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1. 发明授权

US07782452B2 Systems and method for simultaneously inspecting a specimen with two distinct channels 有权
标题翻译：用两个不同通道同时检查样本的系统和方法
公开(公告)号：US07782452B2
公开(公告)日：2010-08-24
申请号：US11848516
申请日：2007-08-31
申请人： Courosh Mehanian , Hans J. Hansen , Yingjian Wang , Yuval Ben-Dov , Zheng-Wu Li , Andrew V. Hill , Mehdi Vaez-Iravani , Kurt Zimmermann
发明人： Courosh Mehanian , Hans J. Hansen , Yingjian Wang , Yuval Ben-Dov , Zheng-Wu Li , Andrew V. Hill , Mehdi Vaez-Iravani , Kurt Zimmermann
IPC分类号： G01N21/00
CPC分类号： G02B21/18 , G01N21/8806 , G01N21/9501 , G01N2021/8825 , G02B21/367
摘要： A system is provided herein for inspecting a specimen. In one embodiment, the system may include a dual-channel microscope, two illuminators, each coupled for illuminating a different channel of the dual-channel microscope and two detectors, each coupled to a different channel of the dual-channel microscope for acquiring images of the specimen. Means are provided for separating the channels of the dual-channel microscope, so that the two detectors can acquire the images of the specimen at substantially the same time. In one embodiment, the channels of the dual-channel microscope may be spectrally separated by configuring the two illuminators, so that they produce light in two substantially non-overlapping spectral ranges. In another embodiment, the channels of the dual-channel microscope may be spatially separated by positioning the two detectors, so that the illumination light do not overlap and the fields of view of the two detectors do not overlap within a field of view of an objective lens included within the system.
摘要翻译：本文提供了用于检查样本的系统。在一个实施例中，系统可以包括双通道显微镜，两个照明器，每个照明器被耦合用于照亮双通道显微镜和两个检测器的不同通道，每个检测器耦合到双通道显微镜的不同通道，用于获取标本。提供了用于分离双通道显微镜的通道的装置，使得两个检测器可以在基本上同时获取样本的图像。在一个实施例中，双通道显微镜的通道可以通过配置两个照明器进行光谱分离，使得它们产生两个基本上非重叠的光谱范围的光。在另一个实施例中，双通道显微镜的通道可以通过定位两个检测器在空间上分离，使得照明光不重叠，并且两个检测器的视场在目标的视场内不重叠镜头包含在系统内。

2. 发明授权

US07470696B2 Tyrosine kinase inhibitors 有权
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US07470696B2
公开(公告)日：2008-12-30
申请号：US11625973
申请日：2007-01-23
申请人： Francis Beaulieu , Carl Ouellet , Kurt Zimmermann , Upender Velaparthi , Mark D. Wittman
发明人： Francis Beaulieu , Carl Ouellet , Kurt Zimmermann , Upender Velaparthi , Mark D. Wittman
IPC分类号： A61K31/52 , C07D473/32
CPC分类号： C07D471/04 , C07D473/32 , C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐。式I化合物抑制酪氨酸激酶，从而使其成为抗癌剂。

3. 发明授权

US5012861A Machine housing 失效
标题翻译：机房
公开(公告)号：US5012861A
公开(公告)日：1991-05-07
申请号：US266102
申请日：1988-11-02
申请人： Volkmar Kunze , Kurt Zimmermann , Erwin Hinterdorfer
发明人： Volkmar Kunze , Kurt Zimmermann , Erwin Hinterdorfer
IPC分类号： F16H57/04 , F16M1/026
CPC分类号： F16H57/0412 , F16M1/026 , Y10T74/2189
摘要： A machine housing having one wall with an outer side provided with ribs for the discharge of heat to the surrounding air. The ribs define undulation crests and there are curved undulation bases between the undulation crests. The ratio between the wall thickness and the rib height and the ratio between the rib pitch or spacing of the wall thickness and the radius of curvature of the undulations as compared with the wall thickness are all recited. The ribs preferably are parallel and preferably extend vertically in the installed position of the machine housing.
摘要翻译：一种具有一个壁的机壳，外壁具有肋条，用于向周围的空气排放热量。肋条定义起伏的波峰，起伏波峰之间有弯曲起伏的底座。全部都列出了壁厚和肋高度之间的比率以及肋间距或者壁厚与波纹的曲率半径之间的比率与壁厚相比。肋优选地平行并且优选地在机器壳体的安装位置垂直地延伸。

4. 发明申请

US20140314830A1 BACTERIALLY FORMED MICROCIN S, A NEW ANTIMICROBIAL PEPTIDE, EFFECTIVE AGAINST PATHOGENIC MICROORGANISMS, E.G. ENTEROHEMORRHAGIC ESCHERICHIA COLI (EHEC) 审中-公开
标题翻译：特异性形成的微生物S，一种新的抗微生物肽，对病原微生物有效，E.G. 食品卫生学院（EHEC）
公开(公告)号：US20140314830A1
公开(公告)日：2014-10-23
申请号：US14238370
申请日：2012-08-13
申请人： Florian Gunzer , Anke Zschuettig , Kurt Zimmermann
发明人： Florian Gunzer , Anke Zschuettig , Kurt Zimmermann
IPC分类号： C07K14/245 , A23L3/3463 , A61K9/70 , C07K16/12 , A01N63/00
CPC分类号： C07K14/245 , A01N63/00 , A23B4/22 , A23C3/08 , A23L3/34635 , A23V2002/00 , A61K9/70 , A61K38/00 , C07K16/1232 , Y02A50/473
摘要： The present invention relates to a new isolated polypeptide nominated microcin S, isolated nucleic acid molecules encoding the microcin S polypeptide and primers and probes hybridizing to the nucleic acid molecules. The invention also relates to plasmids and cells comprising the nucleic acid molecules, an antibody binding to the polypeptide, compositions as well as methods for producing and using the polypeptides. The present invention further relates to medical uses for treating or preventing microbial infections, functional gastrointestinal disorders or treating a tumor. The invention further relates to a method for preserving food and a method for coating dressing material.
摘要翻译：本发明涉及一种新的分离的多肽，指定的microcin S，编码微管S多肽的分离的核酸分子和与核酸分子杂交的引物和探针。本发明还涉及包含核酸分子，结合多肽的抗体，组合物以及生产和使用多肽的方法的质粒和细胞。本发明还涉及用于治疗或预防微生物感染，功能性胃肠道疾病或治疗肿瘤的医学用途。本发明还涉及一种保存食物的方法和一种涂敷敷料的方法。

5. 发明申请

US20110124623A1 PYRROLOTRIAZINE KINASE INHIBITORS 有权
标题翻译：吡咯啉激酶抑制剂
公开(公告)号：US20110124623A1
公开(公告)日：2011-05-26
申请号：US13015687
申请日：2011-01-28
申请人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
发明人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
IPC分类号： A61K31/397 , A61K31/53 , C07D487/04 , A61K31/5386 , A61K31/5377 , A61K31/551 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof.The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐。式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。

6. 发明授权

US07534792B2 Pyrrolotriazine kinase inhibitors 有权
标题翻译：吡咯并三嗪激酶抑制剂
公开(公告)号：US07534792B2
公开(公告)日：2009-05-19
申请号：US11773466
申请日：2007-07-05
申请人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
发明人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
IPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , A61K31/53 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐。式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。

7. 发明申请

US20070135443A1 NOVEL TYROSINE KINASE INHIBITORS 有权
标题翻译：新型酪氨酸激酶抑制剂
公开(公告)号：US20070135443A1
公开(公告)日：2007-06-14
申请号：US11625973
申请日：2007-01-23
申请人： Francis Beaulieu , Carl Ouellet , Kurt Zimmermann , Upender Velaparthi , Mark Wittman
发明人： Francis Beaulieu , Carl Ouellet , Kurt Zimmermann , Upender Velaparthi , Mark Wittman
IPC分类号： A61K31/52 , C07D473/12
CPC分类号： C07D471/04 , C07D473/32 , C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐。式I化合物抑制酪氨酸激酶，从而使其成为抗癌剂。

8. 发明授权

US07223757B2 Tyrosine kinase inhibitors 有权
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US07223757B2
公开(公告)日：2007-05-29
申请号：US11289834
申请日：2005-11-30
申请人： Mark D. Wittman , Neelakantan Balasubramanian , Upender Velaparthi , Kurt Zimmermann , Mark G. Saulnier , Peiying Liu , Xiaopeng Sang , David B. Frennesson , Karen M. Stoffan , James G. Tarrant , Anne Marinier , Stephan Roy
发明人： Mark D. Wittman , Neelakantan Balasubramanian , Upender Velaparthi , Kurt Zimmermann , Mark G. Saulnier , Peiying Liu , Xiaopeng Sang , David B. Frennesson , Karen M. Stoffan , James G. Tarrant , Anne Marinier , Stephan Roy
IPC分类号： C07D401/14 , C07D413/14 , A61K31/496 , A61K31/5377
CPC分类号： C07D417/14 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐。式I化合物抑制酪氨酸激酶，从而使其成为抗癌剂。式I化合物还可用于治疗可通过抑制酪氨酸激酶的治疗的其它疾病。

9. 发明授权

US4777835A Method for ascertaining the phyto-specific characteristics of crops grown by different methods 失效
标题翻译：确定通过不同方法生长的作物的植物特异性特征的方法
公开(公告)号：US4777835A
公开(公告)日：1988-10-18
申请号：US723761
申请日：1985-04-16
申请人： Volker Rusch , Edwin Pahlich , Kurt Zimmermann
发明人： Volker Rusch , Edwin Pahlich , Kurt Zimmermann
IPC分类号： A01G7/00 , G01N33/483 , G01N5/00 , G01N5/02 , G01N5/04
CPC分类号： A01G7/00
摘要： In a method for ascertaining phyto-specific characteristics for differently grown crops to differentiate between crop plants that have been subjected to different methods of growing, the following plant parametersFG.sub.max =maximum fresh weight,TG=dry weightAcP=proportion by weight of cell components capable of swellingAH.sub.2 O=proportion by weight of adsorptive waterWH.sub.2 O=proportion of cell water by weightare ascertained and are related to each other in the form of a ratio relativizing locality-dependent modifications. In accordance with a second form of the invention an enzyme, such as glutamate dehydrogenase, or an enzyme mixture present in the plants to be investigated and reacting particularly sensitively to an alteration in the supply of nitrogen, is isolated and the relaxation time .tau. of the enzyme is ascertained for different enzyme concentrations.
摘要翻译：在确定不同生长作物的植物特异性特征的方法中，以区分已经经历不同生长方式的作物植物之后，以下植物参数FGmax =最大鲜重，TG =干重AcP =细胞组分重量比能够膨胀AH2O =吸附水重量比例WH2O =重量比例的细胞水比例，并以相对于局部依赖性变化的比例的形式相互关联。根据本发明的第二种形式，分离存在于待研究的植物中的酶，例如谷氨酸脱氢酶或酶混合物，并特别敏感地对氮的供应的改变进行反应，并且分离出确定不同酶浓度的酶。

10. 发明授权

US4748358A Electric starter motor with holder for permanent magnets 失效
标题翻译：电动起动电机，带永久磁铁支架
公开(公告)号：US4748358A
公开(公告)日：1988-05-31
申请号：US86698
申请日：1987-07-01
申请人： Walter Ruhle , Peter Kleindieck , Kurt Zimmermann , Manfred Kropp
发明人： Walter Ruhle , Peter Kleindieck , Kurt Zimmermann , Manfred Kropp
IPC分类号： H02K1/18 , F02N11/00 , H02K1/17 , H02K23/04 , H02K21/26
CPC分类号： H02K1/17 , F02N11/00
摘要： An electric machine, particularly for starting devices, is suggested. Permanent magnets (4 to 9) with assigned flux conducting pieces (10 to 15) are arranged in the housing (1) of the electric machine. The permanent magnets (4 to 9), together with the flux conducting pieces (10 to 15), are preassembled in two rings (18, 19) as retaining parts to form a constructional unit. Each ring (18, 19) has a cylindrical portion (20; 30) which contacts the end portions of the inner side (21; 22) of the permanent magnets (4 to 9) or the flux conducting pieces (10 to 15). A flangelike edge (25; 33) of the rings (18; 19) contacts the front sides (23, 24; 31, 32) of the permanent magnets (4 to 9) and the flux conducting pieces (10 to 15). Tabs (26, 27; 34, 35), which contact the end portions of the free longitudinal sides (17; 28 ) of the permanent magnets (4 to 9) or the flux conducting pieces (10 to 15), are bent out from the edges 25 and 33. A ring (19) is provided with fastening means (36 to 41) for the detachable fastening of the magnet group (4 to 15, 18, 19) at projections (3) of the housing (1).
摘要翻译： PCT No.PCT / DE86 / 00386 Sec。 371日期1987年7月1日 102（e）日期1987年7月1日PCT申请日1986年9月23日PCT公布。公开号WO87 / 03148 日期1987年5月21日。建议使用电机，特别是起动装置。在电机的壳体（1）中配置具有分配的导磁片（10〜15）的永磁体（4〜9）。永磁体（4至9）与焊剂导电片（10至15）一起预先组装成两个环（18,19）作为保持部件，以形成结构单元。每个环（18,19）具有与永磁体（4至9）的内侧（21; 22）的端部或焊剂导电片（10至15）接触的圆柱形部分（20; 30）。环（18; 19）的法兰边缘（25; 33）接触永磁体（4至9）的前侧（23,24; 31,32）和磁通传导件（10至15）。与永久磁铁（4〜9）的自由纵向侧面（17; 28）的端部或焊剂导电片（10〜15）接触的凸片（26,27,34,35）从边缘25和33.环（19）设置有用于将磁体组（4至15,18,19）可拆卸地紧固在壳体（1）的突出部（3）处的紧固装置（36至41）。

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