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1. 发明授权

US07589065B2 Catalysis of the cis/trans-isomerisation of secondary amide peptide compounds 失效
标题翻译：仲酰胺肽化合物的顺式/反式异构化的催化
公开(公告)号：US07589065B2
公开(公告)日：2009-09-15
申请号：US10487750
申请日：2002-08-20
申请人： Cordelia Schiene-Fischer , Gunter Fischer , Judith Maria Habazettl , Gerhard Küllertz
发明人： Cordelia Schiene-Fischer , Gunter Fischer , Judith Maria Habazettl , Gerhard Küllertz
IPC分类号： A61K31/16 , A61K38/05 , C07C233/31 , C07K5/06
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected by enzymes which are hereinafter called “secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. Thus, the invention relates to pharmaceutical compositions comprising substances which inhibit APIase activity.
摘要翻译：本发明基于以下发现：可以催化促进寡肽和多肽中的仲酰胺肽键的顺/反异构化。这种催化通过下文称为“仲酰胺肽键顺式/反式异构酶（APIase）”的酶来实现，可以认为APIase活性在多种病理生理过程中起关键作用，因此本发明涉及药物组合物包括抑制APIase活性的物质。

2. 发明申请

US20100160175A1 Catalysis of the cis/trans-isomerisation of secondary amide peptide compounds 审中-公开
标题翻译：仲酰胺肽化合物的顺式/反式异构化的催化
公开(公告)号：US20100160175A1
公开(公告)日：2010-06-24
申请号：US12583818
申请日：2009-08-26
申请人： Cordelia Schiene-Fischer , Gunter Fischer , Judith Maria Habazettl , Gerhard Küllertz
发明人： Cordelia Schiene-Fischer , Gunter Fischer , Judith Maria Habazettl , Gerhard Küllertz
IPC分类号： C12Q1/533 , C40B30/04
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected by enzymes which are hereinafter called “secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. Thus, the invention relates to pharmaceutical compositions comprising substances which inhibit APIase activity.
摘要翻译：本发明基于以下发现：可以催化促进寡肽和多肽中的仲酰胺肽键的顺/反异构化。这种催化由下文称为“仲酰胺肽键顺/反异构酶（APIase）”的酶实现。可以假设APIase活性在许多病理生理过程中起核心作用。因此，本发明涉及包含抑制APIase活性的物质的药物组合物。

3. 发明申请

US20100041747A1 USE OF CERTAIN CHEMICAL COMPOUNDS FOR THE INHIBITION OF THE PEPTIDYL-PROLYL CIS/TRANS ISOMERASE ACTIVITY OF CYCLOPHILINS 审中-公开
标题翻译：某些化学化合物用于抑制环丙沙星的苯丙氨酸/转异构体异构体活性的用途
公开(公告)号：US20100041747A1
公开(公告)日：2010-02-18
申请号：US12377788
申请日：2007-08-14
申请人： Gunter Fischer , Cordelia Schiene-Fischer , Sebastian Daum , Gerhard Küllertz , Manfred Braun
发明人： Gunter Fischer , Cordelia Schiene-Fischer , Sebastian Daum , Gerhard Küllertz , Manfred Braun
IPC分类号： A61K31/12 , A61K31/136 , A61K31/365 , A61P29/00 , A61P37/00 , A61P31/04 , A61P31/10 , A61P35/00 , A61P31/12 , A61P33/00 , A61P33/02 , A61P35/02
CPC分类号： A61K31/12 , A61K31/136 , A61K31/343 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/471 , Y02A50/475 , Y02A50/481 , Y02A50/483
摘要： The present invention relates to the use of certain spiro, ketone and carboxylic acid compounds for the inhibition of the peptidyl-prolyl cis/trans isomerase activity of cyclophilins and the use of these compounds for the production of a cosmetic or pharmaceutical composition for the promotion of hair growth or for the treatment or prevention of inflammatory autoimmune diseases, of diseases caused by fungi, of bacterial infections, of viral infections, of diseases caused by parasites, protozoa or worms, of cancer, of diseases of cells, of fibrosing diseases, and of non-neoplastic changes and diseases which are attributable to prions and changes in the structure and function of cellular proteins and cells.
摘要翻译：本发明涉及某些螺，酮和羧酸化合物用于抑制亲环蛋白的肽基 - 脯氨酰顺/反异构酶活性的用途，以及这些化合物用于生产化妆品或药物组合物以促进毛发生长或用于治疗或预防炎性自身免疫疾病，由真菌引起的疾病，细菌感染，病毒感染，由寄生虫，原虫或蠕虫引起的疾病，癌症，细胞疾病，纤维化疾病和的非肿瘤性变化和疾病，其归因于细胞蛋白和细胞的结构和功能的朊病毒和变化。

4. 发明申请

US20060100130A9 Catalysis of the cis/trans-isomerisation of secondary amide peptide compounds 失效
公开(公告)号：US20060100130A9
公开(公告)日：2006-05-11
申请号：US10487750
申请日：2002-08-20
申请人： Cordelia Schiene-Fischer , Gunter Fischer , Judith Habazettl , Gerhard Kullertz
发明人： Cordelia Schiene-Fischer , Gunter Fischer , Judith Habazettl , Gerhard Kullertz
IPC分类号： A61K38/00
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected by enzymes which are hereinafter called “secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. Thus, the invention relates to pharmaceutical compositions comprising substances which inhibit APIase activity.

5. 发明申请

US20050043213A1 Catalysis of the cis/trans-isomerisation of secondary amide peptide compounds 失效
标题翻译：仲酰胺肽化合物的顺式/反式异构化的催化
公开(公告)号：US20050043213A1
公开(公告)日：2005-02-24
申请号：US10487750
申请日：2002-08-20
申请人： Cordelia Schiene-Fischer , Gunter Fischer , Judith Habazeul , Gerhard Kullertz
发明人： Cordelia Schiene-Fischer , Gunter Fischer , Judith Habazeul , Gerhard Kullertz
IPC分类号： A61K38/00 , C07K7/56
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected by enzymes which are hereinafter called “secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. Thus, the invention relates to pharmaceutical compositions comprising substances which inhibit APIase activity.
摘要翻译：本发明基于以下发现：可以催化促进寡肽和多肽中的仲酰胺肽键的顺/反异构化。这种催化通过下文称为“仲酰胺肽键顺式/反式异构酶（APIase）”的酶来实现，可以认为APIase活性在多种病理生理过程中起关键作用，因此本发明涉及药物组合物包括抑制APIase活性的物质。

6. 发明申请

US20100009860A1 Device and method for analysis of interactions between biomolecules 审中-公开
标题翻译：用于分析生物分子之间相互作用的装置和方法
公开(公告)号：US20100009860A1
公开(公告)日：2010-01-14
申请号：US11631680
申请日：2005-07-07
申请人： Gunter Fischer , Cordelia Schiene-Fischer , Miroslav Malesevic , Mike Schutkowski
发明人： Gunter Fischer , Cordelia Schiene-Fischer , Miroslav Malesevic , Mike Schutkowski
IPC分类号： C40B30/04 , C40B40/04 , C40B40/06 , C40B40/10 , C40B40/12
CPC分类号： C40B30/04 , G01N33/54353
摘要： The present invention relates to a device for the analysis of interactions between biomolecules comprising a support, on which a plurality of biomolecules are immobilized on the surface of a support material in a regular or irregular manner by a linker, whereby two biomolecules are bound to each linker. Further, the present invention relates to a method for the detection of interactions between biopolymers immobilized on a surface comprising the steps of providing a device of one of the preceding claims, adjusting a defined distance between two biopolymers immobilized on the surface and detection of a signal generated by the interaction between the two biopolymers.
摘要翻译：本发明涉及用于分析包含载体的生物分子之间的相互作用的装置，其上多个生物分子通过连接体以规则或不规则的方式固定在载体材料的表面上，由此将两个生物分子结合到每个接头。此外，本发明涉及一种用于检测固定在表面上的生物聚合物之间的相互作用的方法，包括以下步骤：提供前述权利要求之一的装置，调整固定在表面上的两种生物聚合物之间的限定距离和信号的检测由两种生物聚合物之间的相互作用产生。

7. 发明申请

US20100311661A1 USE OF COMPOUNDS DERIVED FROM CYCLOHEXIMIDE FOR THE TREATMENT OR PREVENTION OF, IN PARTICULAR, ISCHAEMIAS AND CARDIOPATHIES 审中-公开
标题翻译：使用衍生自环己酮的化合物进行治疗或预防，特别是ISCHAEMIAS和CARDIOPATHIES
公开(公告)号：US20100311661A1
公开(公告)日：2010-12-09
申请号：US12675034
申请日：2007-08-24
申请人： Gerhard Küllertz , Gunter Fischer , Steffi Rau , Britta Erika Husse
发明人： Gerhard Küllertz , Gunter Fischer , Steffi Rau , Britta Erika Husse
IPC分类号： A61K38/05 , A61K31/45 , A61P9/10 , A61P13/12 , A61P1/16 , A61P1/00 , A61P9/00 , A61P11/00 , A61P1/18 , A61P19/02 , A61P29/00 , A01N1/02
CPC分类号： A61K31/45
摘要： The present invention relates to the use of certain derivatives of cycloheximide or the pharmaceutically acceptable salts thereof for the manufacture of a medicament for the treatment or prevention of ischaemias, of cardiopathies, of endothelial disorders, of traumata, of necroses, of pulmonary disorders, of vascular disorders, of forms of shock, of blood flow impairments or of stroke; or for the manufacture of a medicament for the treatment or prevention of diseases caused by ischaemia; or for the manufacture of a composition for the preservation and/or storage of transplants, especially of organs.
摘要翻译：本发明涉及放线菌酮的某些衍生物或其药学上可接受的盐在制备用于治疗或预防心律失常，心内膜疾病，创伤，坏死，肺部疾病，血管疾病，休克形式，血液流动障碍或中风; 或用于制造用于治疗或预防由缺血引起的疾病的药物; 或用于制造用于保存和/或储存移植物，特别是器官的组合物。

8. 发明申请

US20140316104A1 CYCLOSPORIN DERIVATIVES 有权
标题翻译：环磷酰胺衍生物
公开(公告)号：US20140316104A1
公开(公告)日：2014-10-23
申请号：US14241126
申请日：2012-08-29
申请人： Gunter Fischer , Miroslav Malesevic , Frank Erdmann , Jan Kuhling , Michael Bukrinsky , Stephanie Constant , Gerd Ruhter , Peter Nussbaumer , Klaus Dinkel
发明人： Gunter Fischer , Miroslav Malesevic , Frank Erdmann , Jan Kuhling , Michael Bukrinsky , Stephanie Constant , Gerd Ruhter , Peter Nussbaumer , Klaus Dinkel
IPC分类号： C07K7/64
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
摘要： The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect.
摘要翻译：本发明涉及不与细胞膜交叉的新型环孢菌素衍生物。根据本发明的化合物用于医学中，更特别地用于治疗/诊断急性和慢性炎性疾病，病毒感染，癌症，退行性肌肉疾病，神经变性疾病以及与钙稳态损伤相关的损伤。新型环孢菌素衍生物另外没有免疫抑制作用。

9. 发明申请

US20060089400A1 Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolylcis/trans-isomerases 审中-公开
标题翻译：新的螺酮和羧酸衍生物作为（po3h2）ser /（po3h2）特异性肽基 - 脯氨酰基/反式异构酶的特异性抑制剂
公开(公告)号：US20060089400A1
公开(公告)日：2006-04-27
申请号：US10514279
申请日：2003-05-02
申请人： Birte Hernandez Alvarez , Gunter Fischer , Manfred Braun , Anahita Hessamian-Alinejad , Hans Fliri
发明人： Birte Hernandez Alvarez , Gunter Fischer , Manfred Braun , Anahita Hessamian-Alinejad , Hans Fliri
IPC分类号： A61K31/407 , A61K31/343 , A61K31/277 , C07D209/96 , C07D317/72
CPC分类号： C07D307/94
摘要： The invention provides new spiro and carboxylic acid derivatives, pharmaceutically compositions comprising them and their use for the preparation of pharmaceutical compositions.
摘要翻译：本发明提供新的螺和羧酸衍生物，包含它们的药物组合物及其用于制备药物组合物的用途。

10. 发明授权

US4662332A Engine braking control system 失效
标题翻译：发动机制动控制系统
公开(公告)号：US4662332A
公开(公告)日：1987-05-05
申请号：US762287
申请日：1985-08-05
申请人： Horst Bergmann , Gunter Fischer
发明人： Horst Bergmann , Gunter Fischer
IPC分类号： F01L13/06 , F02B75/02 , F02D9/06 , F02D13/04
CPC分类号： F01L13/065 , F01L1/181 , F02D13/04 , F02D9/06 , F02B2075/027
摘要： In a four-stroke internal combustion engine for driving a motor vehicle, a throttle flap holding back the exhaust gases during vehicle braking is arranged in the outlet channel. Each of the outlet valves controlled by a cam shaft via rockers has assigned to it a limiting device by means of which the stroke of the outlet valves is limited during braking to an amount which prevents the outlet valves from closing. To increase the engine braking power in an internal combustion engine of this type, the stroke of the outlet valves is limited to an amount at which the opened outlet valves achieve a braking effect, and there is a directional valve which is adjustable as a function of the brake-pedal travel and by means of which the throttle flap and the limiting devices can be actuated.
摘要翻译：在用于驱动机动车辆的四冲程内燃机中，在出口通道中布置有在车辆制动期间阻止废气的节流阀。通过摇臂由凸轮轴控制的每个出口阀都赋予了限制装置，通过该限制装置，出口阀的行程在制动期间被限制到防止出口阀关闭的量。为了增加这种内燃机的发动机制动功率，出口阀的行程被限制在开启的出口阀获得制动效果的量，并且存在可作为制动踏板行程，并且通过该行程可以启动节流阀和限位装置。

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