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1. 发明申请

US20210087542A1 LIPOLYTIC ENZYME VARIANTS 有权
公开(公告)号：US20210087542A1
公开(公告)日：2021-03-25
申请号：US17109759
申请日：2020-12-02
申请人： DSM IP ASSETS B.V.
发明人： Rene Marcel DE JONG , Chantal CHRISTIS , Neil CARR
IPC分类号： C12N9/20 , A21D8/04
摘要： The present disclosure describes a variant polypeptide having lipolytic activity, wherein the variant has an amino acid sequence which, when aligned with the amino acid sequence as set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue at a position corresponding to any of the positions 113, 122, 138, 141, 179, 282, 284, 286, 295, said positions being defined with reference to SEQ ID NO: 2, and wherein said variant has at least 70% identity with the mature polypeptide having lipolytic activity as set out in SEQ ID NO: 2. Such a variant polypeptide may be used in the preparation of a baked product.

2. 发明申请

US20160122400A1 POLYPEPTIDES WITH PERMEASE ACTIVITY 有权
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：US20160122400A1
公开(公告)日：2016-05-05
申请号：US14895742
申请日：2014-06-04
申请人： DSM IP ASSETS B.V.
发明人： Paul KLAASSEN , Paulus Petrus DE WAAL , Rene Marcel DE JONG , Arnold Jacob Mattieu DRIESSEN , Jeroen Gerben NIJLAND , Hyun Yong SHIN
IPC分类号： C07K14/395 , C12P19/02
CPC分类号： C07K14/395 , C12P19/02
摘要： The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 Å3 and a side chain hydrophobicity of 10 to 100 ΔtR.
摘要翻译：本发明涉及在对应于SEQ ID NO：59的位置339或376的位置具有一个或多个取代的多肽，其中多肽是主要促进剂超家族（MFS）的成员。在一个实施方案中，取代位于对应于376的位置，并且其中该位置处的氨基酸被具有范德华体积为80至138埃的氨基酸和10至100重量％的侧链疏水性。

3. 发明申请

US20190338261A1 LIPOLYTIC ENZYME VARIANTS 审中-公开
公开(公告)号：US20190338261A1
公开(公告)日：2019-11-07
申请号：US16471121
申请日：2017-12-19
申请人： DSM IP Assets B.V.
发明人： Rene Marcel DE JONG , Chantal CHRISTIS , Neil CARR
IPC分类号： C12N9/20 , A21D8/04
摘要： The present disclosure describes a variant polypeptide having lipolytic activity, wherein the variant has an amino acid sequence which, when aligned with the amino acid sequence as set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue at a position corresponding to any of the positions 113, 122, 138, 141, 179, 282, 284, 286, 295, said positions being defined with reference to SEQ ID NO: 2, and wherein said variant has at least 70% identity with the mature polypeptide having lipolytic activity as set out in SEQ ID NO: 2.Such a variant polypeptide may be used in the preparation of a baked product.

4. 发明申请

US20190225947A1 MALATE DEHYROGENASES 审中-公开
公开(公告)号：US20190225947A1
公开(公告)日：2019-07-25
申请号：US16316988
申请日：2017-07-11
申请人： DSM IP ASSETS B.V.
发明人： Alrik Pieter LOS , Rene Marcel DE JONG , Remko Tsjibbe WINTER , Ben DEN DULK
IPC分类号： C12N9/04 , C12P7/46 , C12R1/865
摘要： The present invention relates to a recombinant host cell which is capable of producing a dicarboxylic acid and which comprises a mutant malate dehydrogenase resulting in an increased production of the dicarboxylic acid. The invention also relates to a process for producing a dicarboxylic acid, which method comprises fermenting said recombinant host cell in a suitable fermentation medium and producing the dicarboxylic acid.

5. 发明申请

US20190335764A1 LIPOLYTIC ENZYME VARIANTS 审中-公开
公开(公告)号：US20190335764A1
公开(公告)日：2019-11-07
申请号：US16471159
申请日：2017-12-19
申请人： DSM IP Assets B.V.
发明人： Rene Marcel DE JONG , Chantal CHRISTIS , Neil CARR
IPC分类号： A21D8/04 , C12N9/20 , C12N15/52
摘要： The present disclosure describes a variant polypeptide having lipolytic activity, wherein the variant has an amino acid sequence which, when aligned with the amino acid sequence as set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue at a position corresponding to any of the positions 53, 112, 141, 178, 179, 182, 202, 203, 235, 282, 284,said positions being defined with reference to SEQ ID NO: 2, and wherein said variant has at least 70% identity with the mature polypeptide having lipolytic activity as set out in SEQ ID NO: 2.Such a variant polypeptide may be used in the preparation of a baked product.

6. 发明申请

US20190185830A1 MUTANT LIPASE AND USE THEREOF 审中-公开
公开(公告)号：US20190185830A1
公开(公告)日：2019-06-20
申请号：US16305348
申请日：2017-06-08
申请人： DSM IP Assets B.V.
发明人： Rene Marcel DE JONG , Willem BIJLEVELD , Evert Tjeerd VAN RIJ
IPC分类号： C12N9/20 , A23C13/16 , A23C15/12 , A23C19/06 , A23C19/082
CPC分类号： C12N9/20 , A23C13/16 , A23C15/123 , A23C19/063 , A23C19/082 , C12Y301/01003
摘要： The present invention relates to a polypeptide having lipase activity wherein the polypeptide, which, when aligned with a polypeptide according to SEQ ID NO: 1, comprises at least one amino acid substitution resulting in Ser (S), Ala (A) or Leu (L) at position 246, Trp (W) at position 307, Leu (L) at position 345, Ile (I) at position 365, and/or Phe (F) at position 534, wherein the position is defined with reference to SEQ ID NO: 1, wherein Ala(A) at position 1 in SEQ ID NO: 1 is counted as number 1 and a method for preparing the polypeptide.The present invention further relates to a process for preparing a food product wherein a polypeptide according to the present invention is used.

7. 发明申请

US20190203234A1 CELLS WITH IMPROVED PENTOSE CONVERSION 审中-公开
公开(公告)号：US20190203234A1
公开(公告)日：2019-07-04
申请号：US16352415
申请日：2019-03-13
申请人： DSM IP ASSETS B.V.
发明人： Maria Bernedina Elizabeth JONKERS , Paul KLAASSEN , Aloysius Wilhelmus Rudolph Hubertus TEUNISSEN , Rene Marcel DE JONG
IPC分类号： C12P7/10 , C12N1/22
CPC分类号： C12P7/10 , C12N1/22 , C12N2330/50 , C12Y501/03004 , C12Y503/01005 , C12Y503/01006
摘要： The invention relates to a cell capable of converting one or more pentose sugar and one or more hexose sugar into fermentation product constitutively expressing one or more heterologous or homologous polypeptide having the amino acid sequence set out in SEQ ID NO: 20, or a variant polypeptide thereof having at least 45% identity to SEQ ID NO 20. In an embodiment the heterologous polypeptide has glyoxalase activity.

8. 发明申请

US20180245059A1 CARBOHYDRATE DEGRADING POLYPEPTIDE AND USES THEREOF 审中-公开
公开(公告)号：US20180245059A1
公开(公告)日：2018-08-30
申请号：US15962058
申请日：2018-04-25
申请人： DSM IP ASSETS B.V.
发明人： Alrik Pieter LOS , Rene Marcel DE JONG , Maaike APPELDOORN
IPC分类号： C12N9/24 , C12P19/14 , C12P19/02 , C12P19/12
CPC分类号： C12N9/2402 , C12P19/02 , C12P19/12 , C12P19/14 , C12Y302/01
摘要： The invention relates to a polypeptide having hemicellulase activity. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional protein and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.

9. 发明申请

US20140248397A1 ALPHA-AMYLASE VARIANTS 有权
公开(公告)号：US20140248397A1
公开(公告)日：2014-09-04
申请号：US13842344
申请日：2013-03-15
申请人： DSM IP ASSETS B.V.
发明人： Rene Marcel DE JONG , Hanna Elisabet ABBAS
IPC分类号： A21D8/04 , C12N9/28
CPC分类号： A21D8/042 , C12N9/2417 , C12Y302/01001
摘要： A variant polypeptide having alpha-amylase activity, wherein the variant has an amino acid sequence which, when aligned with the alpha-amylase comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 4, 6, 13, 14, 15, 16, 20, 45, 47, 51, 54, 61, 68, 69, 70, 71, 72, 73, 74, 75, 77, 78, 80, 82, 87, 88, 94, 95, 100, 103, 104, 117, 124, 125, 126, 128, 130, 133, 134, 136, 143, 144, 146, 168, 174, 177, 178, 183, 186, 188, 189, 190, 194, 195, 199, 200, 201, 204, 207, 210, 214, 217, 219, 222, 225, 227, 233, 234, 235, 236, 240, 251, 252, 254, 258, 259, 260, 261, 262, 263, 264, 266, 267, 269, 271, 273, 281, 282, 283, 284, 286, 288, 299, 322, 323, 325, 327, 328, 331, 334, 350, 356, 358, 367, 370, 371, 374, 377, 378, 388, 391, 414, 421, 422, 445, 450, 467, 488, 505, 536, 548, 583, 588, 603, 637, 648, 651, 652, 660, 676, 677,said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having alpha-amylase activity. Such a variant polypeptide may be used in the preparation of a baked product.
摘要翻译：具有α-淀粉酶活性的变体多肽，其中所述变体具有当与包含SEQ ID NO：2所示的序列的α-淀粉酶比对时的氨基酸序列包含至少一个对应于任何氨基酸4,6,13,14,15,16,20,45,47,51,54,61,68,69,70,71,72,73,74,75,77,78,80， 82,87,88,94,95,100,103,104,117,124,125,126,128,130,133,134,136,143,144,146,168,174,177,178,183， 186,188,189,190,194,195,199,200,2201,204,207,210,214,217,219,222,225,227,233,234,235,236,240,251,252,252,218,218,218,218,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,2 254,258,258,260,261,262,263,264,266,262,263,264,266,276,263,264,266,276,263,267,271,273,281,282,283,284,286,288,29,322,236,265,276,262,263,264,266,262,263,264,266,266,263,264,266,266,263,264,266,266,263,264,266,266,263,264,266,266,263,264,266,266,263 331,334,350,356,358,367,370,371,374,377,378,388,391,414,421,422,445,450,467,488,505,536,548,583,558,538,348,336,350,356,358,367,350,356,358,367,370,356,358,367,370,356,358,367,375,356,358,367,370,356,358,367,370,356,358,367,375,356,358,367,375,356,358 603,637,648,651,652,660,676,677，所述位置参考SEQ ID NO：2定义，其中变体ha 与具有α-淀粉酶活性的参考多肽相比，具有一个或多个改变的特性。这样的变体多肽可用于制备焙烤产品。

10. 发明申请

US20180134986A1 PHOSPHOLIPASE C 审中-公开
公开(公告)号：US20180134986A1
公开(公告)日：2018-05-17
申请号：US15564275
申请日：2016-04-08
申请人： DSM IP ASSETS B.V.
发明人： Arjen SEIN , Rene Marcel DE JONG , Evert Tjeerd VAN RIJ , Willem BIJLEVELD , Maarten Hotse WILBRINK
IPC分类号： C11B3/00 , C12N9/16 , C12P7/64
CPC分类号： C11B3/003 , C12N9/16 , C12P7/20 , C12P7/64 , C12P7/6445 , C12Y301/04003
摘要： The present invention relates to a polypeptide having phospholipase C activity, selected from the group consisting of i. a polypeptide comprising a mature polypeptide sequence of SEQ ID NO: 2; ii. a polypeptide that has least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to the mature polypeptide sequence of SEQ ID NO: 2; iii. a polypeptide encoded by a nucleic acid that hybridizes under medium stringency, preferably under high stringency conditions to the complementary strand of the mature polypeptide coding sequence of SEQ ID NO:1; iv. a polypeptide encoded by a nucleic acid that has at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identity to the mature polypeptide coding sequence of SEQ ID NO: 1. A process for degumming a vegetable oil comprising contacting a vegetable oil comprising phospholipids with a polypeptide having phospholipase C activity of the invention or a composition of the invention, wherein phospholipids are hydrolysed into diacylglycerol and phosphate ester and/or phosphate, separating the phosphate ester and/or phosphate from the vegetable oil wherein a degummed vegetable oil is obtained.

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