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1. 发明授权

US06998124B1 Erythropoietin receptor antibodies 失效
标题翻译：红细胞生成素受体抗体
公开(公告)号：US06998124B1
公开(公告)日：2006-02-14
申请号：US09958620
申请日：2000-04-14
申请人： Connie L. Erickson-Miller , Stephen D. Holmes , Alexander H. Taylor , Peter R. Young
发明人： Connie L. Erickson-Miller , Stephen D. Holmes , Alexander H. Taylor , Peter R. Young
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/74 , C07K2317/75 , C07K2317/92 , C07K2319/30
摘要： Erythropoietin receptor agonist and antagonist antibodies and their use in enhancing erythropoiesis are disclosed.
摘要翻译：公开了红细胞生成素受体激动剂和拮抗剂抗体及其在增强红细胞生成中的用途。

2. 发明申请

US20130281399A1 TREATMENT OF DISEASES BY EPIGENETIC REGULATION 审中-公开
标题翻译：通过细菌调节治疗疾病
公开(公告)号：US20130281399A1
公开(公告)日：2013-10-24
申请号：US13832970
申请日：2013-03-15
申请人： Kevin G. McLure , Peter R. Young
发明人： Kevin G. McLure , Peter R. Young
IPC分类号： C07D239/91 , C07D401/10 , C07D403/10 , C07D401/04 , A61K31/519 , C07D471/04 , C07D401/12 , C07D409/12 , C07D403/12 , A61K31/551 , C07D401/14 , A61K31/55 , A61K45/06 , C07D403/04 , A61K31/517
CPC分类号： C07D239/91 , A61K31/517 , A61K31/519 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D409/12 , C07D471/04
摘要： The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.
摘要翻译：本公开提供了抑制溴结构域和额外末端结构域（BET）蛋白质的非天然存在的多酚化合物。所公开的组合物和方法可用于治疗和预防易于施用BET抑制剂的疾病或病症。

3. 发明授权

US5885800A DNA encoding tumor necrosis related receptor, TR4 失效
标题翻译： DNA编码肿瘤坏死因子受体TR4
公开(公告)号：US5885800A
公开(公告)日：1999-03-23
申请号：US794796
申请日：1997-02-04
申请人： John Emery , KB Tan , Alemseged Truneh , Peter R. Young
发明人： John Emery , KB Tan , Alemseged Truneh , Peter R. Young
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P1/00 , A61P9/10 , A61P11/00 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , C07K14/705 , C07K14/715 , C12N15/09 , C12P21/02 , C12N1/00 , C12N15/00
CPC分类号： C07K14/70578 , A61K39/00
摘要： TR4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR4 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (eg inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer (eg lymphoproliferative disorders), atheroschlerosis, and Alzheimers disease among others, and diagnostic assays for such conditions.
摘要翻译：公开了TR4多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了在设计用于治疗慢性和急性炎症，关节炎，败血症，自身免疫性疾病（例如炎性肠病，牛皮癣），移植排斥，移植物抗宿主病，感染等的方案中使用TR4多肽和多核苷酸的方法，中风，局部缺血，急性呼吸系统疾病综合征，再狭窄，脑损伤，艾滋病，骨病，癌症（如淋巴增生性疾病），动脉粥样硬化和阿尔茨海默病等，以及这些病症的诊断测定。

4. 发明授权

US5783664A Cytokine suppressive anit-inflammatory drug binding proteins 失效
标题翻译：细胞因子抑制性抗炎药物结合蛋白
公开(公告)号：US5783664A
公开(公告)日：1998-07-21
申请号：US250975
申请日：1994-05-31
申请人： John C. Lee , Jerry L. Adams , Timothy F. Gallagher , David W. Green , John Richard Heys , Peter C. McDonnell , Dean E. McNulty , James E. Strickler , Peter R. Young
发明人： John C. Lee , Jerry L. Adams , Timothy F. Gallagher , David W. Green , John Richard Heys , Peter C. McDonnell , Dean E. McNulty , James E. Strickler , Peter R. Young
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N9/12 , C12N15/54 , C12Q1/00 , C07K14/435 , C12N15/12
CPC分类号： C12N9/12 , C07K14/47 , C07K14/705 , A61K38/00
摘要： This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
摘要翻译：本发明涉及药物结合蛋白，与编码该基因的基因以及用于筛选药物的测定和方法。更具体地，本发明涉及细胞因子抑制性抗炎药（CSAID）结合蛋白，涉及编码该基因的基因以及可用于该药理学类药物的评估和表征的测定和筛选。

5. 发明申请

US20130281396A1 TREATMENT OF DISEASES BY EPIGENETIC REGULATION 审中-公开
标题翻译：通过细菌调节治疗疾病
公开(公告)号：US20130281396A1
公开(公告)日：2013-10-24
申请号：US13832437
申请日：2013-03-15
申请人： Kevin G. McLure , Peter R. Young
发明人： Kevin G. McLure , Peter R. Young
IPC分类号： C07D491/052 , A61K45/06 , A61K31/436
CPC分类号： C07D491/052 , A61K31/436 , A61K31/4985 , A61K31/52 , A61K45/06 , A61K2300/00
摘要： The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of cancer as well as sepsis, including NUT midline carcinoma, Burkitt's Lymphoma, Acute Myelogenous Leukemia, and Multiple Myeloma.
摘要翻译：本公开提供了抑制溴结构域和额外末端结构域（BET）蛋白质的非天然存在的多酚化合物。所公开的组合物和方法可用于治疗和预防癌症以及败血症，包括NUT中线癌，伯基特淋巴瘤，急性骨髓性白血病和多发性骨髓瘤。

6. 发明授权

US06346388B1 Method of identifying agonist and antagonists for tumor necrosis related receptors TR1 and TR2 失效
公开(公告)号：US06346388B1
公开(公告)日：2002-02-12
申请号：US09072993
申请日：1998-05-06
申请人： Michael R. Brigham-Burke , Peter R. Young
发明人： Michael R. Brigham-Burke , Peter R. Young
IPC分类号： G01N3353
CPC分类号： G01N33/6863 , G01N2333/525 , G01N2333/715 , Y10S530/81 , Y10S530/812
摘要： The present invention relates to tumor necrosis factor receptor (TNF-R) related polypeptides and their ligands, hereinafter referred to as TR1, TR2, TL2 and TL4. The invention relates to methods to identify agonists and antagonists of TR1, TR2, TL2 and TL4.

7. 发明授权

US06313269B1 Tumor necrosis factor related receptor, TR6 失效
标题翻译：肿瘤坏死因子相关受体TR6
公开(公告)号：US06313269B1
公开(公告)日：2001-11-06
申请号：US09333593
申请日：1999-06-15
申请人： Keith C. Deen , Peter R. Young , Lisa A. Marshall , Amy K. Roshak , Kong B. Tan , Alemseged Truneh
发明人： Keith C. Deen , Peter R. Young , Lisa A. Marshall , Amy K. Roshak , Kong B. Tan , Alemseged Truneh
IPC分类号： C07K14715
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/7151 , C07K2319/00 , C07K2319/30
摘要： TR6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR6 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e.g. inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer, atheroschlerosis, and Alzheimers disease, among others and diagnostic assays for such conditions.
摘要翻译：公开了TR6多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了在设计用于治疗慢性和急性炎症，关节炎，败血症，自身免疫性疾病（例如炎性肠病，牛皮癣），移植排斥，移植物抗宿主病，感染等的方案中使用TR6多肽和多核苷酸的方法，中风，局部缺血，急性呼吸系统疾病综合征，再狭窄，脑损伤，艾滋病，骨病，癌症，动脉粥样硬化，阿尔茨海默病等。

8. 发明申请

US20130281398A1 TREATMENT OF DISEASES BY EPIGENETIC REGULATION 审中-公开
公开(公告)号：US20130281398A1
公开(公告)日：2013-10-24
申请号：US13832625
申请日：2013-03-15
申请人： Kevin G. McLure , Peter R. Young
发明人： Kevin G. McLure , Peter R. Young
IPC分类号： C07D239/91 , A61K31/519 , A61K45/06 , C07D401/12 , C07D403/04 , C07D405/12 , C07D403/12 , C07D413/12 , A61K31/472 , C07D217/24 , A61K31/517 , C07D471/04
CPC分类号： C07D239/91 , A61K31/472 , A61K31/517 , A61K31/519 , A61K45/06 , C07D217/24 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.

9. 发明授权

US06297359B1 Protein phosphatase 1 binding protein, R5 失效
标题翻译：蛋白磷酸酶1结合蛋白，R5
公开(公告)号：US06297359B1
公开(公告)日：2001-10-02
申请号：US09480203
申请日：2000-01-10
申请人： Peter R. Young , Patricia T. W. Cohen , Phillip Cohen
发明人： Peter R. Young , Patricia T. W. Cohen , Phillip Cohen
IPC分类号： C07K1400
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/16
摘要： Human PPP1R5 polypeptides and DNA (RNA) encoding such PPP1R5 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such PPP1R5, or compounds which inhibit or stimulate PPP1R5 for dysfunctions or diseases which involve resistance to the action of insulin on glycogen synthesis are also disclosed. Agonist and antagonists of these PPP1R5 proteins and methods of their use are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the PPP1R5 and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人PPP1R5多肽和编码这种PPP1R5的DNA（RNA）和通过重组技术产生这种多肽的方法。还公开了利用这种PPP1R5的方法，或者抑制或刺激PPP1R5作为功能障碍的化合物或涉及对糖原合成的胰岛素作用的抗性的疾病的方法。还公开了这些PPP1R5蛋白的激动剂和拮抗剂及其使用方法。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码PPP1R5的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

10. 发明授权

US6054559A Interleukin-1 receptor antagonist beta (IL-1ra.beta.) 失效
标题翻译：白细胞介素-1受体拮抗剂β（IL-1raβ）
公开(公告)号：US6054559A
公开(公告)日：2000-04-25
申请号：US69619
申请日：1998-04-29
申请人： Peter R. Young
发明人： Peter R. Young
IPC分类号： G01N33/50 , A61K38/00 , A61K38/28 , A61K45/00 , A61K48/00 , A61P11/02 , A61P11/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07K14/54 , C07K14/545 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/25 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/566 , G01N33/68 , C07K14/52
CPC分类号： G01N33/6869 , C07K14/54 , A61K38/00 , A61K48/00
摘要： IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, septicemia, arthritis, inflammatory bowel disease, graft vs. host disease, autoimmunity, stroke, cardiac ischemia, acute respiratory disease syndrome (ARDS), psoriasis, restenosis, traumatic brain injury, AIDS, cachexia, allergy, parasite infection, allergic rhinitis, allergic asthma, atopic dermatitis, allergic inflammatory diseases, and delayed hypersensitivity., among others, and diagnostic assays for such conditions.
摘要翻译：公开了通过重组技术制备这种多肽的IL-1raβ多肽和多核苷酸和方法。还公开了在设计用于治疗慢性和急性炎症，败血症，关节炎，炎症性肠病，移植物抗宿主病，自身免疫，中风，心脏缺血，急性呼吸系统的方案中利用IL-1raβ多肽和多核苷酸的方法疾病综合征（ARDS），牛皮癣，再狭窄，创伤性脑损伤，艾滋病，恶病质，过敏，寄生虫感染，过敏性鼻炎，过敏性哮喘，特应性皮炎，过敏性炎症疾病和迟发性超敏反应等。。

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