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    • 1. 发明授权
    • Method and apparatus for closed-loop control of anti-tachyarrhythmia pacing using hemodynamic sensor
    • 使用血液动力学传感器闭合控制抗心律失常起搏的方法和装置
    • US08712525B2
    • 2014-04-29
    • US12877583
    • 2010-09-08
    • Dan LiCheng Zhang
    • Dan LiCheng Zhang
    • A61N1/362
    • A61N1/3622A61N1/3712
    • A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and a hemodynamic sensor that senses a hemodynamic signal. The implantable medical device includes a hemodynamic sensor-controlled closed-loop ATP system that uses the hemodynamic signal for ATP capture verification. When ATP pulses are delivered according to a selected ATP protocol to terminate a tachyarrhythmia episode, the implantable medical device performs the ATP capture verification by detecting an effective cardiac contraction from the hemodynamic signal. The ATP protocol is adjusted using an outcome of the ATP capture verification.
    • 心律管理(CRM)系统包括可植入的医疗装置,其传递抗心律失常疗法,包括抗心动过速起搏(ATP)和感测血液动力学信号的血液动力学传感器。 可植入医疗装置包括血液动力学传感器控制的闭环ATP系统,其使用血流动力学信号进行ATP捕获验证。 当根据选定的ATP方案递送ATP脉冲以终止快速性心律失常发作时,可植入医疗装置通过从血液动力学信号检测有效的心脏收缩来执行ATP捕获验证。 使用ATP捕获验证的结果调整ATP方案。
    • 2. 发明授权
    • Method and apparatus for closed-loop control of anti-tachyarrhythmia pacing using hemodynamic sensor
    • 使用血液动力学传感器闭合控制抗心律失常起搏的方法和装置
    • US07801608B2
    • 2010-09-21
    • US11422101
    • 2006-06-05
    • Dan LiCheng Zhang
    • Dan LiCheng Zhang
    • A61N1/08
    • A61N1/3622A61N1/3712
    • A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and a hemodynamic sensor that senses a hemodynamic signal. The implantable medical device includes a hemodynamic sensor-controlled closed-loop ATP system that uses the hemodynamic signal for ATP capture verification. When ATP pulses are delivered according to a selected ATP protocol to terminate a tachyarrhythmia episode, the implantable medical device performs the ATP capture verification by detecting an effective cardiac contraction from the hemodynamic signal. The ATP protocol is adjusted using an outcome of the ATP capture verification.
    • 心律管理(CRM)系统包括可植入的医疗装置,其传递抗心律失常疗法,包括抗心动过速起搏(ATP)和感测血液动力学信号的血液动力学传感器。 可植入医疗装置包括血液动力学传感器控制的闭环ATP系统,其使用血流动力学信号进行ATP捕获验证。 当根据选定的ATP方案递送ATP脉冲以终止快速性心律失常发作时,可植入医疗装置通过从血液动力学信号检测有效的心脏收缩来执行ATP捕获验证。 使用ATP捕获验证的结果调整ATP方案。
    • 3. 发明授权
    • Hypertension diagnosis and therapy using pressure sensor
    • 高血压诊断和治疗使用压力传感器
    • US08027724B2
    • 2011-09-27
    • US11833435
    • 2007-08-03
    • Xuan WeiCheng ZhangShantha Arcot-KrishnamurthyDan Li
    • Xuan WeiCheng ZhangShantha Arcot-KrishnamurthyDan Li
    • A61N1/08
    • A61N1/36564A61B5/0031A61B5/0215A61N1/36114A61N1/36117
    • An example relates to a method for sensing a pulmonary artery pressure (PAP) and providing a sensed PAP signal, detecting an abnormal blood pressure (BP) condition using information from the sensed PAP signal, delivering a pacing energy to a heart, and automatically altering at least one pacing characteristic in response to the detected abnormal BP condition. The detecting an abnormal BP condition can include detecting various forms of hypertension or hypotension. The automatically altering the at least one pacing characteristic can include automatically altering at least one of a pacing rate, a pacing waveform, an atriventricular (AV) delay, an interventricular (VV) delay, a pacing mode, or a pacing site. The method can also include delivering vagal nerve stimulation and automatically altering the vagal nerve stimulation in response to the detected abnormal BP condition. The detecting the abnormal BP condition can also include using a sensed auxiliary physiological parameter.
    • 一个例子涉及一种用于感测肺动脉压(PAP)并提供感测到的PAP信号的方法,使用来自感测到的PAP信号的信息检测异常血压(BP)状况,将起搏能量递送到心脏,并且自动改变 响应于检测到的异常BP状况的至少一个起搏特征。 检测异常BP病症可包括检测各种形式的高血压或低血压。 自动改变至少一个起搏特征可以包括自动改变起搏速率,起搏波形,房室(AV)延迟,心室间(VV)延迟,起搏模式或起搏部位中的至少一个。 该方法还可以包括递送迷走神经刺激并响应于检测到的异常BP状况自动改变迷走神经刺激。 检测异常BP状况还可以包括使用感测的辅助生理参数。
    • 4. 发明申请
    • METHOD AND APPARATUS FOR CLOSED-LOOP CONTROL OF ANTI-TACHYARRHYTHMIA PACING USING HEMODYNAMIC SENSOR
    • 使用血液动力学传感器进行抗沙眼衣原体闭环控制的方法和装置
    • US20100331905A1
    • 2010-12-30
    • US12877583
    • 2010-09-08
    • Dan LiCheng Zhang
    • Dan LiCheng Zhang
    • A61N1/365
    • A61N1/3622A61N1/3712
    • A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and a hemodynamic sensor that senses a hemodynamic signal. The implantable medical device includes a hemodynamic sensor-controlled closed-loop ATP system that uses the hemodynamic signal for ATP capture verification. When ATP pulses are delivered according to a selected ATP protocol to terminate a tachyarrhythmia episode, the implantable medical device performs the ATP capture verification by detecting an effective cardiac contraction from the hemodynamic signal. The ATP protocol is adjusted using an outcome of the ATP capture verification.
    • 心律管理(CRM)系统包括可植入的医疗装置,其传递抗心律失常疗法,包括抗心动过速起搏(ATP)和感测血液动力学信号的血液动力学传感器。 可植入医疗装置包括血液动力学传感器控制的闭环ATP系统,其使用血流动力学信号进行ATP捕获验证。 当根据选定的ATP方案递送ATP脉冲以终止快速性心律失常发作时,可植入医疗装置通过从血液动力学信号检测有效的心脏收缩来执行ATP捕获验证。 使用ATP捕获验证的结果调整ATP方案。
    • 5. 发明申请
    • HYPERTENSION DIAGNOSIS AND THERAPY USING PRESSURE SENSOR
    • 使用压力传感器进行高血压诊断和治疗
    • US20090036940A1
    • 2009-02-05
    • US11833435
    • 2007-08-03
    • Xuan WeiCheng ZhangShantha Arcot-KrishnamurthyDan Li
    • Xuan WeiCheng ZhangShantha Arcot-KrishnamurthyDan Li
    • A61N1/365
    • A61N1/36564A61B5/0031A61B5/0215A61N1/36114A61N1/36117
    • An example relates to a method for sensing a pulmonary artery pressure (PAP) and providing a sensed PAP signal, detecting an abnormal blood pressure (BP) condition using information from the sensed PAP signal, delivering a pacing energy to a heart, and automatically altering at least one pacing characteristic in response to the detected abnormal BP condition. The detecting an abnormal BP condition can include detecting various forms of hypertension or hypotension. The automatically altering the at least one pacing characteristic can include automatically altering at least one of a pacing rate, a pacing waveform, an atriventricular (AV) delay, an interventricular (VV) delay, a pacing mode, or a pacing site. The method can also include delivering vagal nerve stimulation and automatically altering the vagal nerve stimulation in response to the detected abnormal BP condition. The detecting the abnormal BP condition can also include using a sensed auxiliary physiological parameter.
    • 一个例子涉及一种用于感测肺动脉压(PAP)并提供感测到的PAP信号的方法,使用来自感测到的PAP信号的信息检测异常血压(BP)状况,将起搏能量递送到心脏,并且自动改变 响应于检测到的异常BP状况的至少一个起搏特征。 检测异常BP病症可包括检测各种形式的高血压或低血压。 自动改变至少一个起搏特征可以包括自动改变起搏速率,起搏波形,房室(AV)延迟,心室间(VV)延迟,起搏模式或起搏部位中的至少一个。 该方法还可以包括递送迷走神经刺激并响应于检测到的异常BP状况自动改变迷走神经刺激。 检测异常BP状况还可以包括使用感测的辅助生理参数。
    • 6. 发明申请
    • METHOD AND APPARATUS FOR CLOSED-LOOP CONTROL OF ANTI-TACHYARRHYTHMIA PACING USING HEMODYNAMIC SENSOR
    • 使用血液动力学传感器进行抗沙眼衣原体闭环控制的方法和装置
    • US20070282381A1
    • 2007-12-06
    • US11422101
    • 2006-06-05
    • Dan LiCheng Zhang
    • Dan LiCheng Zhang
    • A61N1/362
    • A61N1/3622A61N1/3712
    • A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and a hemodynamic sensor that senses a hemodynamic signal. The implantable medical device includes a hemodynamic sensor-controlled closed-loop ATP system that uses the hemodynamic signal for ATP capture verification. When ATP pulses are delivered according to a selected ATP protocol to terminate a tachyarrhythmia episode, the implantable medical device performs the ATP capture verification by detecting an effective cardiac contraction from the hemodynamic signal. The ATP protocol is adjusted using an outcome of the ATP capture verification.
    • 心律管理(CRM)系统包括可植入的医疗装置,其传递抗心律失常疗法,包括抗心动过速起搏(ATP)和感测血液动力学信号的血液动力学传感器。 可植入医疗装置包括血液动力学传感器控制的闭环ATP系统,其使用血流动力学信号进行ATP捕获验证。 当根据选定的ATP方案递送ATP脉冲以终止快速性心律失常发作时,可植入医疗装置通过从血液动力学信号检测有效的心脏收缩来执行ATP捕获验证。 使用ATP捕获验证的结果调整ATP方案。
    • 9. 发明授权
    • Method and device for providing anti-tachyarrhythmia therapy
    • 提供抗快速性心律失常治疗的方法和装置
    • US09084898B2
    • 2015-07-21
    • US13569208
    • 2012-08-08
    • Dan Li
    • Dan Li
    • A61N1/365A61N1/362A61N1/36A61N1/39
    • A61N1/3621A61N1/3605A61N1/36114A61N1/36564A61N1/3962
    • Various system embodiments comprise at least one sensor input adapted to receive at least one sensed signal associated with a tachyarrhythmia, a feature set extractor adapted to extract at least two features from the at least one sensed signal associated with the tachyarrhythmia, a feature set generator adapted to form a feature set using the at least two features extracted by the feature set extractor, at least one generator adapted for use to selectively apply an anti-tachycardia pacing (ATP) therapy and a neural stimulation (NS) therapy, and a controller adapted to respond to the feature set. The controller is adapted to initiate the NS therapy when the feature set corresponds to criteria for applying the NS therapy to modify the tachyarrhythmia, and initiate the ATP therapy to terminate the modified tachyarrhythmia. Other aspects and embodiments are provided herein.
    • 各种系统实施例包括适于接收与快速性心律失常相关联的至少一个感测信号的至少一个传感器输入,适于从与快速性心律失常相关联的至少一个感测信号中提取至少两个特征的特征集提取器,适于 以使用由所述特征集提取器提取的所述至少两个特征来形成特征集合,适于用于选择性地应用抗心动过速起搏(ATP)治疗和神经刺激(NS)治疗)的至少一个发生器,以及适于 以响应功能集。 当特征集合对应于应用NS治疗来修改快速性心律失常的标准时,控制器适于启动NS治疗,并且启动ATP治疗以终止改变的快速性心律失常。 本文提供了其它方面和实施例。