专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5753233A Seroreactive epitopes on proteins of human papilloma-virus (HPV) 18 失效
标题翻译：人乳头状瘤病毒（HPV）蛋白质上的血清反应性表位18
公开(公告)号：US5753233A
公开(公告)日：1998-05-19
申请号：US466285
申请日：1995-06-06
申请人： Conrad Bleul , Lutz Gissmann , Martin Muller
发明人： Conrad Bleul , Lutz Gissmann , Martin Muller
IPC分类号： A61K39/00 , C07K14/025 , A61K39/12 , C12Q1/70 , G01N33/53
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/20022
摘要： The invention relates to seroreactive epitopes on proteins of human papillomavirus HPV18. In addition, the invention relates to peptides which have amino-acid sequences which coincide in whole or in part with the sequences of the seroreactive epitopes, and to vaccines which contain such peptides.
摘要翻译：本发明涉及人乳头状瘤病毒HPV18蛋白质上的血清反应性表位。此外，本发明涉及具有全部或部分与血清反应性表位的序列重合的氨基酸序列的肽以及含有这些肽的疫苗。

2. 发明授权

US07371391B2 Papilloma virus capsomere vaccine formulations and methods of use 失效
标题翻译：乳头状瘤病毒疫苗的配方及使用方法
公开(公告)号：US07371391B2
公开(公告)日：2008-05-13
申请号：US11358285
申请日：2006-02-21
申请人： Lutz Gissmann , Martin Muller
发明人： Lutz Gissmann , Martin Muller
IPC分类号： A61K39/12
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C12N2710/20022 , C12N2710/20023 , Y10S977/802 , Y10S977/917
摘要： Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
摘要翻译：公开了包含病毒壳聚糖的疫苗制剂及其制备方法。还公开了用于疫苗制剂的治疗和预防方法。

3. 发明申请

US20060198853A1 Papilloma virus capsomere vaccine formulations and methods of use 失效
公开(公告)号：US20060198853A1
公开(公告)日：2006-09-07
申请号：US11358285
申请日：2006-02-21
申请人： Lutz Gissmann , Martin Muller
发明人： Lutz Gissmann , Martin Muller
IPC分类号： C12Q1/70 , A61K39/12
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C12N2710/20022 , C12N2710/20023 , Y10S977/802 , Y10S977/917
摘要： Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.

4. 发明授权

US5629161A Use of HVP-16 E6 and E7-gene derived peptides to diagnose HPV-16-associated invasive cervical cancer 失效
标题翻译：使用HVP-16 E6和E7基因衍生的肽来诊断HPV-16相关浸润性宫颈癌
公开(公告)号：US5629161A
公开(公告)日：1997-05-13
申请号：US363586
申请日：1994-12-23
申请人： Martin Muller , Lutz Gissmann
发明人： Martin Muller , Lutz Gissmann
IPC分类号： A61K39/395 , A61K39/42 , A61K47/48 , C07K14/01 , C07K14/025 , C07K16/00 , C07K16/08 , C12N15/09 , C12N15/34 , C12P21/08 , G01N33/53 , G01N33/569 , G01N33/571 , G01N33/574 , C07K16/44
CPC分类号： C07K14/005 , C07K16/084 , C12N2710/20022
摘要： The present invention relates to the use of human paillomavirus 16 (HPV-16) E7-gene derived peptides for the diagnostic identification of HPV-16-associated invasive cervical cancer.
摘要翻译：本发明涉及人类白斑病毒16（HPV-16）E7基因衍生肽用于HPV-16相关浸润性宫颈癌的诊断鉴定的用途。

5. 发明申请

US20120115207A1 ENHANCED PRODUCTION OF PAPILLOMAVIRUS-LIKE PARTICLES WITH A MODIFIED BACULOVIRUS EXPRESSION SYSTEM 审中-公开
标题翻译：用改良的巴氏杆菌表达系统增强具有类似芽胞杆菌的颗粒的生产
公开(公告)号：US20120115207A1
公开(公告)日：2012-05-10
申请号：US13257248
申请日：2010-03-30
申请人： Tilo Senger , Martin Muller , Lutz Gissmann
发明人： Tilo Senger , Martin Muller , Lutz Gissmann
IPC分类号： C12N7/02 , C12N15/85 , C12N5/10
CPC分类号： C12N15/86 , A61K39/00 , A61K2039/5258 , C12N7/00 , C12N2710/14143 , C12N2710/20023
摘要： The present invention is concerned with the provision of a method for manufacturing papillomavirus like particles (PV-VLP), comprising the steps of a) culturing a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises at least one polynucleotide encoding a PV L1 polypeptide, and b) obtaining VLPs from the host cell. Also proposed is a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises a polynucleotide encoding at least one PV L1 polypeptide. Furthermore, a method for the manufacture of a pharmaceutical composition for the treatment or prevention of PV-related disease comprising the steps of manufacturing PV-VLPs and the further step of formulating the VLPs as a pharmaceutical composition is proposed as well as an expression vector comprising at least one polynucleotide encoding a PV L1 polypeptide but lacking a functional gene for a v-cath protease.
摘要翻译：本发明涉及制备乳头瘤病毒样颗粒（PV-VLP）的方法，其包括以下步骤：a）培养缺乏蛋白酶活性的宿主细胞并包含表达载体，其中所述表达载体包含至少一种多核苷酸编码PV L1多肽，和b）从宿主细胞获得VLP。还提出了缺乏蛋白酶活性并包含表达载体的宿主细胞，其中所述表达载体包含编码至少一种PV L1多肽的多核苷酸。此外，提出了制备用于治疗或预防PV相关疾病的药物组合物的方法，其包括制备PV-VLP的步骤和配制作为药物组合物的VLP的进一步步骤以及包含编码PV L1多肽的至少一种多核苷酸，但缺乏v-cath蛋白酶的功能基因。

6. 发明授权

US07416732B2 Papilloma virus-like particles, fusion proteins as well as processes for their production 失效
标题翻译：乳头瘤病毒样颗粒，融合蛋白以及其生产过程
公开(公告)号：US07416732B2
公开(公告)日：2008-08-26
申请号：US11358474
申请日：2006-02-21
申请人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
发明人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
摘要翻译：本发明涉及适合作为治疗和预防性接种疫苗的蛋白质以及VLP的重组生产。本发明还涉及生产和纯化重组乳头状瘤病毒蛋白和融合蛋白的方法。

7. 发明申请

US20110015376A1 Papilloma Virus-Like Particles, Fusion Proteins as Well as Processes for Their Production 审中-公开
标题翻译：乳头状病毒样颗粒，融合蛋白以及其生产过程
公开(公告)号：US20110015376A1
公开(公告)日：2011-01-20
申请号：US12197591
申请日：2008-08-25
申请人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
发明人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
IPC分类号： C07K14/025
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
摘要翻译：本发明涉及适合作为治疗和预防性接种疫苗的蛋白质以及VLP的重组生产。本发明还涉及生产和纯化重组乳头状瘤病毒蛋白和融合蛋白的方法。

8. 发明申请

US20090028894A1 Papilloma Virus Capsomere Vaccine Formulations and Methods of Use 失效
标题翻译：乳头状瘤病毒Capsomere疫苗配方及使用方法
公开(公告)号：US20090028894A1
公开(公告)日：2009-01-29
申请号：US12105013
申请日：2008-04-17
申请人： Lutz Gissmann , Martin Muller
发明人： Lutz Gissmann , Martin Muller
IPC分类号： A61K39/12 , A61P31/12
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C12N2710/20022 , C12N2710/20023 , Y10S977/802 , Y10S977/917
摘要： Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
摘要翻译：公开了包含病毒壳聚糖的疫苗制剂及其制备方法。还公开了用于疫苗制剂的治疗和预防方法。

9. 发明申请

US20060153864A1 Papilloma virus-like particles, fusion proteins as well as processes for their production 失效
公开(公告)号：US20060153864A1
公开(公告)日：2006-07-13
申请号：US11358474
申请日：2006-02-21
申请人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
发明人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
IPC分类号： A61K39/12 , C12N7/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.

10. 发明申请

US20050026257A1 Production and applications for polyvalent vaccines against diseases caused by papilloma viruses 失效
标题翻译：针对乳头瘤病毒引起的疾病的多价疫苗的生产和应用
公开(公告)号：US20050026257A1
公开(公告)日：2005-02-03
申请号：US10778936
申请日：2004-02-13
申请人： Lutz Gissmann , Kai Pohlmeyer , Martin Muller
发明人： Lutz Gissmann , Kai Pohlmeyer , Martin Muller
IPC分类号： A61K39/12 , A61K39/295 , C07K16/08 , C12P21/04 , C12N15/86
CPC分类号： C07K16/084 , A61K39/12 , C12N2710/20034
摘要： A vaccine against disease caused by papilloma viruses is described in certain embodiments, as well as certain vectors, obtainable by the following methods: (a) one or more expression vectors that contain the DNA code for a structural protein of papilloma viruses or a fragment thereof are injected into mammals, whereby in at least some of the expression vectors randomly generated heterologous sequences are inserted into the DNA code (b) serums are obtained from the mammals and these are tested for the presence of antibodies against particles of various papilloma virus types, and (c) using the serums tested, the structural protein gene clones are identified that code for a polyvalent vaccine, and (d) the vaccine is produced from them. Procedures for producing a vaccine is also described, together with its use for vaccination against diseases caused by papilloma viruses.
摘要翻译：在某些实施方案中描述了针对由乳头瘤病毒引起的疾病的疫苗，以及可通过以下方法获得的某些载体：（a）含有乳头状瘤病毒或其片段的结构蛋白的DNA编码的一种或多种表达载体注射到哺乳动物中，由此在至少一些表达载体中随机产生的异源序列插入到DNA代码（b）中，从哺乳动物获得血清，并测试这些血清是否存在针对各种乳头状瘤病毒类型的颗粒的抗体，和（c）使用测试的血清，鉴定编码多价疫苗的结构蛋白质基因克隆，和（d）从它们产生疫苗。还描述了生产疫苗的程序，以及其用于针对由乳头瘤病毒引起的疾病的疫苗接种的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式