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1. 发明申请

US20090054828A1 Systems for transient conduction control 审中-公开
标题翻译：瞬态传导控制系统
公开(公告)号：US20090054828A1
公开(公告)日：2009-02-26
申请号：US11895026
申请日：2007-08-22
申请人： Craig Stolen , Joseph M. Pastore , Robert J. Sweeney , Mark Schwartz
发明人： Craig Stolen , Joseph M. Pastore , Robert J. Sweeney , Mark Schwartz
IPC分类号： A61N5/06 , A61N1/30
CPC分类号： A61N1/3962 , A61B5/046 , A61B5/0464 , A61N5/0601 , A61N5/062 , A61N2005/0651
摘要： The invention provides a system coupled to a heart having a right atrium (RA) and an atrioventricular (AV) node, which includes an implantable gene regulatory signal delivery device configured to deliver a light to a target site in the heart to transiently control an aberrant cardiac electrical conduction, the light having characteristics suitable for regulating a transcription control element; and an implantable medical device communicatively coupled to the implantable gene regulatory signal delivery device, the implantable medical device including: an atrial fibrillation (AF) detector configured to detect AF; and a control circuit configured to initiate an emission of the light from the implantable gene regulatory signal delivery device in response to the detection of AF. Also provided are methods to transiently control aberrant AV conduction or transiently control cardiac arrhythmias, which employ expression cassettes.
摘要翻译：本发明提供一种耦合到具有右心房（RA）和房室（AV））节点的心脏的系统，其包括可植入的基因调节信号传递装置，其被配置为将光传递到心脏中的目标部位以暂时控制异常心电传导，光具有适于调节转录控制元件的特征; 以及通信地耦合到所述可植入基因调节信号传递装置的可植入医疗装置，所述可植入医疗装置包括：构造成检测AF的心房颤动（AF）检测器; 以及控制电路，其被配置为响应于AF的检测而启动来自所述可植入基因调节信号传递装置的光的发射。还提供了瞬时控制异常AV传导或瞬时控制使用表达盒的心律失常的方法。

2. 发明申请

US20090054883A1 Systems and devices for photoablation 有权
标题翻译：用于光消解的系统和设备
公开(公告)号：US20090054883A1
公开(公告)日：2009-02-26
申请号：US11895035
申请日：2007-08-22
申请人： Craig Stolen , Joseph M. Pastore , Robert J. Sweeney
发明人： Craig Stolen , Joseph M. Pastore , Robert J. Sweeney
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61N5/0601 , A61N2005/063 , A61N2005/0651
摘要： The invention provides a catheter for optical ablation of tissue in a living body, the catheter including: a distal end; a proximal end; an elongate catheter body coupled between the distal end and the proximal end; a light emission device at the distal end and configured to emit an ablation light having characteristics selected to regulate an optically regulatable transcription control element operably linked to a nucleic acid sequence for a gene product, the expression of which gene product in cells directly or indirectly kills cells; and a projection control mechanism coupled to the light emission device and configured to control an effectively illuminated area where the optically regulatable transcription control element is effectively regulatable by the ablation light projected from the light emission device. Also provided is a system which includes the catheter, and methods to prevent, inhibit or treat AF which employ an expression cassette and/or one or more selected wavelengths of light.
摘要翻译：本发明提供了一种用于生物体中组织光学消融的导管，该导管包括：远端; 近端连接在远端和近端之间的细长导管体; 在远端处的发光装置并且被配置为发射具有被选择用于调节与基因产物的核酸序列可操作地连接的可调控转录控制元件的特征的消融光，细胞中哪种基因产物的表达直接或间接地杀死细胞; 以及投影控制机构，其耦合到所述发光装置并且被配置为控制有效照射的区域，其中所述光学可调节转录控制元件通过从所述发光装置投射的消融光有效地调节。还提供了一种包括导管的系统，以及防止，抑制或治疗采用表达盒和/或一个或多个选定波长的光的AF的方法。

3. 发明授权

US08480662B2 Systems and devices for photoablation 有权
公开(公告)号：US08480662B2
公开(公告)日：2013-07-09
申请号：US11895035
申请日：2007-08-22
申请人： Craig Stolen , Joseph M. Pastore , Robert J. Sweeney
发明人： Craig Stolen , Joseph M. Pastore , Robert J. Sweeney
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61N5/0601 , A61N2005/063 , A61N2005/0651
摘要： The invention provides a catheter for optical ablation of tissue in a living body, the catheter including: a distal end; a proximal end; an elongate catheter body coupled between the distal end and the proximal end; a light emission device at the distal end and configured to emit an ablation light having characteristics selected to regulate an optically regulatable transcription control element operably linked to a nucleic acid sequence for a gene product, the expression of which gene product in cells directly or indirectly kills cells; and a projection control mechanism coupled to the light emission device and configured to control an effectively illuminated area where the optically regulatable transcription control element is effectively regulatable by the ablation light projected from the light emission device. Also provided is a system which includes the catheter, and methods to prevent, inhibit or treat AF which employ an expression cassette and/or one or more selected wavelengths of light.

4. 发明申请

US20190351234A1 SYSTEM AND METHOD FOR CONTROLLING BLOOD PRESSURE 审中-公开
公开(公告)号：US20190351234A1
公开(公告)日：2019-11-21
申请号：US16414869
申请日：2019-05-17
申请人： Craig Stolen , Bryan Allen Clark , Manda L. Keller-Ross , Ninitha Margret Julfiya Asirvatham-Jeyaraj , Daniel P. Chantigian
发明人： Craig Stolen , Bryan Allen Clark , Manda L. Keller-Ross , Ninitha Margret Julfiya Asirvatham-Jeyaraj , Daniel P. Chantigian
IPC分类号： A61N1/36 , A61B5/00 , A61N1/05 , A61B5/021 , A61N1/372 , A61B5/11
摘要： An example of a system includes a blood pressure modulation device and a controller. The blood pressure modulation device may be configured to deliver a therapy to chronically maintain blood pressure within a prescribed range. The blood pressure modulation device may include a neuromodulator configured to deliver neuromodulation energy to neural tissue in a spinal cord or near the spinal cord using a first parameter set. The controller may include analyzer circuitry configured to determine an actual or anticipated blood pressure demand event indicated for a blood pressure change, and therapy parameter adjuster circuitry configured to respond to the actual or anticipated blood pressure demand event by delivering neuromodulation energy using a second parameter set to change the blood pressure.

5. 发明授权

US08958873B2 Method and apparatus for safe and efficient delivery of cardiac stress augmentation pacing 有权
标题翻译：安全高效地递送心脏应激增加起搏的方法和装置
公开(公告)号：US08958873B2
公开(公告)日：2015-02-17
申请号：US12770351
申请日：2010-04-29
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Craig Stolen , Robert Shipley
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Craig Stolen , Robert Shipley
IPC分类号： A61N1/365 , A61N1/362 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/37
摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac stress augmentation pacing to create or augment regional stress in the heart according to a delivery schedule programmed for a patient. Various events associated with the patient's conditions, activities, and other treatments may render the cardiac stress augmentation pacing risky or ineffective. The system detects such events before and during each cardiac stress augmentation pacing session and modifies the delivery schedule in response to the detection of each event to ensure patient safety and therapy efficiency.
摘要翻译：心脏起搏系统通过递送心脏应力增加起搏来控制心脏疾病例如心力衰竭的进展，以根据为患者编程的递送计划创建或增加心脏中的区域应力。与患者病情，活动和其他治疗相关的各种事件可能使心脏应激增加起搏风险或无效。该系统在每个心脏应激增强起搏会话之前和期间检测这些事件，并根据每个事件的检测来修改递送计划，以确保患者的安全性和治疗效率。

6. 发明授权

US08855772B2 System for neural therapy 有权
标题翻译：神经治疗系统
公开(公告)号：US08855772B2
公开(公告)日：2014-10-07
申请号：US12269558
申请日：2008-11-12
申请人： Allan C. Shuros , Craig Stolen , Timothy Meyer , Stephen Ruble
发明人： Allan C. Shuros , Craig Stolen , Timothy Meyer , Stephen Ruble
IPC分类号： A61N1/18 , A61N1/32 , A61N1/08 , A61N1/36
CPC分类号： A61N1/08 , A61N1/36071 , A61N1/36114
摘要： This document discusses, among other things, a system and method for calculating a neural stimulation energy at an external patient management (EPM) system using received information about a chemical characteristic indicative of a physiological state of a subject.
摘要翻译：本文件尤其涉及使用接收到的关于指示受试者的生理状态的化学特性的信息来计算外部患者管理（EPM）系统的神经刺激能量的系统和方法。

7. 发明申请

US20130150912A1 METHODS AND SYSTEMS FOR IDENTIFYING AND USING HEART RATE VARIABILITY AND HEART RATE VARIATION 有权
公开(公告)号：US20130150912A1
公开(公告)日：2013-06-13
申请号：US13707204
申请日：2012-12-06
申请人： David L. Perschbacher , Arjun D. Sharma , Craig Stolen , Kira Q. Stolen , Milan Seth , Paul W. Jones
发明人： David L. Perschbacher , Arjun D. Sharma , Craig Stolen , Kira Q. Stolen , Milan Seth , Paul W. Jones
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/1116 , A61B5/7275 , A61N1/36507 , A61N1/36535 , A61N1/36585
摘要： A heart rate variability or heart rate variation can be identified using sensed and/or paced heart beats. One or more patient metrics, such as a variability index or a variation index, can correspond to the identified heart rate variability or heart rate variation. The patient metrics can be used to identify a need for a particular therapy, such as a rate-responsive pacing therapy. The patient metrics can be used to identify patients at an elevated risk of death. Methods and systems to identify therapy indications or at-risk patients are provided. In an example, a patient risk profile can be adjusted, such as in response to an identified patient heart rate variability or heart rate variation. In an example, a rate-responsive pacing mode can be used to adjust the patient risk profile.

8. 发明申请

US20100305648A1 METHOD AND APPARATUS FOR SAFE AND EFFICIENT DELIVERY OF CARDIAC STRESS AUGMENTATION PACING 有权
标题翻译：安全有效地提供CARDIAC应力补充剂的方法和装置
公开(公告)号：US20100305648A1
公开(公告)日：2010-12-02
申请号：US12770351
申请日：2010-04-29
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Craig Stolen , Robert Shipley
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Craig Stolen , Robert Shipley
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/37
摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac stress augmentation pacing to create or augment regional stress in the heart according to a delivery schedule programmed for a patient. Various events associated with the patient's conditions, activities, and other treatments may render the cardiac stress augmentation pacing risky or ineffective. The system detects such events before and during each cardiac stress augmentation pacing session and modifies the delivery schedule in response to the detection of each event to ensure patient safety and therapy efficiency.
摘要翻译：心脏起搏系统通过递送心脏应力增加起搏来控制心脏疾病例如心力衰竭的进展，以根据为患者编程的递送计划创建或增加心脏中的区域应力。与患者病情，活动和其他治疗相关的各种事件可能使心脏应激增加起搏风险或无效。该系统在每个心脏应激增强起搏会话之前和期间检测这些事件，并根据每个事件的检测来修改递送计划，以确保患者的安全性和治疗效率。

9. 发明授权

US08372399B2 Bispecific antibodies and agents to enhance stem cell homing 有权
标题翻译：双特异性抗体和增强干细胞归巢的试剂
公开(公告)号：US08372399B2
公开(公告)日：2013-02-12
申请号：US11469081
申请日：2006-08-31
申请人： Craig Stolen
发明人： Craig Stolen
IPC分类号： A61K39/395 , A61K39/00 , A61K38/19 , C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/31
摘要： A composition having a bispecific antibody which binds a stem cell specific antigen and a tissue, differentiated cell or condition associated antigen and an agent that enhances expression of the tissue, differentiated cell or condition associated antigen, is provided. Also provided are methods of using the bispecific antibodies and/or agents to enhance cell therapy.
摘要翻译：提供了具有结合干细胞特异性抗原和组织，分化细胞或病症相关抗原的双特异性抗体和增强组织表达，分化细胞或病症相关抗原的试剂的组合物。还提供了使用双特异性抗体和/或试剂来增强细胞治疗的方法。

10. 发明授权

US08114668B2 Composition for cold storage of stem cells 有权
标题翻译：干细胞冷藏组成
公开(公告)号：US08114668B2
公开(公告)日：2012-02-14
申请号：US11748315
申请日：2007-05-14
申请人： Craig Stolen , Steven D. Girouard
发明人： Craig Stolen , Steven D. Girouard
IPC分类号： C12N5/00
CPC分类号： A01N1/02 , A01N1/0226 , A01N1/0231 , A61F2/82 , A61L31/043 , A61L31/16 , A61L2300/252 , A61L2300/414
摘要： The invention provides a composition for cold storage of cells which includes a population of isolated stem cells, a cell medium, and isolated trophic factors, as well as devices having a plurality of the trophic factors.
摘要翻译：本发明提供了用于冷藏细胞的组合物，其包括分离的干细胞群，细胞培养基和分离的营养因子，以及具有多种营养因子的装置。

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