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1. 发明申请

US20060221267A1 Projection display using dedicated color pixels 审中-公开
标题翻译：使用专用彩色像素的投影显示
公开(公告)号：US20060221267A1
公开(公告)日：2006-10-05
申请号：US11092648
申请日：2005-03-29
申请人： Cynthia Bell , Thomas Willis , Paul Winer , Anders Grunnet-Jepsen
发明人： Cynthia Bell , Thomas Willis , Paul Winer , Anders Grunnet-Jepsen
IPC分类号： G02F1/1335
CPC分类号： G02F1/133514 , G02F1/136277 , H04N9/3108
摘要： A projection display system may use a microdisplay that has pixels that are dedicated to only one narrow wavelength band. A suitable optical filter for each primary display color may be formed from a small number of optical layers, taking advantage of both the rounded profile and narrow range of the emission peaks in a typical projection light source. Thus, groups of pixels may be dedicated to each wavelength band of the display. A planarization layer may be coated on dichroic filter elements that are applied to a cover glass to provide the dedicated wavelengths for each pixel. The planarization layer may smooth out any surface irregularities resulting from the deposition of the dichroic layers on the cover glass.
摘要翻译：投影显示系统可以使用具有专用于仅一个窄波长带的像素的微显示器。通过利用典型投影光源中的发光峰值的圆形轮廓和窄范围的优点，可以从少量的光学层形成用于每个主要显示颜色的合适的滤光器。因此，像素组可以专用于显示器的每个波长带。平面化层可以涂覆在施加到盖玻璃上以提供每个像素的专用波长的二向色滤光器元件上。平坦化层可以平滑由于覆盖玻璃上二色性层的沉积而导致的任何表面凹凸。

2. 发明申请

US20130005584A1 METHODS OF MONITORING CONDITIONS BY SEQUENCE ANALYSIS 有权
标题翻译：通过序列分析监测条件的方法
公开(公告)号：US20130005584A1
公开(公告)日：2013-01-03
申请号：US13459701
申请日：2012-04-30
申请人： Malek Faham , Thomas Willis
发明人： Malek Faham , Thomas Willis
IPC分类号： C40B20/00
CPC分类号： C12Q1/6886 , C12N15/1072 , C12Q1/6809 , C12Q1/6827 , C12Q1/6869 , C12Q1/6881 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y02A90/26
摘要： There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer. Provided herein are methods for using DNA sequencing to identify personalized biomarkers in patients with autoimmune disease and other conditions. Identified biomarkers can be used to determine the disease state for a subject with an autoimmune disease or other condition.
摘要翻译：需要改进的方法来确定包括自身免疫性疾病和癌症在内的患者的诊断和预后。本文提供了使用DNA测序鉴定患有自身免疫疾病和其他病症的个体化生物标志物的方法。识别的生物标志物可用于确定具有自身免疫疾病或其他病症的受试者的疾病状态。

3. 发明申请

US20110207617A1 SINGLE CELL ANALYSIS BY POLYMERASE CYCLING ASSEMBLY 有权
标题翻译：通过聚合物循环组装进行单细胞分析
公开(公告)号：US20110207617A1
公开(公告)日：2011-08-25
申请号：US13100395
申请日：2011-05-04
申请人： Malek Faham , Thomas Willis
发明人： Malek Faham , Thomas Willis
IPC分类号： C40B30/00
CPC分类号： C12Q1/6886 , C12N15/1072 , C12Q1/6809 , C12Q1/6827 , C12Q1/6869 , C12Q1/6881 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y02A90/26
摘要： The invention provides a method of making measurements on individual cells of a population, particularly cells that have identifying nucleic acid sequences, such as lymphoid cells. In one aspect, the invention provides a method of making multiparameter measurements on individual cells of such a population by carrying out a polymerase cycling assembly (PCA) reaction to link their identifying nucleic acid sequences to other cellular nucleic acids of interest. The fusion products of such PCA reaction are then sequenced and tabulated to generate multiparameter data for cells of the population.
摘要翻译：本发明提供了对群体的单个细胞进行测量的方法，特别是具有鉴定核酸序列的细胞，例如淋巴样细胞。一方面，本发明提供了一种通过进行聚合酶循环组件（PCA）反应以将其鉴定的核酸序列与感兴趣的其它细胞核酸连接的方法来对这样的群体的个体细胞进行多参数测量。然后对这种PCA反应的融合产物进行测序并列表，以产生群体细胞的多参数数据。

4. 发明申请

US20060158405A1 Progressive data delivery to spatial light modulators 有权
标题翻译：逐行数据传输到空间光调制器
公开(公告)号：US20060158405A1
公开(公告)日：2006-07-20
申请号：US11037619
申请日：2005-01-18
申请人： Thomas Willis
发明人： Thomas Willis
IPC分类号： G09G3/34
CPC分类号： G09G3/2037 , G09G2310/0235 , H04N9/3114 , H04N9/3123
摘要： In a spatial light modulator, a frame may be broken up into a plurality of colors. A given frame may include at least a first portion and a second portion. During the first portion of the frame, more significant bits of the data for a given pixel may be displayed and during a second portion of the frame, less significant bits may be disclosed. In some embodiments, the frame may be broken into two color subframes for each color, but in other embodiments, more than two such subframes may be utilized. In one embodiment, the frame may be broken into red, blue, and green and each color may be displayed at least twice, such that more significant bits are displayed first and less significant bits are displayed thereafter.
摘要翻译：在空间光调制器中，帧可以被分解为多种颜色。给定的框架可以包括至少第一部分和第二部分。在帧的第一部分期间，可以显示给定像素的数据的更高有效位，并且在帧的第二部分期间，可以公开较不重要的位。在一些实施例中，对于每种颜色，帧可以被分成两个颜色的子帧，但是在其他实施例中，可以利用多于两个这样的子帧。在一个实施例中，帧可以被分成红色，蓝色和绿色，并且每个颜色可以显示至少两次，使得首先显示更高有效位，此后显示较低有效位。

5. 发明申请

US20060101227A1 Method and apparatus for sharing TLB entries 有权
公开(公告)号：US20060101227A1
公开(公告)日：2006-05-11
申请号：US11316788
申请日：2005-12-22
申请人： Thomas Willis , Achmed Zahir
发明人： Thomas Willis , Achmed Zahir
IPC分类号： G06F12/10
CPC分类号： G06F12/1027
摘要： A sharing mechanism is herein disclosed for multiple logical processors using a translation lookaside buffer (TLB) to translate virtual addresses, for example into physical addresses. The mechanism supports sharing of TLB entries among logical processors, which may access address spaces in common. The mechanism further supports private TLB entries among logical processors, which for example, may each access a different physical address through identical virtual addresses. The sharing mechanism provides for installation and updating of TLB entries as private entries or as shared entries transparently, without requiring special operating system support or modifications. Through use of the disclosed sharing mechanism, fast and efficient virtual address translation is provided without requiring more expensive functional redundancy.

6. 发明申请

US20060061581A1 Sparse refresh of display 有权
公开(公告)号：US20060061581A1
公开(公告)日：2006-03-23
申请号：US11273001
申请日：2005-11-14
申请人： Thomas Willis , Steven Midford
发明人： Thomas Willis , Steven Midford
IPC分类号： G09G5/36
CPC分类号： G09G5/395 , G09G2320/103 , G09G2330/022
摘要： A method, apparatus, and signal-bearing medium for sending to a display device modified regions of a frame buffer. A frame buffer is divided into the regions, and data in the frame buffer represents pixels on the display device. The frame buffer accumulates writes until the region being written to changes, at which time the region is copied to the display device.

7. 发明申请

US20050195208A1 Sparse refresh of display 有权
公开(公告)号：US20050195208A1
公开(公告)日：2005-09-08
申请号：US11119664
申请日：2005-05-02
申请人： Thomas Willis , Steven Midford
发明人： Thomas Willis , Steven Midford
IPC分类号： G06F12/10 , G09G5/36 , G09G5/37
CPC分类号： G06F12/1027 , G06F12/1081 , G09G5/36 , Y02D10/13
摘要： A method, apparatus, and signal-bearing medium for sending to a display device only those regions of the display screen that change. A frame buffer is divided into tiles, which may be composed of one or more regions, and data in the frame buffer represents pixels on the display screen. When data representing a pixel is modified in the frame buffer, the region or tile associated with the pixel is marked as dirty, and those tiles or regions that are dirty in the frame buffer are written to the display.

8. 发明授权

US10385475B2 Random array sequencing of low-complexity libraries 有权
公开(公告)号：US10385475B2
公开(公告)日：2019-08-20
申请号：US13596581
申请日：2012-08-28
申请人： Jianbiao Zheng , Thomas Willis , Malek Faham
发明人： Jianbiao Zheng , Thomas Willis , Malek Faham
IPC分类号： C40B20/00 , C12Q1/6874 , C40B50/14
摘要： The invention is directed to a method of sequencing low-complexity amplicons randomly arrayed at high density on a surface. Methods of the invention include preparing amplicons for sequencing by a sets of primers that ensure initial signals front different amplicons on the surface will be evenly distributed among the different nucleotides being added in a sequencing by synthesis operation.

9. 发明授权

US08771954B2 Methods of monitoring conditions by sequence analysis 有权
公开(公告)号：US08771954B2
公开(公告)日：2014-07-08
申请号：US13214111
申请日：2011-08-19
申请人： Malek Faham , Thomas Willis
发明人： Malek Faham , Thomas Willis
IPC分类号： C12Q1/68 , C12P19/34
摘要： There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer. Provided herein are methods for using DNA sequencing to identify personalized biomarkers in patients with autoimmune disease and other conditions. Identified biomarkers can be used to determine the disease state for a subject with an autoimmune disease or other condition.

10. 发明申请

US20130324422A1 DETECTING DISEASE-CORRELATED CLONOTYPES FROM FIXED SAMPLES 审中-公开
标题翻译：从固定样品中检测疾病相关的克隆
公开(公告)号：US20130324422A1
公开(公告)日：2013-12-05
申请号：US13487980
申请日：2012-06-04
申请人： Malek Faham , Thomas Willis
发明人： Malek Faham , Thomas Willis
IPC分类号： C40B20/04 , C12Q1/68
CPC分类号： C07K16/00
摘要： The invention is directed to a method for determining immunophenotypes of tissue-infiltrating lymphocytes in a solid tissue of a patient by (a) generating clonotype profiles from a sample of nucleic acid extracted from a fixed tissue sample from a solid tissue of the patient, where such tissue contains tissue-infiltrating lymphocytes; and (b) determining immunophenotypes of the tissue-infiltrating lymphocytes by (i) obtaining a sample of lymphocytes from peripheral blood of the patient; (ii) sorting the lymphocytes from peripheral blood into at least one subset based on different immunophenotypes of the lymphocytes; (iii) generating a clonotype profile for each of the at least one subset of lymphocytes; and (iv) determining immunophenotypes of lymphocytes in the fixed tissue sample by a correspondence between clonotypes of the fixed tissue sample and clonotypes of the at least one subset.
摘要翻译：本发明涉及一种用于通过（a）从来自患者的固体组织的固定组织样品提取的核酸样品产生克隆型谱的方法，用于确定患者的固体组织中组织浸润淋巴细胞的免疫表型，其中这种组织含有组织浸润淋巴细胞; （b）通过（i）从患者的外周血中获得淋巴细胞的样品来确定组织浸润淋巴细胞的免疫表型; （ii）基于淋巴细胞的不同免疫表型将淋巴细胞从外周血分离成至少一个亚组; （iii）产生淋巴细胞的至少一个子集中的每一个的克隆型谱; 和（iv）通过所述固定组织样品的克隆型与所述至少一个亚组的克隆型之间的对应关系确定所述固定组织样品中淋巴细胞的免疫表型。

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