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1. 发明授权

US5763443A MDR resistance treatment and novel pharmaceutically active riminophenazines 失效
标题翻译： MDR抗性治疗和新型药学活性的riminophenazines
公开(公告)号：US5763443A
公开(公告)日：1998-06-09
申请号：US738473
申请日：1996-10-28
申请人： Constance Elizabeth Medlen , Ronald Anderson , John Francis O'Sullivan
发明人： Constance Elizabeth Medlen , Ronald Anderson , John Francis O'Sullivan
IPC分类号： A61K31/498 , C07D241/46 , A61K31/495
CPC分类号： A61K31/498
摘要： The invention concerns the new use of riminophenazines in the treatment of a patient who has built up, or could build up, resistance to a therapeutically active substance, such as a patient requiring treatment for cancer. The riminophenazine conveniently may be of the general formula (I). ##STR1## R.sup.1 is a hydrogen atom, a halogen atom or a (C.sub.1 -C.sub.3) alkyl, (C.sub.1 -C.sub.3) alkoxy, fluoromethoxy or trifluoromethyl radical, R.sup.2 is a hydrogen or halogen atom, R.sup.3 is selected from hydrogen, (C.sub.1 -C.sub.4) alkyl, N,N-dialkylamino alkyl, (C.sub.3 -C.sub.12) cycloalkyl, methylcyclohexyl, hydroxycyclohexyl, cycloalkylmethyl, piperidyl, alkyl substituted piperidyl or N-benzyl-substituted pipperidyl, R.sup.4 is a hydrogen or halogen atom or a (C.sub.1 -C.sub.3) alkyl, (C.sub.1 -C.sub.3) alkoxy, fluoromethoxy or trifluoromethyl radical, and n is 1, 2 or 3. The invention also provides novel riminophenazines of general formula (I), their preparation, and compositions containing them.
摘要翻译：本发明涉及用于治疗已经建立或可能增加对治疗活性物质（例如需要治疗癌症的患者）的患者的治疗的患者的新用途。方便地可以具有通式（I）的riminophenazine。（C 1 -C 3）烷基，（C 1 -C 3）烷氧基，氟甲氧基或三氟甲基，R 2是氢或卤素原子，R 3选自氢，（C 1 -C 4）烷基，N，N-二烷基氨基烷基，（C 3 -C 12）环烷基，甲基环己基，羟基环己基，环烷基甲基，哌啶基，烷基取代的哌啶基或N-苄基取代的哌啶子基，R4是氢或卤素原子或（C1-C3）烷基，（C1-C3）烷氧基，或三氟甲基，n为1,2或3.本发明还提供通式（I）的新型riminophenazine，其制备方法和含有它们的组合物。

2. 发明授权

US5763442A Anti-parasitic activity 失效
标题翻译：抗寄生虫活性
公开(公告)号：US5763442A
公开(公告)日：1998-06-09
申请号：US591032
申请日：1996-01-25
申请人： Constance Elizabeth Medlen , Ronald Anderson
发明人： Constance Elizabeth Medlen , Ronald Anderson
IPC分类号： C07D241/46 , A61K31/495 , A61K31/498 , A61P33/02 , A61K31/50
CPC分类号： A61K31/498 , A61K31/495
摘要： The invention provides the use of a riminophenazine in the manufacture of a medicament to treat parasitic infections. The riminophenazine may be used for the prophylactic treatments of maleria or for the therapeutic treatment of maleria. A known anti-maleria drug, e.g. chloroquine or mefloquine may be administered as well. The riminophenazine may be a compound of the general formula: ##STR1## wherein: R.sup.1 is selected from hydrogen atoms, halogen atoms, alkyl, alkoxy and trifluoromethyl radicals, R.sub.2 is selected from hydrogen or halogen atoms, R.sup.3 is selected from hydrogen atoms, alkyl, substituted alkyl, cycloalkyl, cycloalkylalkyl, unsubstituted heterocyclic radicals, substituted heterocyclic radicals, unsubstituted heterocyclicalkyl and substituted heterocyclicalkyl radicals.
摘要翻译：本发明提供了在制备用于治疗寄生虫感染的药物中使用边缘吩吩嗪的用途。所述的林必泛嗪可用于预防性治疗恶性肿瘤或用于治疗恶性肿瘤。已知的抗疟药物，例如，也可以施用氯喹或甲氟喹。边缘吩吩嗪可以是以下通式的化合物：其中：R 1选自氢原子，卤素原子，烷基，烷氧基和三氟甲基，R 2选自氢或卤素原子，R 3选自氢原子，烷基，取代的烷基，环烷基，环烷基烷基，未取代的杂环基，取代的杂环基，未取代的杂环烷基和取代的杂环烷基。

3. 发明授权

US08445452B2 Fulvic acid and antibiotic combination 有权
标题翻译：氟酸和抗生素组合
公开(公告)号：US08445452B2
公开(公告)日：2013-05-21
申请号：US12996480
申请日：2009-06-04
申请人： Antonio Celestino Fernandes , Constance Elizabeth Medlen , Stephen Leivers
发明人： Antonio Celestino Fernandes , Constance Elizabeth Medlen , Stephen Leivers
IPC分类号： A61K31/70 , A61K31/35 , A61K31/215
CPC分类号： A61K31/366 , A61K31/352 , A61K31/431 , A61K31/7036 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： This invention relates to a fulvic acid and antibiotic combination for use in the treatment of various diseases and conditions. The invention further relates to the use of the combination for the treatment of various diseases and conditions, including bacterial infection. In particular, the bacteria are antibiotic resistant bacteria.
摘要翻译：本发明涉及用于治疗各种疾病和病症的富里酸和抗生素组合物。本发明还涉及该组合用于治疗各种疾病和病症（包括细菌感染）的用途。特别地，细菌是抗生素抗性细菌。

4. 发明授权

US06569900B1 Fulvic acid and its use in the treatment of various conditions 有权
标题翻译：氟酸及其在治疗各种病症中的应用
公开(公告)号：US06569900B1
公开(公告)日：2003-05-27
申请号：US09807004
申请日：2001-07-09
申请人： Johannes Dekker , Constance Elizabeth Medlen
发明人： Johannes Dekker , Constance Elizabeth Medlen
IPC分类号： A01N3708
CPC分类号： A61K31/352 , Y02A50/473
摘要： Fulvic acid salts, esters or derivatives thereof in pharmaceutical preparations are effective for treating inflammation, acne, exzema or bacterial or fungal or viral infections. These pharmaceutical preparations may be given either orally or topically in the form of a solution, paste, ointment, powder to humans or animals.
摘要翻译：药物制剂中的呋喃酸盐，酯或其衍生物对于治疗炎症，痤疮，湿疹或细菌或真菌或病毒感染是有效的。这些药物制剂可以口服或局部给予溶液，糊剂，软膏，粉末给人或动物的形式。

5. 发明授权

US06630179B1 Oxihumic acid and its use in the treatment of various conditions 失效
标题翻译：氧化辛酸及其在治疗各种病症中的应用
公开(公告)号：US06630179B1
公开(公告)日：2003-10-07
申请号：US09787876
申请日：2001-06-20
申请人： Johannes Dekker , Constance Elizabeth Medlen
发明人： Johannes Dekker , Constance Elizabeth Medlen
IPC分类号： A61K3578
CPC分类号： A61K35/10 , Y10S514/885
摘要： A pharmaceutical composition comprising an oxihumic acid, salt, ester, or derivative thereof as an active ingredient is disclosed. The composition is preferably administered only for stimulating lymphocytes in a human, animal, or bird. It may be used in treating viral and bacterial infections, HIV infections, opportunistic diseases, inflammation, pain and fever, cancer growth, and diseases associated with viral infection and a depressed immune system.
摘要翻译：公开了一种药物组合物，其包含作为有效成分的氧化辛酸，其盐，酯或衍生物。组合物优选仅用于刺激人，动物或鸟类中的淋巴细胞。它可用于治疗病毒和细菌感染，HIV感染，机会性疾病，炎症，疼痛和发烧，癌症生长以及与病毒感染和免疫系统相关的疾病。

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