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1. 发明授权

US09574038B2 Contact lenses made with HEMA-compatible polysiloxane macromers 有权
标题翻译：用HEMA相容的聚硅氧烷大分子单体制成隐形眼镜
公开(公告)号：US09574038B2
公开(公告)日：2017-02-21
申请号：US15115271
申请日：2015-02-25
申请人： CooperVision International Holding Company, LP
发明人： Hiroyuki Ueyama , Charlie Chen , Yuan Xu , Yuwen Liu , Ying Zheng , Paul Richardson , Hong Xue
IPC分类号： C08F220/20 , C08G77/20 , C08G77/46 , B29C35/02 , C08F220/28 , B29K83/00 , B29L11/00
CPC分类号： C08F220/20 , B29C35/02 , B29K2083/00 , B29L2011/0041 , C08F230/08 , C08F2220/281 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/46 , C08L83/06 , C08L83/12 , G02B1/043 , C08L83/04 , C08L101/14 , C08L33/10
摘要： HEMA-compatible siloxane monomers are described that can be used to manufacture contact lenses that combine the attributes of HEMA-based contact lenses with the high oxygen permeability of silicone hydrogel lenses. Optically clear silicone hydrogel contact lens can be manufactured that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising: a) at least 25 wt. % of at least one hydroxyalkyl methacrylate; and b) at least 20 wt. % of at least one HEMA-compatible polysiloxane.
摘要翻译：描述了可与HEMA相容的硅氧烷单体，其可用于制造将HEMA基隐形眼镜的属性与硅氧水凝胶镜片的高透氧性组合的隐形眼镜。可以制造光学透明的硅酮水凝胶隐形眼镜，其包含作为可聚合组合物的反应产物的聚合物透镜体，其包含：a）至少25wt。％至少一种甲基丙烯酸羟烷基酯; 和b）至少20wt。％的至少一种HEMA相容的聚硅氧烷。

2. 发明授权

US09453110B2 Contact lenses made with HEMA-compatible polysiloxane macromers 有权
标题翻译：用HEMA相容的聚硅氧烷大分子单体制成隐形眼镜
公开(公告)号：US09453110B2
公开(公告)日：2016-09-27
申请号：US15065889
申请日：2016-03-10
申请人： CooperVision International Holding Company, LP
发明人： Hiroyuki Ueyama , Charlie Chen , Yuan Xu , Yuwen Liu , Ying Zheng , Paul Richardson , Prasad Dande
IPC分类号： G02B1/04 , C08L33/10 , C08L83/12 , C08L101/14 , C08L83/04 , C08L83/06 , C08G77/442 , C08G77/46 , C08G77/32 , C08G77/20
CPC分类号： C08G77/20 , C08G77/442 , C08G77/46 , C08L83/12 , G02B1/04 , G02B1/043 , C08L83/04 , C08L101/14 , C08L33/10 , C08L83/06
摘要： Optically clear silicone hydrogel contact lenses are described that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising at least 25 wt. % of at least one hydroxyalkyl methacrylate; and at least 20 wt. % of at least one HEMA-compatible bifunctional polysiloxane comprising at least 6 siloxane groups and having an HLB value of at least 5 and/or a hydroxyl group content of at least 1 wt. %.
摘要翻译：描述了光学透明的硅酮水凝胶隐形眼镜，其包含聚合物透镜体，其是可聚合组合物的反应产物，其包含至少25wt。％至少一种甲基丙烯酸羟烷基酯; 和至少20wt。至少一种含有至少6个硅氧烷基团并且具有至少5个和/或至少1重量％的羟基含量的HLB值的至少一种与HEMA相容的双官能聚硅氧烷的％％。

3. 发明申请

US20140066540A1 Contact Lenses Made With HEMA-Compatible Polysiloxane Macromers 有权
标题翻译：隐形眼镜用HEMA兼容的聚硅氧烷大单体制成
公开(公告)号：US20140066540A1
公开(公告)日：2014-03-06
申请号：US14010609
申请日：2013-08-27
申请人： CooperVision International Holding Company, LP
发明人： Hiroyuki Ueyama , Charlie Chen , Yuan Xu , Yuwen Liu , Ying Zheng , Paul Richardson , Prasad Dande
IPC分类号： G02B1/04
CPC分类号： C08G77/20 , C08G77/442 , C08G77/46 , C08L83/12 , G02B1/04 , G02B1/043 , C08L83/04 , C08L101/14 , C08L33/10 , C08L83/06
摘要： Optically clear silicone hydrogel contact lenses are described that comprise a polymeric lens body that is the reaction product of a polymerizable composition comprising at least 25 wt. % of at least one hydroxyalkyl methacrylate; and at least 20 wt. % of at least one HEMA-compatible bifunctional polysiloxane comprising at least 6 siloxane groups and having an HLB value of at least 5 and/or a hydroxyl group content of at least 1 wt. %.
摘要翻译：描述了光学透明的硅酮水凝胶隐形眼镜，其包含聚合物透镜体，其是可聚合组合物的反应产物，其包含至少25wt。％至少一种甲基丙烯酸羟烷基酯; 和至少20wt。至少一种含有至少6个硅氧烷基团并且具有至少5个和/或至少1重量％的羟基含量的HLB值的至少一种与HEMA相容的双官能聚硅氧烷的％％。

4. 发明授权

US09625616B2 Silicone hydrogel contact lenses 有权
公开(公告)号：US09625616B2
公开(公告)日：2017-04-18
申请号：US14768869
申请日：2014-03-14
申请人： CooperVision International Holding Company, LP
发明人： Yuwen Liu , AKM Shahab Siddiqui , Yuan Ji , Junhao Ge
IPC分类号： C08L83/06 , G02B1/04 , B29D11/00
CPC分类号： G02B1/043 , B29D11/00192 , B29D11/0025 , C08L83/06
摘要： A method is provided for manufacturing ophthalmically-acceptable, distortion-free silicone hydrogel contact lenses without the use of volatile organic solvents in the manufacturing process. The contact lenses are extract with an extraction liquid comprising an aqueous solution of a non-volatile organic solvent, such as ethyl lactate.

5. 发明申请

US20160003980A1 Silicone Hydrogel Contact Lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US20160003980A1
公开(公告)日：2016-01-07
申请号：US14768869
申请日：2014-03-14
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP
发明人： Yuwen Liu , AKM Shahab Siddiqui , Yuan Ji , Junhao Ge
IPC分类号： G02B1/04 , C08L83/06
CPC分类号： G02B1/043 , B29D11/00192 , B29D11/0025 , C08L83/06
摘要： A method is provided for manufacturing ophthalmically-acceptable, distortion-free silicone hydrogel contact lenses without the use of volatile organic solvents in the manufacturing process. The contact lenses are extract with an extraction liquid comprising an aqueous solution of a non-volatile organic solvent, such as ethyl lactate.
摘要翻译：提供了在制造过程中不使用挥发性有机溶剂制造眼科可接受的，无变形的硅酮水凝胶隐形眼镜的方法。用包含非挥发性有机溶剂如乳酸乙酯的水溶液的提取液提取隐形眼镜。

6. 发明申请

US20140174962A1 Silicone Hydrogel Contact Lenses For Sustained Release Of Beneficial Polymers 有权
标题翻译：硅胶水凝胶隐形眼镜用于持久释放有益聚合物
公开(公告)号：US20140174962A1
公开(公告)日：2014-06-26
申请号：US14109979
申请日：2013-12-18
申请人： CooperVision International Holding Company, LP
发明人： Andrew Luk , Victoria Rogers , Junhao Ge , Hong Xue , Yuwen Liu , Arthur Back , Yun Zhang , Ying Ye , Peter Zhu
IPC分类号： A45C11/00 , B65B55/02
CPC分类号： A45C11/005 , B65B55/02 , G02B1/043
摘要： Silicone hydrogel contact lenses comprising an ionic component sustain release of beneficial cationic polymers.
摘要翻译：含有离子组分的有机硅水凝胶隐形眼镜可持续释放有益的阳离子聚合物。

7. 发明授权

US08658747B2 Wettable silicone hydrogel contact lenses 有权
标题翻译：可湿性硅酮水凝胶隐形眼镜
公开(公告)号：US08658747B2
公开(公告)日：2014-02-25
申请号：US13906367
申请日：2013-05-31
申请人： CooperVision International Holding Company, LP
发明人： Yuwen Liu , Charlie Chen , Charles A. Francis , Junhao Ge , Yuan Xu , Li Yao , Arthur Back , Ying Zheng
IPC分类号： C08F230/06 , C08F290/06 , G02B1/04
CPC分类号： G02C7/04 , B65B5/04 , G02B1/043 , C08L83/12 , C08L33/08 , C08L33/10
摘要： Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group, the first siloxane monomer having a number average molecular weight of from 400 daltons to 700 daltons; and a second siloxane monomer having a number average molecular weight greater than 7,000 daltons; wherein a total amount of siloxane monomers present in the polymerizable composition is from 30 unit parts to 50 unit parts; the lenses also include units derived from at least one hydrophilic amide monomer having one N-vinyl group that is present in the polymerizable composition in an amount from 30 to 60 unit parts. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了眼科可接受的可湿性硅氧水凝胶隐形眼镜。透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是具有1至4个碳原子的烷基，式（1）的每个R 2独立地为氢原子或甲基，第一硅氧烷单体的数均分子量为400道尔顿至700道尔顿和数均分子量大于7,000道尔顿的第二硅氧烷单体; 其中存在于聚合性组合物中的硅氧烷单体的总量为30单位份〜50单位份; 透镜还包括衍生自至少一种具有一个N-乙烯基的亲水性酰胺单体的单元，该单体存在于可聚合组合物中的量为30至60单位份。当完全水合时，镜片具有眼科可接受的可润湿透镜表面。还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

8. 发明申请

US20190129202A1 Methods of Manufacturing Coated Contact Lenses 审中-公开
公开(公告)号：US20190129202A1
公开(公告)日：2019-05-02
申请号：US16136484
申请日：2018-09-20
申请人： CooperVision International Holding Company, LP
发明人： Hong Xue , Yuwen Liu
IPC分类号： G02C7/04 , G02B1/04 , B29D11/00
摘要： Methods are disclosed for manufacturing a coated contact lens that comprises a polymeric lens body comprising an acid group, a first coating polymer comprising a first amine group ionically bound to the acid group, and a second coating bound to the first coating polymer through covalent linkage between a nitrogen atom of a second amine group on the first coating polymer and an amine-reactive group of the second coating polymer. In some examples the lenses exhibit improved surface properties compared to uncoated lenses, such as reduced adhesion, increased wettability, increased lubricity, and/or increased lipid resistance.

9. 发明授权

US09864103B2 Phosphine-containing hydrogel contact lenses 有权
公开(公告)号：US09864103B2
公开(公告)日：2018-01-09
申请号：US14158879
申请日：2014-01-20
申请人： CooperVision International Holding Company, LP
发明人： Guigui Wang , Yun Zhang , Yuwen Liu , Ye Hong , Charlie Chen , Peter Zhu
IPC分类号： G02B1/04 , A45C11/00 , B65D81/22
CPC分类号： G02B1/043 , A45C11/005 , B65D81/22 , C08L83/04
摘要： Hydrogel contact lenses that are derived from a polymerizable composition including at least one hydrophilic monomer and at least one phosphine-containing component are described. The hydrogel of the contact lenses can be a silicone hydrogel or a non-silicone hydrogel. Use of polymerizable compositions comprising a phosphine-containing component can be cured under both inert and air atmospheres, and can be used to form hydrogel contact lenses having improved shape retention properties, having improved resistance to discoloration. Batches of hydrogel contact lenses and methods of making hydrogel contact lenses are also described.

10. 发明申请

US20140131227A1 Phosphine-Containing Hydrogel Contact Lenses 审中-公开
标题翻译：含磷的水凝胶隐形眼镜
公开(公告)号：US20140131227A1
公开(公告)日：2014-05-15
申请号：US14158879
申请日：2014-01-20
申请人： CooperVision International Holding Company, LP
发明人： Guigui Wang , Yun Zhang , Yuwen Liu , Ye Hong , Charlie Chen , Peter Zhu
IPC分类号： G02B1/04 , B65D81/22 , A45C11/00
CPC分类号： G02B1/043 , A45C11/005 , B65D81/22 , C08L83/04
摘要： Hydrogel contact lenses that are derived from a polymerizable composition including at least one hydrophilic monomer and at least one phosphine-containing component are described. The hydrogel of the contact lenses can be a silicone hydrogel or a non-silicone hydrogel. Use of polymerizable compositions comprising a phosphine-containing component can be cured under both inert and air atmospheres, and can be used to form hydrogel contact lenses having improved shape retention properties, having improved resistance to discoloration. Batches of hydrogel contact lenses and methods of making hydrogel contact lenses are also described.
摘要翻译：描述了衍生自包含至少一种亲水性单体和至少一种含膦组分的可聚合组合物的水凝胶隐形眼镜。隐形眼镜的水凝胶可以是硅酮水凝胶或非硅氧水凝胶。包含含膦组分的可聚合组合物的使用可以在惰性和空气气氛下固化，并且可用于形成具有改善的变色保持性能的具有改进的抗变色性的水凝胶隐形眼镜。还描述了水凝胶隐形眼镜的批次和制备水凝胶隐形眼镜的方法。

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