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1. 发明授权

US10653605B2 Dentifrice composition 有权
公开(公告)号：US10653605B2
公开(公告)日：2020-05-19
申请号：US13985570
申请日：2011-02-18
申请人： Dally Moya Argilagos , Cornelia Scheffel , Turan Matur , Andre Brunella
发明人： Dally Moya Argilagos , Cornelia Scheffel , Turan Matur , Andre Brunella
IPC分类号： A61K8/21 , A61K8/73 , A61Q11/00
摘要： A dentifrice, such as toothpaste, containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions, for use against erosive tooth demineralization, and kits containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions, wherein one of the two active agents is comprised in a dentifrice, are described. The dentifrice in the form of toothpaste may furthermore comprise dissolved tin, in particular stannous ions. Toothpastes containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions are tested in the treatment or prevention of erosive tooth demineralisation caused by citric acid.

2. 发明申请

US20130319883A1 Mouthrinse Composition 有权
标题翻译：口味组合物
公开(公告)号：US20130319883A1
公开(公告)日：2013-12-05
申请号：US13985568
申请日：2011-02-18
申请人： Dally Moya Argilagos , Cornelia Scheffel , Turan Matur , Andre Brunella
发明人： Dally Moya Argilagos , Cornelia Scheffel , Turan Matur , Andre Brunella
IPC分类号： A61K8/73 , A61Q11/00 , A61K8/21
CPC分类号： A61K8/736 , A61K8/19 , A61K8/21 , A61Q11/00
摘要： A mouthrinse containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions, for use against erosive tooth demineralization, and kits containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions, wherein one of the two active agents is comprised in a mouthrinse, are described. The mouthrinse may furthermore comprise dissolved tin, in particular stannous ions. Mouthrinses containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions are tested in the treatment or prevention of erosive tooth demineralisation caused by citric acid.
摘要翻译：含有壳聚糖或其药学上可接受的酸加成盐与氟离子的漱口剂用于抵抗侵蚀性牙齿脱矿质，以及含有壳聚糖或其药学上可接受的酸加成盐与氟离子的试剂盒，其中两种活性剂之一包含在漱口水中，被描述。漱口剂还可以包含溶解的锡，特别是亚锡离子。在处理或防止由柠檬酸引起的侵蚀性牙齿脱矿质时，测试含有壳聚糖或其药学上可接受的酸加成盐与氟离子的唾液。

3. 发明申请

US20130209375A1 ORAL CARE COMPOSITION COMPRISING DISSOLVED TIN AND FLUORIDE 审中-公开
标题翻译：口服护理组合物包含溶解的锡和氟化物
公开(公告)号：US20130209375A1
公开(公告)日：2013-08-15
申请号：US12989578
申请日：2009-04-24
申请人： Dally Moya Argilagos , Turan Matur , Cornelia Scheffel
发明人： Dally Moya Argilagos , Turan Matur , Cornelia Scheffel
IPC分类号： A61K8/19 , A61K8/69 , A61K8/36 , A61Q11/00 , A61K8/41
CPC分类号： A61K8/19 , A61K8/21 , A61K8/345 , A61K8/36 , A61K8/416 , A61K8/69 , A61Q11/00
摘要： An oral care composition comprising a liquid phase containing 30% to 90%, preferably 30% to 80% by weight, based on the liquid phase, of water; dissolved tin; 200 to 2000 ppm fluoride ions, based on the oral composition; and 5 to 60% by weight, based on the oral care composition, of a C(3-5) sugar alcohol; characterised in that the content of dissolved tin [Sn] in the liquid phase is at least 750 ppm, preferably at least 1000 ppm, based on the composition; that 60 mol % or more, preferably 75 mol % or more of the content of dissolved tin [Sn] is in the formal oxidation state +II; and that the composition comprises an organic acid and ammonium cations of the Formula (I): R—NH+Ra—[(CH2)u—NH+Rb]v—Rc (I), wherein R is a saturated or unsaturated straight-chain hydrocarbon residue of 10 to 20 carbon atoms, v is an integer from 0 to 1, u is an integer from 2 to 3 and Ra, Rb and Rc are independently selected from hydrogen and —CH2CH2OH. The composition is preferably a mouthrinse. These compositions are tested in the treatment or prevention of erosive tooth demineralisation caused by food acids.
摘要翻译：一种口腔护理组合物，其包含基于液相含有30％至90％，优选30％至80％重量的液相的液相; 溶解锡; 200至2000ppm氟离子，基于口服组合物; 和基于口腔护理组合物的5-60重量％的C（3-5）糖醇; 其特征在于，基于组成，液相中溶解的锡[Sn]的含量为至少750ppm，优选至少1000ppm; 溶解锡[Sn]的含量的60摩尔％以上，优选为75摩尔％以上为正式氧化态+ II; 并且组合物包含式（I）的有机酸和铵阳离子：R-NH + R a - [（CH 2）u -NH + R b] v -Rc（I），其中R是饱和或不饱和直链 - 10〜20个碳原子的链状烃残基，v为0〜1的整数，u为2〜3的整数，R a，R b，R c分别独立地选自氢和-CH 2 CH 2 OH。组合物优选是漱口水。在治疗或预防由食用酸引起的侵蚀性牙齿脱矿质中测试这些组合物。

4. 发明授权

US09370479B2 Mouthrinse composition 有权
标题翻译：口味组成
公开(公告)号：US09370479B2
公开(公告)日：2016-06-21
申请号：US13985568
申请日：2011-02-18
申请人： Dally Moya Argilagos , Cornelia Scheffel , Turan Matur , Andre Brunella
发明人： Dally Moya Argilagos , Cornelia Scheffel , Turan Matur , Andre Brunella
IPC分类号： A61K8/73 , A61K8/21 , A61Q11/00 , A61K8/19
CPC分类号： A61K8/736 , A61K8/19 , A61K8/21 , A61Q11/00
摘要： A mouthrinse containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions, for use against erosive tooth demineralization, and kits containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions, wherein one of the two active agents is comprised in a mouthrinse, are described. The mouthrinse may furthermore comprise dissolved tin, in particular stannous ions. Mouthrinses containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions are tested in the treatment or prevention of erosive tooth demineralization caused by citric acid.
摘要翻译：含有壳聚糖或其药学上可接受的酸加成盐与氟离子的漱口剂用于抵抗侵蚀性牙齿脱矿质，以及含有壳聚糖或其药学上可接受的酸加成盐与氟离子的试剂盒，其中两种活性剂之一包含在漱口水中，被描述。漱口剂还可以包含溶解的锡，特别是亚锡离子。在处理或防止由柠檬酸引起的侵蚀性牙齿脱矿质时，测试含有壳聚糖或其药学上可接受的酸加成盐与氟离子的枸橼酸酯。

5. 发明申请

US20130323186A1 Dentifrice Composition 审中-公开
标题翻译：牙粉组合物
公开(公告)号：US20130323186A1
公开(公告)日：2013-12-05
申请号：US13985570
申请日：2011-02-18
申请人： Dally Moya Argilagos , Cornelia Scheffel , Turan Matur , Andre Brunella
发明人： Dally Moya Argilagos , Cornelia Scheffel , Turan Matur , Andre Brunella
IPC分类号： A61K8/73 , A61K8/21 , A61Q11/00
CPC分类号： A61K8/736 , A61K8/21 , A61K2800/88 , A61Q11/00
摘要： A dentifrice, such as toothpaste, containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions, for use against erosive tooth demineralization, and kits containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions, wherein one of the two active agents is comprised in a dentifrice, are described. The dentifrice in the form of toothpaste may furthermore comprise dissolved tin, in particular stannous ions. Toothpastes containing chitosan or pharmaceutically acceptable acid addition salt thereof with fluoride ions are tested in the treatment or prevention of erosive tooth demineralisation caused by citric acid.
摘要翻译：含有壳聚糖或其药学上可接受的酸性加成盐与氟离子的牙膏，用于抵抗侵蚀性牙齿脱矿质的洁牙剂，以及含有壳聚糖或其药学上可接受的酸加成盐与氟离子的试剂盒，其中两种活性剂之一是被描述在洁齿剂中。牙膏形式的洁齿剂还可以包含溶解的锡，特别是亚锡离子。在处理或防止由柠檬酸引起的侵蚀性牙齿脱矿质时，测试含有壳聚糖或其药学上可接受的酸加成盐与氟离子的牙膏。

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