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1. 发明授权

US5459036A Extracellular signal-regulated kinase, sequences, and methods of production and use 失效
标题翻译：细胞外信号调节激酶，序列和生产和使用方法
公开(公告)号：US5459036A
公开(公告)日：1995-10-17
申请号：US29404
申请日：1993-03-19
申请人： Cornelia Lechner , Niels P. H. Moller , Axel Ullrich
发明人： Cornelia Lechner , Niels P. H. Moller , Axel Ullrich
IPC分类号： C12N15/02 , A61K38/00 , A61K38/45 , A61K39/395 , A61K48/00 , A61P3/08 , A61P3/10 , A61P25/28 , A61P43/00 , C07H21/04 , C07K5/103 , C07K14/47 , C07K16/40 , C12N5/06 , C12N5/10 , C12N5/12 , C12N9/12 , C12N15/09 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91
CPC分类号： C07K16/40 , C12N9/12 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/021 , Y10S530/809
摘要： The present invention relates, in general, to an extracellular signal regulated kinase, ERK-5. In particular, the present invention relates to nucleic acid molecules coding for ERK-5; ERK-5 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antisense ERK-5 nucleic acid constructs; antibodies having binding affinity to an ERK-5 polypeptide; hybridomas containing the antibodies; nucleic acid probes for the detection of ERK-5 nucleic acid; a method of detecting ERK-5 nucleic acid or polypeptide in a sample; kits containing nucleic acid probes or antibodies; a method of detecting a compound capable of binding to ERK-5 or a fragment thereof; a method of detecting an agonist or antagonist of ERK-5 activity; a method of agonizing or antagonizing ERK-5 associated activity in a mammal; and a pharmaceutical composition comprising an ERK-5 agonist or antagonist.
摘要翻译：本发明一般涉及细胞外信号调节激酶ERK-5。特别地，本发明涉及编码ERK-5的核酸分子; ERK-5多肽; 重组核酸分子; 含有重组核酸分子的细胞; 反义ERK-5核酸构建体; 对ERK-5多肽具有结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测ERK-5核酸的核酸探针; 在样品中检测ERK-5核酸或多肽的方法; 含有核酸探针或抗体的试剂盒; 检测能够结合ERK-5或其片段的化合物的方法; 检测ERK-5活性的激动剂或拮抗剂的方法; 在哺乳动物中激动或拮抗ERK-5相关活性的方法; 和包含ERK-5激动剂或拮抗剂的药物组合物。

2. 发明授权

US6030822A Extracellular signal-regulated kinase, sequences, and methods of production and use 失效
公开(公告)号：US6030822A
公开(公告)日：2000-02-29
申请号：US459953
申请日：1995-06-02
申请人： Cornelia Lechner , Niels Peter M.o slashed.ller , Axel Ullrich
发明人： Cornelia Lechner , Niels Peter M.o slashed.ller , Axel Ullrich
IPC分类号： C12N15/02 , A61K38/00 , A61K38/45 , A61K39/395 , A61K48/00 , A61P3/08 , A61P3/10 , A61P25/28 , A61P43/00 , C07H21/04 , C07K5/103 , C07K14/47 , C07K16/40 , C12N5/06 , C12N5/10 , C12N5/12 , C12N9/12 , C12N15/09 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , C07K14/46
CPC分类号： C07K16/40 , C12N9/12 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/021 , Y10S530/809
摘要： The present invention relates, in general, to an extracellular signal regulated kinase, ERK-5. In particular, the present invention relates to nucleic acid molecules coding for ERK-5; ERK-5 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antisense ERK-5 nucleic acid constructs; antibodies having binding affinity to an ERK-5 polypeptide; hybridomes containing the antibodies; nucleic acid probes for the detecting of ERK-5 nucleic acid; a method of detecting ERK-5 nucleic acid or polypeptide in a sample; kits containing nucleic acid probes or antibodies; a method of detecting a compound capable of binding to ERK-5 or a fragment thereof; a method of detecting an agonist or antagonist of ERK-5 activity; a method of agonizing or antagonizing ERK-5 associated activity in a mammal; a method of treating diabetes mellitus, skeletal muscle diseases, Alzheimer's disease, or peripheral neuropathies in a mammal with an agonist or antagonist of ERK-5 activity; and a pharmaceutical composition comprising an ERK-5 agonist or antagonist.

3. 发明授权

US06579972B1 Extracellular signal-regulated kinase, sequences, and methods of production and use 失效
标题翻译：细胞外信号调节激酶，序列和生产和使用方法
公开(公告)号：US06579972B1
公开(公告)日：2003-06-17
申请号：US09393212
申请日：1999-09-09
申请人： Cornelia Lechner , Niels Peter Møller , Axel Ullrich
发明人： Cornelia Lechner , Niels Peter Møller , Axel Ullrich
IPC分类号： C07K1640
CPC分类号： C07K16/40 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/12 , C12N2799/021 , Y10S530/809
摘要： The present invention relates, in general, to an extracellular signal regulated kinase, ERK-5. In particular, the present invention relates to nucleic acid molecules coding for ERK-5; ERK-5 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antisense ERK-5 nucleic acid constructs; antibodies having binding affinity to an ERK-5 polypeptide; hybridomes containing the antibodies; nucleic acid probes for the detecting of ERK-5 nucleic acid; a method of detecting ERK-5 nucleic acid or polypeptide in a sample; kits containing nucleic acid probes or antibodies; a method of detecting a compound capable of binding to ERK-5 or a fragment thereof; a method of detecting an agonist or antagonist of ERK-5 activity; a method of agonizing or antagonizing ERK-5 associated activity in a mammal; a method of treating diabetes mellitus, skeletal muscle diseases, Alzheimer's disease, or peripheral neuropathies in a mammal with an agonist or antagonist of ERK-5 activity; and a pharmaceutical composition comprising an ERK-5 agonist or antagonist.
摘要翻译：本发明一般涉及细胞外信号调节激酶ERK-5。特别地，本发明涉及编码ERK-5的核酸分子; ERK-5多肽; 重组核酸分子; 含有重组核酸分子的细胞; 反义ERK-5核酸构建体; 对ERK-5多肽具有结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测ERK-5核酸的核酸探针; 在样品中检测ERK-5核酸或多肽的方法; 含有核酸探针或抗体的试剂盒; 检测能够结合ERK-5或其片段的化合物的方法; 检测ERK-5活性的激动剂或拮抗剂的方法; 在哺乳动物中激动或拮抗ERK-5相关活性的方法; 在具有ERK-5活性的激动剂或拮抗剂的哺乳动物中治疗糖尿病，骨骼肌疾病，阿尔茨海默氏病或周围神经病变的方法; 和包含ERK-5激动剂或拮抗剂的药物组合物。

4. 发明授权

US07371828B2 Extracellular signal-regulated kinase sequences and methods of production and use 失效
标题翻译：细胞外信号调节激酶序列及其生产和使用方法
公开(公告)号：US07371828B2
公开(公告)日：2008-05-13
申请号：US10461402
申请日：2003-06-16
申请人： Cornelia Lechner , Niels P. Moller , Axel Ullrich
发明人： Cornelia Lechner , Niels P. Moller , Axel Ullrich
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/12 , C12N2799/021 , Y10S530/809
摘要： The present invention relates, in general, to an extracellular signal regulated kinase, ERK-5. In particular, the present invention relates to nucleic acid molecules coding for ERK-5; ERK-5 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antisense ERK-5 nucleic acid constructs; antibodies having binding affinity to an ERK-5 polypeptide; hybridomes containing the antibodies; nucleic acid probes for the detecting of ERK-5 nucleic acid; a method of detecting ERK-5 nucleic acid or polypeptide in a sample; kits containing nucleic acid probes or antibodies; a method of detecting a compound capable of binding to ERK-5 or a fragment thereof; a method of detecting an agonist or antagonist of ERK-5 activity; a method of agonizing or antagonizing ERK-5 associated activity in a mammal; a method of treating diabetes mellitus, skeletal muscle diseases, Alzheimer's disease, or peripheral neuropathies in a mammal with an agonist or antagonist of ERK-5 activity; and a pharmaceutical composition comprising an ERK-5 agonist or antagonist.
摘要翻译：本发明一般涉及细胞外信号调节激酶ERK-5。特别地，本发明涉及编码ERK-5的核酸分子; ERK-5多肽; 重组核酸分子; 含有重组核酸分子的细胞; 反义ERK-5核酸构建体; 对ERK-5多肽具有结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测ERK-5核酸的核酸探针; 在样品中检测ERK-5核酸或多肽的方法; 含有核酸探针或抗体的试剂盒; 检测能够结合ERK-5或其片段的化合物的方法; 检测ERK-5活性的激动剂或拮抗剂的方法; 在哺乳动物中激动或拮抗ERK-5相关活性的方法; 在具有ERK-5活性的激动剂或拮抗剂的哺乳动物中治疗糖尿病，骨骼肌疾病，阿尔茨海默氏病或周围神经病变的方法; 和包含ERK-5激动剂或拮抗剂的药物组合物。

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