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1. 发明申请

US20080014194A1 Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease 审中-公开
标题翻译：预防和治疗突触核蛋白病和淀粉样变性疾病
公开(公告)号：US20080014194A1
公开(公告)日：2008-01-17
申请号：US11697646
申请日：2007-04-06
申请人： Dale Schenk , Kcote Games , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Eliezar Masliah
发明人： Dale Schenk , Kcote Games , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Eliezar Masliah
IPC分类号： A61K39/395 , A61P25/00 , C07K16/18 , C12N5/06
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/34
摘要： The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
摘要翻译：本发明提供用于治疗与突触核蛋白病相关疾病（包括患者脑中的α-突触核蛋白的路易体）的改进剂和方法。这种方法需要对路易体诱导有益的免疫原性应答的给药剂。该方法对帕金森病的预防和治疗特别有用。

2. 发明申请

US20060058233A1 Prevention and treatment of synucleinopathic and amyloidogenic disease 有权
公开(公告)号：US20060058233A1
公开(公告)日：2006-03-16
申请号：US11185907
申请日：2005-07-19
申请人： Dale Schenk , Eliezer Masliah , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Kate Games
发明人： Dale Schenk , Eliezer Masliah , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Kate Games
IPC分类号： A61K38/17
CPC分类号： C07K16/18 , A61K38/1709 , A61K39/00 , A61K2039/505 , A61P25/16 , A61P25/28
摘要： The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.

3. 发明申请

US20080096818A1 PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE 审中-公开
标题翻译：预防和治疗淀粉样变性疾病
公开(公告)号：US20080096818A1
公开(公告)日：2008-04-24
申请号：US11842085
申请日：2007-08-20
申请人： Dale Schenk , Nicki Vasquez , Theodore Yednock
发明人： Dale Schenk , Nicki Vasquez , Theodore Yednock
IPC分类号： A61K38/00 , A61P25/28
CPC分类号： C07K16/18 , A61K9/0019 , A61K9/2009 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K9/7023 , A61K31/00 , A61K31/739 , A61K38/1709 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K2317/24 , C07K2317/567 , C07K2319/00 , A61K2300/00
摘要： The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease. Preferred agents including N-terminal fragments of Aβ and antibodies binding to the same.
摘要翻译：本发明提供用于治疗与患者脑中Aβ的淀粉样蛋白沉积相关的疾病的改进剂和方法。这种方法需要对淀粉样蛋白沉积物诱导有益的免疫原性应答的施用试剂。该方法可用于预防和治疗阿尔茨海默氏病。优选的试剂包括Abeta的N-末端片段和与其结合的抗体。

4. 发明申请

US20050249725A1 Humanized antibodies that recognize beta amyloid peptide 审中-公开
公开(公告)号：US20050249725A1
公开(公告)日：2005-11-10
申请号：US10789273
申请日：2004-02-27
申请人： Dale Schenk , Guriq Basi
发明人： Dale Schenk , Guriq Basi
IPC分类号： G01N33/50 , A61K9/26 , A61K33/06 , A61K38/00 , A61K38/17 , A61K38/19 , A61K38/28 , A61K39/00 , A61K39/39 , A61K39/395 , A61K47/02 , A61K47/24 , A61K47/34 , A61P25/28 , C07H21/04 , C07K14/47 , C07K16/18 , C07K16/40 , C12N15/09 , G01N33/15 , G01N33/53 , G01N33/567
CPC分类号： C07K16/18 , A61K9/0019 , A61K9/2009 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K9/7023 , A61K31/00 , A61K31/739 , A61K38/1709 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K2317/24 , C07K2317/567 , C07K2319/00 , A61K2300/00
摘要： The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies.

5. 发明申请

US20050053614A1 Prevention and treatment of amyloidogenic disease 有权
标题翻译：预防和治疗淀粉样变性疾病
公开(公告)号：US20050053614A1
公开(公告)日：2005-03-10
申请号：US10884892
申请日：2004-07-01
申请人： Dale Schenk
发明人： Dale Schenk
IPC分类号： A61K38/17 , A61K38/19 , A61K39/00 , C07K16/18
CPC分类号： C07K16/18 , A61K38/1709 , A61K38/193 , A61K39/0007 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , G01N2800/2821 , Y10T436/105831 , A61K2300/00
摘要： The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
摘要翻译：本发明提供了治疗淀粉样变性疾病的组合物和方法。这样的方法需要施用一种诱导针对患者淀粉样沉积物的有益免疫应答的药剂。该方法对阿尔茨海默病的预防和治疗特别有用。在这种方法中，合适的试剂是Aβ肽或其抗体。

6. 发明申请

US20050037026A1 PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE 有权
标题翻译：预防和治疗淀粉样变性疾病
公开(公告)号：US20050037026A1
公开(公告)日：2005-02-17
申请号：US10934609
申请日：2004-09-02
申请人： Dale Schenk
发明人： Dale Schenk
IPC分类号： G01N33/50 , A61K9/26 , A61K33/06 , A61K38/00 , A61K38/17 , A61K38/19 , A61K38/28 , A61K39/00 , A61K39/39 , A61K39/395 , A61K47/02 , A61K47/24 , A61K47/34 , A61P25/28 , C07H21/04 , C07K14/47 , C07K16/18 , C07K16/40 , C12N15/09 , G01N33/15 , G01N33/53 , G01N33/567 , A61K39/02
CPC分类号： C07K16/18 , A61K9/0019 , A61K9/2009 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K9/7023 , A61K31/00 , A61K31/739 , A61K38/1709 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K2317/24 , C07K2317/567 , C07K2319/00 , Y02A50/472 , A61K2300/00
摘要： The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
摘要翻译：本发明提供了治疗淀粉样变性疾病的组合物和方法。这样的方法需要施用一种诱导针对患者淀粉样沉积物的有益免疫应答的药剂。该方法对阿尔茨海默病的预防和治疗特别有用。在这种方法中，合适的试剂是Aβ肽或其抗体。

7. 发明授权

US5422244A Detection of brain .alpha.1-antichymotrypsin 失效
标题翻译：检测脑α1-抗胰凝乳蛋白酶
公开(公告)号：US5422244A
公开(公告)日：1995-06-06
申请号：US880216
申请日：1992-05-05
申请人： Kelly Johnson-Wood , Dale Schenk
发明人： Kelly Johnson-Wood , Dale Schenk
IPC分类号： C07K14/81 , C07K16/38 , G01N33/573 , G01N33/574 , G01N33/68 , G01N33/543
CPC分类号： G01N33/573 , C07K14/8121 , C07K16/38 , G01N33/57434 , G01N33/6896 , Y10S435/971 , Y10S436/811 , Y10S436/827
摘要： The present invention is related generally to methods and compositions for identifying and quantitating particular .alpha.1-antichymotrypsin species in a biological sample. More particularly, the present invention is related to methods and compositions for detecting and measuring a brain .alpha.1-antichymotrypsin species that is produced in brain tissue of individuals having a neuropathological condition and which is detectable in accessible biological samples. The invention provides detection assays, such as sandwich binding assays, for detecting and quantitating brain .alpha.1-antichymotrypsin in a biological sample, such as blood, urine, cerebrospinal fluid, or tissue. These detection assays are useful for detecting and diagnosing neuropathological diseases and for identifying cells of a human central nervous system lineage, and for other medical applications. The invention also provides binding components, such as antibodies that bind to brain .alpha.1-antichymotrypsin, and which have potential therapeutic and diagnostic medical imaging applications.
摘要翻译：本发明一般涉及鉴定和定量生物样品中特定α1-抗胰凝乳蛋白酶物质的方法和组合物。更具体地说，本发明涉及用于检测和测量在具有神经病理学病症的个体的脑组织中产生并且在可及生物样品中可检测的脑α1-抗胰凝乳蛋白酶物质的方法和组合物。本发明提供了用于检测和定量生物样品例如血液，尿液，脑脊髓液或组织中的脑α1-抗胰凝乳蛋白酶的检测测定法，例如夹心结合测定法。这些检测测定法可用于检测和诊断神经病理学疾病和用于鉴定人类中枢神经系谱系的细胞和其它医学应用。本发明还提供结合组分，例如结合脑α1-抗胰凝乳蛋白酶的抗体，并具有潜在的治疗和诊断医学成像应用。

8. 发明申请

US20070199079A1 Monitoring APP cleavage in transgenic rodents comprising an APP swedish mutation 失效
标题翻译：监测包含APP瑞典突变的转基因啮齿动物中的APP切割
公开(公告)号：US20070199079A1
公开(公告)日：2007-08-23
申请号：US11643717
申请日：2006-12-20
申请人： Lisa McConlogue , Jun Zhao , Sukanto Sinha , Dale Schenk
发明人： Lisa McConlogue , Jun Zhao , Sukanto Sinha , Dale Schenk
IPC分类号： A01K67/033 , C07H21/04
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0312 , A01K2267/0318 , A01K2267/0356 , A01K2267/0393 , C07K14/4711 , C07K16/18 , C12N2830/008 , G01N2800/2821
摘要： The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
摘要翻译：本发明提供了转基因非人动物和含有编码包含瑞典突变的APP多肽的转基因的转基因非人哺乳动物细胞。

9. 发明申请

US20060121038A9 Prevention and treatment of amyloidogenic disease 审中-公开
标题翻译：预防和治疗淀粉样变性疾病
公开(公告)号：US20060121038A9
公开(公告)日：2006-06-08
申请号：US10890071
申请日：2004-07-12
申请人： Dale Schenk , Frederique Bard , Theodore Yednock
发明人： Dale Schenk , Frederique Bard , Theodore Yednock
IPC分类号： A61K39/395
CPC分类号： A61K39/395 , A61K2039/505 , C07K16/18 , C07K2317/34 , C07K2317/77
摘要： The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease. Preferred agents including N-terminal fragments of Aβ and antibodies binding to the same.
摘要翻译：本发明提供用于治疗与患者脑中Aβ的淀粉样蛋白沉积相关的疾病的改进剂和方法。这种方法需要对淀粉样蛋白沉积物诱导有益的免疫原性应答的施用试剂。该方法可用于预防和治疗阿尔茨海默氏病。优选的试剂包括Abeta的N-末端片段和与其结合的抗体。

10. 发明申请

US20060029611A1 Prevention and treatment of amyloidogenic disease 审中-公开
公开(公告)号：US20060029611A1
公开(公告)日：2006-02-09
申请号：US11245916
申请日：2005-10-07
申请人： Dale Schenk
发明人： Dale Schenk
IPC分类号： A61K39/00 , A61K38/19 , A61K31/739
CPC分类号： C07K16/18 , A61K9/0019 , A61K9/2009 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K9/7023 , A61K31/00 , A61K31/739 , A61K38/1709 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K2317/24 , C07K2317/567 , C07K2319/00 , A61K2300/00
摘要： The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.

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