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1. 发明授权

US07868135B2 Compositions of lipopeptide antibiotic derivatives and methods of use thereof 失效
标题翻译：脂肽抗生素衍生物的组合物及其使用方法
公开(公告)号：US07868135B2
公开(公告)日：2011-01-11
申请号：US10880442
申请日：2004-06-28
申请人： Dale R. Cameron , Vincent A. Boyd , Richard A. Leese , William V. Curran , Donald B. Borders , Paulo W. M. Sgarbi , Shirley A. Wacowich-Sgarbi , Matthew Nodwell , Yuchen Chen , Qi Jia , Dominique Dugourd
发明人： Dale R. Cameron , Vincent A. Boyd , Richard A. Leese , William V. Curran , Donald B. Borders , Paulo W. M. Sgarbi , Shirley A. Wacowich-Sgarbi , Matthew Nodwell , Yuchen Chen , Qi Jia , Dominique Dugourd
IPC分类号： A61K38/12
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.
摘要翻译：本发明提供显示抗微生物抗微生物活性的脂肽抗生素衍生物，用于合成这种抗微生物衍生物和类似物的方法和化合物，以及在多种情况下使用该化合物的方法，包括在治疗和预防微生物感染中。

2. 发明申请

US20050153876A1 Compositions of lipopeptide antibiotic derivatives and methods of use thereof 失效
标题翻译：脂肽抗生素衍生物的组合物及其使用方法
公开(公告)号：US20050153876A1
公开(公告)日：2005-07-14
申请号：US10880442
申请日：2004-06-28
申请人： Dale Cameron , Vincent Boyd , Richard Leese , William Curran , Donald Borders , Paulo Sgarbi , Shirley Wacowich-Sgarbi , Mathew Nodwell , Yuchen Chen , Qi Jia , Dominique Dugourd
发明人： Dale Cameron , Vincent Boyd , Richard Leese , William Curran , Donald Borders , Paulo Sgarbi , Shirley Wacowich-Sgarbi , Mathew Nodwell , Yuchen Chen , Qi Jia , Dominique Dugourd
IPC分类号： A61K38/00 , A61K38/12 , A61P31/04 , C07K7/56 , C07K7/64
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.
摘要翻译：本发明提供显示抗微生物抗微生物活性的脂肽抗生素衍生物，用于合成这种抗微生物衍生物和类似物的方法和化合物，以及在多种情况下使用该化合物的方法，包括在治疗和预防微生物感染中。

3. 发明授权

US09655940B2 Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent 有权
公开(公告)号：US09655940B2
公开(公告)日：2017-05-23
申请号：US11279925
申请日：2006-04-17
申请人： Qi Jia
发明人： Qi Jia
IPC分类号： A61K31/35 , A61K36/00 , A61K36/539 , A61K36/11 , A61K36/15 , A61K36/185 , A61K36/28 , A61K36/47 , A61K36/48 , A61K36/484 , A61K36/486 , A61K36/53 , A61K36/54 , A61K36/60 , A61K36/906 , A61K36/9062 , A61K31/353 , A61K31/7048 , A61K36/74
CPC分类号： A61K36/539 , A61K31/35 , A61K31/353 , A61K31/7048 , A61K36/11 , A61K36/15 , A61K36/185 , A61K36/28 , A61K36/47 , A61K36/48 , A61K36/484 , A61K36/486 , A61K36/53 , A61K36/54 , A61K36/60 , A61K36/74 , A61K36/906 , A61K36/9062
摘要： The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.

4. 发明授权

US08445696B2 Synthetic methods for spiro-oxindole compounds 有权
标题翻译：螺 - 羟吲哚化合物的合成方法
公开(公告)号：US08445696B2
公开(公告)日：2013-05-21
申请号：US12904880
申请日：2010-10-14
申请人： Jean-Jacques Cadieux , Mikhail Chafeev , Sultan Chowdhury , Jianmin Fu , Qi Jia , Stefanie Abel , Emad El-Sayed , Elke Huthmann , Thomas Isarno
发明人： Jean-Jacques Cadieux , Mikhail Chafeev , Sultan Chowdhury , Jianmin Fu , Qi Jia , Stefanie Abel , Emad El-Sayed , Elke Huthmann , Thomas Isarno
IPC分类号： C07D491/20
CPC分类号： C07D491/20 , C07D405/04
摘要： This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译：本发明涉及制备某些螺 - 羟吲哚衍生物的方法，其可用于治疗和/或预防钠通道介导的疾病或病症如疼痛。

5. 发明授权

US08415370B2 Spiro-oxindole compounds and their uses as therapeutic agents 有权
标题翻译：螺 - 羟吲哚化合物及其作为治疗剂的用途
公开(公告)号：US08415370B2
公开(公告)日：2013-04-09
申请号：US13557833
申请日：2012-07-25
申请人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
发明人： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译：本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。

6. 发明申请

US20120201769A1 BAKUCHIOL COMPOSITIONS FOR TREATMENT OF POST INFLAMMATORY HYPERPIGMENTATION 有权
标题翻译：用于治疗后炎症反应的苦瓜组合物
公开(公告)号：US20120201769A1
公开(公告)日：2012-08-09
申请号：US13365172
申请日：2012-02-02
申请人： Mei Feng Hong , Qi Jia , Lidia Alfaro Brownell
发明人： Mei Feng Hong , Qi Jia , Lidia Alfaro Brownell
IPC分类号： A61K31/05 , A61P17/00 , A61Q19/02 , A61K31/60 , A61P17/02 , A61P17/10 , A61P29/00 , A61K8/34
CPC分类号： A61K31/05 , A61K8/347 , A61K31/60 , A61K2800/30 , A61Q19/02
摘要： Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.
摘要翻译：公开了治疗过度色素沉着的方法，包括治疗炎症后色素沉着过度（PIH）。所公开的方法包括向哺乳动物施用包含基本上不含呋喃香豆素的苯醚酚的组合物。还公开了包含bakuchiol的组合物及其制备方法。

7. 发明授权

US08124134B2 Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia 有权
标题翻译：从相思树中分离双重COX-2和5-脂氧合酶抑制剂
公开(公告)号：US08124134B2
公开(公告)日：2012-02-28
申请号：US11457388
申请日：2006-07-13
申请人： Qi Jia , Timothy C. Nichols , Eric Rhoden , Scott Waite
发明人： Qi Jia , Timothy C. Nichols , Eric Rhoden , Scott Waite
IPC分类号： A01N65/00
CPC分类号： A61K31/353 , A61K31/33 , A61K36/00 , A61K36/48
摘要： The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.
摘要翻译：本发明提供了同时抑制环氧合酶COX-2和5-脂氧合酶（5-LO）酶的新方法。同时双重抑制COX-2和5-LO的方法包括将含有单个植物或多种植物的多种黄烷的个体和/或混合物的组合物施用于植物相思树属植物中的宿主需要。本发明还包括预防和治疗COX-2和5-LO介导的疾病和病症的新方法。预防和治疗COX-2和5-LO介导的疾病和病症的方法包括向有需要的宿主施用有效量的组合物，其包含从单一植物分离的个体和/或多种黄烷的混合物或植物相思树属植物多种植物和药学上可接受的载体。本发明包括分离和纯化来自植物相思树属的COX-2和5-LO双重特异性的黄烷组合物的方法。

8. 发明申请

US20120014906A1 ORGANIC COMPOUNDS 有权
标题翻译：有机化合物
公开(公告)号：US20120014906A1
公开(公告)日：2012-01-19
申请号：US13238081
申请日：2011-09-21
申请人： Sultan Chowdhury , Natalie Dales , Julia Fonarev , Jianmin Fu , Duanjie Hou , Qi Jia , Vishnumurthy Kodumuru , Natalia Pokrovskaia , Shaoyi Sun , Zaihui Zhang
发明人： Sultan Chowdhury , Natalie Dales , Julia Fonarev , Jianmin Fu , Duanjie Hou , Qi Jia , Vishnumurthy Kodumuru , Natalia Pokrovskaia , Shaoyi Sun , Zaihui Zhang
IPC分类号： A61K31/785 , C07D417/14 , C07D471/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/501 , A61K31/437 , C12N9/99 , A61K38/28 , A61K38/26 , A61K31/455 , A61K31/616 , A61P3/00 , A61P3/10 , A61P3/08 , A61P3/06 , A61P9/12 , A61P7/02 , A61P3/04 , A61P17/00 , A61P17/06 , A61P17/10 , A61P17/02 , C07D417/04
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译：本发明提供调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。还包括使用这些衍生物调节硬脂酰辅酶A去饱和酶活性的方法和包含这些衍生物的药物组合物。

9. 发明申请

US20110245333A1 IDENTIFICATION OF FREE-B-RING FLAVONOIDS AS POTENT COX-2 INHIBITORS 审中-公开
标题翻译：作为COCO-2抑制剂的自由B环氟虫酯的鉴定
公开(公告)号：US20110245333A1
公开(公告)日：2011-10-06
申请号：US13084419
申请日：2011-04-11
申请人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Walte
发明人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Walte
IPC分类号： A61K31/352 , A61P29/00
CPC分类号： A61K31/7048 , A61K31/353 , A61K36/539
摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供抑制环加氧酶COX-2的新方法。该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物和药学上可接受的载体。

10. 发明申请

US20110207806A1 FORMULATION OF DUAL CYCLOXYGENASE (COX) AND LIPOXYGENASE (LOX) INHIBITORS FOR MAMMAL SKIN CARE 有权
公开(公告)号：US20110207806A1
公开(公告)日：2011-08-25
申请号：US13028853
申请日：2011-02-16
申请人： Qi Jia
发明人： Qi Jia
IPC分类号： A61K31/353 , A61K8/49 , A61P17/00 , A61Q19/08
CPC分类号： A61K8/97 , A61K8/498 , A61K8/67 , A61K31/352 , A61K31/353 , A61K31/7048 , A61K36/11 , A61K36/15 , A61K36/185 , A61K36/28 , A61K36/47 , A61K36/48 , A61K36/484 , A61K36/486 , A61K36/53 , A61K36/539 , A61K36/54 , A61K36/60 , A61K36/906 , A61K36/9062 , A61K45/06 , A61K2800/782 , A61Q19/00 , A61Q19/004 , A61Q19/08 , A61K2300/00
摘要： The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-Ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX). The method for preventing and treating COX and LOX mediated diseases and conditions of the skin is comprised of topically administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of COX and LOX mediated diseases and conditions, including but not limited to sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial and viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma, as well as other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind and dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin. Use of the composition described herein also affords the benefit of smooth and youthful skin with improved elasticity, reduced and delayed aging, enhanced youthful appearance and texture, and increased flexibility, firmness, smoothness and suppleness.

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