： C07K16/18 , C07K14/705 , A61K39/395 , A61K45/06 , A61K38/00
CPC分类号： C07K14/70503 , A61K38/00 , A61K39/395 , A61K45/06 , C07K16/18 , C07K2319/30 , C07K2319/74 , C12N5/0636 , Y02A50/401
摘要： This invention relates to C1ORF32 protein and its variants and fragments and fusion proteins thereof, pharmaceutical composition comprising same and methods of use thereof for treatment of immune related disorders and infections.
摘要翻译：本发明涉及C1ORF32蛋白及其变体及其片段和融合蛋白，包含其的药物组合物及其用于治疗免疫相关疾病和感染的方法。

8. 发明授权

US08828940B2 Method of treating an ischemia-reperfusion injury-related disorder by administering GPCR ligands 有权
标题翻译：通过施用GPCR配体治疗缺血再灌注损伤相关疾病的方法
公开(公告)号：US08828940B2
公开(公告)日：2014-09-09
申请号：US12968050
申请日：2010-12-14
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
IPC分类号： A61K38/00 , A61P39/06 , A61K38/10 , A61K38/16 , A61K38/08 , C07K14/47 , C07K5/103
CPC分类号： C07K14/47 , A61K38/08 , A61K38/10 , A61K38/1709 , C07K5/101 , C07K7/06 , C07K7/08
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译：公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体活化相关的疾病。

9. 发明申请

US20140170141A1 POLYPEPTIDES AND USES THEREOF FOR TREATMENT OF AUTOIMMUNE DISORDERS AND INFECTION 有权
标题翻译：用于治疗自身免疫性疾病和感染的多肽及其用途
公开(公告)号：US20140170141A1
公开(公告)日：2014-06-19
申请号：US14129974
申请日：2012-07-01
申请人： Amir Toporik , Avi Yeshah Rosenberg , Galit Rotman , Iris Hecht , Zurit Levine
发明人： Amir Toporik , Avi Yeshah Rosenberg , Galit Rotman , Iris Hecht , Zurit Levine
IPC分类号： C07K16/18 , A61K45/06 , A61K39/395
CPC分类号： C07K14/70503 , A61K38/00 , A61K39/395 , A61K45/06 , C07K16/18 , C07K2319/30 , C07K2319/74 , C12N5/0636 , Y02A50/401
摘要： This invention relates to C1ORF32 protein and its variants and fragments and fusion proteins thereof, pharmaceutical composition comprising same and methods of use thereof for treatment of immune related disorders and infections.
摘要翻译：本发明涉及C1ORF32蛋白及其变体及其片段和融合蛋白，包含其的药物组合物及其用于治疗免疫相关疾病和感染的方法。

10. 发明授权

US08415455B2 Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics 有权
公开(公告)号：US08415455B2
公开(公告)日：2013-04-09
申请号：US12676359
申请日：2008-09-03
申请人： Zurit Levine , Tania Pergam , Dalit Landesman-Milo , Anat Cohen-Dayag , Amir Toporik , Yaron Kinar , Sergey Nemzer , Avi Rosenberg , Galit Rotman , Amit Novik , Cynthia Koifman , Merav Beiman , Liat Dassa , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Ofer Levy , Marina Bubis
发明人： Zurit Levine , Tania Pergam , Dalit Landesman-Milo , Anat Cohen-Dayag , Amir Toporik , Yaron Kinar , Sergey Nemzer , Avi Rosenberg , Galit Rotman , Amit Novik , Cynthia Koifman , Merav Beiman , Liat Dassa , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Ofer Levy , Marina Bubis
IPC分类号： C07K14/00 , A61K38/36
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.

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