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1. 发明申请

US20080019929A1 Micro-Particulate Organic Uv Absorber Composition 审中-公开
标题翻译：微粒有机Uv吸收剂组合物
公开(公告)号：US20080019929A1
公开(公告)日：2008-01-24
申请号：US11661173
申请日：2005-08-29
申请人： Cyrille Deshayes , Sebastien Mongiat
发明人： Cyrille Deshayes , Sebastien Mongiat
IPC分类号： A61K8/00 , A61Q17/00
CPC分类号： A61K8/342 , A61Q17/04
摘要： Disclosed is a topically applicable water-in-oil (w/o) or water-in-silicone (w/Si) formulation comprising: (a) at least one aqueous phase; (b) at least one fatty phase; (c) an effective UV-photoprotecting composition comprising (c1) 20% to 99% of at least one insoluble micronized organic UV-screening active with a mean particle size ranging from 0.01 μm to 2 μm; and (c2) 0.5% to 80% of at least one primary C6-C28 fatty alcohol. The combination of a micronized organic UV absorber and a specific fatty alcohol allows a maximum of miscibility of micronized organic particles within the continuous oil phase of w/o emulsion wherein the micronized particles are stabilized in the oil phase of the composition. Simultaneously the crystal growth of micronized organic UV absorbers within W/O emulsions is limited or even eliminated.
摘要翻译：公开了一种局部适用的油包水（w / o）或水包硅（w / Si）制剂，其包含：（a）至少一种水相; （b）至少一个脂肪相; （c）有效的UV光保护组合物，其包含20％至99％的至少一种平均粒径为0.01μm至2μm的不溶性微粉化有机UV-筛选活性物质的（c-1）和（c 2/2）0.5％至80％的至少一种C 6 -C 28脂肪醇。微粉化有机UV吸收剂和特定脂肪醇的组合允许在w / o乳液的连续油相中的微粉化有机颗粒的最大混溶性，其中微粉化颗粒在组合物的油相中稳定。同时，W / O乳液中微粉化有机UV吸收剂的晶体生长受到限制或甚至消除。

2. 发明申请

US20100143274A1 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS 审中-公开
标题翻译：用于有机微波紫外线吸收剂稳定化的氨基和氨基
公开(公告)号：US20100143274A1
公开(公告)日：2010-06-10
申请号：US12529573
申请日：2008-02-27
申请人： Cyrille Deshayes , Thomas Ehlis , Julie Grumelard
发明人： Cyrille Deshayes , Thomas Ehlis , Julie Grumelard
IPC分类号： A61K8/35 , A61Q17/04
CPC分类号： A61K8/41 , A61K8/35 , A61K8/494 , A61K2800/52 , A61Q17/04
摘要： Disclosed is the use of amines and amides for the stabilization of a cosmetic composition comprising: (a) an organic micronized UV absorber selected from a benzophenone derivative and (b) a dibenzoylmethane derivative. The use of the amines and amides results in the stabilization of the end-product formulations.
摘要翻译：公开了胺和酰胺用于稳定化妆品组合物的用途，包括：（a）选自二苯甲酮衍生物和（b）二苯甲酰甲烷衍生物的有机微粉化UV吸收剂。使用胺和酰胺导致最终产品配方的稳定化。

3. 发明申请

US20100144753A1 CRYSTAL MODIFICATIONS OF TRANSMISSION DYES 有权
标题翻译：传染性染色体的晶体修饰
公开(公告)号：US20100144753A1
公开(公告)日：2010-06-10
申请号：US12597930
申请日：2008-04-28
申请人： Martin Vogt , Stefan Müller , Julie Grumelard , Cyrille Deshayes , Holger Paul , Jürg Haase , Thomas Ehlis
发明人： Martin Vogt , Stefan Müller , Julie Grumelard , Cyrille Deshayes , Holger Paul , Jürg Haase , Thomas Ehlis
IPC分类号： A61K31/4965
CPC分类号： C07D295/192 , A61K8/04 , A61K8/494 , A61K31/495 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.
摘要翻译：公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰在X-射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

4. 发明授权

US08557820B2 Crystal modifications of transmission dyes 有权
标题翻译：透射染料的水晶修饰
公开(公告)号：US08557820B2
公开(公告)日：2013-10-15
申请号：US12597930
申请日：2008-04-28
申请人： Martin Vogt , Stefan Müller , Julie Grumelard , Cyrille Deshayes , Holger Paul , Jürg Haase , Thomas Ehlis
发明人： Martin Vogt , Stefan Müller , Julie Grumelard , Cyrille Deshayes , Holger Paul , Jürg Haase , Thomas Ehlis
IPC分类号： A61K31/497 , A61K8/00 , C07D241/04 , C07D295/00 , A61Q17/04
CPC分类号： C07D295/192 , A61K8/04 , A61K8/494 , A61K31/495 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.
摘要翻译：公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰在X-射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

5. 发明授权

US07101536B2 UV-protection formulations 有权
标题翻译：紫外线防护剂
公开(公告)号：US07101536B2
公开(公告)日：2006-09-05
申请号：US10452234
申请日：2003-05-30
申请人： Sébastien Mongiat , Cyrille Deshayes
发明人： Sébastien Mongiat , Cyrille Deshayes
IPC分类号： A61Q17/04 , A61Q17/00 , A61Q19/00 , A61K8/00 , A61K8/02
CPC分类号： A61K8/4913 , A61K2800/52 , A61Q17/04
摘要： The present invention relates to new UV-protection formulations with improved stability in respect to crystallisation, characterized in that a compound of formula (1) or a mixture thereof wherein R1 is substituted or unsubstituted C6–C12alkyl, R2, R3 and R4 are independently from each other hydrogen; substituted or unsubstituted C1–C4alkyl, preferably hydrogen; unsubstituted C1–C2alkyl or substituted C1–C2alkyl, more preferably hydrogen. is added to the UV-protection formulation.
摘要翻译：本发明涉及在结晶方面具有改进的稳定性的新的UV保护制剂，其特征在于式（1）化合物或其混合物，其中R 1是取代或未取代的C 1 -C 6烷基， C 1 -C 12烷基，R 2，R 3和R 4各自独立地为每个其他氢; 取代或未取代的C 1 -C 4烷基，优选氢; 未取代的C 1 -C 2烷基或取代的C 1 -C 2烷基，更优选氢。加入到UV保护制剂中。

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