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    • 1. 发明授权
    • Pharmacologically active amino-ethyl oximes
    • 药理学活性氨基乙氧基
    • US3692835A
    • 1972-09-19
    • US3692835D
    • 1968-03-25
    • DIJK JAN VANJENKIN ERIC DAVIES
    • DIJK JAN VANDAVIES JENKIN ERIC
    • A61K31/00C07C271/16C07D20060101C07D215/12C07D317/58C07D319/18C07D327/08C07C131/00
    • C07C271/16C07C2603/18C07D215/12C07D317/58C07D319/18C07D327/08
    • Certain substituted amino-ethyl oximes such as 0-(2-aminoethyl)-4''-methoxy acetophenone oxime and 0-2(amino-ethyl)2''chlorohexano-phenone oxime have been found to exhibit antidepressive activity. The invention relates to new compounds of formula I and salts thereof with pharmaceutically acceptable acids, in which formula all the substituents may be hydrogen, while R1 and R2 may furthermore be a methyl group, R3 an alkyl group, an alkoxy-alkylene group, an alkylthioalkylene group, an alkylsulphoxyalkylene group or an alkylsulphonalkylene group having up to eight carbon atoms or a benzyl group, and R4, R5 and R6 a halogen atom, an alkyl group, an alkoxy group or an alkylthio group having up to six carbon atoms, a benzyloxy group, -OH, -NH2, a mono- or dialkylamino group, in which the alkyl group(s) contain(s) one or two carbon atoms, -CN or -CF3, and two of the substitutents R4, R5 and R6 may each represent a metanitro group or together a trimethylene group, a tetramethylene group, a methylene dioxy group, an ethylene dioxy group, a benzo group, a pyridino group, an indeno-1,2-, a 1,4-benzthiazino-2,3 group or a 1,4-benzoxthino-2,3 group, with the exception of the HCl salt of the compound in which R5 and R6 each represent an orthochlorine atom and R1, R2, R3 and R4 each represent hydrogen.
    • 已经发现某些取代的氨基乙基肟如O-(2-氨基 - 乙基)-4'-甲氧基苯乙酮肟和0-2(氨基 - 乙基)-2'-氯代己酮肟表现出抗抑郁活性。