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1. 发明申请

US20190083788A1 Multilayer supporting structure for subsurface electrodes for electric field shaping 审中-公开
公开(公告)号：US20190083788A1
公开(公告)日：2019-03-21
申请号：US16177309
申请日：2018-10-31
申请人： Daisong Zhang , Sergio Lara Pereira Monteiro
发明人： Daisong Zhang , Sergio Lara Pereira Monteiro
IPC分类号： A61N1/368 , A61N1/02 , A61N1/36 , A61N1/05 , A61N1/372
CPC分类号： A61N1/3686 , A61N1/025 , A61N1/0529 , A61N1/0565 , A61N1/36185 , A61N1/372
摘要： An electric stimulator for heart (as in heart pacemakers), brain (as in DBS), organs and general cells, with a supporting structure where there exists a plurality of electrically isolated electrodes called passive electrodes or field-shaping electrodes that are located under the surface of the supporting structure. The passive electrodes are controlled by an appropriate electronics control unit and powered by some electric energy storage, as a battery. Passive or field-shaping electrodes are electrically insulated, being unable to inject current in the surrounding medium, but they are capable of shaping the electric field in the space surrounding the electrodes, which has consequence on the path of the stimulating currents injected by other devices or by the organism itself. The invention also discloses locating the passive electrodes at different depths from the surface of the supporting structure.

2. 发明授权

US10549104B2 Multilayer supporting structure for subsurface electrodes for electric field shaping 有权
公开(公告)号：US10549104B2
公开(公告)日：2020-02-04
申请号：US16177309
申请日：2018-10-31
申请人： Daisong Zhang , Sergio Lara Pereira Monteiro
发明人： Daisong Zhang , Sergio Lara Pereira Monteiro
IPC分类号： A61N1/368 , A61N1/05 , A61N1/36 , A61N1/02 , A61N1/372
摘要： An electric stimulator for heart (as in heart pacemakers), brain (as in DBS), organs and general cells, with a supporting structure where there exists a plurality of electrically isolated electrodes called passive electrodes or field-shaping electrodes that are located under the surface of the supporting structure. The passive electrodes are controlled by an appropriate electronics control unit and powered by some electric energy storage, as a battery. Passive or field-shaping electrodes are electrically insulated, being unable to inject current in the surrounding medium, but they are capable of shaping the electric field in the space surrounding the electrodes, which has consequence on the path of the stimulating currents injected by other devices or by the organism itself. The invention also discloses locating the passive electrodes at different depths from the surface of the supporting structure.

3. 发明申请

US20230000378A1 Method and means to measure oxygen saturation/concentration in animals 有权
公开(公告)号：US20230000378A1
公开(公告)日：2023-01-05
申请号：US17943114
申请日：2022-09-12
申请人： Sergio Lara Pereira Monteiro
发明人： Heather Marisa Richardson , Sergio Lara Pereira Monteiro
IPC分类号： A61B5/024 , A61B5/00 , A61B5/11
摘要： We disclose an improvement for oximeters, which makes oximeters more reliable when making measurements on patients of darker skin complexion. The device of our invention discloses a re-entrant cavity, inside which some of the tissues of the patient are forced into, by pressing the device of our invention against the skin of the patient. The probing electromagnetic radiation beams (typically deep red and infra-red radiation) are directed to propagate through said re-entrant cavity, inside which some of the outer tissues of the patient are forced, along a path that is approximately parallel to, and just under, the skin of the patient. This probed volume inside said re-entrant cavity contains more arterial and less venous blood, when compared with measurements made by perpendicular beams, that penetrate deep under the skin, which causes that the measurements made by our device are more accurate than many existing oximeters.

4. 发明申请

US20220167854A1 Method and means to make infrared image of the female breast, other human organs and other objects - 2 有权
公开(公告)号：US20220167854A1
公开(公告)日：2022-06-02
申请号：US17676000
申请日：2022-02-18
申请人： Gunnar Erik Skulason , Sergio Lara Pereira Monteiro
发明人： Gunnar Erik Skulason , Sergio Lara Pereira Monteiro
IPC分类号： A61B5/00
摘要： A method to form images of internal parts of objects that are of such a nature that images are smeared out due to scattering. The method consists in using scanning beams of radiation, then separating radiation that have not suffered scattering events, from the radiation that have suffered scattering events. The separation between these is made using collimators, which selectively allow only radiation that propagates along the initial propagation direction. The invention also discloses a transparent window pressed against the object, which serves to keep the incident radiation along a known direction. The radiation that suffered scattering may be also used to make a separate image of the internal parts of the object.

5. 发明申请

US20220032061A1 Device and means to ameliorate discomfort and pain during breast cancer biopsies and similar procedures 有权
公开(公告)号：US20220032061A1
公开(公告)日：2022-02-03
申请号：US17501291
申请日：2021-10-14
申请人： Heather Marisa Richardson , Sergio Lara Pereira Monteiro
发明人： Heather Marisa Richardson , Sergio Lara Pereira Monteiro
IPC分类号： A61N1/36 , A61N1/05
摘要： A device and means to decrease the pain associated with cancer biopsies procedures The device uses anesthetic injections and electrical currents of both positive or negative polarity, or alternating current. The device can be incorporated into existing biopsiy devices. Application on breast cancer biopsies and other types of biopsies.

6. 发明申请

US20190083787A1 Subsurface electrodes for electric field shaping with wrapping supporting structures 审中-公开
公开(公告)号：US20190083787A1
公开(公告)日：2019-03-21
申请号：US16175840
申请日：2018-10-31
申请人： Sergio Lara Pereira Monteiro
发明人： Sergio Lara Pereira Monteiro
IPC分类号： A61N1/368 , A61N1/36 , A61N1/375 , A61N1/02
CPC分类号： A61N1/3686 , A61N1/025 , A61N1/0529 , A61N1/0565 , A61N1/36185 , A61N1/375
摘要： An electric stimulator for heart (as in heart pacemakers), brain (as in DBS), organs and general cells, with a supporting structure where there exists a plurality of electrically isolated electrodes called passive electrodes or field-shaping electrodes that are located under the surface of the supporting structure. The passive electrodes are controlled by an appropriate electronics control unit and powered by some electric energy storage, as a battery. Passive or field-shaping electrodes are electrically insulated, being unable to inject current in the surrounding medium, but they are capable of shaping the electric field in the space surrounding the electrodes, which has consequence on the path of the stimulating currents injected by other devices or by the organism itself. The invention also discloses locating the passive electrodes on surfaces that surround the desired target volume.

7. 发明申请

US20160228699A1 Cell electric stimulator with subsurface electrodes for electric field shaping and separate electrodes for stimulation 审中-公开
标题翻译：细胞电刺激器，具有用于电场成形的地下电极和用于刺激的单独电极
公开(公告)号：US20160228699A1
公开(公告)日：2016-08-11
申请号：US15019969
申请日：2016-02-09
申请人： Sergio Lara Pereira Monteiro
发明人： Sergio Lara Pereira Monteiro
IPC分类号： A61N1/362 , A61N1/372 , A61N1/02 , A61N1/05
CPC分类号： A61N1/025 , A61N1/0534 , A61N1/0565 , A61N1/36067 , A61N1/36185 , A61N1/3686 , A61N1/37223
摘要： An electric stimulator for heart (as in heart pacemakers), brain (as in DBS), organs and general cells, with a supporting structure where there exists a first plurality of electrically isolated electrodes called field-shaping electrodes that are located under the surface of the supporting structure, and a second plurality of ordinary electrically stimulating electrodes called active electrodes, that are located at the surface of the supporting structure, capable of injecting electric charges in the space surrounding the supporting structure. Both types of electrodes are controlled by an appropriate electronics control unit and powered by some electric energy storage, as a battery. Field-shaping electrodes are electrically insulated, being unable to inject current in the surrounding medium, but they are capable of shaping the electric field, which has consequence on the path of the stimulating currents injected by active electrodes. The invention also discloses positioning the field-shaping electrodes underneath the active electrodes.
摘要翻译：用于心脏的电刺激器（如心脏起搏器），脑（如DBS中），器官和通用细胞，具有支撑结构，其中存在称为场成形电极的第一多个电隔离电极，位于下表面支撑结构，以及位于支撑结构的表面处的能够在围绕支撑结构的空间中注入电荷的称为有效电极的第二多个普通电刺激电极。两种类型的电极由适当的电子控制单元控制，并由一些电能存储器供电，作为电池。场成形电极是电绝缘的，不能在周围介质中注入电流，但是它们能够对电场进行整形，这对由有源电极注入的刺激电流的路径产生影响。本发明还公开了将场成形电极定位在有源电极下方。

8. 发明授权

US09089687B2 Device and means for adjusting the position of DBS brain and other neural and muscular implants 有权
标题翻译：用于调整DBS脑和其他神经和肌肉植入物位置的装置和方法
公开(公告)号：US09089687B2
公开(公告)日：2015-07-28
申请号：US14150767
申请日：2014-01-09
申请人： Chong Il Lee , Sergio Lara Pereira Monteiro
发明人： Chong Il Lee , Sergio Lara Pereira Monteiro
IPC分类号： A61N1/04 , A61N1/05 , A61N1/36 , A61N1/368 , A61N1/375
CPC分类号： A61N1/05 , A61B34/70 , A61N1/0534 , A61N1/0539 , A61N1/057 , A61N1/36182 , A61N1/36185 , A61N1/3684 , A61N1/3686 , A61N1/375
摘要： A device, method and means to adjust the position of a picafina Deep Brain Stimulator (DBS). It is notoriously difficult to find the correct positioning of the picafina for best stimulating results, because it is not possible for the neurosurgeon to visually observe its position. We disclose a device, method and means to adjust the position of the picafina after it is inserted in the brain, for the best stimulating effect.
摘要翻译：调整picafina深脑刺激器（DBS）的位置的装置，方法和装置。因为神经外科医生不可能在视觉上观察其位置，因此极难找到皮条斑的正确定位以获得最佳的刺激效果。我们公开了一种装置，方法和手段，以便在将斑马鱼插入大脑后调整斑马鱼的位置，以获得最佳的刺激效果。

9. 发明申请

US20140222107A1 System of redundant wires and connectors for picafina DBS and heart pacemaker electrical stimulating device implanted in animals including human animals 审中-公开
标题翻译：用于picafina DBS和心脏起搏器电刺激装置的冗余电线和连接器植入动物包括人类动物的系统
公开(公告)号：US20140222107A1
公开(公告)日：2014-08-07
申请号：US14250909
申请日：2014-04-11
申请人： Chong Il Lee , Sergio Lara Pereira Monteiro
发明人： Chong Il Lee , Sergio Lara Pereira Monteiro
IPC分类号： A61N1/375 , A61N1/372 , A61N1/36
CPC分类号： A61N1/36185 , A61B5/0004 , A61B5/04001 , A61B5/05 , A61B5/6868 , A61B5/6869 , A61B5/6877 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/37235 , A61N1/37247 , A61N1/3752 , G01R1/06744 , G01R1/06766 , G01R1/07307
摘要： A system to increase the reliability of the electrical connections between the electrodes and the battery/controlling electronics of an electrical stimulating device as DBS (Deep Brain Stimulator), heart pacemakers and the like. We disclose a redundant male/female connector and/or a set of redundant wires to improve the reliability of the connections between the electrodes at a first location and the battery/controlling electronics at a second location. The redundant male/female connector serves as a backup for a potential loss of electrical continuity due to the adverse effect of body fluids, and the redundant wires serve as a backup for potential loss of electrical continuity due to repetitive muscle movement causing wire movement and stress. DBS connecting wires, that ran behind the ear down the neck of the patient, are subjected to repetitive stresses due to neck twisting and therefore at high risk of breaking.
摘要翻译：一种用于增加电极和电刺激装置的电池/控制电子设备之间的电连接的可靠性的系统，如DBS（深脑刺激器），心脏起搏器等。我们公开了冗余的公/母连接器和/或一组冗余电线，以提高第一位置处的电极与第二位置处的电池/控制电子器件之间的连接的可靠性。冗余的母/母连接器用作由于体液的不利影响导致电气连续性的潜在损失的备用，并且冗余线作为由于重复的肌肉运动导致线运动和应力的电连续性的潜在损失的备用。在患者颈部后方的DBS连接线由于颈部扭转而受到重复的应力，因此具有高的断裂风险。

10. 发明授权

US08509872B2 Redundant connections to picafina probing device 有权
标题翻译：与picafina探测设备的冗余连接
公开(公告)号：US08509872B2
公开(公告)日：2013-08-13
申请号：US13676944
申请日：2012-11-14
申请人： Chong Il Lee , Sergio Lara Pereira Monteiro
发明人： Chong Il Lee , Sergio Lara Pereira Monteiro
IPC分类号： A61B5/0478 , A61B5/0408
CPC分类号： A61N1/36185 , A61B5/0004 , A61B5/04001 , A61B5/05 , A61B5/6868 , A61B5/6869 , A61B5/6877 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/37235 , A61N1/37247 , A61N1/3752 , G01R1/06744 , G01R1/06766 , G01R1/07307
摘要： A picafina device that is an electrode for measurement of neuron electrical activity where the number of measurement points is very large, and methods of selecting a subset of available measuring electrodes on the surface of the device. The device can keep the selection for a predetermined length of time, or for an indefinite length of time, both under control of the researcher or the neurosurgeon. Selecting a different measuring pad, or a combination of pads, is equivalent to making measurement at a different location or on a nearby neuron. Several parallel measurements can be made, in which case correlations can be made between the firing of different neurons.
摘要翻译：作为用于测量测量点数非常大的神经元电活动的电极的皮卡法装置，以及在装置表面上选择可用测量电极子集的方法。该装置可以在研究人员或神经外科医师的控制下将选择保持预定的时间长度或不确定的时间长度。选择不同的测量垫或垫的组合相当于在不同的位置或附近的神经元进行测量。可以进行几个平行测量，在这种情况下，可以在不同神经元的烧制之间进行相关性。

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