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1. 发明授权

US07803620B2 Pufa polyketide synthase systems and uses thereof 有权
标题翻译： Pufa聚酮化合物系统及其用途
公开(公告)号：US07803620B2
公开(公告)日：2010-09-28
申请号：US11689453
申请日：2007-03-21
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： C12N15/82 , C12N1/20 , C07H21/04
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
摘要翻译：公开了来自细菌微生物Shewanella japonica和Shewanella olleyana的完全多不饱和脂肪酸（PUFA）聚酮化合物（PKS）系统及其生物活性片段和同系物。更具体地，本发明涉及编码这种PUFA PKS系统的核酸，其包含这种PUFA PKS系统的蛋白质和结构域到包含这种PUFA PKS系统的转基因生物（植物和微生物），以及制备和使用本文公开的PUFA PKS系统。本发明还涉及基因修饰的植物和微生物以及通过操作PUFA聚酮化合物合酶（PKS）系统来有效地产生富含多种不饱和脂肪酸（PUFA）以及其它生物活性分子的脂质的方法。

2. 发明授权

US07718431B2 PUFA polyketide synthase systems and uses thereof 有权
公开(公告)号：US07718431B2
公开(公告)日：2010-05-18
申请号：US11781871
申请日：2007-07-23
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： A01H5/00 , C12N15/82 , C07H21/04
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

3. 发明授权

US08309796B2 Chimeric PUFA polyketide synthase systems and uses thereof 有权
标题翻译：嵌合PUFA聚酮化合物合成酶系统及其用途
公开(公告)号：US08309796B2
公开(公告)日：2012-11-13
申请号：US13170011
申请日：2011-06-27
申请人： Craig A. Weaver , Ross Zirkle , Daniel H. Doherty , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , Daniel H. Doherty , James G. Metz
IPC分类号： A01H5/00 , C12N1/20
CPC分类号： C12P7/6427 , C12N9/93 , C12N15/52 , C12N15/8247 , C12N15/8273 , C12P7/62 , C12P7/625 , C12P7/6472
摘要： Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids and proteins encoding such chimeric PUFA PKS proteins and systems, genetically modified organisms comprising such chimeric PUFA PKS proteins and systems, and methods of making and using such chimeric PUFA PKS proteins and systems.
摘要翻译：公开了嵌合多不饱和脂肪酸（PUFA）聚酮化合物合成酶（PKS）蛋白和嵌合PUFA PKS系统，包括嵌合PUFA PKS蛋白和源自裂殖壶菌和破囊壶菌的系统。公开了编码这种嵌合PUFA PKS蛋白质和系统的核酸和蛋白质，包含这种嵌合PUFA PKS蛋白质和系统的遗传修饰的生物体，以及制备和使用这种嵌合PUFA PKS蛋白质和系统的方法。

4. 发明授权

US07906706B2 PUFA polyketide synthase systems and uses thereof 有权
公开(公告)号：US07906706B2
公开(公告)日：2011-03-15
申请号：US11689450
申请日：2007-03-21
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： A01H9/00 , C12N1/12 , C12N15/87 , C12P7/64
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

5. 发明授权

US07897392B2 PUFA polyketide synthase systems and uses thereof 有权
公开(公告)号：US07897392B2
公开(公告)日：2011-03-01
申请号：US11781875
申请日：2007-07-23
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： C12N15/82 , C12N5/12 , C12N1/20 , C07H21/04
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

6. 发明申请

US20120021470A1 Chimeric PUFA Polyketide Synthase Systems and Uses Thereof 有权
标题翻译：嵌合PUFA聚酮合成酶系统及其用途
公开(公告)号：US20120021470A1
公开(公告)日：2012-01-26
申请号：US13170011
申请日：2011-06-27
申请人： Craig A. WEAVER , Ross Zirkle , Daniel H. Doherty , James G. Metz
发明人： Craig A. WEAVER , Ross Zirkle , Daniel H. Doherty , James G. Metz
IPC分类号： C12P7/64 , C12N1/21 , C12N1/15 , C12N1/11 , C12N1/00 , C12N1/19 , A01H5/00 , C12N1/13
CPC分类号： C12P7/6427 , C12N9/93 , C12N15/52 , C12N15/8247 , C12N15/8273 , C12P7/62 , C12P7/625 , C12P7/6472
摘要： Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids and proteins encoding such chimeric PUFA PKS proteins and systems, genetically modified organisms comprising such chimeric PUFA PKS proteins and systems, and methods of making and using such chimeric PUFA PKS proteins and systems.
摘要翻译：公开了嵌合多不饱和脂肪酸（PUFA）聚酮化合物合成酶（PKS）蛋白和嵌合PUFA PKS系统，包括嵌合PUFA PKS蛋白和源自裂殖壶菌和破囊壶菌的系统。公开了编码这种嵌合PUFA PKS蛋白质和系统的核酸和蛋白质，包含这种嵌合PUFA PKS蛋白质和系统的遗传修饰的生物体，以及制备和使用这种嵌合PUFA PKS蛋白质和系统的方法。

7. 发明授权

US07939716B2 PUFA polyketide synthase systems and uses thereof 有权
公开(公告)号：US07939716B2
公开(公告)日：2011-05-10
申请号：US11689443
申请日：2007-03-21
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： A01H9/00 , C12N1/12 , C12N15/87 , C12P7/64
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

8. 发明授权

US07799564B2 PUFA polyketide synthase systems and uses thereof 有权
标题翻译： PUFA聚酮化合物系统及其用途
公开(公告)号：US07799564B2
公开(公告)日：2010-09-21
申请号：US11781877
申请日：2007-07-23
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： C12N15/82 , C12N1/20 , C07H21/04
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
摘要翻译：公开了来自细菌微生物Shewanella japonica和Shewanella olleyana的完全多不饱和脂肪酸（PUFA）聚酮化合物（PKS）系统及其生物活性片段和同系物。更具体地，本发明涉及编码这种PUFA PKS系统的核酸，其包含这种PUFA PKS系统的蛋白质和结构域到包含这种PUFA PKS系统的转基因生物（植物和微生物），以及制备和使用本文公开的PUFA PKS系统。本发明还涉及基因修饰的植物和微生物以及通过操作PUFA聚酮化合物合酶（PKS）系统来有效地产生富含多种不饱和脂肪酸（PUFA）以及其它生物活性分子的脂质的方法。

9. 发明授权

US08003772B2 Chimeric PUFA polyketide synthase systems and uses thereof 有权
标题翻译：嵌合PUFA聚酮化合物合成酶系统及其用途
公开(公告)号：US08003772B2
公开(公告)日：2011-08-23
申请号：US11749686
申请日：2007-05-16
申请人： Craig A. Weaver , Ross Zirkle , Daniel H. Doherty , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , Daniel H. Doherty , James G. Metz
IPC分类号： C07H21/04 , C12P7/64
CPC分类号： C12P7/6427 , C12N9/93 , C12N15/52 , C12N15/8247 , C12N15/8273 , C12P7/62 , C12P7/625 , C12P7/6472
摘要： Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids and proteins encoding such chimeric PUFA PKS proteins and systems, genetically modified organisms comprising such chimeric PUFA PKS proteins and systems, and methods of making and using such chimeric PUFA PKS proteins and systems.
摘要翻译：公开了嵌合多不饱和脂肪酸（PUFA）聚酮化合物合成酶（PKS）蛋白和嵌合PUFA PKS系统，包括嵌合PUFA PKS蛋白和源自裂殖壶菌和破囊壶菌的系统。公开了编码这种嵌合PUFA PKS蛋白质和系统的核酸和蛋白质，包含这种嵌合PUFA PKS蛋白质和系统的遗传修饰的生物体，以及制备和使用这种嵌合PUFA PKS蛋白质和系统的方法。

10. 发明授权

US07902427B2 PUFA polyketide synthase systems and uses thereof 有权
公开(公告)号：US07902427B2
公开(公告)日：2011-03-08
申请号：US11689439
申请日：2007-03-21
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： A01H9/00 , C12N1/12 , C12N15/87 , C12P7/64
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

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