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1. 发明授权

US07912661B2 Impedance analysis technique for frequency domain characterization of magnetoelastic sensor element by measuring steady-state vibration of element while undergoing constant sine-wave excitation 失效
标题翻译：通过测量元件的稳态振动同时进行恒定正弦波激励的磁弹性传感器元件频域表征的阻抗分析技术
公开(公告)号：US07912661B2
公开(公告)日：2011-03-22
申请号：US11710294
申请日：2007-02-23
申请人： Kefeng Zeng , Keat Ghee Ong , Xiping Yang , Craig A. Grimes
发明人： Kefeng Zeng , Keat Ghee Ong , Xiping Yang , Craig A. Grimes
IPC分类号： G01R23/16
CPC分类号： G01N29/2412 , G01L1/125 , G01L1/127 , G01N29/028 , G01N29/036 , G01N29/4436 , G01N2291/02818 , G01N2291/02827
摘要： Circuitry and program code adapted for carrying out an associated technique for characterizing the response of one or more magnetoelastic sensor elements during exposure to an excitation field generated by an interrogation coil: including: (a) measuring a total sensor signal from the coil with the sensor element positioned within the excitation field within a spacing created by a winding of the coil; and (b) automatically determining: (i) a total measured impedance spectrum from said total sensor signal so measured, and (ii) a plurality of magnitude values representing the real part of a reconstructed impedance spectrum for the sensor element. The reconstructed impedance spectrum for the sensor element, having been calculated by subtracting an impedance generally attributable to the coil during the time an AC excitation signal is provided, from the total measured impedance. Subtraction of coil impedance from total complex impedance is accomplished by separate subtraction of the real part and of the imaginary part, represented as follows Re[Zs(ω)]=Re[Zt(ω)]−Re[Zc(ω)] Equation (12) and Im[Zs(ω)]=Im[Zt(ω)]−Im[Zc(ω)] Equation (13) where subscript “t” indicates total complex impedance, “s” indicates sensor element impedance, and “c” indicates coil impedance.
摘要翻译：电路和程序代码，适于执行相关技术，用于表征一个或多个磁弹性传感器元件在暴露于由询问线圈产生的激励场的响应时的响应：包括：（a）用传感器测量来自线圈的总传感器信号元件位于由线圈的绕组产生的间隔内的激励场内; 和（b）自动确定：（i）来自所测量的所述总传感器信号的总测量阻抗谱，以及（ii）表示传感器元件的重构阻抗谱的实部的多个幅度值。通过从总测量的阻抗中减去通常归因于线圈的阻抗计算的传感器元件的重构阻抗谱。线圈阻抗从总复阻抗的减法是通过实部和虚部的分离减法来实现的，如下所示：Re [Zs（ω）] = Re [Zt（ω）] -Re [Zc（ω）（12）和Im [Zs（ω）] = Im [Zt（ω）] - Im [Zc（ω）]等式（13）其中下标“t”表示总复阻抗，“s”表示传感器元件阻抗， “c”表示线圈阻抗。

2. 发明申请

US20080261261A1 System/unit and method employing a plurality of magnetoelastic sensor elements for automatically quantifying parameters of whole blood and platelet-rich plasma 审中-公开
标题翻译：采用多个磁弹性传感器元件的系统/单元和方法，用于自动量化全血和富血小板血浆的参数
公开(公告)号：US20080261261A1
公开(公告)日：2008-10-23
申请号：US12080472
申请日：2008-04-02
申请人： Craig A. Grimes , Kefeng Zeng , Keat Ghee Ong , Xiping Yang
发明人： Craig A. Grimes , Kefeng Zeng , Keat Ghee Ong , Xiping Yang
IPC分类号： C12Q1/02 , C12M1/00
CPC分类号： G01N33/4905
摘要： A system/analyzer-unit and method/platform—using information obtained from at least one, adapted for a plurality of, magnetoelastic sensor elements in contact with one or more samples comprising blood from a patient—for automatically quantifying one or more parameters of the patient's blood. Information obtained from emissions measured from each of the sensor elements is uniquely processed to determine a quantification about the patient's blood, such as, quantifying platelet aggregation to determine platelet contribution toward clot formation; quantifying fibrin network contribution toward clot formation; quantifying platelet-fibrin clot interactions; quantifying kinetics of thrombin clot generation; quantifying platelet-fibrin clot strength; and so on. Structural aspects of the analyzer-unit include: a cartridge having at least one bay within which a sensor element is positioned; each bay in fluid communication with both (a) an entry port for injecting a first blood sample composed of blood taken from the patient (human or other mammal), and (b) a gas vent through which air displaced by injecting the first blood sample into the bay.
摘要翻译：从至少一个获得的系统/分析仪单元和方法/平台使用信息，其从适于与包含来自患者的血液的一个或多个样本接触的多个磁弹性传感器元件获得，用于自动量化一个或多个参数患者血液从每个传感器元件测量的排放获得的信息被独特地处理以确定关于患者血液的量化，例如量化血小板聚集以确定血小板对凝块形成的贡献; 量化纤维蛋白网络对凝块形成的贡献; 定量血小板 - 纤维蛋白凝块相互作用; 定量凝血酶凝块产生动力学; 定量血小板 - 纤维蛋白凝块强度; 等等。分析器单元的结构方面包括：具有传感器元件定位在其中的至少一个隔间的盒; 每个隔间与（a）用于注射由患者（人或其他哺乳动物）取得的血液组成的第一血液样本的进入口和（b）通过注射第一血液样本而排出空气的排气口进入海湾。

3. 发明授权

US07319411B2 Network of sensor nodes assemblies and method of remote sensing within liquid environments 失效
标题翻译：传感器节点组件网络和液体环境中的遥感方法
公开(公告)号：US07319411B2
公开(公告)日：2008-01-15
申请号：US10622244
申请日：2003-07-18
申请人： Keat Ghee Ong , Craig A. Grimes
发明人： Keat Ghee Ong , Craig A. Grimes
IPC分类号： G08C17/00
CPC分类号： G08C19/04 , G01N2001/021
摘要： A network of remote sensing node assemblies, a first and second of which each has a sensor element, as well as associated technique and program code for transmitting information collected about a liquid environment. The network provides the capability of sensing the liquid to collect a wide variety of types of information/data about the liquid and any surrounding environments, and transmitting from the originating node assembly to a different node within acoustic transmission range, and then transmitting further to a third node assembly where the information may be processed and communicated to a user, or further transmitted by way of suitable medium, preferably as electromagnetic signals, to a host location for processing into a compilation of data. Each of at least two sensing node assemblies has at least one sensor element adapted for operation while immersed within the liquid, a source of power, and a transducer for receiving acoustic waves/signals transmitted from another node assembly. The transducer is adapted for emitting sensor information collected by one or more sensor element(s) at that node, as well as acting as a pass-through node for information collected at other nodes. A third node assembly of the network is adapted for receiving and processing sensor information acoustically transmitted from other nodes. The third node can have its own processor unit(s) and means for transmitting sensor information to a remote host, whether originating at the third node (if so equipped) or another node assembly.
摘要翻译：遥感节点组件的网络，其中第一和第二个具有传感器元件，以及用于发送关于液体环境收集的信息的相关技术和程序代码。网络提供了感测液体以收集关于液体和任何周围环境的各种类型的信息/数据的能力，以及从发声节点组件到声传播范围内的不同节点的传送，然后进一步传送到第三节点组件，其中信息可以被处理并传送给用户，或者通过合适的介质进一步发送，优选地作为电磁信号发送到主机位置以用于处理数据的汇编。至少两个感测节点组件中的每一个具有至少一个适于在浸入液体内的操作的传感器元件，功率源和用于接收从另一个节点组件传输的声波/信号的换能器。传感器适于发射由该节点处的一个或多个传感器元件收集的传感器信息，以及用作在其他节点处收集的信息的直通节点。网络的第三节点组件适于接收和处理从其他节点声学传输的传感器信息。第三节点可以具有其自己的处理器单元和用于将传感器信息发送到远程主机的装置，无论是从第三节点（如果配备的话）发起的还是来自另一节点组件。

4. 发明授权

US06639402B2 Temperature, stress, and corrosive sensing apparatus utilizing harmonic response of magnetically soft sensor element (s) 失效
标题翻译：利用磁性软传感器元件的谐波响应的温度，应力和腐蚀性感测装置
公开(公告)号：US06639402B2
公开(公告)日：2003-10-28
申请号：US10061840
申请日：2002-01-31
申请人： Craig A. Grimes , Keat Ghee Ong
发明人： Craig A. Grimes , Keat Ghee Ong
IPC分类号： G01N2700
CPC分类号： G01N27/72 , G01N17/00
摘要： A temperature sensing apparatus including a sensor element made of a magnetically soft material operatively arranged within a first and second time-varying interrogation magnetic field, the first time-varying magnetic field being generated at a frequency higher than that for the second magnetic field. A receiver, remote from the sensor element, is engaged to measure intensity of electromagnetic emissions from the sensor element to identify a relative maximum amplitude value for each of a plurality of higher-order harmonic frequency amplitudes so measured. A unit then determines a value for temperature (or other parameter of interst) using the relative maximum harmonic amplitude values identified. In other aspects of the invention, the focus is on an apparatus and technique for determining a value for of stress condition of a solid analyte and for determining a value for corrosion, using the relative maximum harmonic amplitude values identified. A magnetically hard element supporting a biasing field adjacent the magnetically soft sensor element can be included.
摘要翻译：一种温度感测装置，包括可操作地布置在第一和第二时变询问磁场内的由软磁材料制成的传感器元件，所述第一时变磁场以比第二磁场的频率高的频率产生。离开传感器元件的接收器被接合以测量来自传感器元件的电磁辐射的强度，以识别如此测量的多个高次谐波频率振幅中的每一个的相对最大振幅值。然后，单元使用所标识的相对最大谐波振幅值来确定温度值（或interst的其他参数）。在本发明的其它方面，重点是用于确定固体分析物的应力条件的值并使用所标识的相对最大谐波振幅值来确定腐蚀值的装置和技术。可以包括支持邻近磁性软传感器元件的偏置场的磁性硬质元件。

5. 发明申请

US20230031122A1 MAGNETOELASTIC MICROCARRIERS AND MONITORING SYSTEM 有权
公开(公告)号：US20230031122A1
公开(公告)日：2023-02-02
申请号：US17789707
申请日：2020-12-31
申请人： Keat Ghee Ong , Robert E. Guldberg , William Skinner , Salil S. Karipott , University of Oregon
发明人： Keat Ghee Ong , Robert E. Guldberg , William Skinner , Salil S. Karipott
IPC分类号： G01N33/487 , G01N27/74 , C12N11/14 , C12N13/00 , C12M1/42 , C12M1/12
摘要： Certain examples of the disclosure concern an apparatus including a microcarrier configured to receive and support attachment and growth of cells, and a magnetoelastic sensor enclosed by the microcarrier. The magnetoelastic sensor is configured to vibrate in response to an activation magnetic field, and the vibration can produce a return magnetic field having detectable field characteristics associated with the attachment or growth of the cells.

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