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1. 发明授权

US08853194B2 Sterol derivatives and their synthesis and use 有权
标题翻译：甾醇衍生物及其合成和用途
公开(公告)号：US08853194B2
公开(公告)日：2014-10-07
申请号：US13387559
申请日：2010-01-15
申请人： Dagang Chen , Haimin Lei
发明人： Dagang Chen , Haimin Lei
IPC分类号： A61K31/58 , C07J71/00
CPC分类号： C07J71/0005 , C07J9/00
摘要： Sterol derivatives with structural formula I or II are disclosed, wherein R is defined as the description of the invention. Their synthesizing methods and anti-tumor use are also disclosed. Especially, the compound of formula I, in which R is O (i.e. the compound CL 168-6), has the anti-tumor therapeutic index of 49.3. The compound can be used to prepare a medicine for prevention or treatment of immunological diseases and cancers such as liver cancer and lung cancer.
摘要翻译：公开了具有结构式I或II的甾醇衍生物，其中R定义为本发明的描述。还公开了它们的合成方法和抗肿瘤用途。特别是其中R为O的式I化合物（即化合物CL 168-6）的抗肿瘤治疗指数为49.3。该化合物可用于制备预防或治疗免疫疾病和癌症如肝癌和肺癌的药物。

2. 发明申请

US20120130067A1 Sterol Derivatives and Their Synthesis and Use 有权
标题翻译：甾醇衍生物及其合成与使用
公开(公告)号：US20120130067A1
公开(公告)日：2012-05-24
申请号：US13387559
申请日：2010-01-15
申请人： Dagang Chen , Haimin Lei
发明人： Dagang Chen , Haimin Lei
IPC分类号： C07J71/00 , C07J75/00
CPC分类号： C07J71/0005 , C07J9/00
摘要： Sterol derivatives with structural formula I or II are disclosed, wherein R is defined as the description of the invention. Their synthesizing methods and anti-tumor use are also disclosed. Especially, the compound of formula I, in which R is O (i.e. the compound CL 168-6), has the anti-tumor therapeutic index of 49.3. The compound can be used to prepare a medicine for prevention or treatment of immunological diseases and cancers such as liver cancer and lung cancer.
摘要翻译：公开了具有结构式I或II的甾醇衍生物，其中R定义为本发明的描述。还公开了它们的合成方法和抗肿瘤用途。特别是其中R为O的式I化合物（即化合物CL 168-6）的抗肿瘤治疗指数为49.3。该化合物可用于制备预防或治疗免疫疾病和癌症如肝癌和肺癌的药物。

3. 发明申请

US20140011786A1 SYNTHESIS AND USE OF ANTI-TUMOR DRUG LQC-Y 有权
标题翻译：合成和使用抗肿瘤药物LQC-Y
公开(公告)号：US20140011786A1
公开(公告)日：2014-01-09
申请号：US14017857
申请日：2013-09-04
申请人： Haimin Lei
发明人： Haimin Lei
IPC分类号： C07J43/00 , C07D405/14 , C07D241/12
CPC分类号： C07J43/003 , C07D241/12 , C07D405/14 , C07J63/008
摘要： Disclosed are the general structural formula of LQC-Y as well as the synthesis and use thereof. Pharmacological experiments demonstrated the marked antitumor effect of such compounds. Single day administration of LQC-Y3 to mice at a maximum dose of 6000 mg/kg showed no toxicity response during the 14-day continuous observation period, indicating the high safety of the compounds, and the compounds can be used to prepare medicaments for preventing and treating carcinomas such as liver cancer, lung cancer. In the general structural formula of LQC-Y, R represents steroid compounds such as cholic acid, deoxycholic acid, ursodeoxycholic acid, chenodeoxycholic acid, and hyodeoxycholic acid and so on; triterpenoid compounds such as oleanolic acid, ursolic acid, pachymic acid, glycyrrhetinic acid and glycosides thereof and so on; emodic acid, emodin and other mono-substituted or poly-substituted structures of anthraquinone parent nucleus; baicalein, baicalin and other flavonoid; shikimic acid, mono-substituted shikimic acid or poly-substituted shikimic acid; gardenia acid and other iridoid acid derivatives; paeonol, curcumin and structural derivatives thereof.
摘要翻译：公开了LQC-Y的一般结构式及其合成和用途。药理实验表明这些化合物具有明显的抗肿瘤作用。最大剂量为6000mg / kg的LQC-Y3单次给予小鼠在14天连续观察期间没有显示毒性反应，表明化合物的安全性高，并且该化合物可用于制备预防药物并治疗肝癌，肺癌等癌症。在LQC-Y的一般结构式中，R代表类固醇化合物如胆酸，脱氧胆酸，熊去氧胆酸，鹅脱氧胆酸和猪脱氧胆酸等; 三萜类化合物如齐墩果酸，熊果酸，披针酸，甘草次酸及其糖苷等; 泛酸，大黄素等蒽醌母核的单取代或多取代结构; 黄芩苷，黄芩苷等黄酮类; 莽草酸，单取代莽草酸或多取代莽草酸; 栀子酸等环烯醚萜酸衍生物; 芍药醇，姜黄素及其结构衍生物。

4. 发明申请

US20140011813A1 Medicine for Treating Ischemic Brain Injury and its Sequelae, and Preparation Method Thereof 有权
标题翻译：治疗缺血性脑损伤及其后遗症的药物及其制备方法
公开(公告)号：US20140011813A1
公开(公告)日：2014-01-09
申请号：US14017851
申请日：2013-09-04
申请人： Haimin Lei
发明人： Haimin Lei , Ying Hong
IPC分类号： C07D241/12
CPC分类号： C07D241/12
摘要： Disclosed in the present invention are a compound of the general structure formula LQC-T as shown below, wherein R represents an aromatic organic acid or phenol or the structural analogue thereof, such as protocatechuic acid, protocatechuic aldehyde, vanillic acid, gallic acid, caffeic acid, ferulic acid etc., and the synthesis and use of the compound. The compounds promote new blood vessel growth in the chick embryo chorioallantoic membrane, wherein LQC-T4 can be used to prepare a medicine for treating ischemic brain injury (stroke) and its sequelae.
摘要翻译：在本发明中公开的是下列通式结构式LQC-T的化合物，其中R表示芳族有机酸或苯酚或其结构类似物，例如原儿茶酸，原儿茶醛，香草酸，没食子酸，咖啡因酸，阿魏酸等，以及该化合物的合成和用途。这些化合物促进鸡胚绒毛尿囊膜中的新血管生长，其中LQC-T4可用于制备治疗缺血性脑损伤（中风）及其后遗症的药物。

5. 发明申请

US20140221275A1 OLIGOPEPTIDE FOR TREATING LIVER FIBROSIS AND/OR TREATING HEPATITIS B AND/OR IMPROVING LIVER FUNCTION 有权
标题翻译：用于治疗肝纤维化和/或治疗乙型肝炎和/或改善肝功能的低聚糖
公开(公告)号：US20140221275A1
公开(公告)日：2014-08-07
申请号：US14346087
申请日：2011-11-01
申请人： Haimin LEI
发明人： Haimin Lei , Qiang Li
IPC分类号： C07K7/06
CPC分类号： C07K7/06 , A61K38/00
摘要： Disclosed is an oligopeptide for treating liver fibrosis and/or hepatitis B and/or improving liver function. The oligopeptide is obtained by reflux extraction via water, ethanol precipitation and isolation through a cation exchange resin column and a gelatinous resin column from a turtle shell. Pharmaceutically conventional excipients can be added to the oligopeptide prepared according to the present invention to prepare various dosage forms. The oligopeptide has good efficacy in treating liver fibrosis and improving liver function.
摘要翻译：公开了用于治疗肝纤维化和/或乙型肝炎和/或改善肝功能的寡肽。寡肽通过水回流提取，乙醇沉淀和通过阳离子交换树脂柱和凝胶状树脂柱从乌龟壳分离。可以将药学上常规的赋形剂加入到根据本发明制备的寡肽中以制备各种剂型。寡肽在治疗肝纤维化和改善肝功能方面具有良好的疗效。

6. 发明授权

US08987449B2 Medicine for treating ischemic brain injury and its sequelae, and preparation method thereof 有权
标题翻译：用于治疗缺血性脑损伤及其后遗症的药物及其制备方法
公开(公告)号：US08987449B2
公开(公告)日：2015-03-24
申请号：US14017851
申请日：2013-09-04
申请人： Haimin Lei , Ying Hong
发明人： Haimin Lei , Ying Hong
IPC分类号： C07D403/12 , C07D241/12
CPC分类号： C07D241/12
摘要： Disclosed in the present invention are a compound of the general structure formula LQC-T as shown below, wherein R represents an aromatic organic acid or phenol or the structural analog thereof, such as protocatechuic acid, protocatechuic aldehyde, vanillic acid, gallic acid, caffeic acid, ferulic acid etc., and the synthesis and use of the compound. The compounds promote new blood vessel growth in the chick embryo chorioallantoic membrane, wherein LQC-T4 can be used to prepare a medicine for treating ischemic brain injury (stroke) and its sequelae.
摘要翻译：在本发明中公开的是下列通式结构式LQC-T的化合物，其中R表示芳族有机酸或苯酚或其结构类似物，例如原儿茶酸，原儿茶醛，香草酸，没食子酸，咖啡因酸，阿魏酸等，以及该化合物的合成和用途。这些化合物促进鸡胚绒毛尿囊膜中的新血管生长，其中LQC-T4可用于制备治疗缺血性脑损伤（中风）及其后遗症的药物。

7. 发明授权

US08957019B2 Oligopeptide for treating liver fibrosis and/or treating hepatitis B and/or improving liver function 有权
标题翻译：用于治疗肝纤维化和/或治疗乙型肝炎和/或改善肝功能的寡肽
公开(公告)号：US08957019B2
公开(公告)日：2015-02-17
申请号：US14346087
申请日：2011-11-01
申请人： Haimin Lei , Qiang Li
发明人： Haimin Lei , Qiang Li
IPC分类号： A61K39/29 , A61K35/407 , A61K38/08 , C07K7/06 , C07K14/47 , A61K38/00
CPC分类号： C07K7/06 , A61K38/00
摘要： Disclosed is an oligopeptide for treating liver fibrosis and/or hepatitis B and/or improving liver function. The oligopeptide is obtained by reflux extraction via water, ethanol precipitation and isolation through a cation exchange resin column and a gelatinous resin column from a turtle shell. Pharmaceutically conventional excipients can be added to the oligopeptide prepared according to the present invention to prepare various dosage forms. The oligopeptide has good efficacy in treating liver fibrosis and improving liver function.
摘要翻译：公开了用于治疗肝纤维化和/或乙型肝炎和/或改善肝功能的寡肽。寡肽通过水回流提取，乙醇沉淀和通过阳离子交换树脂柱和凝胶状树脂柱从乌龟壳分离。可以将药学上常规的赋形剂加入到根据本发明制备的寡肽中以制备各种剂型。寡肽在治疗肝纤维化和改善肝功能方面具有良好的疗效。

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