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1. 发明申请

US20120034606A1 DETECTION OF SALMONELLA ENTERICA SUBSPECIES ENTERICA SEROVAR ENTERITIDIS IN FOOD AND ENVIRONMENTAL SAMPLES, METHODS AND COMPOSITIONS THEREFOR 有权
标题翻译：食品安全食品中的食品和环境样品的检测方法及其组合物
公开(公告)号：US20120034606A1
公开(公告)日：2012-02-09
申请号：US13197758
申请日：2011-08-03
申请人： Robert TEBBS , Craig Cummings , Arlene Nunez , Priya Balachandran , Payman Fatemi , Olga Petrauskene
发明人： Robert TEBBS , Craig Cummings , Arlene Nunez , Priya Balachandran , Payman Fatemi , Olga Petrauskene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2561/113 , C12Q2600/156 , Y02A50/451
摘要： Embodiments of the disclosure relate to compositions of isolated nucleic acid sequences, methods, workflows and kits of use thereof for detection of Salmonella enterica, subspecies enterica, serovar Enteritidis (S. Enteritidis) in a sample, particularly in a food (egg, poultry) or environmental sample (including poultry-related environmental samples). Embodiments of the disclosure may also be used to differentially detect S. Enteritidis without cross-reacting with S. Paratyphi C or other closely related Salmonella species. In some embodiments, methods and kits of the disclosure may comprise a TaqMan® assay. Following sample enrichment, methods of detection may be completed in approximately 3 hours.
摘要翻译：本公开的实施方案涉及分离的核酸序列的组合物，方法，工作流程和其用于检测肠炎沙门氏菌，肠亚科，血清型肠炎沙丁杆菌（肠炎沙丁杆菌）的样品中尤其是食品（鸡蛋，家禽）或环境样品（包括家禽相关环境样品）。本公开的实施方案也可用于差异检测肠杆菌，而不与副伤寒杆菌C或其他密切相关的沙门氏菌属物种交叉反应。在一些实施方案中，本公开的方法和试剂盒可以包含TaqMan测定。样品富集后，检测方法可在约3小时内完成。

2. 发明申请

US20110165568A1 SEQUENCES OF E.COLI 055:H7 GENOME 审中-公开
标题翻译： E.COLI 055：H7基因组序列
公开(公告)号：US20110165568A1
公开(公告)日：2011-07-07
申请号：US12981795
申请日：2010-12-30
申请人： Paolo Vatta , Pius Brzoska , Elizabeth Newton , Melissa Barker , Olga V. Petrauskene , Manohar Furtado , Craig Cummings
发明人： Paolo Vatta , Pius Brzoska , Elizabeth Newton , Melissa Barker , Olga V. Petrauskene , Manohar Furtado , Craig Cummings
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/245 , C12Q1/689 , C12Q2600/156
摘要： Disclosed is the genomic sequence for E. coli O55:H7 as well as compositions, methods, and kits for detecting, identifying and distinguishing E. coli O55:H7 from non-O55:H7 strains. In some embodiments, isolated nucleic acid compositions unique and/or specific to E. coli O55:H7 are described. Methods of detection and/or indentifying E. coli O55:H7 comprising detecting at least one nucleic acid sequences comprising or derived from SEQ ID NO:1-5, SEQ ID NO: 66, SEQ ID NO: 252, SEQ ID NO: 1113, and SEQ ID NO: 1461, are described. Primer and probe compositions and methods of use of primers and probes are also provided. Kits for identification of E. coli O55:H7 are also described.
摘要翻译：公开了大肠杆菌O55：H7的基因组序列以及用于从非O55：H7菌株检测，鉴定和区分大肠杆菌O55：H7的组合物，方法和试剂盒。在一些实施方案中，描述了对大肠杆菌O55：H7独特和/或特异性的分离的核酸组合物。检测和/或鉴定大肠杆菌O55：H7的方法，包括检测至少一个包含或源自SEQ ID NO：1-5，SEQ ID NO：66，SEQ ID NO：252，SEQ ID NO：1113的核酸序列，和SEQ ID NO：1461。还提供引物和探针组合物以及引物和探针的使用方法。还描述了用于鉴定大肠杆菌O55：H7的试剂盒。

3. 发明申请

US20100273143A1 DISCRIMINATORY POSITIVE/EXTRACTION CONTROL DNA 有权
标题翻译：歧视积极/提取控制DNA
公开(公告)号：US20100273143A1
公开(公告)日：2010-10-28
申请号：US12731806
申请日：2010-03-25
申请人： Michael Brewer , Olga Petrauskene , Jen-Kuei Liu , Craig Cummings , Sueh-Ning Liew
发明人： Michael Brewer , Olga Petrauskene , Jen-Kuei Liu , Craig Cummings , Sueh-Ning Liew
IPC分类号： C12Q1/70 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2561/107 , C12Q2545/107 , C12Q2537/107
摘要： The present teachings generally relate to methods and kits incorporating a discriminating positive control for determining whether a particular microorganism or group of microorganisms are present in a sample, for example but not limited to a food, environmental, agricultural, biopharmaceutical, pharmaceutical, or water sample. According to certain methods, at least part of a starting material, for example but not limited to, a food, environmental, agricultural, biopharmaceutical, pharmaceutical, or water sample can be combined with a culture medium and incubated under conditions suitable for microbial growth followed by extracting microorganism and added control nucleic acids for analysis. The extracted nucleic acids are amplified and the amplified nucleic acids are detected, directly or indirectly, and the fidelity of the methods and the presence or absence of the corresponding microorganism is determined because the discriminating positive control provides both confirmatory results for the methods used but eliminates false positive results.
摘要翻译：本教导通常涉及包含用于确定特定微生物或一组微生物是否存在于样品中的鉴别性阳性对照的方法和试剂盒，例如但不限于食品，环境，农业，生物制药，药物或水样品。根据某些方法，至少部分原料，例如但不限于食品，环境，农业，生物制药，药物或水样品可以与培养基组合，并在适合于微生物生长的条件下温育通过提取微生物和添加的对照核酸进行分析。所提取的核酸被扩增并且直接或间接检测扩增的核酸，并且确定方法的保真度和相应的微生物的存在或不存在，因为鉴别阳性对照提供所使用的方法的确认结果但消除假阳性结果。

4. 发明申请

US20120322676A1 COMPOSITIONS AND METHODS FOR DETECTION OF CRONOBACTER SPP. AND CRONOBACTER SPECIES AND STRAINS 审中-公开
标题翻译：用于检测CRONOBACTER SPP的组合物和方法。和克隆物种和菌株
公开(公告)号：US20120322676A1
公开(公告)日：2012-12-20
申请号：US13495748
申请日：2012-06-13
申请人： Yongmei JI , Sheung-Mei ("Rita") Shih , Lovorka Degoricija , Zhaohui Zhou , Craig Cummings , Manohar Furtado , Pius Brzoska , Angela Burrell , Harrison Leong , Xingwang Fang , Mangkey Bounpheng , Rohan Shah
发明人： Yongmei JI , Sheung-Mei ("Rita") Shih , Lovorka Degoricija , Zhaohui Zhou , Craig Cummings , Manohar Furtado , Pius Brzoska , Angela Burrell , Harrison Leong , Xingwang Fang , Mangkey Bounpheng , Rohan Shah
IPC分类号： C12Q1/68 , C40B30/04 , G01N21/76 , C07H21/04 , G01N27/62
CPC分类号： C12Q1/689 , C12R1/01
摘要： Disclosed are genomic sequences for nine strains of Cronobacter spp. (C. sakazakii—696, 701, 680; C. malonaticus—507, 681; C. turicensis—564; C. muytjensii—530; C. dublinensis—582; C. genomosp1—581) and compositions, methods, and kits for detecting, identifying and distinguishing Cronobacter spp. strains from each other and from non-Cronobacter spp. strains. Some embodiments describe isolated nucleic acid compositions unique to certain Cronobacter strains as well as compositions that are specific to all Cronobacter spp. Primer and probe compositions and methods of use of primers and probes are also provided. Kits for identification of Cronobacter spp. are also described. Some embodiments relate to computer software methods for setting a control based threshold for analysis of PCR data.
摘要翻译：公开了九个克罗杆菌属菌株的基因组序列。（C.sakazakii-696,701,680; C. malonaticus-507,681; C. turicensis-564; C. muytjensii-530; C.dublinensis-582; C.基因组sp1-581）和组合物，方法和试剂盒用于检测，识别和鉴别克罗杆菌属。菌株彼此和非克罗杆菌属。菌株。一些实施方案描述了某些克罗杆菌菌株特有的分离的核酸组合物以及对所有克罗杆菌属特异性的组合物。还提供引物和探针组合物以及引物和探针的使用方法。克隆杆菌属鉴定试剂盒也被描述。一些实施例涉及用于设置用于PCR数据分析的基于控制的阈值的计算机软件方法。

5. 发明授权

US5569849A Visual tire cap pressure gauge 失效
标题翻译：目视轮胎压力表
公开(公告)号：US5569849A
公开(公告)日：1996-10-29
申请号：US518681
申请日：1995-08-24
申请人： Craig Cummings
发明人： Craig Cummings
IPC分类号： B60C23/00 , B60C23/02
CPC分类号： B60C23/0496 , Y10T137/3662
摘要： A visual tire cap pressure gauge which comprises a cap member. A structure within the cap member is for securing the cap member to a valve stem on a tire in a motor vehicle. A lens is mounted in a top end of the cap member. An assembly within the cap member is for visually indicating when air pressure within the tire drops below a set point, so as to enable a person at a glance to tell if the tire needs more air.
摘要翻译：一种视觉轮胎帽压力表，包括盖构件。盖构件内的结构用于将盖构件固定到机动车辆中的轮胎上的阀杆。透镜安装在盖构件的顶端。盖构件内的组件用于可视地指示轮胎内的空气压力是否下降到设定点以下，以使人能够一目了然地判断轮胎是否需要更多的空气。

6. 发明授权

US09175354B2 Detection of Salmonella enterica subspecies enterica serovar Enteritidis in food and environmental samples, methods and compositions therefor 有权
标题翻译：检测食品和环境样品中肠炎沙门氏菌亚型肠炎肠炎沙门氏菌，其方法和组成
公开(公告)号：US09175354B2
公开(公告)日：2015-11-03
申请号：US13197758
申请日：2011-08-03
申请人： Robert Tebbs , Craig Cummings , Arlene Nunez , Priya Balachandran , Payman Fatemi , Olga Petrauskene
发明人： Robert Tebbs , Craig Cummings , Arlene Nunez , Priya Balachandran , Payman Fatemi , Olga Petrauskene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2561/113 , C12Q2600/156 , Y02A50/451
摘要： Embodiments of the disclosure relate to compositions of isolated nucleic acid sequences, methods, workflows and kits of use thereof for detection of Salmonella enterica, subspecies enterica, serovar Enteritidis (S. Enteritidis) in a sample, particularly in a food (egg, poultry) or environmental sample (including poultry-related environmental samples). Embodiments of the disclosure may also be used to differentially detect S. Enteritidis without cross-reacting with S. Paratyphi C or other closely related Salmonella species. In some embodiments, methods and kits of the disclosure may comprise a TaqMan® assay. Following sample enrichment, methods of detection may be completed in approximately 3 hours.
摘要翻译：本公开的实施方案涉及分离的核酸序列的组合物，方法，工作流程和其用于检测肠炎沙门氏菌，肠亚科，血清型肠炎沙丁杆菌（肠炎沙丁杆菌）的样品中尤其是食品（鸡蛋，家禽）或环境样品（包括家禽相关环境样品）。本公开的实施方案也可用于差异检测肠杆菌，而不与副伤寒杆菌C或其他密切相关的沙门氏菌属物种交叉反应。在一些实施方案中，本公开的方法和试剂盒可以包含TaqMan测定。样品富集后，检测方法可在约3小时内完成。

7. 发明申请

US20130122505A1 COMPOSITIONS AND METHODS FOR DETECTION OF MULTIPLE MICROORGANISMS 审中-公开
标题翻译：用于检测多种微生物的组合物和方法
公开(公告)号：US20130122505A1
公开(公告)日：2013-05-16
申请号：US13594682
申请日：2012-08-24
申请人： Robert TEBBS , Craig Cummings , Pius Brzoska , Sharon Matheny , Catherine O'Connell , Manohar Furtado , Rixun Fang , Olga Petrauskene , Sueh-Ning Liew , Michael Schumaker
发明人： Robert TEBBS , Craig Cummings , Pius Brzoska , Sharon Matheny , Catherine O'Connell , Manohar Furtado , Rixun Fang , Olga Petrauskene , Sueh-Ning Liew , Michael Schumaker
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/689 , C12Q2600/16
摘要： The present teachings describe compositions, methods and kits for detection of one or multiple microorganism contaminants in samples. Some embodiments relate to detecting one or more microorganisms producing virulence factors such as a shiga toxin (stx) or an eae. In some embodiments, compositions, methods and kits can detect and identify individual strains and serotypes of shiga toxin producing microorganisms. Some embodiments describe compositions, methods and kits for detecting STEC microbes. Workflows for multiple microbe detection and identification are also described.
摘要翻译：本教导描述了用于检测样品中一种或多种微生物污染物的组合物，方法和试剂盒。一些实施方案涉及检测产生毒力因子（例如志贺毒素（stx）或eae）的一种或多种微生物。在一些实施方案中，组合物，方法和试剂盒可以检测和鉴定产生志贺毒素的微生物的个体菌株和血清型。一些实施方案描述了用于检测STEC微生物的组合物，方法和试剂盒。还描述了用于多个微生物检测和鉴定的工作流程。

8. 发明申请

US20050095666A1 Apparatus and methods for tissue preparation 审中-公开
标题翻译：组织制备的装置和方法
公开(公告)号：US20050095666A1
公开(公告)日：2005-05-05
申请号：US10902547
申请日：2004-07-29
申请人： Sameer Jhavar , Stefan Reinsberg , Andrew Jackson , Craig Cummings , Rosalind Eeles , Alison Falconer , Martin Leach
发明人： Sameer Jhavar , Stefan Reinsberg , Andrew Jackson , Craig Cummings , Rosalind Eeles , Alison Falconer , Martin Leach
IPC分类号： A61B10/00 , A61B10/02 , A61B17/32 , G01N1/06 , G01N1/28 , G01N1/31 , A61B18/18 , B26D5/08 , G01N33/48
CPC分类号： A61B17/3211 , A61B10/02 , A61B2017/320052 , G01N1/06 , G01N1/31 , G01N2001/282 , G01N2001/2873 , Y10T83/869
摘要： The present invention features a multi-bladed cutter and a cradle adapted to grip a tissue sample 10 during cutting. The cutter has a series 4 of juxtaposed blades 5 and the cradle has a series of slits 13 adapted to receive the blades during cutting. The cradle may have opposing curved walls 8,9 which may be brought together to clasp the sample. The apparatus is suitable for cutting tissue such as prostate tissue, which is difficult to section. The apparatus is particularly suited to cutting tissue where chemical fixing is undesirable because nucleic acids are to be sampled from the tissue.
摘要翻译：本发明的特征在于一种多刀片切割器和一个适于在切割过程中夹紧组织样本10的托架。切割器具有一系列并置的叶片5，并且托架具有适于在切割期间接收叶片的一系列狭缝13。托架可以具有相对的弯曲壁8,9，其可以被带到一起以扣紧样品。该装置适用于切割难以切片的组织如前列腺组织。该装置特别适用于切割组织，其中化学固定是不希望的，因为核酸将从组织中取样。

9. 发明授权

US09834815B2 Discriminatory positive/extraction control DNA 有权
公开(公告)号：US09834815B2
公开(公告)日：2017-12-05
申请号：US12731806
申请日：2010-03-25
申请人： Michael Brewer , Olga Petrauskene , Jen-Kuei Liu , Craig Cummings , Sueh-Ning Liew
发明人： Michael Brewer , Olga Petrauskene , Jen-Kuei Liu , Craig Cummings , Sueh-Ning Liew
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6851 , C12Q2561/107 , C12Q2545/107 , C12Q2537/107
摘要： The present teachings generally relate to methods and kits incorporating a discriminating positive control for determining whether a particular microorganism or group of microorganisms are present in a sample, for example but not limited to a food, environmental, agricultural, biopharmaceutical, pharmaceutical, or water sample. According to certain methods, at least part of a starting material, for example but not limited to, a food, environmental, agricultural, biopharmaceutical, pharmaceutical, or water sample can be combined with a culture medium and incubated under conditions suitable for microbial growth followed by extracting microorganism and added control nucleic acids for analysis. The extracted nucleic acids are amplified and the amplified nucleic acids are detected, directly or indirectly, and the fidelity of the methods and the presence or absence of the corresponding microorganism is determined because the discriminating positive control provides both confirmatory results for the methods used but eliminates false positive results.

10. 发明申请

US20120270216A1 COMPOSITIONS AND METHODS FOR DETECTING AND IDENTIFYING SALMONELLA ENTERICA STRAINS 审中-公开
标题翻译：用于检测和鉴定沙门氏菌菌株的组合物和方法
公开(公告)号：US20120270216A1
公开(公告)日：2012-10-25
申请号：US13451479
申请日：2012-04-19
申请人： Craig Cummings , Elena Bolchakova , Manohar Furtado
发明人： Craig Cummings , Elena Bolchakova , Manohar Furtado
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C12N15/1089 , C12Q2600/156 , C12Q2600/158 , Y02A50/451
摘要： The present specification describes several novel SNPs of Salmonella enterica subsp. enterica. SNP profiles comprising allelic compositions at each SNP position are described which may be used to identify and differentiate different strains and serovars of Salmonella enterica subsp. enterica. The specification also describes several compositions, methods and kits useful for identifying and differentially distinguishing strains and serovars of Salmonella enterica subsp. enterica.
摘要翻译：本说明书描述了几种新型的肠炎沙门氏菌的SNP。肠衣描述了包含在每个SNP位置处的等位基因组成的SNP谱，其可用于鉴定和区分不同的肠炎沙门氏菌菌株和血清型。肠衣本说明书还描述了用于鉴定和差异区分肠炎沙门氏菌菌株和血清型的几种组合物，方法和试剂盒。肠衣

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