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1. 发明授权

US06350745B1 Thrombin inhibitors 失效
标题翻译：凝血酶抑制剂
公开(公告)号：US06350745B1
公开(公告)日：2002-02-26
申请号：US09585740
申请日：2000-06-02
申请人： Craig A. Coburn , Christopher S. Burgey
发明人： Craig A. Coburn , Christopher S. Burgey
IPC分类号： C07D49804
CPC分类号： C07D498/04
摘要： Compounds of the invention, useful as thrombin inhibitors and having therapeutic value in for example, preventing coronary artery disease, have the following structure: or a pharmaceutically acceptable salt thereof, wherein A is wherein Y1 and Y2 are independently hydrogen, C1-4 alkyl, C1-4 alkoxy, FuHvC(CH2)0-1 O—, wherein u and v are either 1 or 2, provided that when u is 1, v is 2, and when u is 2, v is 1, C3-7 cycloalkyl, thio C1-4 alkyl, C1-4 sulfinylalkyl, C1-4 sulfonylalkyl, halogen cyano, or trifluoromethyl, and wherein b is 0 or 1.
摘要翻译：可用作凝血酶抑制剂并具有例如预防冠状动脉疾病的治疗价值的本发明化合物具有以下结构：或其药学上可接受的盐，其中A在其中Y 1和Y 2独立地为氢，C 1-4烷基，C 1-4烷氧基（CH 2）0-1 O-，其中u和v为1或2，条件是当u为1时，v为2，当u为2时，v为1，C 3-7环烷基，硫代C1- C4烷基，C1-4亚磺酰基烷基，C1-4磺酰基烷基，卤代，三氟甲基，其中b为0或1。

2. 发明申请

US20110206783A1 P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN 有权
标题翻译： P2X3，用于治疗疼痛的受体拮抗剂
公开(公告)号：US20110206783A1
公开(公告)日：2011-08-25
申请号：US13125935
申请日：2009-10-21
申请人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw
发明人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw
IPC分类号： A61K31/444 , C07D413/14 , A61K31/5377 , C07D401/12 , A61K31/4439 , C07D401/14 , A61K31/506 , C07D413/12 , C07D471/04 , A61K31/437 , C07D417/12 , C07D417/14 , A61K33/00 , A61K31/5513 , A61P25/04 , A61P25/20 , A61P25/08
CPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14
摘要： The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
摘要翻译：本发明涉及在治疗与疼痛有关的疾病状态，特别是外周疼痛，炎症性疼痛或可用P2X3受体亚基调节剂治疗的组织损伤疼痛中发挥关键作用的新型P2X3受体拮抗剂。

3. 发明申请

US20100113419A1 CGRP RECEPTOR ANTAGONISTS 审中-公开
标题翻译： CGRP受体拮抗剂
公开(公告)号：US20100113419A1
公开(公告)日：2010-05-06
申请号：US12684478
申请日：2010-01-08
申请人： Christopher S. Burgey , James Z. Deng , Craig Potteiger , Theresa M. Williams
发明人： Christopher S. Burgey , James Z. Deng , Craig Potteiger , Theresa M. Williams
IPC分类号： A61K31/55 , C07D401/14 , A61P25/00
CPC分类号： C07D491/20 , C07D471/10 , C07D471/20 , C07D491/10
摘要： The present invention is directed to compounds of Formula I:Formula I: Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：本发明涉及式I化合物：式I：式II :(其中变量R1，R2，R3，R4，A，B，J，Q，T，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

4. 发明授权

US07476665B2 Benzodiazepine CGRP receptor antagonists 有权
标题翻译：苯二氮卓CGRP受体拮抗剂
公开(公告)号：US07476665B2
公开(公告)日：2009-01-13
申请号：US10562297
申请日：2004-06-24
申请人： Christopher S. Burgey , Craig A. Stump , Theresa M. Williams
发明人： Christopher S. Burgey , Craig A. Stump , Theresa M. Williams
IPC分类号： A61P25/06 , A61K31/55 , C07D401/14
CPC分类号： C07D401/14 , C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of Formula I: I (where variables R1?, R2?, R3?, R6?, R7?, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：本发明涉及式I化合物：其中变量R 1 ?, R 2 ?, R 3？，R 6？R 7β，G，J，Q，T，U，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，如头痛，偏头痛和丛集性头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

5. 发明申请

US20080125413A1 Cgrp Receptor Antagonists 有权
标题翻译： Cgrp受体拮抗剂
公开(公告)号：US20080125413A1
公开(公告)日：2008-05-29
申请号：US11795678
申请日：2006-01-13
申请人： Christopher S. Burgey , Theresa M. Williams , Zhengwu J. Deng , Craig A. Stump
发明人： Christopher S. Burgey , Theresa M. Williams , Zhengwu J. Deng , Craig A. Stump
IPC分类号： A61K31/5513 , C07D243/14 , A61P43/00
CPC分类号： C07D401/14
摘要： Compounds of Formula I: (where variables R1, R2, R3, R7, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache, and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：式I化合物（其中变量R1，R2，R3，R7，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛，以及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗CGRP所涉及的疾病中的用途。

6. 发明授权

US07205292B2 CGRP receptor antagonists 有权
标题翻译： CGRP受体拮抗剂
公开(公告)号：US07205292B2
公开(公告)日：2007-04-17
申请号：US10551830
申请日：2004-04-09
申请人： Christopher S. Burgey , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
发明人： Christopher S. Burgey , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
IPC分类号： C07D405/14 , A61K31/4545 , A61P25/06
CPC分类号： C07D401/14 , C07D413/14
摘要： The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：本发明涉及式I和式II化合物（其中变量R1，R2，R3，R4，R6，A，B，G，J，W，X和Y如本文所定义）可用作CGRP的拮抗剂受体，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

7. 发明公开

US20230227441A1 2-OXO-OXAZOLIDINE-5-CARBOXAMIDES AS NAV1.8 INHIBITORS 审中-公开
公开(公告)号：US20230227441A1
公开(公告)日：2023-07-20
申请号：US18009306
申请日：2021-06-14
申请人： Ashok ARASAPPAN , Ian M. BELL , Christopher James BUNGARD , Christopher S. BURGEY , Jason M. COX , Deodial Guy GUIADEEN , Michael J. KELLY , Mark E. LAYTON , Hong LIU , Jian LIU , James T. OLSEN , James J. PERKINS , Jeffrey W. SCHUBERT , Akshay A. SHAH , Michael D. VANHEYST , Zhe WU , Shawn J. STACHEL , MERCK SHARP & DOHME CORP.
发明人： Ashok Arasappan , Ian M. Bell , Christopher James Bungard , Christopher S. Burgey , Jason Michael Cox , Deodial Guy Guiadeen, III , Michael J. Kelly, III , Mark E. Layton , Hong Liu , Jian Liu , James T. Olsen , James J. Perkins , Jeffrey W. Schubert , Akshay A. Shah , Shawn J. Stachel , Michael David VanHeyst , Zhe Wu
IPC分类号： C07D413/12 , C07D263/24 , C07D417/12
CPC分类号： C07D413/12 , C07D263/24 , C07D417/12
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

8. 发明申请

US20090325936A1 IMIDAZOPYRIDINE ANALOGS AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES 审中-公开
标题翻译：作为CB2受体调节剂的咪唑吡啶类似物，有助于治疗疼痛，呼吸和非呼吸系统疾病
公开(公告)号：US20090325936A1
公开(公告)日：2009-12-31
申请号：US12519789
申请日：2007-12-14
申请人： Mark T. Bilodeau , Christopher S. Burgey , Zhengwu James Deng , Nathan R. Kett , Jeffrey Melamed , Peter M. Munson , Kausik K. Nanda , Wayne Thompson , B. Wesley Trotter , Zhicai Wu , John C. Hartnett
发明人： Mark T. Bilodeau , Christopher S. Burgey , Zhengwu James Deng , Nathan R. Kett , Jeffrey Melamed , Peter M. Munson , Kausik K. Nanda , Wayne Thompson , B. Wesley Trotter , Zhicai Wu , John C. Hartnett
IPC分类号： A61K31/437 , C07D471/04 , A61K31/506 , A61K31/497 , A61K31/5377 , A61K31/551 , A61K31/541 , A61P19/00 , A61P25/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds represented by Formula (I) and Formula (II): (I) (II) or pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical compositions comprising the instant compounds. This invention further provides methods to treat and prevent pain, respiratory and non-respiratory diseases.
摘要翻译：本发明涉及由式（I）和式（II）表示的化合物：（I）（II）或其药学上可接受的盐。本发明还提供包含本发明化合物的药物组合物。本发明还提供了治疗和预防疼痛，呼吸和非呼吸道疾病的方法。

9. 发明授权

US07632832B2 CGRP receptor antagonists 有权
标题翻译： CGRP受体拮抗剂
公开(公告)号：US07632832B2
公开(公告)日：2009-12-15
申请号：US11795678
申请日：2006-01-13
申请人： Christopher S. Burgey , Theresa M. Williams , Zhengwu J. Deng , Craig A. Stump
发明人： Christopher S. Burgey , Theresa M. Williams , Zhengwu J. Deng , Craig A. Stump
IPC分类号： C07D401/14 , A61K31/4745 , A61P25/06
CPC分类号： C07D401/14
摘要： Compounds of Formula I: (where variables R1, R2, R3, R7, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache, and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：式I化合物（其中变量R1，R2，R3，R7，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛，以及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗CGRP所涉及的疾病中的用途。

10. 发明申请

US20080261972A1 Cgrp Receptor Antagonists 有权
标题翻译： Cgrp受体拮抗剂
公开(公告)号：US20080261972A1
公开(公告)日：2008-10-23
申请号：US11885926
申请日：2006-03-14
申请人： Daniel V. Paone , Diem N. Nguyen , Anthony W. Shaw , Christopher S. Burgey , Thomas J. Tucker , Samuel L. Graham
发明人： Daniel V. Paone , Diem N. Nguyen , Anthony W. Shaw , Christopher S. Burgey , Thomas J. Tucker , Samuel L. Graham
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , A61K31/4545 , A61P25/06 , C07D401/14 , A61K31/497
CPC分类号： C07D401/14 , C07D409/14 , C07D471/04 , C07D487/04
摘要： Compounds of Formula (I), (where variables R1, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：式（I）化合物（其中变量R 1，A，B，W，X，Y和Z如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及的疾病，如头痛，偏头痛和丛集性头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

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