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1. 发明申请

US20150164857A1 SEIZURE THERAPY 有权
标题翻译：抢救治疗
公开(公告)号：US20150164857A1
公开(公告)日：2015-06-18
申请号：US14405816
申请日：2013-06-12
申请人： Creighton University
发明人： Kristina A. Simeone , Timothy A. Simeone
IPC分类号： A61K31/355 , A61K31/19 , A61K31/375
CPC分类号： A61K31/355 , A61K31/19 , A61K31/375 , A61K2300/00
摘要： A method and a composition are utilized to affect mitochondrial functions on a seizure-genic brain region.
摘要翻译：利用方法和组合物来影响癫痫基因脑区域的线粒体功能。

2. 发明申请

US20160199364A1 SEIZURE TREATMENT COMPOSITIONS AND METHODS 审中-公开
标题翻译：筛选治疗组合物和方法
公开(公告)号：US20160199364A1
公开(公告)日：2016-07-14
申请号：US14994320
申请日：2016-01-13
申请人： Creighton University
发明人： Timothy A. Simeone , Kristina A. Simeone
IPC分类号： A61K31/4439 , A61K9/00 , A61K31/167
CPC分类号： A61K31/4439 , A23L33/10 , A23L33/30 , A61K9/0019 , A61K9/0053 , A61K31/167 , A61K31/7088
摘要： A composition, a method for administering an anti-seizure composition, and a method for treating a seizure are described. In an implementation, a composition comprises a peroxisome proliferator activated receptor gamma (PPARγ) antagonist that is administered to an individual, where the individual has been administered a ketogenic diet. In an implementation, a method for administering an anti-seizure composition comprises administering a ketogenic diet to an individual; and concurrently administering a therapeutically effective dose of a peroxisome proliferator activated receptor gamma (PPARγ) antagonist to the individual In an implementation, a method for treating a seizure comprises administering a therapeutically effective dose of a peroxisome proliferator activated receptor gamma (PPARγ) antagonist to an individual on a ketogenic diet and suffering from seizures.
摘要翻译：描述了一种组合物，一种用于施用抗癫痫发作组合物的方法和一种治疗癫痫发作的方法。在一个实施方案中，组合物包含向个体施用的过氧化物酶体增殖物激活受体γ（PPARγ）拮抗剂，其中个体已经施用了生酮饮食。在一个实施方案中，施用抗缉获组合物的方法包括向个体施用酮生成饮食; 并且同时向个体施用治疗有效剂量的过氧化物酶体增殖物激活受体γ（PPARγ）拮抗剂。在一个实施方案中，治疗癫痫发作的方法包括将治疗有效剂量的过氧化物酶体增殖物激活受体γ（PPARγ）拮抗剂施用于个人对致生物饮食和癫痫发作。

3. 发明授权

US09700541B2 Seizure therapy 有权
公开(公告)号：US09700541B2
公开(公告)日：2017-07-11
申请号：US14405816
申请日：2013-06-12
申请人： Creighton University
发明人： Kristina A. Simeone , Timothy A. Simeone
IPC分类号： A61K31/355 , A61K31/375 , A61K31/19
CPC分类号： A61K31/355 , A61K31/19 , A61K31/375 , A61K2300/00
摘要： A method and a composition are utilized to affect mitochondrial functions on a seizure-genic brain region. In one aspect, the disclosure comprises methods of treating seizures. Seizures are a transient symptom of abnormal excessive or synchronous neuronal activity in the brain. Seizures may manifest as a wild thrashing movement, a brief loss of awareness, an alteration in mental state, tonic or clonic movements, convulsions, a full body slump, and various other psychic symptoms such as déjà vu or jamais vu. Recurrent, unprovoked seizures are medically known as epilepsy. In one implementation, the method of treating a seizure includes administering a composition that restores mitochondrial function to a seizure-genic brain region. In some embodiments, the composition can include ascorbic acid, vitamin E, and pyruvate.

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