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1. 发明授权

US07993675B2 Solvating system and sealant for medical use in the sinuses and nasal passages 有权
标题翻译：用于鼻窦和鼻通道的医疗用溶剂系统和密封剂
公开(公告)号：US07993675B2
公开(公告)日：2011-08-09
申请号：US11739480
申请日：2007-04-24
申请人： Dana A. Oliver , Cecil O. Lewis , Edze Jan Tijsma , Maria Nieves Gonzalez Lopez , Matthew F. Myntti , James Britton Hissong
发明人： Dana A. Oliver , Cecil O. Lewis , Edze Jan Tijsma , Maria Nieves Gonzalez Lopez , Matthew F. Myntti , James Britton Hissong
IPC分类号： A61K9/00
CPC分类号： A61K9/0043 , A61K9/7007
摘要： Chronic rhinosinusitis and other bacterial sinus conditions may be treated by applying a solvating system containing a surfactant to a bacterial biofilm in a nasal or sinus cavity, disrupting the biofilm, and applying a protective layer of a polymeric film-forming medical sealant.
摘要翻译：可以通过将包含表面活性剂的溶剂化体系应用于鼻腔或窦腔中的细菌生物膜，破坏生物膜和施加聚合物成膜医用密封剂的保护层来治疗慢性鼻鼻窦炎和其它细菌窦状况。

2. 发明申请

US20070264342A1 SOLVATING SYSTEM AND SEALANT FOR MEDICAL USE IN THE SINUSES AND NASAL PASSAGES 有权
标题翻译：用于医疗用途和鼻腔通道的溶解系统和密封剂
公开(公告)号：US20070264342A1
公开(公告)日：2007-11-15
申请号：US11739480
申请日：2007-04-24
申请人： Dana A. Oliver , Cecil O. Lewis , Edze Jan Tijsma , Maria Nieves Gonzalez Lopez , Matthew F. Myntti , James Britton Hissong
发明人： Dana A. Oliver , Cecil O. Lewis , Edze Jan Tijsma , Maria Nieves Gonzalez Lopez , Matthew F. Myntti , James Britton Hissong
IPC分类号： A61K9/00
CPC分类号： A61K9/0043 , A61K9/7007
摘要： Chronic rhinosinusitis and other bacterial sinus conditions may be treated by applying a solvating system containing a surfactant to a bacterial biofilm in a nasal or sinus cavity, disrupting the biofilm, and applying a protective layer of a polymeric film-forming medical sealant.
摘要翻译：可以通过将包含表面活性剂的溶剂化体系应用于鼻腔或窦腔中的细菌生物膜，破坏生物膜和施加聚合物成膜医用密封剂的保护层来治疗慢性鼻鼻窦炎和其它细菌窦状况。

3. 发明授权

US06787234B2 Triggered start products and processes for the production and use thereof 有权
标题翻译：触发生产和使用的起始产品和工艺
公开(公告)号：US06787234B2
公开(公告)日：2004-09-07
申请号：US10146314
申请日：2002-05-15
申请人： Edze Jan Tijsma , Johannes Gijsbertus Antonius Terlingen , Saskia Haas-Schrijen , Hein Herman Vriesema
发明人： Edze Jan Tijsma , Johannes Gijsbertus Antonius Terlingen , Saskia Haas-Schrijen , Hein Herman Vriesema
IPC分类号： B32B516
CPC分类号： C05G3/06 , C05F11/08 , C05G3/0029 , Y10T428/2991 , Y10T428/2998 , Y10T428/31801 , C05G3/0035
摘要： A coated triggered start product is formed from a particulate core material comprising at least one water soluble active constituent and at least one coating layer applied on the particulate core material. The coating layer causes the product to exhibit “lock-off” type release characteristics whereby release of the active constituent of the core material from the coated product is essentially completely suppressed until release is initiated by application of a trigger material to the coating layer. Processes for preparing and using such triggered start products are also provided.
摘要翻译：涂覆的触发起始产物由包含至少一种水溶性活性成分和施加在颗粒芯材上的至少一个涂层的颗粒芯材料形成。涂层使得产品具有“锁定”型释放特性，从而基本上完全抑制了芯材料的活性成分从被覆产品的释放，直到通过向涂层施加触发材料开始释放。还提供了准备和使用这种触发启动产品的过程。

4. 发明授权

US09433636B2 Protective gel based on chitosan and oxidized polysaccharide 有权
标题翻译：基于壳聚糖和氧化多糖的保护凝胶
公开(公告)号：US09433636B2
公开(公告)日：2016-09-06
申请号：US12429141
申请日：2009-04-23
申请人： Edze Jan Tijsma , Maria Nieves Gonzalez , Erica M. TenBroek , Nancy Schaffhausen
发明人： Edze Jan Tijsma , Maria Nieves Gonzalez , Erica M. TenBroek , Nancy Schaffhausen
IPC分类号： A01N43/04 , A61B17/08 , A61K31/722 , A61K9/00 , A61K9/06 , A61K31/717 , A61K31/718 , A61K47/36 , A61L26/00 , A61L31/04 , A61L31/14 , A61L31/16
CPC分类号： A61K31/722 , A61K9/0043 , A61K9/06 , A61K31/717 , A61K31/718 , A61K47/36 , A61L26/0052 , A61L26/0066 , A61L26/008 , A61L26/009 , A61L31/041 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2300/00 , A61K2300/00 , C08L5/08
摘要： Bodily tissue and structures may be protected using a fluid layer containing a mixture of chitosan and oxidized polysaccharide. The mixture forms a protective gel layer via in situ crosslinking. Compared to crosslinking using a low molecular weight aldehyde such as glutaraldehyde or genipin, oxidized polysaccharides appear to provide faster gelation while avoiding the use of potentially less bioacceptable low molecular weight aldehydes.
摘要翻译：可以使用含有壳聚糖和氧化多糖的混合物的流体层来保护身体组织和结构。混合物通过原位交联形成保护性凝胶层。与使用低分子量醛如戊二醛或者京尼平的交联相比，氧化多糖似乎提供更快的凝胶化，同时避免使用潜在的较少生物可接受的低分子量醛。

5. 发明授权

US06987082B2 Controlled release products and processes for the preparation thereof 有权
标题翻译：控制释放产品及其制备方法
公开(公告)号：US06987082B2
公开(公告)日：2006-01-17
申请号：US10684162
申请日：2003-10-10
申请人： Edze Jan Tijsma , Johannes Gijsbertus Antonius Terlingen , Saskia Haas-Schrijen , Hein Herman Vriesema
发明人： Edze Jan Tijsma , Johannes Gijsbertus Antonius Terlingen , Saskia Haas-Schrijen , Hein Herman Vriesema
IPC分类号： C05G3/02
CPC分类号： C05G3/0029 , A01N25/26 , Y10T436/101666
摘要： A controlled release product is provided having a suppressed initial release period and a predetermined longevity. The product includes a particulate water soluble core material and a semi-permeable coating layer applied on the core material for controlling the release rate of the core material. The semi-permeable coating layer is formulated in accordance with the following equation to provide a release rate wherein initial release of core material from the product is suppressed so that less than about 15 weight percent of core material is released from the product within a 24 hour period after application of the product and wherein longevity of release, at ambient temperature, between the time of application and the time at which at least about 75 weight percent of the core material is released from the product is 60 days or less: WVTR = ϕ · δ π ⁢ ⁢ d 2 wherein: (i) WVTR is the water vapor transmission rate of the semi-permeable coating expressed in grams·μm/meters2·day; (ii) φ is the water diffusion rate (water flux) through the semi-permeable coating expressed in grams/day; (iii) δ is the thickness of the coating layer expressed in μm; and (iv) d is the average diameter of the particulate core material expressed in meters.
摘要翻译：提供具有抑制的初始释放期和预定寿命的控释产品。该产品包括颗粒状水溶性芯材和应用于芯材上的半渗透涂层，用于控制芯材的释放速率。根据以下等式配制半透性涂层以提供释放速率，其中芯材料从产品中的初始释放被抑制，使得在24小时内从产品中小于约15重量％的芯材料被释放在使用产品之后的时间段，并且在环境温度下，在施用时间和从产品中释放核心材料的至少约75重量％的时间之间的释放寿命为60天或更短： $WVTR=pi$

6. 发明授权

US07176261B2 Angiotensin-(1-7) eluting polymer-coated medical device to reduce restenosis and improve endothelial cell function 失效
标题翻译：血管紧张素（1-7）洗脱聚合物涂覆的医疗器械，以减少再狭窄并改善内皮细胞功能
公开(公告)号：US07176261B2
公开(公告)日：2007-02-13
申请号：US11256582
申请日：2005-10-21
申请人： Edze Jan Tijsma , Anita Driessen-Levels , Marc Hendriks
发明人： Edze Jan Tijsma , Anita Driessen-Levels , Marc Hendriks
IPC分类号： C08F20/10 , A61K38/08 , A61F2/04
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/25 , A61L2300/416 , A61L2300/608 , A61L2420/08 , C08L71/02
摘要： Medical devices with polymer coatings designed to control the release of angiotensin-(1-7) receptor agonists from medical devices are disclosed. The present application also discloses providing vascular stents with angiotensin-(1-7) receptor agonist-containing controlled-release coatings. Methods for treating or inhibiting post-stent implantation restenosis as well as improving vascular endothelial function in patients are also provided.
摘要翻译：公开了设计用于控制来自医疗装置的血管紧张素（1-7）受体激动剂释放的聚合物涂层的医疗装置。本申请还公开了向血管支架提供含血管紧张素（1-7）受体激动剂的控制释放包衣。还提供了治疗或抑制支架内植入再狭窄以及改善患者血管内皮功能的方法。

7. 发明授权

US06656882B2 Controlled release products and processes for the preparation thereof 有权
标题翻译：控制释放产品及其制备方法
公开(公告)号：US06656882B2
公开(公告)日：2003-12-02
申请号：US09795840
申请日：2001-02-28
申请人： Edze Jan Tijsma , Johannes Gijsbertus Antonius Terlingen , Saskia Haas-Schrijen , Hein Herman Vriesema
发明人： Edze Jan Tijsma , Johannes Gijsbertus Antonius Terlingen , Saskia Haas-Schrijen , Hein Herman Vriesema
IPC分类号： C05G302
CPC分类号： C05G3/0029 , A01N25/26 , Y10T436/101666
摘要： A controlled release product is provided having a suppressed initial release period and a predetermined longevity. The product includes a particulate water soluble core material and a semi-permeable coating layer applied on the core material for controlling the release rate of the core material. The semi-permeable coating layer is formulated in accordance with the following equation to provide a release rate wherein initial release of core material from the product is suppressed so that less than about 15 weight percent of core material is released from the product within a 24 hour period after application of the product and wherein longevity of release, at ambient temperature, between the time of application and the time at which at least about 75 weight percent of the core material is released from the product is 60 days or less: WVTR = φ · δ π ⁢ ⁢ d 2 wherein: (i) WVTR is the water vapor transmission rate of the semi-permeable coating expressed in grams·&mgr;m/meters2·day; (ii) &phgr; is the water diffusion rate (water flux) through the semi-permeable coating expressed in grams/day; (iii) &dgr; is the thickness of the coating layer expressed in &mgr;m; and (iv) d is the average diameter of the particulate core material expressed in meters.
摘要翻译：提供具有抑制的初始释放期和预定寿命的控释产品。该产品包括颗粒状水溶性芯材和应用于芯材上的半渗透涂层，用于控制芯材的释放速率。根据以下等式配制半透性涂层以提供释放速率，其中芯材料从产品中的初始释放被抑制，使得在24小时内从产品中小于约15重量％的芯材料被释放施用产品之后的时间段，其中在环境温度下，在施用时间和从产物中释放核心材料的至少约75重量％的时间之间的释放寿命为60天以下：其中:( i）WVTR是半渗透膜的水蒸汽透过率，以克/米2日为单位表示;（ii）phi是通过半渗透性涂层的水扩散速率（水通量），以克表示 /天;（iii）三角洲是以妈妈表示的涂层的厚度; 和（iv）d是表示为米的颗粒状芯材的平均直径。

8. 发明授权

US6139597A Controlled release fertilizer compositions and processes for the preparation thereof 有权
标题翻译：控制释放肥料组合物及其制备方法
公开(公告)号：US6139597A
公开(公告)日：2000-10-31
申请号：US172055
申请日：1998-10-14
申请人： Edze Jan Tijsma , Johannes Gijsbertus Antonius Terlingen , Hendrikus Gijsbertus Adrianus van Kaathoven
发明人： Edze Jan Tijsma , Johannes Gijsbertus Antonius Terlingen , Hendrikus Gijsbertus Adrianus van Kaathoven
IPC分类号： B01J2/00 , C05G3/00 , C05G5/00 , A01N25/00 , C05B7/00
CPC分类号： C05G3/0029
摘要： A controlled release fertilizer is provided which exhibits a Gaussian nutrient release rate pattern. The fertilizer composition includes a granular nutrient core material having a single layer coating of a substantially water-insoluble, uniform, substantially continuous polymer film thereon. Processes are also provided for producing the fertilizer compositions. Methods are also provided for treating plants with the fertilizer compositions.
摘要翻译：提供了一种显示高斯营养释放速率模式的控释肥料。肥料组合物包括具有基本上不溶于水的，均匀的基本上连续的聚合物膜的单层涂层的颗粒状营养芯材料。还提供了用于生产肥料组合物的方法。还提供了用肥料组合物处理植物的方法。

9. 发明授权

US5993505A Controlled release fertilizer compositions and processes for the preparation thereof 失效
标题翻译：控制释放肥料组合物及其制备方法
公开(公告)号：US5993505A
公开(公告)日：1999-11-30
申请号：US83734
申请日：1998-05-22
申请人： Edze Jan Tijsma , Johannes Gijsbertus Antonius Terlingen , Seija Helena Aalto , Hendrikus Gijsbertus Adrianus van Kaathoven
发明人： Edze Jan Tijsma , Johannes Gijsbertus Antonius Terlingen , Seija Helena Aalto , Hendrikus Gijsbertus Adrianus van Kaathoven
IPC分类号： C05G3/00 , A01N25/00 , C05B7/00
CPC分类号： C05G3/0029
摘要： A controlled release fertiliser composition is provided having a fertiliser compound in a granular core with a coating applied on the core material. The fertiliser composition is structured to enable a cumulative release of fertiliser compound of less than 10% of the total weight of the fertiliser compound in the granular core within 30 days after exposure of the fertiliser composition to moisture and the coating consists of a single layer of a uniform, substantially continuous polymer film which is present on at least 90% of the granular core material A process is also provided for producing the fertiliser composition.
摘要翻译：提供了一种控释肥料组合物，其在颗粒核中具有施肥化合物，其中涂覆有芯材料。肥料组合物的结构是使肥料化合物在肥料组合物暴露于水分后30天内累积释放少于肥料化合物总重量的10％，涂层由单层存在于至少90％的颗粒状芯材料A方法上的均匀的基本上连续的聚合物膜也用于生产肥料组合物。

10. 发明申请

US20100055147A1 ANGIOTENSIN (1-7) ELUTING STENT 审中-公开
标题翻译： ANGIOTENSIN（1-7）ELUTING STENT
公开(公告)号：US20100055147A1
公开(公告)日：2010-03-04
申请号：US12447415
申请日：2007-10-26
申请人： Edze Jan Tijsma , Anita Driessen-Levels
发明人： Edze Jan Tijsma , Anita Driessen-Levels
IPC分类号： A61F2/00 , A61K39/395 , A61K38/08 , A61P9/00
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/45 , A61L2300/602 , C08L33/10
摘要： Medical devices with polymer coatings designed to control the release of bioactive agents in combination with angiotensin-(1-7) receptor agonists from medical devices are disclosed. Methods for treating or inhibiting post-stent implantation restenosis as well as improving vascular endothelial function in patients are also provided.
摘要翻译：公开了具有聚合物涂层的医疗装置，其设计用于控制生物活性剂与来自医疗装置的血管紧张素（1-7）受体激动剂的组合的释放。还提供了治疗或抑制支架内植入再狭窄以及改善患者血管内皮功能的方法。

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