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1. 发明授权

US10172659B2 Bone treatment systems and methods 有权
公开(公告)号：US10172659B2
公开(公告)日：2019-01-08
申请号：US15477678
申请日：2017-04-03
申请人： DFINE, Inc.
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B17/88 , A61B17/00 , A61F2/44 , A61B17/70 , A61B17/56
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the flow of bone cement into the interior of a vertebra and the application of forces causes by the cement flow. An exemplary system utilizes Rf energy in combination a conductive bone cement for selectively polymerizing the inflow plume to increase the viscosity of the cement. In one aspect of the invention, the system utilizes a controller to control bone cement flow parameters to either allow or disallow cement interdigitation into cancellous bone. A method of the invention includes pulsing the flows of bone cement wherein high acceleration of the flow pulses can apply expansion forces across the surface of the cement plume to reduce a vertebral fracture.

2. 发明授权

US10136934B2 Bone treatment systems and methods 有权
公开(公告)号：US10136934B2
公开(公告)日：2018-11-27
申请号：US14741864
申请日：2015-06-17
申请人： DFINE, INC.
发明人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/88 , A61B17/00 , A61B90/00
摘要： Systems and methods for treating vertebral compression fractures are discussed. In an embodiment, a method includes mixing bone cement precursors thereby causing a first chemical curing reaction characterized by a first time-viscosity profile, controllably applying energy to the bone cement from an external source to modify the first time-viscosity profile to a second time-viscosity profile, and injecting the cement into bone at a substantially constant viscosity greater than about 1000 Pa·s to greater than about 5000 Pa·s over an extended working time. In another embodiment, a bone cement injector system is provided that includes a first handle component that is detachably coupled to a second sleeve component having a distal end for positioning in bone and a flow channel extending through the first and second components. The system includes first and second thermal energy emitters for delivering energy to bone cement flows in a flow channel portion in the first and second components, respectively.

3. 发明申请

US20170333103A1 BONE TREATMENT SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20170333103A1
公开(公告)日：2017-11-23
申请号：US15477678
申请日：2017-04-03
申请人： DFINE, Inc.
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B17/88 , A61F2/44 , A61B17/56 , A61B17/00 , A61B17/70
CPC分类号： A61B17/8805 , A61B17/70 , A61B17/8822 , A61B17/8827 , A61B17/8836 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61B2017/564 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the flow of bone cement into the interior of a vertebra and the application of forces causes by the cement flow. An exemplary system utilizes Rf energy in combination a conductive bone cement for selectively polymerizing the inflow plume to increase the viscosity of the cement. In one aspect of the invention, the system utilizes a controller to control bone cement flow parameters to either allow or disallow cement interdigitation into cancellous bone. A method of the invention includes pulsing the flows of bone cement wherein high acceleration of the flow pulses can apply expansion forces across the surface of the cement plume to reduce a vertebral fracture.

4. 发明授权

US09610110B2 Bone treatment systems and methods 有权
公开(公告)号：US09610110B2
公开(公告)日：2017-04-04
申请号：US14683506
申请日：2015-04-10
申请人： DFINE, Inc.
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61F2/44 , A61B17/88 , A61B17/00 , A61B17/70 , A61B17/56
CPC分类号： A61B17/8805 , A61B17/70 , A61B17/8822 , A61B17/8827 , A61B17/8836 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61B2017/564 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the flow of bone cement into the interior of a vertebra and the application of forces causes by the cement flow. An exemplary system utilizes Rf energy in combination a conductive bone cement for selectively polymerizing the inflow plume to increase the viscosity of the cement. In one aspect of the invention, the system utilizes a controller to control bone cement flow parameters to either allow or disallow cement interdigitation into cancellous bone. A method of the invention includes pulsing the flows of bone cement wherein high acceleration of the flow pulses can apply expansion forces across the surface of the cement plume to reduce a vertebral fracture.

5. 发明授权

US09572613B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US09572613B2
公开(公告)日：2017-02-21
申请号：US14886633
申请日：2015-10-19
申请人： DFINE, INC.
发明人： Csaba Truckai , John Shadduck
IPC分类号： A61B17/58 , A61B17/60 , A61F2/00 , A61B17/88
CPC分类号： A61B17/8822 , A61B17/88 , A61B17/8805 , A61B17/8811 , A61B17/8816 , A61B17/8836
摘要： Systems and methods for treating bone, such as vertebral compression fractures are disclosed. A method includes controllably applying energy to a bone cement volume outside of a patient's body to selectively accelerate the polymerization rate of the bone fill material volume prior to introduction into a bone. The method further includes sequentially introducing a plurality of cement carrying structures with the accelerated polymerization rate bone cement volume into the bone. A system for use in the method includes at least one elongated cement-carrying structure sized to carry a bone cement volume therein and an energy source operatively coupleable to the cement-carrying structure. The energy source applies energy to the bone cement volume to selectively accelerate a polymerization rate thereof. An elongated injector insertable into the bone has a passageway that removably receives the elongated cement-carrying structure to allow delivery of the accelerated polymerization rate bone cement into the bone.
摘要翻译：公开了用于治疗骨骼的系统和方法，例如椎体压缩性骨折。一种方法包括可控制地将能量施加到患者体外的骨水泥体积，以在引入骨之前选择性地加速骨填充材料体积的聚合速率。该方法还包括将具有加速的聚合速率骨水泥体积的多个水泥承载结构依次引入骨中。用于该方法的系统包括至少一个尺寸适于承载骨水泥体积的细长的水泥承载结构和能够与水泥承载结构连接的能量源。能量源将能量施加到骨水泥体积以选择性地加速其聚合速率。可插入骨头的细长的注射器具有可移除地容纳细长的粘结剂承载结构以允许将加速的聚合速率骨水泥输送到骨中的通道。

6. 发明授权

US09161797B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US09161797B2
公开(公告)日：2015-10-20
申请号：US14304300
申请日：2014-06-13
申请人： DFINE, INC.
发明人： Csaba Truckai , John Shadduck
IPC分类号： A61B17/58 , A61B17/60 , A61F2/00 , A61B17/88
CPC分类号： A61B17/8822 , A61B17/88 , A61B17/8805 , A61B17/8811 , A61B17/8816 , A61B17/8836
摘要： Systems and methods for treating bone, such as vertebral compression fractures are disclosed. A method includes controllably applying energy to a bone cement volume outside of a patient's body to selectively accelerate the polymerization rate of the bone fill material volume prior to introduction into a bone. The method further includes sequentially introducing a plurality of cement carrying structures with the accelerated polymerization rate bone cement volume into the bone. A system for use in the method includes at least one elongated cement-carrying structure sized to carry a bone cement volume therein and an energy source operatively coupleable to the cement-carrying structure. The energy source applies energy to the bone cement volume to selectively accelerate a polymerization rate thereof. An elongated injector insertable into the bone has a passageway that removably receives the elongated cement-carrying structure to allow delivery of the accelerated polymerization rate bone cement into the bone.
摘要翻译：公开了用于治疗骨骼的系统和方法，例如椎体压缩性骨折。一种方法包括可控制地将能量施加到患者体外的骨水泥体积，以在引入骨之前选择性地加速骨填充材料体积的聚合速率。该方法还包括将具有加速的聚合速率骨水泥体积的多个水泥承载结构依次引入骨中。用于该方法的系统包括至少一个尺寸适于承载骨水泥体积的细长的水泥承载结构和能够与水泥承载结构连接的能量源。能量源将能量施加到骨水泥体积以选择性地加速其聚合速率。可插入骨头的细长的注射器具有可移除地容纳细长的粘结剂承载结构以允许将加速的聚合速率骨水泥输送到骨中的通道。

7. 发明申请

US20150282852A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20150282852A1
公开(公告)日：2015-10-08
申请号：US14683506
申请日：2015-04-10
申请人： DFINE, Inc.
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B17/88
CPC分类号： A61B17/8805 , A61B17/70 , A61B17/8822 , A61B17/8827 , A61B17/8836 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61B2017/564 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the flow of bone cement into the interior of a vertebra and the application of forces causes by the cement flow. An exemplary system utilizes Rf energy in combination a conductive bone cement for selectively polymerizing the inflow plume to increase the viscosity of the cement. In one aspect of the invention, the system utilizes a controller to control bone cement flow parameters to either allow or disallow cement interdigitation into cancellous bone. A method of the invention includes pulsing the flows of bone cement wherein high acceleration of the flow pulses can apply expansion forces across the surface of the cement plume to reduce a vertebral fracture.
摘要翻译：本发明在某些实施例中涉及用于治疗脊椎压缩性骨折的医疗装置。更具体地，本发明的实施例涉及通过控制骨水泥进入椎骨内部并且由水泥流引起的力的施加来可控地恢复椎体高度的仪器和方法。一个示例性系统利用Rf能量组合导电骨水泥，用于选择性聚合流入羽流以增加水泥的粘度。在本发明的一个方面，该系统利用控制器来控制骨水泥流动参数以允许或不允许水泥交叉指向松质骨。本发明的方法包括脉动骨粘固剂的流动，其中流动脉冲的高加速度可以施加穿过水泥羽流表面的膨胀力，以减少椎骨骨折。

8. 发明申请

US20140371734A1 POLYMER COMPOSITES FOR BIOMEDICAL APPLICATIONS AND METHODS OF MAKING 有权
标题翻译：用于生物医学应用的聚合物复合材料及其制备方法
公开(公告)号：US20140371734A1
公开(公告)日：2014-12-18
申请号：US14309248
申请日：2014-06-19
申请人： DFINE, INC.
发明人： Csaba Truckai
IPC分类号： A61B17/12 , A61B18/04
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12045 , A61B17/12118 , A61B17/12136 , A61B17/1214 , A61B17/12168 , A61B17/12181 , A61B17/12186 , A61B18/04 , A61B2017/12068 , A61B2017/12072 , A61B2018/00416 , A61B2018/00589 , D04H1/42 , Y10T428/249924
摘要： A biomedical polymer composite that exhibits ultra-low thermal conductivity properties. In a preferred embodiment, the biomedical polymer composite comprises a base polymer component with a dispersed thermally non-conductive filler component consisting of glass or ceramic nanospheres or microspheres that have a thermal conductivity of less than 5 W/m-K, and preferably less than 2 W/m-K. In one embodiment, the polymer composite has an electrically conductive filler and can be used in a filament for treating arteriovascular malformations. In another embodiment, the polymeric composite can be used as an energy-coupling means to apply energy to tissue.
摘要翻译：具有超低导热性能的生物医学聚合物复合材料。在优选实施方案中，生物医学聚合物复合物包含具有分散的热不导电填料组分的基础聚合物组分，其由玻璃或陶瓷纳米球或微球组成，其热导率小于5W / mK，优选小于2W / mK。在一个实施方案中，聚合物复合材料具有导电填料并可用于治疗动脉血管畸形的细丝。在另一个实施方案中，聚合物复合材料可用作将能量施加到组织的能量耦合装置。

9. 发明授权

US11672579B2 Bone treatment systems and methods 有权
公开(公告)号：US11672579B2
公开(公告)日：2023-06-13
申请号：US16200176
申请日：2018-11-26
申请人： DFINE, INC.
发明人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/88 , A61B17/00 , A61B90/00
CPC分类号： A61B17/8836 , A61B17/8816 , A61B17/8822 , A61B2017/00022 , A61B2017/00411 , A61B2017/00955 , A61B2017/8844 , A61B2090/064
摘要： Systems and methods for treating vertebral compression fractures are discussed. In an embodiment, a method includes mixing bone cement precursors thereby causing a first chemical curing reaction characterized by a first time-viscosity profile, controllably applying energy to the bone cement from an external source to modify the first time-viscosity profile to a second time-viscosity profile, and injecting the cement into bone at a substantially constant viscosity greater than about 1000 Pa·s to greater than about 5000 Pa·s over an extended working time. In another embodiment, a bone cement injector system is provided that includes a first handle component that is detachably coupled to a second sleeve component having a distal end for positioning in bone and a flow channel extending through the first and second components. The system includes first and second thermal energy emitters for delivering energy to bone cement flows in a flow channel portion in the first and second components, respectively.

10. 发明申请

US20190167328A1 BONE TREATMENT SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20190167328A1
公开(公告)日：2019-06-06
申请号：US16200176
申请日：2018-11-26
申请人： DFINE, INC.
发明人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/88
摘要： Systems and methods for treating vertebral compression fractures are discussed. In an embodiment, a method includes mixing bone cement precursors thereby causing a first chemical curing reaction characterized by a first time-viscosity profile, controllably applying energy to the bone cement from an external source to modify the first time-viscosity profile to a second time-viscosity profile, and injecting the cement into bone at a substantially constant viscosity greater than about 1000 Pa·s to greater than about 5000 Pa·s over an extended working time. In another embodiment, a bone cement injector system is provided that includes a first handle component that is detachably coupled to a second sleeve component having a distal end for positioning in bone and a flow channel extending through the first and second components. The system includes first and second thermal energy emitters for delivering energy to bone cement flows in a flow channel portion in the first and second components, respectively.

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